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Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish

Zoological Research 2024年第4期45卷 791-804页

作者： Wen-Hao li Zhi-Qiang li Meng-Di Bu jia-Zhen li liang-Biao chen Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China International Research Center for Marine Biosciences Ministry of Science and TechnologyCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China

As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish(Danio rerio) ovaries exposed to a temperature gradient ranging from the thermopreferendum temperature of the species,27℃, to lower temperatures of 22℃, 20℃, and 13℃ over a period of two weeks. Comparative metabolomic(six biological replicates for each temperature) and transcriptomic(four biological replicates for each temperature) analyses were conducted under the four temperature conditions. Results indicated that lower temperatures inhibited oocyte development and differential metabolites were involved in steroid hormone production,antioxidant function, and lipid and protein *** reproductive hormones, increased proteolysis,and lipid degradation significantly impeded oocyte development and egg maturation. Notably, a significant increase in bile acid content was noted in the ovaries of the cold-treated fish, indicating that bile acids play a critical role in ovarian failure. Overall, these findings provide valuable insights into the mechanisms governing the reproductive response of fish to cold stress.

关键词： old stress Ovarian failure Metabolome Zebrafish

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Applicability and improvement of different potential evapotranspiration models in different climate zones of China

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Ecological Processes 2024年第1期13卷 262-282页

作者： Zedong li Yiran li Xinxiao Yu Guodong jia Peng chen Pengfei Zheng Yusong Wang Bingbing Ding Key Laboratory of Soil & Water Conservation and Desertification Combating of Ministry of Education Beijing Forestry University College of Horticulture and Forestry Sciences Tarim University State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical Science Beijing Normal University

Background Accurate estimation of potential evapotranspiration(PET) is the key for studying land-air interaction hydrological processes. Several models are used to estimate the PET based on standardized meteorological data. Although combination-based models have the highest level performance estimation of PET, they require more meteorological data and may therefore be difficult to apply in areas lacking meteorological observation *** The results showed significant differences in the spatial trends of PET calculated by different models in China, the Doorenbots–Pruitts model revealed the highest PET(1902.6 mm), and the Kuzmin model revealed the lowest PET(349.6 mm), with the largest difference being 5.5 times. The Romanenko and the Rohwer models were the recommended temperature-based and aerodynamic-based models. On the other hand, the Abtew model was more suitable for arid and semi-arid regions, while the Priestley–Taylor model was more suitable for humid regions. Combination-based models revealed ideal calculation accuracies, among which the Penman–Monteith model was the best option for PET *** The accuracy range of Romanenko, Rohwer, Abten, Priestley Taylor, and Penman Monteith models improved in MPZ and TCZ is higher than that improved in TMZ and SMZ. This does not mean that the improved models have higher accuracy in MPZ and TCZ than in TMZ and SMZ. On the contrary, the original model performed poorly in MPZ and TCZ, so the improved accuracy was relatively large. The unimproved model was already more suitable in TMZ and SMZ, so the improved accuracy was relatively small. Therefore, regional calibration of the PET models can improve the accuracy and applicability of PET calculation, providing a reference for studying hydrological processes in different climatic zones.

关键词： Potential evapotranspiration Climatic zone Temperature-based model Aerodynamic-based model Radiation-based model Combination-based model Model calibration

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High-rate lithium-ion battery performance of a ternary sea urchin-shaped CoNiO_(2)@NiP_(6)Mo_(18)/CNTs composites

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Journal of Energy Chemistry 2024年第9期96卷 516-525页

作者： li-ping Cui Shuang Sun Kai Yu Shu Zhang Mei-lin Wang jia-jia chen Bai-bin Zhou Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Chemistry for Energy MaterialsXiamen UniversityXiamen 361005FujianChina

Bimetallic oxides are attractive anode materials for lithium-ion batteries(liBs)due to their large theoretical ***,the low conductivity,short cycle life,and poor rate capability are the bottlenecks for their further *** overcome above issues,the basket-like polymolybdate(NiP_(6)Mo_(18))and carbon nanotubes(CNTs)were uniformly embedded on the urchin-shaped CoNiO_(2)nanospheres to yield a ternary composites CoNiO_(2)@NiP_(6)Mo_(18)/CNTs via electrostatic *** multi-level morphology of urchin spinules accelerates the diffusion rate of li^(+);CNT improves the conductivity and enhances cycle stability of the material;and heteropoly acid contributes more redox activity ***,CoNiO_(2)@NiP_(6)Mo_(18)/CNTs as an anode of liBs exhibits a high initial capacity(1396.7 mA h g^(−1)at 0.1 A g^(−1)),long-term cycling stability(750.2 mA h g^(−1)after 300 cycles),and rate performance(450.3 mA h g^(−1)at 2 A g^(−1)),which are superior to reported metallic oxides anode of *** density functional theory(DFT)and kinetic mechanism suggest that CoNiO_(2)@NiP_(6)Mo_(18)/CNTs delivers an outstanding pseudocapacitance and rapid li^(+)diffusion behaviors,which is due to the rich surface area of the urchin-like CoNiO_(2)with the uniform embeddedness of NiP_(6)Mo_(18)and *** study provides a new idea for optimizing the performance of bimetallic oxides and developing high-rate lithium-ion battery composites.

关键词： Bi-metal oxides Transition metal oxides Polyoxometalates Nanocomposite liBs

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Two-dimensional ballistic transistors for advanced-node integrated circuits

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National Science Review 2024年第3期11卷 9-10页

作者： jia li Xidong Duan Hunan Provincial Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University

As the feature size of metal-oxide-semiconductor-field-effect-transistors(MOSFETs) in integrated circuits(ICs)is reduced to sub-10-nm, the traditional channel materials are plagued by enhanced scattering and short-cha... 详细信息

关键词： CONTACT

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Predicting MDCK cell permeation coefficients of organic molecules using membrane-interaction QSAR analysis

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Acta Pharmacologica Sinica 2005年第11期26卷 1322-1333页

作者： li-li chen, jia YAO, jian-bo YANG, Jie YANG~2 State Key Laboratory of Pharmaceutical Biotechnology, College of life Sciences, Nanjing University, Nanjing 210093, China State Key Laboratory of Pharmaceutical Biotechnology College of Life Sciences Nanjing University Nanjing China

Aim: To use membrane-interaction quantitative structure-activity relationship analysis (MI-QSAR) to develop predictive models of partitioning of organic compounds in gastrointestinal cells. Methods: A training set of 22 structurally diverse compounds, whose apparent permeability accross cellular membranes of Madin-Darby canine kidney (MDCK) cells were measured, were used to construct MI-QSAR models. Molecular dynamic simulations were used to determine the explicit interaction of each test compound (solute) with a dimyristoyl-phosphatidyl-cho-line monolayer membrane model. An additional set of intramolecular solute descriptors were computed and considered in the trial pool of descriptors for building MI-QSAR models. The QSAR models were optimized using multidimensional linear regression fitting and the stepwise method. A test set of 8 compounds were evaluated using the MI-QSAR models as part of a validation process. Results: MI-QSAR models of the gastrointestinal absorption process were constructed. The descriptors found in the best MI-QSAR models are as follows: 1) ClogP (the logarithm of the 1-octanol/water partition coefficient); 2) EHOMO(the highest occupied molecular orbital energy); 3) Es(stretch energy); 4) PMY(the principal moment of inertia Y, the inertia along the y axis in the rectangular coordinates; 5) C,(total connectivity); and 6) Enb(the energy of interactions between all of the non-bonded atoms). The most important descriptor in the models is ClogP. Conclusion: Permeability is not only determined by the properties of drug molecules, but is also very much influenced by the molecule-membrane interaction process.

关键词： quantitative structure-activity relationship molecular models organic chemicals artificial membranes cell membrane permeability MDCK cells

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Synthesis of SiC/graphene nanosheet composites by helicon wave plasma

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Chinese Physics B 2021年第7期30卷 339-344页

作者： jia-li chen Pei-Yu Ji cheng-Gang Jin Lan-jian Zhuge Xue-Mei Wu School of Physical Science and Technology and Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China The Key Laboratory of Thin Films of jiangsu Province Soochow UniversitySuzhou 215006China Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbin 150001China Analysis and Testing Center Soochow UniversitySuzhou 215123China

We report an approach to the rapid, one-step, preparation of a variety of wide-bandgap silicon carbide/graphene nanosheet(Si C/GNSs) composites by using a high-density helicon wave plasma(HWP) source. The microstructure and morphology of the Si C/GNSs are characterized by using scanning electron microscopy(SEM), Raman spectroscopy, x-ray diffraction(XRD), x-ray photoelectron spectroscopy(XPS), and fluorescence(PL). The nucleation mechanism and the growth model are discussed. The existence of Si C and graphene structure are confirmed by XRD and Raman *** electron excitation temperature is calculated by the intensity ratio method of optical emission spectroscopy. The main peak in the PL test is observed at 420 nm, with a corresponding bandgap of 2.95 e V that indicates the potential for broad application in blue light emission and ultraviolet light emission, field electron emission, and display devices.

关键词： helicon wave plasma SiC/graphene nanosheet x-ray photoelectron spectroscopy(XPS) fluorescence

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A mutation in the promoter of the yellow stripe-like transporter gene in cucumber results in a yellow cotyledon phenotype

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Journal of Integrative Agriculture 2024年第3期23卷 849-862页

作者： jiawei Pan jia Song Rahat Sharif Xuewen Xu Shutong li Xuehao chen School of Horticulture and Landscape Architecture Yangzhou UniversityYangzhou 225009China Institute of Vegetables Tianjin Academy of Agricultural SciencesTianjin 300384China

Leaf color mutants in higher plants are considered to be ideal materials for studying the chlorophyll biosynthesis,photosynthesis mechanism and chloroplast ***,we identified a spontaneous mutant,yc412,in cultivated cucumber that exhibited yellow *** yellow-lethal mutant was diagnosed with an abnormal chloroplast ultrastructure,and reduced photosynthetic capacity and pigment *** bulked segregant analysis-based whole-genome sequencing and fine genetic mapping,we narrowed the yellow cotyledons (yc) locus to a 96.8 kb interval on chromosome *** resequencing and molecular cloning,we showed that Csyc is a potential candidate gene,which encodes a yellow stripe-like (YSL) *** T to C mutation in the promoter region of Csyc caused the yellow cotyledon phenotype in *** to YZU027A (WT),the expression of Csyc was significantly downregulated in the cotyledons of *** of Csyc in cucumber via virus-induced gene silencing resulted in chlorotic leaves,mainly by suppressing the chlorophyll ***,a comparative transcriptome analysis revealed that chloroplast-related genes and chlorophyll biosynthesis genes were significantly downregulated in yc412 *** results provide new insights into the molecular function of the YSL transporter in plant chloroplast development and chlorophyll synthesis.

关键词： cucumber yellow-lethal cotyledons chloroplast development yellow stripe-like transporter

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纳米生物活性玻璃在牙体硬组织再矿化作用中的研究进展

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赣南医学院学报 2024年第3期44卷 302-305页

作者：李佳晨黄雨梦李雨蕾张梓玮李恩光伍廷芸荆楚理工学院医学部湖北荆门448000

纳米生物活性玻璃作为一种生物活性材料,有利于牙体硬组织骨性结合,在其再矿化作用中起重要作用。研究发现纳米生物活性玻璃对牙体硬组织的再矿化效果优于传统的氟制剂。本文对纳米生物活性玻璃的结构及再矿化机制、在牙体硬组织各部分... 详细信息

纳米生物活性玻璃作为一种生物活性材料,有利于牙体硬组织骨性结合,在其再矿化作用中起重要作用。研究发现纳米生物活性玻璃对牙体硬组织的再矿化效果优于传统的氟制剂。本文对纳米生物活性玻璃的结构及再矿化机制、在牙体硬组织各部分再矿化作用的研究进展进行综述,以期为再矿化研究带来新思路,为今后的相关研究提供依据。

关键词：纳米生物活性玻璃牙体硬组织再矿化

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Optical edge-to-screw singularity state conversions

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Photonics Research 2024年第8期12卷 1689-1695页

作者： HAOliN liN JUNHUI jia GUOHUA liU YANWEN HU ZHEN li ZHENQIANG chen SHENHE FU Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Guangzhou 510632China Guangdong Provincial Engineering Research Center of Crystal and Laser Technology Guangzhou 510632China

Optical singularity states,which significantly affect propagation properties of light in free space or optical medium,can be geometrically classified into screw and edge *** different types of singularity states do not exhibit direct connection,being decoupled from each other in the absence of external *** we demonstrate a novel optical process in which a higher-order edge singularity state initially nested in the propagating Gaussian light field gradually involves into a screw singularity with a new-born topological charge determined by order of the edge *** considered edge state comprises an equal superposition of oppositely charged vortex and antivortex *** theoretically and experimentally realize this edge-to-screw conversion process by introducing intrinsic vortex–antivortex *** also present a geometrical representation for mapping this dynamical process,based on the higher-order orbital Poincaré*** this framework,the edge-to-screw conversion is explained by a mapping of state evolution from the equator to the north or south pole of the Poincaré*** demonstration provides a novel approach for manipulating singularity state by the intrinsic vortex–antivortex *** presented phenomenon can be also generalized to other wave systems such as matter wave,water wave,and acoustic wave.

关键词： interaction Poincaré wave

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Response characteristics of PWR primary circuit under SBLOCAs considering steam bypass discharging

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Nuclear Science and Techniques 2024年第6期35卷 189-201页

作者： Shuai Yang Xiang-Bin li Yu-Sheng liu jia-Ning Xu De-chen Zhang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China Beijing Key Laboratory of Passive Safety Technology for Nuclear Energy Beijing 102206China Nuclear and Radiation Safety Center MEPBeijing 100084China

Small-break superposed station blackout(SBO)accidents are the basic design accidents of nuclear power *** the condition of a small break in the cold leg,SBO further increases the severity of the accident,and the steam bypass discharg-ing system(GCT)in the second circuit can play an important role in guaranteeing core *** explore the influence of the GCT on the thermal-hydraulic characteristics of the primary circuit,RELAP5 software was used to establish a numerical model based on a typical pressurized water reactor nuclear power *** different small breaks in the cold-leg super-posed SBO were selected,and the impact of the GCT operation on the transient response characteristics of the primary and secondary circuit systems was *** results show that the GCT plays an indispensable role in core heat removal during an accident;otherwise,core safety cannot be *** GCT was used in conjunction with the primary safety injection system during the placement *** the break diameter was greater than a certain critical value,the core cooling rate could not be guaranteed to be less than 100 K/h;however,the core remained in a safe state.

关键词： Steam bypass discharging Pressurized water reactor SBLOCA Numerical simulation

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