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World Journal of Gastroenterology 2008年第18期14卷 2894-2899页

作者： li li xin-yan Zhao Bao-En Wang liver Research Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China

AIM: To investigate the effect of herbal compound 861 (Cpd861) on the transforming growth factor-β1 (TGFβ1)/ activin receptor-like kinase 1 (ALK1, type Ⅰ receptor) signaling-pathway-related gene expression in the LX-2 cell line, and the inhibitory mechanism of Cpd861 on the activation of LX-2 cells. METHODS: LX-2 cells were treated with TGFβ1 (5 ng/mL) Cpd861 (0.1 mg/mL), TGFβ1 (5 ng/mL) plus Cpd861 (5 ng/mL) for 24 h to investigate the effect of Cpd861 on the TGFβ1/ALK1 pathway. Real-time PCR was performed to examine the expression of α-SMA (α-smooth muscle actin), ALK1, Id1 (inhibitor of differentiation 1). Western blotting was carried out to measure the levels of α-SMA and phosphorylated Smad1, and immunocytochemical analysis for the expression of α-SMA. RESULTS: In LX-2 cells, TGFβ1/ALK1-pathway-related gene expression could be stimulated by TGFβ1, which led to excessive activation of the cells. Cpd861 decreased the activation of LX-2 cells by reducing the expression of α-SMA mRNA and protein expression. This effect was related to inhibition of the above TGFβ1/ALK1-pathway- related expression of genes such as Id1 and ALK1, and phosphorylation of Smad1 in LX-2 cells, even with TGFβ1 co-treatment for 24 h. CONCLUSION: Cpd861 can restrain the activation of LX-2 cells by inhibiting the TGFβ1/ALK1/Smad1 pathway.

关键词： Herbal compound 861 LX-2 cell Activin receptor-like kinase 1 Inhibitor of differentiation 1 Smad1

On Characterization of Poisson Integrals of Schr?dinger Operators with Morrey Traces

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Acta Mathematica Sinica,English Series 2018年第4期34卷 787-800页

作者： liang SONG Xiao Xiao TIAN li xin yan Department of Mathematics Sun Yat-sen University

Let L be a Schrodinger operator of the form L = -△ ＋ V acting on L2（Rn） where the nonnegative potential V belongs to the reverse Holder class Bq for some q _〉 n. In this article we will show that a function f∈ L2,λ（Rn）, 0 〈λ 〈 n, is the trace of the solution of Lu = -utt ＋ Lu = O, u（x, 0） = f（x）, where u satisfies a Carleson type condition sup t-λB xB,rB∫τB 0∫B（xB,τB）t{ u（x,t）}2dxdt≤C〈∞.Its proof heavily relies on investigate the intrinsic relationship between the classical Morrey spaces and the new Campanato spaces .L2,λL（Rn） associated to the operator L, i.e. Conversely, this Carleson type condition characterizes all the L-harmonic functions whose traces belong to the space L2,λ（Rn） for all 0 〈λ〈 n.

关键词： SchrSdinger operators Dirichlet problem Morrey spaces Campanato spaces Poissonsemigroup

CH_4 Concentrations and Emissions from Three Rivers in the Chaohu Lake Watershed in Southeast China

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Journal of Integrative Agriculture 2012年第4期11卷 665-673页

作者： yanG li-biao li xin-yan yan Wei-jin MA Pei WANG Jia-ning Institute of Geographical Science and Natural Resources Research Chinese Academy of Sciences Beijing 100101 P.R.China Graduate University Chinese Academy of Sciences Beijing 100049 P.R. China

This study was conducted at three rivers of the Chaohu Lake watershed during the summer season of 2008,aiming to investigate the diurnal variations of dissolved CH4 concentrations and emissions,as well as the dynamics of CH4 accumulation emission rates over consecutive 72 *** results showed that CH4 concentrations in the Fengle,Hangbu,and Nanfei rivers ranged from 56.33-124.79,160.82-341.03,and 213.49-716.81 nmol L-1,respectively,over a daily cycle;while the saturation of CH4 ranged from 188.72-418.07,538.74-1 142.46,and 715.23-2 401.38%,respectively,which indicated that surface waters were in all cases oversaturated with respect to the *** obvious diurnal variation pattern of the dissolved CH4 concentrations demonstrated a higher value during daytime but a lower value for night ***,the highest dissolved CH4 concentrations were detected in the Nanfei River which received substantial urban wastewater ***4 emissions measured with floating chambers ranged from 5.82-15.46,5.77-8.41,and 13.51-49.25 mg C m-2 h-1 for the Fengle,Hangbu,and Nanfei rivers,respectively,over a daily *** higher CH4 emissions were also observed from the Nanfei *** accumulative CH4 emissions for each river increased with time,while a decline trend on the accumulation rates was investigated over the consecutive 72 h.

关键词： methane concentration emission river diurnal variation

Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion

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World Journal of Gastroenterology 2009年第17期15卷 2145-2150页

作者： Jing Zhao Xiang-Dong Luo Chun-li Da yan xin The Fourth Laboratory of Cancer Institute Department of Tumor Pathology of General Surgery Institute First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous ***： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.

关键词： B-cell-specific Moloney murine leukemiavirus insertion site 1 Gastric carcinoma Precancerouslesion Cell proliferation Apoptosis

Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions

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World Journal of Gastroenterology 2009年第32期15卷 4055-4061页

作者： Chun-li Da yan xin Jing Zhao Xiang-Dong Luo The Fourth Laboratory of Cancer Institute Department of Tumor Pathology of General Surgery Institute the First Hospital of China Medical University Shenyang 11000 1 Liaoning Province China

AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous ***: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric ***: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P<0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P<0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk=0.279, P<0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P<0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was signifi cantly higher than that in the group without lymph node metastasis (41.2%), P<0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk=0.246, P<***: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.

关键词： Apoptosis Cell proliferation Gastric cancer Immunohistochemistry Neoplastic processes Survivinprotein Yes-associated protein

Square-Preserving and Symplectic Structure and Scheme for Quantum Sysyem

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Chinese Physics Letters 1996年第4期13卷 245-248页

作者： DING Pei-zhu WU Cheng-xun MU Ying-kui li yan-xin JIN Ming-xing Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130023 Department of Physics Jilin UniversityChangchun 130023 Changchun Finance Manager College Changchun 130031

The time-dependent Schrodinger equation is a square-preserving and symplectic(SPS)*** canonical'equations of quantum systems are deduced by using eigenfanction *** normal-square of wavefunction of the quantum systems is an invariant integral of the canonical equations and then the symplectic schemes that based on both Cayley transformation and diagonal Fade approximation to exp(x)are also sq *** evaluated example show that the SPS approach is reasonable and effective for solving time-evolution of quantum system.

关键词： expansion. preserving quantum

Laser-RF synchronization based on digital phase detector

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Nuclear Science and Techniques 2017年第4期28卷 97-102页

作者： Jin yang Ying-Chao Du li-xin yan Gang Huang Qiang Du Yi-Lun Xu Wen-Hui Huang Huai-Bi Chen Department of Engineering Physics Tsinghua UniversityBeijing 100084 China Key Laboratory of Particle and Radiation Imaging (Tsinghua University) Ministry of Education Beijing 100084 China Lawrence Berkeley National Laboratory BerkeleyCA 94720 USA

Laser oscillator synchronization with RF reference signal is ultra-important for a modern light source based on the *** Tsinghua Thomson scattering X-ray source,we have synchronized the mode-locked laser oscillator to RF reference signal with 48.2 fs RMS relative *** fundamental and harmonic signals derived from photo diode detection are used for laser-RF synchronization in our *** fundamental signal is for coarse laser-RF synchronization and multiple laser oscillator *** harmonic signal is for high precise phase *** digital phase detector is implemented in the synchronization scheme for less noise,replacing the mixing to DC phase detection *** digital processing algorithm for synchronization is commonly used in low-level RF control *** order to test the phase locking loop logic without damaging the real laser oscillator,a laser oscillator emulator was developed for phase *** paper will report the laser-RF synchronization scheme and its *** laser oscillator emulator system will also be introduced here.

关键词： Laser oscillator Synchronization RF LLRF Emulator

Effects of heat treatment on magnetic properties of Co-Fe-plated hollow ceramic microspheres

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Progress in Natural Science:Materials International 2011年第5期21卷 392-400页

作者： Xiang li,Yue-xin DUAN,yan ZHAO,Lei ZHU School of Materials Science and Engineering,Beijing University of Aeronautics and Astronautics, Beijing 100191,China School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

Functional hollow ceramic microspheres plated with Co-Fe were obtained through electroless plating technique for the application of lightweight microwave *** were treated at different temperatures by vacuum annealing *** surface-coated hollow microspheres were characterized by scanning electron microscopy(SEM) and X-ray diffraction analysis (XRD).The microwave electromagnetic loss and absorbing properties of hollow microspheres plated with Co-Fe were tested by network vector *** magnetic properties were tested by vibrating sample magnetometer(VSM).The results show that the annealing treatment changed the crystal phase of Co from HCP to FCC,simultaneously increased the crystallinity and crystal size of Co and Fe in coating ***,after annealing at 800℃or 1 000℃,the microwave absorbing properties and soft magnetic properties of hollow microspheres plated with Co-Fe were further improved.

关键词： electroless plating hollow ceramic microspheres magnetic properties heat treatment Co-Fe

Finesse measurement for high-power optical enhancement cavity

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Chinese Physics B 2024年第1期33卷 414-421页

作者：陆心怡柳兴田其立王焕汪嘉俊颜立新 Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging Ministry of EducationBeijing 100084China

Finesse is a critical parameter for describing the characteristics of an optical enhancement cavity(OEC). This paper first presents a review of finesse measurement techniques, including a comparative analysis of the advantages, disadvantages, and potential limitations of several main methods from both theoretical and practical perspectives. A variant of the existing method called the free spectral range(FSR) modulation method is proposed and compared with three other finesse measurement methods, i.e., the fast-switching cavity ring-down(CRD) method, the rapidly swept-frequency(SF) CRD method, and the ringing effect method. A high-power OEC platform with a high finesse of approximately 16000 is built and measured with the four methods. The performance of these methods is compared, and the results show that the FSR modulation method and the fast-switching CRD method are more suitable and accurate than the other two methods for high-finesse OEC measurements. The CRD method and the ringing effect method can be implemented in open loop using simple equipment and are easy to perform. Additionally, recommendations for selecting finesse measurement methods under different conditions are proposed, which benefit the development of OEC and its applications.

关键词： optical enhancement cavity finesse measurement cavity ring-down ringing effect

Effects of insulin-like growth factor binding protein-related protein 1 in mice with hepatic fibrosis induced by thioacetamide

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Chinese Medical Journal 2010年第18期123卷 2521-2526页

作者： liU li-xin ZHANG Hai-yan ZHANG Qian-qian GUO Xiao-hong Experimental Center of Science and Research of the First Teaching Hospital of Shanxi Medical University Institute of liver Disease and Key Laboratory of Cell Physiology Provincial Department of the Ministry of Education of Shanxi Medical University Taiyuan Shanxi 030001 China

Background Insulin-like growth factor binding protein-related protein 1 （IGFBPrP1） can activate hepatic stellate cells and increase extracellular matrix （ECM） in vitro. However, the effects of IGFBPrP1 in mice with hepatic fibrosis, and the mechanisms of these effects, are currently unknown. We aim to address these issues in this study. Methods Intraperitoneal injection of thioacetamide （TAA） is a classic method for establishing a mouse model of hepatic fibrosis. Using this model, we administered anti-IGFBPrP1 antibody, again via intraperitoneal injection. The morphological changes of liver fibrosis were observed with both HE and Masson stainning. The immunohistochemical assays and Western blotting were used to measure changes in IGFBPrP1, a-smooth muscle actin （a-SMA） and ECM in liver tissues, and the expression of transforming growth factor-β1 （TGF-β1） and Smad3. Data were statistically analyzed using one-way analysis of variance （ANOVA）, the SNK-q test for inter-group differences. Results The Masson staining analysis showed that compared with normal control group, content of collagen fiber in TAA5w group was significantly increased （P 〈0.01）, and it was significantly decreased in TAA5w/alGFBPrP1 group compared with in TAA5w group （P 〈0.01）. The expression of hepatic IGFBPrP1, a-SMA, TGF-β1, Smad3, collagen 1 and fibronectin （FN） was significantly up-regulated in the TAA5w group （P 〈0.01）. Anti-IGFBPrP1 treatment reversed these changes （P 〈0.01）. Conclusions IGFBPrP1 plays an important role in the development of hepatic fibrosis. Anti-IGFBPrP1 prevents fibrosis in mice by suppressing the activation of hepatic stellate cells, inhibiting the synthesis of major components of the ECM （namely, collagen I and FN）. The mechanism for this suppression of fibrosis is associated with the TGF-β1/Smad3 signaling pathways.

关键词： insulin-like growth factor binding protein-related protein 1 hepatic fibrosis extracellular matrix Smad3 protein transforming growth factor beta 1