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Nanoscale storage encryption: data storage in synthetic DNA using a cryptosystem with a neural network

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Science China(life Sciences) 2022年第8期65卷 1673-1676页

作者： Yue Teng Shan Yang liyan liu Ruicun liu Yaofeng Chen jinyu li Qian Yang Tuoyu liu Yujun Cui Peng Cheng Shengqi Wang State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Beijing Institute of Radiation Medicine Beijing 100850China

Dear Editor,Synthetic DNA is emerging as a new data storage medium with high density and durable preservation capability potential(Ceze et al., 2019;Yazdi et al., 2015), thus enhancing the security of data stored in D... 详细信息

关键词： neural network synthetic

头面部伤员不同担架搬运策略对救治效果影响的比较

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联勤军事医学 2024年第3期38卷 242-245页

作者：于忠英田素科李金雨黄令杰郁毅刚孟莹莫群联勤保障部队909医院(厦门大学附属东南医院)泌尿外科福建漳州363000 联勤保障部队909医院(厦门大学附属东南医院)卫勤处福建漳州363000 联勤保障部队909医院(厦门大学附属东南医院)急诊科福建漳州363000 联勤保障部队909医院(厦门大学附属东南医院)皮肤科福建漳州363000 联勤保障部队909医院(厦门大学附属东南医院)院部福建漳州363000

目的比较头面部伤员不同搬运方法搬运伤员的救治效果。方法2022-08月于野外训练场,60对男性担架员和60名抢救员分别随机分为正向搬运组和反向搬运组,每组各30对担架员和30名抢救员。分别采用头在前的正向和脚在前的反向搬运法按规定路... 详细信息

目的比较头面部伤员不同搬运方法搬运伤员的救治效果。方法2022-08月于野外训练场,60对男性担架员和60名抢救员分别随机分为正向搬运组和反向搬运组,每组各30对担架员和30名抢救员。分别采用头在前的正向和脚在前的反向搬运法按规定路线将伤员搬运至目标地域。比较两组观察位担架员视线垂直角和伤员装载登车耗时。比较两组双人组观察位担架员、三人抢救小组抢救员日间和夜间条件下伤员病情变化发现率和发现时间。结果正向搬运组和反向搬运组担架员均可将伤员搬运至目标地域。正向搬运组观察位担架员视线垂直角和伤员装载登车耗时均小于反向搬运组(P均<0.05)。正向搬运组双人组观察位担架员、三人抢救小组抢救员的日间和夜间的病情发现率高于反向搬运组,病情发现时间短于反向搬运组(P均<0.05)。反向搬运组双人组观察位担架员、三人抢救小组抢救员夜间伤员病情发现率低于日间,病情发现时间长于日间(P均<0.05)。结论应用头在前的正向搬运法搬运头面部伤员安全有效,相比反向搬运法更便于发现病情变化且可提高伤员装载效率。

关键词：野外担架伤员搬运方法

In silico-based reengineering of a murine urokinase-type plasminogen activator inhibitor as potent inhibitors of the human ortholog for cancer therapy

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In silico-based reengineering of a murine urokinase-type pla...

CD44 receptor targeted Paclitaxel-loaded amphiphilic hyaluronic acid polymeric micelle with tunable pH and redox-sensitive property for breast cancer therapy

2019中国化学会第十五届全国计算（机）化学学术会议

作者：刘格 Peng Xu Mingdong Huang jinyu li 福州大学 Institute of Molecular and Cell Biology A*STAR National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies College of Chemistry Fuzhou University

Urokinase-type plasminogen activator（uPA） is a potential therapeutic target for cancerXREFX.1 Very recently, we reported a cyclic peptide-based inhibitor（IG-2, CPAYSRYIGC） of murine u PA with high potency and specificity（Ki=6.8 nM）.2-3 However, the potency of IG-2 against human uPA（huPA） was much weaker（Ki=340 n M）, hindering the clinical translation of peptide-based uPA targeting strategy. Here, we performed in silico-based large-scale screening on an IG-2-based peptide library（221 peptides） to generate potent hu PA inhibitors. We identified 19 novel huPA peptide inhibitors and their binding free energies to huPA were significantly lower than that of IG2 by ～10%, indicating that the reengineered peptides may have much better binding affinities to huPA. We also compared the binding modes of these peptide inhibitors with huPA, which provided the mechanism of their improved binding affinities. The peptide inhibitors obtained here display high potential for huPA-targeted cancer therapy.

关键词： uPA peptide inhibitor molecular dynamic simulation cancer therapy

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CD44 receptor targeted Paclitaxel-loaded amphiphilic hyaluro...

Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections

2018年第十二届中国药物制剂大会

作者：杨月 jinyu li Yunjian li Fen Chen Weisan Pan 沈阳药科大学药学院 Department of Pharmaceutics School of Pharmacy Shenyang Pharmaceutical University Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Liaoning University of Traditional Chinese Medicine

Paclitaxel（PTX） is a naturally occurring alkaloid against a wide spectrum of cancers. However, its potential in clinical uses is severely hindered by low tumor selectivity, poor water solubility and distinct side effects. Polymer micelles, tough structure self-assembled from amphiphilic copolymers, are a class of nanocarrier systems with potential application in cancer therapy by enhancing the water solubility of anticancer drugs, prolonging the blood circulation and good biocompatibility. Here, histidine（His） and vitamin E succinate（VES） grafted hyaluronic acid（HA） tripolymer using a disulfide bond as the linker（HisHA-SS-VES） was synthesized in the presence of 1-Ethyl-3-（3-dimethylaminopropyl） carbodiimide（EDC） and N-Hydroxysuccinimide（NHS）. The chemical structure of His-HA-SS-VES conjugate was determined by H1-nuclear magnetic resonance（H1-NMR） and Fourier transform infrared spectroscopy（FTIR）. The degree of substitution of His and VES were assayed through H1-NMR spectrum, which were 4.59% and 15.76%, respectively. The water-insoluble anticancer drug PTX was successfully entrapped into into the core via probe ultrasonication method. The near-spherical PTX-loaded micelle was formed in aqueous media with diameter 108 ± 0.126 nm and a drug loading of 12.54 ± 0.523%. Moreover, the redox and pH-sensitivity of the micelle were confirmed by the particle size change under the simulated tumor environment. These results demonstrate the potential of His-HA-SS-VES micelles as a promising delivery system for pooly soluble antitumor drugs or their derivatives in cancer therapy.

关键词： Paclitaxel Polymer micelle hyaluronic acid vitamin E succinate pH and redox-sensitive H~1-nuclear magnetic resonance

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World Journal of Gastroenterology 2021年第14期27卷 1465-1482页

作者： Sarah A Malik Chencan Zhu jinyu li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen li Department of Medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794United States Stony Brook Cancer Center Biostatistics and Bioinformatics Shared Resource Stony Brook UniversityStony BrookNY 11794United States Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Surgery Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Family Population and Preventive MedicineStony Brook UniversityStony BrookNY 11794United States Cold Spring Harbor Laboratory Cancer Center Sequencing Technologies and Analysis Shared Resource Cold Spring HarborNY 11724United States Department of Medicine University of Colorado Anschutz Medical CampusAuroraCO 80045United States

BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human ***-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)*** hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk *** To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection *** Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from *** 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on *** sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥*** PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach *** mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level *** confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics *** coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor *** expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race *** Recent adoption of additional preoperative antibiotics as sta

关键词： Colorectal cancer Antibiotics African Continental Ancestry Group Diabetes mellitus 16S rRNA gene RNA-sequencing

RACK1A promotes hypocotyl elongation by scaffolding light signaling components in Arabidopsis

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Journal of Integrative Plant Biology 2024年第5期66卷 956-972页

作者： Yajuan Fu Wei Zhu Yeling Zhou Yujing Su Zhiyong li Dayan Zhang Dong Zhang jinyu Shen Jiansheng liang Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes Department of BiologySchool of Life SciencesInstitute of Plant and Food SciencesSouthern University of Science and TechnologyShenzhen 518055China

Plants deploy versatile scaffold proteins to intricately modulate complex cell *** these,RACK1A(Receptors for Activated C Kinase 1A)stands out as a multifaceted scaffold protein functioning as a central integrative hub for diverse signaling ***,the precise mechanisms by which RACK1A orchestrates signal transduction to optimize seedling development remain largely ***,we demonstrate that RACK1A facilitates hypocotyl elongation by functioning as a flexible platform that connects multiple key components of light signaling ***1A interacts with PHYTOCHROME INTERACTING FACTOR(PIF)3,enhances PIF3 binding to the promoter of BBX11 and down-regulates its ***,RACK1A associates with ELONGATED HYPOCOTYL 5(HY5)to repress HY5 biochemical activity toward target genes,ultimately contributing to hypocotyl *** darkness,RACK1A is targeted by CONSTITUTIVELY PHOTOMORPHOGENIC(COP)1 upon phosphorylation and subjected to COP1-mediated degradation via the 26 S proteasome *** findings provide new insights into how plants utilize scaffold proteins to regulate hypocotyl elongation,ensuring proper skoto-and photo-morphogenic development.

关键词： Arabidopsis hypocotyl development light signaling components RACK1 scaffoldprotein

Effects of Carbon Ion on M1 Seedlings of Sugar Sorghum under Drought Stress

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 128-129页

作者： He jinyu li Wenjian Yu lixia Dong Xicun

6-29 Status Report of 320 kV High-voltage Platform in 2014

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IMP & HIRFL Annual Report 2014年第1期 283-284页

作者： li jinyu liu Huiping Kang Long Zhang Tongmin 不详

In 2014, the total operation time of 320 kV high-voltage platform for multi-discipline research with highly chargedions was 5 500 h, including 3 200 h for experiments, 2 300 h for the machine preparation and commissioning due tobeam change and failure time. 46 experiments have been carried out, 28 of which were performed by the researchersfrom other affiliations than the Institute of Modern Physics (IMP), 14 by those from IMP, and 4 attributed tothe commissioning for new ion species. 41% of operation time was contributed to IMP, 26% to other institutions,24% to universities, 9% to enterprises (shown in Fig. 1). Among the research purpose, 69.7% of operation time wasfor material research, 22% for atomic and molecular dynamics, 8.3% for plasma physics, nuclear astrophysics, andmolecular spectroscopy (represented in Fig. 2).

关键词： Status Report Platform

Variation of Feeding Value in Alfalfa Irradiated by Carbon Ion Beam

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 130-131页

作者： He jinyu li Wenjian Yu lixia Qu Ying