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Impaired implicit emotion regulation in patients with panic disorder:An event-related potential study on affect labeling

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World Journal of Psychiatry 2024年第2期14卷 234-244页

作者： Hai-Yang Wang li-zhu li Yi Chang Xiao-Mei Pang Bing-Wei Zhang Department of Neurology Jining No.1 People's HospitalShandong First Medical UniversityJining 272000Shandong ProvinceChina Department of Neurology and Psychiatry First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neurology Sixth Peoples'Hospital of ShenyangShenyang 110003Liaoning ProvinceChina

BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly *** research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom ***,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological *** To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical *** study utilized a case-control design with random sampling,selecting participants for the case group from March to December *** performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control *** and behavioral data were recorded to compare the late positive potential(LPP)within and between the *** Both PD and HC groups showed longer reaction times and decreased accuracy under the affect *** the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by ***,a significant group×condition interaction effect was *** effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC ***,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and *** PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative *** late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.

关键词： Panic disorder Implicit Emotion regulation Affect labeling Late positive potential

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Electrochemical behavior of different shelled microcapsule composite copper coatings

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International Journal of Minerals,Metallurgy and Materials 2011年第3期18卷 377-384页

作者： Xiu-qing Xu Yan-hong Guo Wei-ping li li-qun zhu School of Materials Science and Engineering Beihang University Beijing 100191 China

Copper/liquid microcapsule composite coatings with polyvinyl alcohol （PVA）, gelatin or methyl cellulose （MC） as shell materials were prepared by electrodeposition. The influence of shell materials on the corrosion resistance of the composite coatings in 0.1 M H2SO4 was investigated by means of electrochemical techniques, scanning electron microscopy （SEM）, and energy dispersion spectrometry （EDS）. The results show that the participation of microcapsules can enhance the corrosion resistance of the composite coatings compared with the traditional copper layer. Based on the analysis of electrochemical test results, the release ways of microcapsules were deduced. Gelatin and MC as the shell materials of microcapsules are easy to release quickly in the composite coating. On the contrary, the releasing speed of PVA microcapsules is relatively slow due to their characteristics.

关键词： composite coatings shell materials copper microcapsules electrochemical properties corrosion resistance electrodeposition

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Synthesis and Antitumor Activity of 2-[1-(2-Formylamido-3-phenylpropionyloxy)alkyl]-1,4dihydroxy-9,10-anthraquinone Derivatives

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Chemical Research in Chinese Universities 2012年第6期28卷 971-975页

作者： J1N li-li JIN Guang-zhu College of Pharmacy Yanbian University Yanji 133002 P. R. China

A series of 2-[1-（2-formylamido-3-phenylpropionyloxy）alkyl]-1,4-dihydroxy-9,10-anthraquinone（2FPADHAQ） derivatives was designed and *** antitumor activities were tested against L1210 tumor cells and P388 mouse leukemic tumor cells in vitro and in ICR mice bearing sarcoma 180 cells in ***,the introduction of 2-formylamido-3-phenyl-propanoic acid（2-FPPA） into the C-2-alkyl side chain C＇-1 hydroxy group in 2-（1-hydroxyalkyl）-1,4-dihydroxy-9,10-anthraquinones（2-HDHAQ） enhanced the antitumor activity compared with the starting materials.2-FPADHAQ with alkyl chains longer than the pentyl group had negligible activity,whereas compounds 2b,2c,2d and 2e possessing shorter chains demonstrated moderate cytotoxic activity[50% effective dose（ED 50） of L1210 and P388 are 2.61―4.75 and 5.84―8.74 μg/mL],whereas compound 2l with an aromatic system showed strong cytotoxic activity.T/C（%） values[（average survival days in the test group）/（average survival days in the control group）×100%] also show that the introduction of 2-FPPA into the side chain of 2-HDHAQ enhanced antitumor *** data suggest that the introduction of an amino acid into the starting material may increase its affinity for DNA or its selectivity for proliferating cancer cells.

关键词： Anthraquinone Antitumor Cytotoxicity Phenylalanine

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Few-shot incremental radar target recognition framework based on scattering-topology properties

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Chinese Journal of Aeronautics 2024年第8期37卷 246-260页

作者： Chenxuan li Weigang zhu Bakun zhu Yonggang li Graduate School Space Engineering UniversityBeijing 101400China Department of Electronic and Optical Engineering Space Engineering UniversityBeijing 101400China

The continuous emergence of new targets in open scenarios leads to a substantial decrease in the performance of Inverse Synthetic Aperture Radar(ISAR)recognition ***,data scarcity further exacerbates the challenge of identifying new classes of ISAR *** this paper,a few-shot incremental target recognition framework based on Scattering-Topology Properties(STPIL)is ***,STPIL extracts scattering-topology properties of ISAR targets as recognition ***,the pseudo-incremental training strategy effectively alleviates the algorithm’s forgetting of old knowledge,and improves compatibility with new ***,a feature embedding network,with few parameters,is designed based on the graph neural *** embedding network is highly adaptable to changes in data ***,STPIL fully considers the joint distribution and marginal distribution in scattering features,and uses the Brownian distance metric module to make the scattering-topology features more *** results on both the simulation dataset and the public measured data indicate that STPIL can effectively balance new classes with old classes,and has superior performance to other advanced methods in the incremental recognition of targets.

关键词： Brownian distance metric Graph neural networks Incremental learning Inverse Synthetic Aperture Radar(ISAR) Scattering

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MicroRNA encoded by the HSV-1 latency-associated transcript anti-apoptotic function in human mesenchymal stem cells

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Chinese Science Bulletin 2008年第11期53卷 1691-1698页

作者： ZHANG Jing li YongMei DU WenCai li GuangMing li WeiXia zhu Ze Department of Medical Microbiolgy Tianjin Key Laboratory of Cellular and Molecular Immunology '13anjin Medical University Tianjin300070 China

Human mesenchymal stem cells (HMSCs) have emerged as a promising cell type for tissue repopulat-ing and for use as ex vivo gene delivery vehicles. Herpes simplex virus-1 (HSV-1) possesses many vector features, which make it especially suitable for HMSC applications. Here we performed real-time RT-PCR to detect the level of mature microRNA encoded by the HSV-1 latency-associated transcript (microRNA-LAT) in HMSCs cytoplasm with a specific stem loop reverse primer. Three small interfering RNAs (siRNAs) were chemically synthesized towards microRNA-LAT, TGF-β1 and SMAD3. The results demonstrate that HSV-1 and microRNA-LAT prevented HMSCs from undergoing cisplatin-induced apoptosis. In comparison with cells only treated with cisplatin, the apoptosis phenomenon with HSV-1 and microRNA-LAT were markedly reduced. The apoptosis rates of these two groups were both lower (Pling pathway components were by these means knocked down. Moreover, the levels of the mature microRNA-LAT were decreased in cis-platin-treated HMSCs. In conclusion, HSV-1 and microRNA-LAT exert their anti-apoptotic effect on HMSCs by down-regulation of the TGF-β signalling pathway. Thus HSV-1, having anti-apoptotic effect naturally encoded in its microRNA-LAT, is a good candidate to be developed for HMSC vector.

关键词：间叶细胞干细胞组织再生单纯疱疹病毒1 基因转录

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Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode *** this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery *** mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this *** leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/***,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami *** interaction of Al and F is advantageous to realize the defluoridation to some *** is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

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Characterization of Interspecific Hybrids Between Oryza sativa L, and Three Wild Rice Species of China by Genomic In Situ Hybridization

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Journal of Integrative Plant Biology 2006年第9期48卷 1077-1083页

作者： Guang-Xuan Tan Zhi-Yong Xiong Hua-Jun Jin Gang li li-li zhu li-Hui Shu Guang-Cun He Key Laboratory of the Ministry of Education for Plant Development Biology Wuhan University College of Life Sciences Wuhan 430072 China Zhoukou Normal University Zhoukou 466001 China

In the genus Oryza, interspecific hybrids are useful bridges for transferring the desired genes from wild species to cultivated rice （Oryza sativa L.）. In the present study, hybrids between O. sativa （AA genome） and three Chinese wild rices, namely O. rufipogon （AA genome）, O. officinalis （CC genome）, and O. meyeriana （GG genome）, were produced. Agricultural traits of the F1 hybrids surveyed were intermediate between their parents and appreciably resembled wild rice parents. Except for the O. sativa × O. rufipogon hybrid, the other F1 hybrids were completely sterile. Genomic in situ hybridization （GISH） was used for hybrid verification. Wild rice genomic DNAs were used as probes and cultivated rice DNA was used as a block. With the exception of O. rufipogon chromosomes, this method distinguished the other two wild rice and cultivated rice chromosomes at the stage of mitotic metaphase with different blocking ratios. The results suggest that a more distant phylogenetic relationship exists between O. meyeriana and O. sativa and that O. rufipogon and O. sativa share a high degree of sequence homology. The average mitotic chromosome length of O. officinalis and O. meyeriana was 1.25- and 1.51-fold that of O. sativa, respectively. 4＇,6＇-Diamidino- 2-phenylindole staining showed that the chromosomes of O. officinalis and O. meyeriana harbored more heterochromatin, suggesting that the C and G genomes were amplified with repetitive sequences compared with the A genome. Although chromocenters formed by chromatin compaction were detected with wild rice-specific signals corresponding to the C and G genomes in discrete domains of the F1 hybrid interphase nuclei, the size and number of O. meyeriana chromocenters were bigger and greater than those of O. officinalis. The present results provide an important understanding of the genomic relationships and a tool for the transfer of useful genes from three native wild rice species in China to cultivars.

关键词： Chinese wild rice species interspecific hybrids genomic in situ hybridization (GISH) Oryza sativa

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Electrical and magnetic properties of ZnNiO thin films deposited by pulse laser deposition

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第7期12卷 561-566页

作者： Jie JIANG Xue-tao WANG li-ping zhu li-qiang ZHANG Zhi-guo YANG Zhi-zhen YE State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China

ZnNiO thin films with different contents of Ni(0-10 at.%) were fabricated on quartz and Si(100) substrates by pulsed laser deposition(PLD).We measured the samples by X-ray diffraction(XRD),field-emission scanning electron microscope(FE-SEM),X-ray photoelectron spectroscopy(XPS),ultraviolet-visible spectrometer(UV-VIS),and Hall *** the Ni contents were below 3 at.%,partial Zn2+ ions were replaced by the Ni2+ ions without forming any other phases,which enhanced the conductivity of the *** the Ni contents were above 3 at.%,Ni ions were at the interstitial sites,and Ni-related clusters and defects were able to emerge in the films,resulting in a worsening of electrical and optical properties.A ferromagnetic hysteresis with a coercive force of approximately 30 Oe was observed in the ZnNiO film with a Ni content of 3 at.% at room temperature.

关键词： ZnNiO thin films Electric property Ferromagnetic Transmittance Pulsed laser deposition(PLD)

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Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst

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Cellular & Molecular Immunology 2015年第5期12卷 633-644页

作者： Jun Wang Qing Wang Tao Han Yong-Kui li Sheng-li zhu Fang Ao Jian Feng Ming-Zhen Jing li Wang lin-Bai Ye Ying zhu The State Key Laboratory of Virology College of Life Sciences Wuhan University Wuhan China

Influenza A virus （IAV） infection is a major worldwide public health problem. However, the factors involved in mediating the inflammatory response to this infection and their relationships remain poorly understood. Here, we show that IAV infection stimulates the expression of the soluble IL-6 receptor （slL-6R）, a multifunctional protein involved in IL-6 signaling. Interestingly, slL-6R expression upregulated the levels of its own ligand, IL-6 and those of the pro-inflammatory cytokine IL-32. shRNA-mediated knockdown of slL-6R suppressed I L-6 and IL-32, indicating that this regulation is dependent on slL-6R during IAV infection. Furthermore, our results demonstrate that IL-32 participates in a negative feedback loop that inhibits slL-6R while upregulating IL-6 expression during IAV infection. Therefore, we show that slL-6R is a critical cellular factor involved in the acute inflammatory response to viral infection.

关键词： IL-32 IL-6 inflammation network influenza A virus soluble IL-6 receptor

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Prenatal cadmium exposure impairs neural tube closure via inducing excessive apoptosis in neuroepithelium

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Journal of Environmental Sciences 2024年第4期138卷 572-584页

作者： Shiyong zhu Xuenan li Xueyan Dai Jinlong li College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin 150030China

Birth defects have become a public health *** hazardous environmental factors exposure to embryos could increase the risk of birth ***,a toxic environmental factor,can cross the placental barrier during *** woman may be subjected to cadmium before taking precautionary protective ***,the link between birth defects and cadmium remains *** exposure can induce excessive apoptosis in neuroepithelium during embryonic development *** exposure activated the p53 via enhancing the adenosine 5‘-monophosphate(AMP)-activated protein kinase(AMPK)and reactive oxygen species'(ROS)*** cadmium decreases the level of Paired box 3(Pax3)and murine double minute 2(Mdm2),disrupting the process of p53 *** p53 accumulation induced excessive apoptosis in neuroepithelium during embryonic development *** apoptosis led to the failure of neural tube *** study emphasizes that environmental materials may increase the health risk for *** caused the failure of neural tube closure during early embryotic *** women may be exposed by cadmium before taking precautionary protective actions,because of cadmium concentration-containing foods and environmental tobacco *** suggests that prenatal cadmium exposure is a threatening risk factor for birth defects.

关键词： Cadmium Neural tube closure Excessive apoptosis p53 Embryogenesis

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