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Synthesis and Structural Characterization of Manganese Carbonyl Incorporated Polyoxomolybdate (n-Bu_4N)_2[Mo_6O_(16)(OCH_3)_2{HOCH_2C(CH_2O)_3}_2{Mn(CO)_3}_2]

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Chemical Research in Chinese Universities 2008年第6期24卷 675-678页

作者： WANG jing-ping li ji-li NIU jing-yang Institute of Molecular and Crystal Engineering School of Chemistry and Chemical Engineering Henan University Kaifeng 475001 P R. China

The polyoxoanion incorporated {Mn（CO）3^＋} complex, （n-Bu4N）2[Mo6O16（OCH3）2{HOCH2C（CH2O）3}2·{Mn（CO）3}2]（1）, has been synthesized by the reaction of （n-Bu4N）4[Mo8O26] with Mn（CO）5Br in methanol, in the presence of C（CH2OH）4. The complex 1 has been characterized by IR, UV-Vis, X-ray single crystal diffraction, and TG. Crystal data for the complex 1：C25H48MnMo3NO16 （1）, Triclinic Pi, a=0.9405（3） nm, b=1.3351（4） nm, c=1.5455（4） nm, α=103.206（5）°, β=102.165（5）°, γ=100.784（5）°, V=1.7896（9） nm^3, Z=2, R1=0.0703, wR2= 0.1495. The structure analysis of complex 1 shows that the complex consists of two tetrabutylammonium cations and a polyoxomolybdate anion that incorporates two fac-Mn（CO）3^＋ units. The anion of complex 1 can be considered as the dimer of two rhomb-like anions by sharing of two comers.

关键词： Polyoxomolybdate Manganese Carbonyl

Avenanthramides attenuate inflammation and atrophy in muscle cells

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Journal of Sport and Health Science 2019年第2期8卷 189-195页

作者： Dongwook Yeo Chounghun Kang Tianou Zhang li li ji Laboratory of Physiological Hygiene and Exercise Science School of Kinesiology University of Minnesota-Twin Cities The Department of Physical Education Inha University

Background: Chronic inflammation is an important etiologic mechanism for muscle atrophy. Oat-derived phytochemical avenanthramides(AVAs) have been shown to suppress inflammatory responses in human clinical studies and in several cell lines in vitro, but their role in skeletal muscle is unclear. The aim of this study was to investigate whether AVA treatment can prevent tumor necrosis factor(TNF)-a-induced muscle fiber atrophy in C2 C12 ***: We treated 70% confluent cells for 24 h with AVA. Then, TNF-a was added to cell-cultured medium. Subsequently, cells were harvested at different time points. The cells were examined using various biochemical techniques for measuring protein, messenger RNA levels,nuclear binding activity, and viability. Fluorescence microscope was used for analysis of the myotube ***: Cells treated with TNF-a significantly increased nuclear factor k B activation, indicated by a marked decrease of Ik B(p lished in all AVA-treated cells. Reactive oxygen species production was1.3-fold higher in the TNF-a-treated group(p ligase atrogin-1 increased 23% in TNF-a vs. control(p lished by AVAs. Cells treated with TNF-a demonstrated a reduced prolifer

关键词： Atrogenes Interleukin NF-k B Skeletal muscle TNF-a

Effect of Mn Promoter on Structure and Performance of K-Co-Mo Catalyst for Synthesis of Higher Alcohols from CO Hydrogenation

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Chinese Journal of Chemical Physics 2016年第6期29卷 671-680,I0001页

作者： Wei Xie li-li ji ji-long Zhou Hai-bin Pan Jun-fa Zhu Yi Zhang Song Sun Jun Bao Chen Gao NationalSynchrotronRadiationLaboratory CollaborativeInnovationCenterofChemistryforEnergyMaterialsUniversityofScienceandTechnologyofChinaHefei230029China StateKeyLaboratoryofOrganic-InorganicComposites BellingUniversityofChemicalTechnologyBeijing100029China CASKeyLaboratoryofMaterialsforEnergyConversion DepartmentofMaterialsScienceandEngineeringUniversityofScienceandTechnologyofChinaHefei230025China

A series of Mn-doped K-Co-Mo catalysts were prepared by a sol-gel method. The catalyst structure was well characterized by X-ray diffraction, N2 physisorption, NH3 temperature- programmed adsorption, in situ diffuse reflectance infrared Fourier transform spectroscopy, and X-ray absorption fine structure spectroscopy. The catalytic performance for higher alcohol synthesis from syngas was measured. It was found that the Mn-doped catalysts ex- hibited a much higher activity as compared to the unpromoted catalyst, and in particular the C2＋ alcohol selectivity increased significantly. The distribution of alcohol products de- viated from the Anderson-Schulz-Flory law. The portion of methanol in total alcohol was suppressed remarkably and the ethanol became the predominant product. Characterization results indicated that the incorporation of Mn enhanced the interaction of Co and Mo and thus led to the formation of Co-Mo-O species, which was regarded as the active site for the alcohol synthesis. Secondly, the presence of Mn reduced the amount of strong acid sites significantly and meanwhile promoted the formation of weak acid sites, which had a positive effect on the synthesis of alcohol. Furthermore, it was found that the incorporation of Mn can enhance the adsorption of linear- and bridge-type CO significantly, which contributed to the formation of alcohol and growth of carbon chain and thus increased the selectivity to C2＋OH.

关键词： CO hydrogenation Sol-gel method Mo-based catalyst Mn promoter Higheralcohols synthesis

The role of mitochondria in redox signaling of muscle homeostasis

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Journal of Sport and Health Science 2020年第5期9卷 386-393页

作者： li li ji Dongwook Yeo Chounghun Kang Tianou Zhang The Laboratory of Physiological Hygiene and Exercise Science University of Minnesota Twin CitiesMinneapolisMN 55455USA Department of Orthopedic Surgery Mayo ClinicRochesterMN 55905USA Department of Physical Education Inha UniversityIncheon 22212Republic of Korea Department of Kinesiology Health and NutritionUniversity of Texas at San AntonioSan AntonioTX 78249USA

In the past,contraction-induced production of reactive oxygen species(ROS)has been implicated in oxidative stress to skeletal *** research advances,clear evidence has revealed a more complete role of ROS under both physiologic and pathologic *** to the role of ROS is the redox signaling pathways that control exercise-induced major physiologic and cellular responses and adaptations,such as mitochondrial biogenesis,mitophagy,mitochondrial morphologic dynamics,antioxidant defense,and *** current review focuses on how muscle contraction and immobilization may activate or inhibit redox signalings and their impact on muscle mitochondrial homeostasis and physiologic implications.

关键词： Antioxidant Exercise Peroxisome-proliferator-activated receptorγcoactivator 1-α Reactive oxygen species Redox signaling Skeletal muscle

Cellular mechanism of immobilization-induced muscle atrophy:A mini review

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Sports Medicine and Health Science 2019年第1期1卷 19-23页

作者： li li ji Dongwook Yeo The Laboratory of Physiological Hygiene and Exercise Science School of KinesiologyUniversity of Minnesota Twin CitiesMinneapolisUSA

It is well-established that regular contraction maintains morphological and functional integrity of skeletal muscle,whereas rigorous exercise training can upregulate muscle metabolic and contractile ***,when muscles stop contraction,such as during immobilization(IM)and denervation,withdrawal of IGF/Akt/mTOR signaling allows FoxO-controlled protein degradation pathways to *** play an important role in regulating both protein synthesis and degradation via several redox sensitive signaling pathways such as mitochondrial biogenesis,fusion and fission dynamics,ubiquitin-proteolysis,autophagy/mitophagy,and *** prolonged IM,downregulation of PGC-1αand increased mitochondrial oxidative damage facilitate fission protein and inflammatory cytokine production and activate mitophagic process,leading to a vicious cycle of protein ***“mitostasis theory of muscle atrophy”is the opposite pathway of hormesis,which defines enhanced muscle function with contractile *** demonstration that PGC-1αoverexpression via transgene or in vivo DNA transfection can successfully restore mitochondrial homeostasis and reverse myocyte atrophy supports such a *** the mechanism governing mitostasis can be instrumental to the treatment of muscle atrophy associated with bedrest,cancer cachexia and sarcopenia.

关键词： Atrophy Immobilization Mitochondria Muscle Signaling

Streptozotocin induced diabetic retinopathy in rat and the expression of vascular endothelial growth factor and its receptor

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 573-577页

作者： Chen-Yuan Gong Bin Lu Qian-Wen Hu li-li ji The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese Medicine

·AIM: To establishtherat model of streptozotocin (STZ)- induced diabetic retinopathy (DR), which is the most common cause of visual loss and blindness in patients with diabetes, and observe the gene expression of vascular endothelial growth factor (VEGF) and its receptors during the development of DR. ·METHODS: A rat model of diabetes was established by intraperitoneal injection of STZ. The diabetic rats were housed for 2, 3 and 4 months after the development of diabetes. Retinal histopathological observation was performed. The retinal vessels were observed by immunofluorescence staining by CD31. The mRNA expression of VEGF, VEGF receptor 1 and 2 (VEGFR1/2) in rat retina was detected by reverse transcription - polymerase chain reaction (RT-PCR) analysis. · RESULTS: Retinal histopathological observation showed the morphological changes of inner nuclear layer (INL) and outer nuclear layer (ONL) at any time -point, and also demonstrated the increased new vessels at both 3, 4 months after the development of diabetes. The CD31 staining results showed that the number of vessels was increased in the retinas of diabetic rats at both 3 and 4 months after the development of diabetes. As compared to the normal rats, the mRNA expression of VEGF was increased in retinas of diabetic rats at 3 months after the development of diabetes, while VEGFR1 and VEGFR2 mRNA expression was increased at 2, 3 and 4 months after the development of diabetes.·CONCLUSION:Takentogether,ourresultsdemonstrated that DR was occurred at 3 months after the development of diabetes, and the mRNA expression of VEGF, VEGFR1 and VEGFR2 were increased in the process of DR. The present study further evidenced the involvement of VEGF and its receptors in the process of DR. ·

关键词： diabetic retinopathy vascular endothelial growth factor vascular endothelial growth factor receptor

Scutellaria barbata attenuates diabetic retinopathy by preventing retinal inflammation and the decreased expression of tight junction protein

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 870-877页

作者： Xi-Yu Mei ling-Yu Zhou Tian-Yu Zhang Bin Lu li-li ji The MOE Key Laboratory for Standardization of Chinese Medicines Shanghai Key Laboratory of Complex Prescription Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

AIM： To observe the attenuation of ethanol extract of Herba Scutellaria barbata （SE） against diabetic retinopathy （DR） and its engaged mechanism. METHODS： C57BL/6J mice were intraperitoneally injected with streptozotocin （STZ, 55 mg/kg） for 5 consecutive days to induce diabetes, The diabetic mice were orally given with SE （100, 200 mg/kg） for lmo at lmo after STZ injection. Blood-retinal barrier （BRB） breakdown was detected by using Evans blue permeation assay. Real-time polymerase chain reaction （RT-PCR）, Western blot and immunofiuorescence staining were used to detect mRNA and protein expression. Enzyme-linked immunosorbent assay （EliSA） was used to detect serum contents of tumor necrosis factor-e （TNF-a） and interleukin （IL）-II. RESULTS： SE （100, 200 mg/kg） reversed the breakdown of BRB in STZ-induced diabetic mice. The decreased expression of retinal claudin-1 and claudin-19, which are both tight junction （T J） proteins, was reversed by SE. SE decreased the increased serum contents and retinal mRNA expression of TNF-a and IL-113. SE also decreased the increased retinal expression of intercellular cell adhesion molecule-1 （ICAM-1）. SE reduced the increased phosphorylation of nuclear factor kappa B （NFKB） p65 and its subsequent nuclear translocation in retinas from STZ- induced diabetic mice. Results of Western blot and retinal immunofluorescence staining of ionized calcium-binding adapter molecule 1 （Ibal） demonstrated that SE abrogated the activation of microglia cells in STZ-induced diabetic mice. CONCLUSION： SE attenuates the development of DR by inhibiting retinal inflammation and restoring the decreased expression of TJ proteins including claudin-1 and claudin-19.

关键词： scutellaria barbata diabetic retinopathy tightjunction inflammation nuclear factor kappa B microglia

Investigating pharmacological mechanisms of andrographolide on non-alcoholic steatohepatitis(NASH):A bioinformatics approach of network pharmacology

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Chinese Herbal Medicines 2021年第3期13卷 342-350页

作者： Lei li Sheng-he li jin-peng jiang Chang liu li-li ji Key Laboratory of Quality&Safety Control for Pork Ministry of Agriculture and RuralAnhui Key Laboratory of Animal Nutritional Regulation and HealthCollege of Animal ScienceAnhui Science and Technology UniversityFengyang 233100China Shanghai Key Laboratory of Compound Chinese Medicines MOE Key Laboratory for Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:To investigate the mechanisms of andrographolide against non-alcoholic steatohepatitis(NASH)based on network pharmacology,so as to provide a reference for further study of andrographolide in the treatment of NASH and other metabolic ***:The methionine-and choline-deficient(MCD)diet-induced NASH mice were treated by administration of andrographolide,and serum transaminase and pathological changes were *** network pharmacology-based bioinformatic strategy was then used to search the potential targets,construct protein–protein interaction(PPI)network,analyze gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment,and conduct molecular docking to explore the molecular ***:The predicted core targets TNF,MAPK8,IL6,IL1B and AKT1 were enriched in non-alcoholic fatty liver disease(NAFLD)signaling pathway and against NASH by regulation of de novo fatty acids synthesis,anti-inflammation and ***:This work provides a scientific basis for further demonstration of the anti-NASH mechanisms of andrographolide.

关键词： andrographolide network pharmacology non-alcoholic steatohepatitis molecular docking

Theoretical Studies on the Structures and Reactions of Halocarbenoids(Ⅰ)Structures and Stability of Chlorocarbenoid CHCl_2

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Chemical Research in Chinese Universities 1997年第3期13卷 256-261页

作者： li li ji-hai, FENG Sheng-yu,liu Wei (Chemical College,Shandong University,jinan, 250100) SHANDONG UNIV CHEM COLLJINAN 250100PEOPLES R CHINA

The chlorocarbenoid , CHCl2li , was studied by means of ab initio molecular or- bital theory. Three equilibrium structures and two isomerization transition states were located. The calculations showed that the three-membered ring structure is the most stable. The 'classical tetrahedral' structure is not the local minimum on the potential energy surface.

关键词： Chlorocarbenoid isomeric structure Ab initio molecular orbital calcu- lation