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Effect of Y substitution on the microstructure,magneto-optical,and thermal properties of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)transparent ceramics

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Journal of Advanced Ceramics 2024年第4期13卷 529-538页

作者： Lixuan Zhang Dianjun Hu Xiao Li Ziyu Liu Chen Hu lexiang wu Tingsong Li Dariusz Hreniak Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China Institute of Low Temperature and Structure Research Polish Academy of SciencesWroclaw 50-422Poland

Faraday isolators can prevent the front-end system from disturbance and damage caused by a back-reflected beam,so they are important elements in laser systems.As magneto-optical materials are the most important component in Faraday isolators,the studies on magneto-optical materials have attracted much attention these years.Tb_(3)Al_(5)O_(12)(TAG)ceramics are considered to be one of the most promising magneto-optical materials for visible to near-infrared wavelength band application because of their outstanding comprehensive magneto-optical performance.However,the optical quality of TAG ceramics needs further optimization to meet the application requirements.In this work,high optical quality(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)(x=0,0.05,0.1,0.2,and 0.3)magneto-optical ceramics were fabricated successfully by solid-state reaction sintering combined with hot isostatic pressing(HIP)post-treatment.All the ceramics obtained showed a single garnet phase for different values of x in the range studied.The addition of Y2O3 was found to suppress the secondary phase and improve optical quality significantly.The ceramic samples obtained had clear grain boundaries and possessed the in-line transmittance values of 82.9%at 1064 nm and 82.2%at 633 nm,respectively.The Verdet constants of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics with x=0,0.05,0.1,0.2,and 0.3 were−188.1,−175.4,−168.5,−143.0,and−119.9 rad/(T·m),respectively.The thermal conductivity of TAG ceramics was found to be 5.23 W/(m·K)at 25℃,and when 20%Y was substituted in place of Tb,the thermal conductivity decreased by only 9.4%.

关键词： (Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics magneto-optical materials optical quality thermal properties

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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda Jian Ge lexiang Yu Zhongzhi wu Jianwen Que Wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and aging.However,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain malignancies.In contrast,ERβis more broadly expressed in metabolic tissues and the skin.Thus,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERαactivation.Here,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or genistein.Treatment of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in vitro.We further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound healing.Therefore,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity

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Compositional regulation of multi-component GYGAG:Ce scintillation ceramics:Self-sintering-aid effect and afterglow suppression

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Journal of Advanced Ceramics 2023年第10期12卷 1919-1929页

作者： Danyang Zhu lexiang wu Alena Beitlerova Romana Kucerkova Weerapong Chewpraditkul Martin Nikl Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Institute of Physics of the Czech Academy of Sciences Prague 16200Czech Republic King Mongkut’s University of Technology Thonburi Bangkok 10140Thailand

(Gd,Y,Ce)_(3)(Y_(x)Ga_(1−x))_(2)GaAl_(2)O_(12)(GYGAG:Ce)scintillation ceramics with different Y excess,where x=0.005−0.08,were fabricated by the solid-state reaction method.The effects of stoichiometry on the phase composition,optical quality,and microstructure of GYGAG:Ce ceramics were analyzed.GYGAG:Ce ceramics have a pure garnet phase and obtain good in-line transmittance when x<0.04,while more Y excess leads to the creation of the secondary phase.The change of x value influences the sintering behavior of the GYGAG:Ce ceramics:The excess of Y works as the self-sintering aid and significantly reduces the sintering temperature of ceramics.When x=0.01–0.04,the X-ray excited luminescence(XEL)spectra and light yields of GYGAG:Ce ceramics are similar.The fast scintillation decay time and afterglow intensity of GYGAG:Ce ceramics show a slight decrease with increasing x value.Finally,additional 50–500 ppm MgO and 100–500 ppm CaO were introduced to the GYGAG:Ce ceramic with x=0.04,and both were found to significantly increase the fast scintillation component and reduce the afterglow intensity by two orders of magnitude to 0.01%after X-ray cut-off.

关键词： GYGAG:Ce ceramics multi-component garnet compositional regulation afterglow

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Fabrication and properties of non-stoichiometric Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)magneto-optical ceramics

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Journal of Advanced Ceramics 2022年第5期11卷 784-793页

作者： Lixuan ZHANG Xiaoying LI Dianjun HU Ziyu LIU Tengfei XIE lexiang wu Zhaoxiang YANG Jiang LI Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBejing 100049China

Non-stoichiometric Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)(x=-0.07-0.45)magneto-optical ceramics were fabricated by solid-state reactive sintering in vacuum combined with hot isostatic pressing(HIP)posttreatment without any sintering aids.The phase composition,densification process,microstructure,optical transmittance,and Verdet constant of Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics were investigated.The in-line transmittance of(Tb_(0.93)Hf_(0.04))_(2)Hf_(2)O_(7.07)ceramics with a thickness of 2.0 mm reaches 74.6%at 1064 nm.The Verdet constant of Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics is-153.4,-155.8,and-181.2 rad/(T-m)at the wavelength of 633 nm when x=-0.07,0,and 0.1,respectively.The Verdet constant increases with the increase of Tb content,and these values are higher than that of the commercial Tb_(3)Ga_(5)O_(12) crystal,indicating that non-stoichiometric Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics have a great potential for the application in Faraday isolators.

关键词： magneto-optical ceramics Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics reactive sintering Verdet constant

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Composition and luminescence properties of highly robust green-emitting LuAG:Ce/Al_(2)O_(3)composite phosphor ceramics for high-power solid-state lighting

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Journal of Advanced Ceramics 2023年第3期12卷 625-633页

作者： Ziqiu Cheng Xin Liu Xinrong Chen Jian Xu Yanbin Wang Tengfei Xie lexiang wu Zhengfa Dai Guohong Zhou Jun Zou Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Lab of New Energy Materials and Devices School of Physics and Electronic InformationHenan Polytechnic UniversityJiaozuo 454000China School of Material Science and Engineering Jiangsu University301 Xuefu RoadZhenjiang 212013China Shanghai Institute of Technology Shanghai 201418China Institute of New Materials&Industrial Technology Wenzhou UniversityWenzhou 325024China

The major advantage of laser lighting over white light-emitting-diode is the possibility to achieve ultra-high luminance.However,phosphors usually suffer laser-induced luminescence saturation,which limits the peak luminance of laser lighting devices.The aim of the present study is to develop LuAG:Ce/Al_(2)O_(3)composite ceramics(LACCs)with a high saturation threshold for high-luminance laser lighting.Owning to the rigid crystal structure,proper synthetic process,and optimized thermal design,the LACCs possess small thermal quenching(16%loss in luminescence at 225℃),high quantum yield(>95%),and excellent luminescence properties.When the LACCs are irradiated by blue laser diodes in a reflection mode,a high luminous flux of 4634 lm and luminous efficacy of 283 lm·W^(−1)are realized.Furthermore,they show no sign of luminescence saturation even when the power density reaches 20.5 W·mm^(−2).With these favorable properties,the designed LACCs show great potential in high-luminance laser lighting.

关键词： LuAG:Ce/Al_(2)O_(3)composite ceramics(LACCs) luminescence saturation luminous efficacy high-luminance laser lighting

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Fabrication and performance evaluation of novel transparent ceramics RE:Tb_(3)Ga_(5)O_(12)(RE=Pr,Tm,Dy)toward magneto-optical application

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Journal of Advanced Ceramics 2021年第2期10卷 271-278页

作者： Xiaoying Li Ilya LSnetkov Aleksey Yakovlev Qiang Liu Xin Liu Ziyu Liu Penghui Chen Danyang Zhu lexiang wu Zhaoxiang Yang Tengfei Xie Haohong Chen Oleg Palashov Jiang Li Key Laboratory of Transparent Opto-functional Inorganic Materials Shanghai Institute of CeramicsChinese Academy of SciencesShanghai201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Institute of Applied Physics of the Russian Academy of Sciences Nizhny Novgorod603950Russia School of Material Science and Engineering Jiangsu UniversityZhenjiang212013China

Transparent ceramics are at the heart of modern magneto-optical materials providing promising opportunities for Faraday isolators.1.0 at%RE:Tb3Ga5O12(rare earth(RE)=Pr,Tm,Dy)transparent ceramics were successfully prepared by air sintering and sequential HIP technique using the coprecipitated powders as the raw material.All the powders have shown to be a pure cubic terbium gallium garnet(TGG)phase and exhibit good dispersion.Additionally,a change could not be observed in particle shape with the different doped ions.After the two-step sintering,all the obtained ceramics have good optical quality,and the in-line transmittances at 1070 nm are higher than 80%.Moreover,no secondary phase can be detected from the microstructures.However,the pores which remain entrapped in the ceramics can be noted.The Verdet constant of ceramic samples is optimized by RE doping,and the Verdet constant at 632.8 nm is about−143 rad·T^(−1)·m^(−1),which is about 5%higher than that of TGG ceramics.Finally,the thermo-optical properties of 1.0 at%RE:TGG transparent ceramics are compared.The annealed TGG ceramic showed the best thermo-optical properties,and the thermally induced depolarization of 1.0 at%Ce:TGG and 1.0 at%Tm:TGG was inferior to that of annealed TGG ceramic.

关键词： magneto-optical material rare earth(RE) terbium gallium garnet(TGG)ceramics Verdet constant thermo-optical properties

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对比多源遥感数据在滨海湿地提取中的差异

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测绘地理信息 2023年第3期48卷 71-78页

作者：曾炜健张棋斐吴志峰钱乐祥广州大学地理科学与遥感学院广东广州510006 南方海洋科学与工程广东省实验室(广州) 广东广州511485

Landsat 8与Sentinel-2数据是当前遥感分类最典型、常用的光学数据源,但这两种数据源在滨海湿地分类中的差异性仍有待进一步研究。基于Landsat 8、Sentinel-2和Sentinel-1数据,采用随机森林(random forest,RF)算法对南沙区湿地进行分类... 详细信息

Landsat 8与Sentinel-2数据是当前遥感分类最典型、常用的光学数据源,但这两种数据源在滨海湿地分类中的差异性仍有待进一步研究。基于Landsat 8、Sentinel-2和Sentinel-1数据,采用随机森林(random forest,RF)算法对南沙区湿地进行分类,并探讨光学数据源、主成分变换融合方法以及各特征变量对南沙区滨海湿地RF分类精度的影响。结果表明:(1)Sentinel-2数据参与的方案分类精度均优于Landsat 8数据参与的方案,其分类精度分别为90.24%(单一光学数据参与分类)、85.89%(光学数据与雷达数据融合参与分类)。(2)主成分变换融合方法对分类精度的提高不大,融合数据使滨海湿地总体分类精度下降(p<0.05),但融合数据在一些滨海湿地类型提取中具有一定优势。融合Sentinel-2与Sentinel-1数据减小了沿海滩涂与浅海水域之间的错分现象;融合Landsat 8与Sentinel-1数据更有利于库塘、红树林湿地信息提取以及湿地与非湿地信息的区分。

关键词：随机森林 Landsat 8 Sentinel-2 Sentinel-1 主成分变换融合南沙区

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hsa_circ_0005777在肝母细胞瘤中的表达及对细胞增殖周期的影响研究

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中华小儿外科杂志 2022年第1期43卷 66-70页

作者：陈露平伍耀豪娄蕾邱荣林曾乐祥苏健航邓小耿中山大学孙逸仙纪念医院小儿外科广州510120

目的探索环状RNA hsa_circ_0005777在肝母细胞瘤中的表达及对肝母细胞瘤细胞增殖周期的影响。方法实验细胞包括人肝母细胞瘤细胞株HepG2和HUH6,将实验细胞培养在含10%胎牛血清及1%双抗的DMEM培养基中,置于37℃、5%CO2的恒温培养箱中。... 详细信息

目的探索环状RNA hsa_circ_0005777在肝母细胞瘤中的表达及对肝母细胞瘤细胞增殖周期的影响。方法实验细胞包括人肝母细胞瘤细胞株HepG2和HUH6,将实验细胞培养在含10%胎牛血清及1%双抗的DMEM培养基中,置于37℃、5%CO2的恒温培养箱中。实验组织标本包括肝母细胞瘤肿瘤及癌旁组织标本,来源于中山大学孙逸仙纪念医院小儿外科住院患儿手术切除的组织。所有肿瘤组织标本和癌旁组织标本在手术切除后,均立即浸泡在RNA later保存液中防止RNA降解,随后放在-80℃冰箱保存。在肝母细胞瘤细胞株中转染hsa_circ_0005777过表达质粒,为过表达组;未转染过表达质粒的细胞株作为阴性对照,为对照组。检测内容包括:①鉴定hsa_circ_0005777在肝母细胞瘤细胞株中的性质及分布情况;②检测hsa_circ_0005777在肝母细胞瘤肿瘤、癌旁组织组织标本和肝母细胞瘤细胞株中的表达情况;③检测过表达组对肝母细胞瘤细胞株细胞增殖能力的影响;④检测过表达组对肝母细胞瘤细胞株细胞周期的影响及过表达组对细胞周期蛋白Cyclin D1表达水平的影响。结果①hsa_circ_0005777在肝母细胞瘤细胞株中成环并富集在细胞质中;②hsa_circ_0005777在肝母细胞瘤组织标本中的表达显著高于癌旁组织,在肝母细胞瘤肿瘤组织标本及细胞株中明显高表达;③过表达组可明显提高肝母细胞瘤细胞株的增殖能力;④过表达组可明显促进细胞周期蛋白Cyclin D1的表达,可促进肝母细胞瘤细胞株细胞G1/S期转化。结论hsa_circ_0005777可促进肝母细胞瘤肿瘤细胞增殖,有望成为治疗肝母细胞瘤的新靶点。

关键词：细胞增殖肝母细胞瘤环状RNA hsa_circ_0005777

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沙枣叶提取物体外抗菌、抗氧化活性研究

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饲料工业 2022年第21期43卷 35-40页

作者：德勒黑杨斌萨茹丽钱琳娜陈乐祥吴苏日古嘎内蒙古农业大学动物科学学院内蒙古呼和浩特010018 内蒙古自治区农牧业科学院兽医研究所内蒙古呼和浩特010031 通辽市畜牧业发展中心内蒙古通辽028000

试验旨在研究沙枣叶提取物体外抗菌、抗氧化活性,以期为沙枣叶抗菌、抗氧化功能的综合开发利用提供理论依据。试验以沙枣叶为研究对象,提取沙枣叶醇提物、水提物原液(1 g/mL),将1 g/mL沙枣叶提取物分别稀释为500、333、250、200、100、5... 详细信息

试验旨在研究沙枣叶提取物体外抗菌、抗氧化活性,以期为沙枣叶抗菌、抗氧化功能的综合开发利用提供理论依据。试验以沙枣叶为研究对象,提取沙枣叶醇提物、水提物原液(1 g/mL),将1 g/mL沙枣叶提取物分别稀释为500、333、250、200、100、50、20、10 mg/mL的不同稀释浓度的待测样本检测其体外抗氧化活性及抗菌活性。抗菌试验选用鼠伤寒沙门氏菌、马链球菌、变形杆菌、大肠杆菌、白葡萄球菌、绿脓杆菌、枯草芽孢杆菌、金黄色葡萄球菌等8种菌菌株各一株,分别测定沙枣叶提取物抑菌活性。结果表明:沙枣叶醇提物对大肠杆菌、白葡萄球菌、绿脓杆菌、变形杆菌具有抗菌作用,其抗菌作用从大到小依次为沙枣叶醇提物1 g/mL、500 mg/mL、333 mg/mL及250 mg/mL浓度的样品,200 mg/mL浓度的沙枣叶醇提物对大肠杆菌、白葡萄球菌、绿脓杆菌及变形杆菌为低度敏感;其他浓度沙枣叶醇提物及水提物各浓度样品对上述8种菌均为不敏感或无抑菌活性。试验条件下,沙枣叶水提物(1 g/mL)总抗氧化能力略高于醇提物(1 g/mL),二者差异不显著(P>0.05);沙枣叶水提物1 g/mL组和500 mg/mL组清除DPPH自由基的能力高于醇提物1 g/mL组和500 mg/mL组,二者之间差异显著(P<0.05);沙枣叶水提物的抑制羟自由基能力随其浓度下降而提高,略高于醇提组;沙枣叶醇提物1 g/mL、500 mg/mL浓度的抑制超氧自由基能力显著高于其他浓度组(P<0.05)。沙枣叶提取物具有一定的抗菌、抗氧化活性,其抗菌、抗氧化活性与其浓度存在一定的剂效关系。

关键词：沙枣叶抗菌活性抗氧化活性羟自由基大肠杆菌

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现代医院自律与维权的对策

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中医药管理杂志 2006年第2期14卷 17-18页

作者：吴乐香广州中医药大学第一附属医院 510405

加强医院的自律与维权,将有助于改善当前医患之间的紧张关系,增进彼此间的信任。文章系统分析了医院自律与维权的现状,提出了医院自律与维权的原则,阐述了现代医院自律与维权的对策。

关键词：医疗纠纷自律维权对策

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