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Chinese Journal of Aeronautics 2024年第6期37卷 20-37页

作者： Zhiyu li Kaiyuan ZHANG zhigang li Jun li Institute of Turbomachinery Xi’an Jiaotong UniversityXi’an 710049China

The mid-passage gap is an inevitable structure in a vane passage due to turbine vanes being manufactured *** coolant from this gap is able to prevent hot mainstream ingression and provide cooling protection for the endwall.A novel idea of enlarging the endwall’s coverage area and reducing the endwall’s thermal load by applying the mid-passage gap with variable surface angles is carried out in this *** endwall’s aerothermal and film cooling performances under four mid-passage gap modes at three typical mass flow ratio conditions are numerically *** indicate that under the traditional mid-passage mode,the coolant flows into the mainstream with a perpendicular incidence angle and can’t stick to the ***,cooling failure occurs,and the endwall’s thermal load is badly *** film cooling level at the suction-side endwall is improved when applying the mid-passage gap of a 45surface angle due to the secondary vortex being *** addition,when applying the mid-passage gap of a 135surface angle,the horseshoe vortex is pushed away,and the coverage area at the pressure-side endwall is enlarged *** best film cooling performance is achieved when the upstream surface angle is 135and the downstream surface angle is 45due to the adiabatic film cooling effectiveness being increased at both the pressure-and suction-side *** the mass flow ratio is 1.5%,the coverage area is enlarged by 43%,and the area-averaged adiabatic film cooling effectiveness is increased by 37%,when compared with those under the traditional mid-passage mode.

关键词： Film cooling Heat transfer Surface angle Mid-passagegap Turbinevane endwall

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

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Genes & Diseases 2024年第5期11卷 315-323页

作者： Jiankun Fan zhigang li li Pei Yu Hou Institute of life Sciences Chongqing Medical UniversityChongqing 400016China Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Hematopoiesis represents a meticulously regulated and dynamic biological *** aberrations affecting blood cells,induced by various factors,frequently give rise to hematological *** instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events,including RNA alternative splicing,RNA localization,RNA degradation,and ***,post-transcriptional regulation plays a pivotal role in preserving hematopoietic *** DEAD-Box RNA helicase genes emerge as crucial post-transcriptional regulatory factors,intricately involved in sustaining normal hematopoiesis through diverse mechanisms such as RNA alternative splicing,RNA modification,and ribosome *** review consolidates the existing knowledge on the role of DEAD-box RNA helicases in regulating normal hematopoiesis and underscores the pathogenicity of mutant DEADBox RNA helicases in malignant *** is placed on elucidating both the positive and negative contributions of DEAD-box RNA helicases within the hematopoietic system.

关键词： DEAD-box RNA helicase Hemopoietic system Post-transcriptional regulation Ribosomes assembly RNA alternative splicing

Investigating Optical Transport Network Performance:A Recurrence Plot Approach

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China Communications 2024年第5期21卷 166-176页

作者： Sun Xiaochuan Cao Difei Wei Biao li zhigang li Yingqi College of Artificial Intelligence North China University of Science and TechnologyTangshan 063210China Hebei Key Laboratory of Industrial Intelligent Perception Tangshan 063210China

In future optical transport networks,lightpath performance analysis is of great practical significance for fully automated *** general,the quality of transmission(QoT)of lightpaths,measured by optical quality factor or optical signal-to-noise ratio,has a complex time-varying process,along with the interactions of the other lightpath state parameters(LSPs),such as transmit power,chromatic dispersion,polarization mode *** studies are mostly focused on lightpath QoT estimation,but ignoring lightpath-level data *** this case,our article proposes a novel lightpath performance analysis method considering recurrence plot(RP)and cross recurrence plot(CRP).Firstly,we give a detailed interpretation on the recurrence patterns of LSPs via a qualitative 2-D RP representation and its quantitative *** can potentially enable the accurate and fast lightpath failure detection with a low computational *** the other hand,CRP is devoted to modeling the relationships between lightpath QoT and LSPs,and the correlation degree is determined by a geometric mean of multiple indexes of cross recurrence quantification *** the view of application,such CRP analysis can provide the effective knowledge sharing to guarantee more credible QoT *** experiments on a real-world optical network dataset have clearly demonstrated the effectiveness of our proposal.

关键词： CRP analysis lightpath QoT optical transport networks RP analysis

Convexification of Hybrid AC-DC Optimal Power Flow with line-Commutated Converters

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 617-628页

作者： Hongyuan liang zhigang li J.H.Zheng Q.H.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

line-commutated converter (LCC)-based high-voltage DC (HVDC) systems have been integrated with bulk AC power grids for interregional transmission of renewable power. The nonlinear LCC model brings additional nonconvexity to optimal power flow (OPF) of hybrid AC-DC power grids. A convexification method for the LCC station model could address such nonconvexity but has rarely been discussed. We devise an equivalent reformulation for classical LCC station models that facilitates second-order cone convex relaxation for the OPF of LCC-based AC-DC power grids. We also propose sufficient conditions for exactness of convex relaxation with its proof. Equivalence of the proposed LCC station models and properties, exactness, and effectiveness of convex relaxation are verified using four numerical simulations. Simulation results demonstrate a globally optimal solution of the original OPF can be efficiently obtained from relaxed model.

关键词： AC-DC power system convex relaxation linecommutated converter optimal power flow second-order cone programming

Facet-dependent transformation and toxicity of nanoscale zinc oxide in the synthetic saliva

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Journal of Environmental Sciences 2024年第5期139卷 170-181页

作者： Xiang Zhang Yunpeng Huang Jikun Wang Jie Tang YangMei Nali Zhu zhigang li lingxiangyu li YaweiWang School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Chemistry University of PennsylvaniaPhiladelphia 19104USA

The nanoscale zinc oxide(n-ZnO)was used in food packages due to its superior antibac terial activity,resulting in potential intake of n-ZnO through the digestive system,wherein n-ZnO interacted with *** recent,facet engineering,a technique for controlling the exposed facets,was applied to n-ZnO,whereas risk of n-ZnO with specific exposed facets in saliva was *** nanoflakes(ZnO-0001)and nanoneedles(ZnO-1010)with the pri mary exposed facets of{0001}and{1010}respectively were prepared in this study,investigat ing stability and toxicity of ZnO-0001 and ZnO-1010 in synthetic *** ZnO-0001 and ZnO-1010 partially transformed into amorphous Zn_(3)(PO_(4))_(2)within 1 hr in the saliva even containing orgnaic components,forming a ZnO-Zn_(3)(PO_(4))_(2)core-shell *** less,ZnO-1010 relative to ZnO-0001 would likely transform into Zn_(3)(PO_(4))_(2),being attributed to superior dissolution of{1010}facet due to its lower vacancy formation energy(1.15 eV than{0001}facet(3.90 eV)).The toxicity of n-ZnO to Caco-2 cells was also dependent on the primary exposed facet;ZnO-0001 caused cell toxicity through oxidative stress,whereas ZnO-1010 resulted in lower cells viability than ZnO-0001 through oxidative stress and mem brane *** functional theory calculations illustrated that·O_(2)^(-)was formed and released on{1010}facet,yet O_(2)^(2-)instead of·O_(2)^(-)was generated on{0001}facet,leading to low oxidative stress from *** findings demonstrated that stability and toxicity of n-ZnO were dependent on the primary exposed facet,improving our understanding o health risk of nanomaterials.

关键词： The exposed facet Nanoscale ZnO Chemical transformation Synthetic salica Nanotoxicity

A Projection and Decomposition Approach for Multi-agent Coordinated Scheduling in Power Systems

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 991-996页

作者： Haifeng Qiu zhigang li Hongjun Gao Hung Dinh Nguyen Veerapandiyan Veerasamy Hoay Beng Gooi the School of Electrical and Electronic Engineering Nanyang Technological University639798 Singapore the School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China the College of Electrical Engineering Sichuan UniversityChengdu 610065China

Aiming at multi-agent coordinated scheduling problems in power systems under uncertainty,a generic projection and decomposition(P&D)approach is proposed in this *** canonical min-max-min two-stage robust optimization(TSRO)model with coupling constraints is equivalent to a concise robust optimization(RO)model in the version of mixed-integer linear programming(MILP)via feasible region *** decentralized decoupling of the non-convex MILP problem is realized through a dual decomposition algorithm,which ensures the fast convergence to a high-quality solution in the distributed *** tests verify the superior performance of the proposed P&D approach over the existing distributed TSRO method.

关键词： Coordinated scheduling multi-agent system distributed robust optimization projection and decomposition

Observability Analysis of Integrated Electricity and Heating Systems with Thermal Quasi-dynamics in Pipelines

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1145-1158页

作者： zhigang li Wenjian Zheng Junbo Zhao J.H.Zheng Q.H.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China Fuzhou Changle District Power Supply Company of State Grid Fujian Electric Power Co. Ltd.Fuzhou 350000China Department of Electrical and Computer Engineering University of ConnecticutStorrsCT 06269USA CSEE IEEE

Observability analysis(OA)is vital to obtaining the available input measurements of state estimation(SE)in an integrated electricity and heating system(IEHS).Considering the thermal quasi-dynamics in pipelines,the measurement equations in heating systems are dependent on the estimated results,leading to an interdependency between OA and *** OA methods require measurement equations be known exactly before SE is performed,and they are not applicable to *** bridge this gap,a scenario-based OA scheme for IEHSs is devised that yields reliable analysis results for a predefined set of time-delay scenarios to cope with this *** its core procedure,the observable state identification and observability restoration are formulated in terms of integer linear *** tests are conducted to demonstrate the validity and superiority of the proposed formulation.

关键词： Integrated electricity and heating system measurement observability analysis state estimation thermal quasi-dynamics

Connection-Free Transmission for Critical MTC

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China Communications 2024年第8期21卷 162-171页

作者： li zhigang Yuan Zhifeng Ma Yihua liang Chulong ZTE Corporation Shenzhen 518057China State Key Laboratory of Mobile Network and Mobile Multimedia Technology Shenzhen 518055China

In this paper,a contention-based connection-free transmission scheme is proposed to meet the stringent requirements of ultra-reliability and low-latency for critical machine-type communication(cMTC).To improve reliability,we design multiple independent sparse orthogonal pilots(MISOP)to significantly reduce the probability of pilot collision to the order of 10^(−5).Besides,the advancements of massive MIMO(mMIMO)are exploited to further enhance the *** achieve low latency,connection-free slot-based one-shot transmission without retransmissions is *** the receiver side,single round of multi-user detection(MUD)without interference cancellation(IC)can reduce the processing *** imprecise synchronization between cMTC device and the gNB in connection-free transmission,e.g.,time and frequency offsets,are also *** simulation results shows that the proposed scheme can well satisfy the ambitious requirements of cMTC,and has the potential applications in supporting massive cMTC devices in 6G.

关键词： connection-free critical MTC pilot collision sparse orthogonal pilot

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

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Genes & Diseases 2024年第1期11卷 397-412页

作者： Zhe Chen Qian Guo Shichen Huang Lei li Feng Wu Zhilong liu zhigang li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML ***,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive *** metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of ***,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of *** a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA *** synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft *** results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition FOXO3A GNG7 mTOR

Association of the expression of Th1/Th2 cytokines and lymphocyte subsets with clinical characteristics and outcomes in 207 Chinese children with Burkitt’s lymphoma

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中华医学杂志(英文版) 2024年第16期137卷 2011-2013页

作者： Huang Shuang Jin ling Yang Jing Peng Yaguang Gong Wenyu Hou Shuo Xing Tianyu li zhigang Duan Yanlong Medical Oncology Department Pediatric Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing Key Laboratory of Pediatric Hematology Oncology National Key Clinical Discipline of Pediatric Oncology Key Laboratory of Major Disease in Children Ministry of Education Beijing China Clinical Epidemiology and Evidence-based Medicine National Center for Children’s Health Beijing Children’s Health Beijing Children’s Hospital Capital Medical University Beijing China Hematologic Disease Laboratory Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Key Laboratory of Major Diseases in Children Ministry of Education Beijing Pediatric Research Institute Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China