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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 141-153页

作者： Bo Zhang Lu Zhang Wei Tang gen li Chen Wang the College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China the Electric Energy Group Department of Engineering TechnologyTechnical University of Denmark(DTU)2750 BallerupDenmark the Power Distribution Technology Center State Grid Beijing Electric Power Research InstituteBeijing 100075China

The increasing integration of distributed household photovoltaics(PVs)and electric vehicles(EVs)may further ag gravate voltage violations and unbalance of low-voltage distribu tion networks(LVDNs).DC distribution networks can increase the accommodation of PVs and EVs and mitigate mutilple pow er quality problems by the flexible power regulation capability of voltage source *** paper proposes schemes to es tablish hybrid AC/DC LVDNs considering the conversion of the existing three-phase four-wire low-voltage AC systems to DC op *** characteristics and DC conversion constraints of typical LVDNs are *** addition,converter configura tions for typical LVDNs are proposed based on the three-phase four-wire characteristics and quantitative analysis of various DC ***,an optimal planning method of hybrid AC/DC LVDNs is proposed,which is modeled as a bi-level programming model considering the annual investments and three-phase *** are conducted to verify the effectiveness of the proposed optimal planning *** ulation results show that the proposed optimal planning method can increase the integration of PVs while simultaneously reduc ing issues related to voltage violation and unbalance.

关键词： Optimal planning low-voltage distribution net work three-phase unbalance DC conversion

Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： li-hua Zhu Yu-pei liang lian Yang Feng Zhu li-jun Jia He-gen li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid

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Chinese Chemical Letters 2024年第5期35卷 307-313页

作者： Fengyun li Zerong Pei Shuting Chen gen li Mengyang liu liqin Ding Jingbo liu Feng Qiu School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Horticulture and Landscape Architecture Tianjin Agricultural UniversityTianjin 300384China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Multifunctional drug delivery systems(DDSs)have shown great prospects in overcoming the heterogeneous barrier of delivery drugs to the complex tumor microenvironment(TME).In this study,multifunctional AS/Ge-pNAB microgels with dual-active targeting,triple environment responsiveness,and fluorescence imaging capability were prepared through a straightforward *** was aimed to improve the antitumor therapeutic application of gambogic acid(GA)based on the biological characteristics of *** microgels have a uniform double-layer structure with aptamer in the outer layer which helps in recognizing receptors on the tumor *** GA loaded nano-herb exhibited environment-responsive drug release profiles under acidic pH,reductant and high *** nano-herb significantly improved the accumulation of GA in tumor sites through the synergistic combination of the enhanced permeability and retention effect and dual-ligand mediated ***,it accelerated intracellular drug release and killed tumor ***,the nano-herb had specific therapeutic effects on the tumor in vitro and in vivo as they remarkably inhibited tumor growth while depicting optimal biosafety and lower levels of off-target ***,these findings demonstrate the great potential of the multifunctional AS/Ge-pNAB microgels for precisely targeted GA delivery and open a new avenue for the facile preparation of multifunctional DDSs.

关键词： Tumor microenvironment Microgels Gambogic acid Dual-active targeting Triple environment responsiveness Silver nanoclusters

Effect of Al content on modification behavior of non-metallic inclusions in high-strength steel treated with rare earth

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Journal of Iron and Steel Research International 2024年第8期31卷 1886-1899页

作者： Zhan-peng Tie Xue-yuan Jiang Hai-yan Tang ·gen li Yu-hang Wang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Continuous Casting Business Section CISDI Engineering Co.Ltd.Chongqing 401122China Special Steel Institute Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

The influence of Al content(0.0053,0.0171,and 0.0578 wt.%)on the modification behavior of non-metallic inclusions in 20CrMoVTiB steel treated with rare earth elements was studied through high-temperature experiments and thermodynamic *** results showed that the modification products varied with the Al content in steel under 0.01 wt.%of Ce *** formation sequence of typical rare earth inclusions in steel with the increase in Al content was Ce_(2)O_(3)→CeAlO_(3)→CeAl_(11)O_(18),and the final stable products were highly Al content *** the Al content was 0.0053 wt.%,the stable phase in steel was Ce2O3;while the[Al]reached 0.0171 wt.%,the stable phase became CeA1O_(3).As the A1 content reached 0.0578 wt.%,CeAl_(11)O_(18) became the stable *** a result,increasing the Al content could inhibit the precipitation of Ce_(2)O_(3) inclusions in steel while promote the formation of CeAIO3 and CeAl_(11)O_(18) *** addition,both Ca treatment and Ce treatment could effectively refine the size of inclusions in steel by changing their ***,the feeding amount of Ca wire into molten steel should be appropriately reduced under the condition of adding Ce simultaneously,which is expected to be beneficial for an improved Ce treatment effect.

关键词： Rare earth Al content Steel Inclusion Thermodynamics Ca treatment

Through-polymer,via technology-enabled,flexible,lightweight,and integrated devices for implantable neural probes

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Microsystems & Nanoengineering 2024年第2期10卷 279-291页

作者： Cunkai Zhou Ye Tian gen li Yifei Ye Lusha Gao Jiazhi li Ziwei liu Haoyang Su Yunxiao Lu Meng li Zhitao Zhou Xiaoling Wei Lunming Qin Tiger H.Tao liuyang Sun College of Electronics and Information Engineering Shanghai University of Electric PowerShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina School of Graduate Study University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina School of Physical Science and Technology ShanghaiTech UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Neuroxess Co. Ltd.(Jiangxi)NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology HengqinZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal *** advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated *** conventional approach adds considerable weight and volume to the package,especially for high channel count *** address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional *** innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FliD).The total weight of the FliDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FliDs to nearly match the levels of control animals without ***,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FliD realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action *** findings showcase the potential of FliDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.

关键词： alloy neural recording

微观史学以小见大的逻辑差异——兼谈与其他史学路径的关系

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史学月刊 2024年第1期 117-134页

作者：李根东北师范大学历史文化学院东北长春130024

以小见大是微观史学的特色。其合理性历经学界的误解和质疑,逐渐被认可。可是,由于当前研究往往就少量微观史作品谈其共性,尚未辨明其以小见大的逻辑差异,因此对微观史学的概念理解仍显模糊,与之相关的各种理论争议也没有被澄清。基于... 详细信息

以小见大是微观史学的特色。其合理性历经学界的误解和质疑,逐渐被认可。可是,由于当前研究往往就少量微观史作品谈其共性,尚未辨明其以小见大的逻辑差异,因此对微观史学的概念理解仍显模糊,与之相关的各种理论争议也没有被澄清。基于对20余项微观史作品的以小见大逻辑剖析,可以分辨出“单子同构”“结构细化”“符号阐释”和“例外反推”四种类型。识别以上差异,有助于更精准地厘清微观史学与“全球微观史”“碎片化”“后现代主义”和“新文化史”的关系。全球微观史关注大空间跨度的文化反差,使个案极具代表性。这不能解决乡村主题微观史的论证可靠性问题,但证明关注冲突是以小见大的最合理思路;所谓“碎片化”的研究必不涉及宏观历史的思考,微观史学能提供更新历史共识的“反例”,有以小见大的意义,可避免成为“碎片”;后现代主义主张放弃整体史观,不抵制虚构,微观史作品则均致力于以小见大,也言出有据,存疑明确,与后现代无关;新文化史关注文化挪用,与大多数微观史类型有论证逻辑的差别,只有“例外反推型”与之契合。明确微观史学的逻辑差异,可以为澄清多重理论误解提供直观参照。

关键词：微观史学以小见大全球微观史碎片化后现代主义新文化史

以现代主义文学的风格书写微观史?——卡洛·金兹伯格的“如实”历史叙事思考与实践

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江海学刊 2024年第4期 190-199,256页

作者：李根东北师范大学历史文化学院

卡洛·金兹伯格的微观史书写采用了现代主义文学的风格,其目的在于保证历史叙事的如实性。这缘于他在思考如何真实讲述小人物历史时,发现史料限制使书写难以如实,且这是实证主义历史书写的范式弊端。同时,他认为借鉴现代主义文学的自我... 详细信息

卡洛·金兹伯格的微观史书写采用了现代主义文学的风格,其目的在于保证历史叙事的如实性。这缘于他在思考如何真实讲述小人物历史时,发现史料限制使书写难以如实,且这是实证主义历史书写的范式弊端。同时,他认为借鉴现代主义文学的自我剖白式书写可以保持历史叙事的如实。这种风格在金氏微观史的叙事中体现为三个特征,即弱化作者的叙事权威性,采用多视角的“复调”叙事结构,以及引导读者的自主思考。金兹伯格关于历史叙事如实性的探究,示范了一条克服后现代主义怀疑论的合理思路,揭示了“叙事史复兴”这一史学史概念中尚未被明确的内容。在信息多元化的趋势下,现代主义文学风格的历史叙事可能成为书写当代史的合理选择。

关键词：金兹伯格微观史现代主义文学历史叙事

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基于方差异质性随机参数模型的汇合行为分析

吉林大学学报（工学版） 2024年第4期54卷 883-889页

作者：邬岚赵乐李根南京林业大学汽车与交通工程学院南京210037

为研究高速公路交织区入口匝道车辆汇入主线的换道行为,基于方差异质性随机参数模型构建了车辆汇入换道模型,先从NGSIM数据集中提取7个在统计上显著且对换道行为有影响的解释变量,然后将其引入方差异质性随机参数模型探索潜在异质性,计... 详细信息

为研究高速公路交织区入口匝道车辆汇入主线的换道行为,基于方差异质性随机参数模型构建了车辆汇入换道模型,先从NGSIM数据集中提取7个在统计上显著且对换道行为有影响的解释变量,然后将其引入方差异质性随机参数模型探索潜在异质性,计算各变量平均边际效应量化对换道行为的影响,最后提出了“个体样本精度”指标对模型进行比较。研究结果表明:汇入车辆与目标车道领车的车头间距、目标车道领车宽度、辅助车道领车速度对换道行为产生了显著的影响,且汇入车辆在辅助车道上的纵向位置显著影响汇入车辆与目标车道领车的车头间距,方差异质性随机参数模型比未考虑方差异质性的随机参数模型和二元Logit模型具有更高的拟合优度和模型精度,能够更好地解释车辆汇入行为中的潜在异质性。本文的研究成果可应用于自动驾驶辅助系统和交通流仿真软件中,对阐明车道变换行为的机理有一定的参考价值。

关键词：交通运输安全工程方差异质性随机参数模型汇合行为高速公路交织区

隐私何以让渡:量化自我与私人数据的日常实践

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苏州大学学报（哲学社会科学版） 2024年第2期45卷 172-181页

作者：俞立根顾理平南京师范大学新闻与传播学院江苏南京210024

随着“量化自我”的兴起,让渡隐私成为与自我监测伴生的显著问题,呈现出功能性的悖论。立足于此,对该群体的质性研究发现:受数字化生存惯习的影响,量化自我群体的隐私感经历着技术社会的“脱敏”,让渡数据变得习以为常;而在使用过程中,... 详细信息

随着“量化自我”的兴起,让渡隐私成为与自我监测伴生的显著问题,呈现出功能性的悖论。立足于此,对该群体的质性研究发现:受数字化生存惯习的影响,量化自我群体的隐私感经历着技术社会的“脱敏”,让渡数据变得习以为常;而在使用过程中,量化自我从多样的情境中形成让渡有益的行为理念,从而将数据监控化用为自我跟踪;最终,隐私关注与授权超越了“是否构成/侵犯隐私”的规制界定,以“如何私密”的实践策略反映出对私人数据的选择和管理。鉴于此,理解数字社会的隐私让渡需要从侵权范式回到“隐私与关系”之中,在动态的实践视角下探寻平衡之道。

关键词：隐私让渡隐私保护量化自我私人数据数字化生存

基于NSGA-Ⅱ算法的五连杆悬架硬点优化分析

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机械设计与研究 2024年第2期40卷 45-50页

作者：李根代迪沃尔沃汽车技术(上海)有限公司上海201800

在探讨五连杆悬架的硬点结构中,利用MATLAB分析各个硬点坐标的灵敏度,从而确定其中的重要因子,将其纳入五连杆悬架的结构优化设计中,通过NSGA-Ⅱ算法进行多目标优化,使悬架具有最佳的运动学性能。对平行轮跳过程中的各个参数进行优化后... 详细信息

在探讨五连杆悬架的硬点结构中,利用MATLAB分析各个硬点坐标的灵敏度,从而确定其中的重要因子,将其纳入五连杆悬架的结构优化设计中,通过NSGA-Ⅱ算法进行多目标优化,使悬架具有最佳的运动学性能。对平行轮跳过程中的各个参数进行优化后,五连杆悬架的跳动转向、外倾梯度和侧倾中心高度的变化都能够达到预期的状态,从而达到最佳的性能表现。

关键词：五连杆悬架运动学特性硬点灵敏度分析 NSGA-Ⅱ