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Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons

Translational Neurodegeneration 2020年第3期9卷 393-408页

作者： Kalimuthusamy Natarajaseenivasan Santhanam Shanmughapriya Prema Velusamy matthew Sayre Alvaro Garcia Nestor mas gomez Dianne Langford Department of Neurosciences and Center for Neurovirology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140USA Department of microbiology Bharathidasan UniversityTiruchirappalli 620024India Heart and Vascular Institute Department of MedicineDepartment of Cellular and Molecular PhysiologyPenn State College of MedicineHersheyPA 17033USA

Background:Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain *** neurodegenerative disorders,people living with human immunodeficiency virus(HIm)and Alzheimer's disease(AD)are particularly vulnerable to metabolic disturbances,but the mechanistic connections of inflammation,neurodegeneration and bioenergetic deficits in the central nervous system(CNS)are poorly *** particularly interesting new cysteine histidine-rich-protein(PINCH)is nearly undetectable in healthy mature neurons,but is robustly expressed in tauopathy-associated neurodegenerative diseases including HIV infection and *** robust PINCH expression has been reported in neurons in the brains of patients with HIV and AD,the molecular mechanisms and cellular consequences of increased PINCH expression in CNS disease remain largely ***:We investigated the regulatory mechanisms responsible for PINCH protein-mediated changes in bioenergetics,mitochondrial subcellular localization and bioenergetic deficits in neurons exposed to physialogical levels of TNFa or the HIV protein *** in the PINCH-ILK-Parvin(PIP)complex association with cofilin and TESK1 were assessed to identify factors responsible for actin depolymerization and mitochondrial *** and pharmacological inhibition experiments were conducted to confirm PINCH specificity and to reinstate proper protein-protein complex ***:We identified mEF2A as the PINCH transcription factor in neuroinflammation and determined the biological consequences of increased PINCH in ***-mediated activation of mEF2A via increased cellular calcium induced PINCH,leading to disruption of the PIP ternary complex,cofilin activation by TESK1 inactivation,and actin *** disruption of actin led to perinuclear mislocalization of mitochondria by destabilizing the kinesin-dependent mitochondrial transport machinery,resulting i

关键词： Neuron mitochondria Actin PINCH Neuroinflammation

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THz plasmonics and electronics in germanene nanostrips

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Journal of Semiconductors 2023年第10期44卷 37-49页

作者： Talia Tene marco Guevara Gabriela Tubon-Usca Oswaldo Villacrés Cáceres Gabriel moreano Cristian Vacacela gomez Stefano Bellucci Department of Chemistry Universidad Técnica Particular de Loja110160 LojaEcuador UNICARIBE Research Center University of CalabriaI-87036 RendeCSItaly Grupo de Investigación en materiales Avanzados(GImA) Facultad de CienciasEscuela Superior Politécnica de Chimborazo(ESPOCH)RiobambaEcuador Facultad de Ciencias Escuela Superior Politécnica de Chimborazo(ESPOCH)RiobambaEcuador Faculty of mechanical Engineering Escuela Superior Politécnica de Chimborazo(ESPOCH)Riobamba 060155Ecuador INFN-Laboratori Nazionali di Frascati Via E.Fermi 54I-00044 FrascatiItaly

Germanene nanostrips(GeNSs)have garnered significant attention in modern semiconductor technology due to their exceptional physical characteristics,positioning them as promising candidates for a wide range of *** exhibit a two-dimensional(buckled)honeycomb-like lattice,which is similar to germanene but with controllable *** modeling of GeNSs is essential for developing appropriate synthesis methods as it enables understanding and controlling the growth process of these ***,one can adjust the strip width,which in turn can tune the bandgap and plasmonic response of the material to meet specific device *** this study,the objective is to investigate the electronic behav-ior and THz plasmon features of GeNSs(≥100 nm wide).A semi-analytical model based on the charge-carrier velocity of free-standing germanene is utilized for this *** charge-carrier velocity of freestanding germanene is determined through the GW approximation(V_(F)=0.702×10^(6)m·s^(−1)).Within the width range of 100 to 500 nm,GeNSs exhibit narrow bandgaps,typi-cally measuring only a few ***,upon analysis,it was found that the bandgaps of the investigated GeNSs ranged between 29 and 6 *** well,these nanostrips exhibit√q-like plasmon dispersions,with their connected plasmonic fre-quency(≤30 THz)capable of being manipulated by varying parameters such as strip width,excitation plasmon angle,and sam-ple *** manipulations can lead to frequency variations,either increasing or decreasing,as well as shifts towards larger momentum *** outcomes of our study serve as a foundational motivation for future experiments,and further con-firmation is needed to validate the reported results.

关键词： nanostrips carrier velocity germanene plasmonics electronics

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Processus pour le développement d’une stratégie d’évaluation de la qualitéde vie en cancer avancépédiatrique Process for Developing a Quality of Life Assessment Strategy in Advanced Pediatric Cancer

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Psycho-Oncologie 2024年第2期18卷 127-135页

作者： Lye-Ann Robichaud marianne Olivier-D’Avignon Julie Felipe Hermann Ferdinand Thomas Ehrenfeld marc-Antoine marquis Bruno michon Émélie Rondeau mathias Tyo-gomez michel Duval Serge Sultan Département de Psychologie Universitéde MontréalMontréalH3C 3J7Canada Centre de Recherche Centre Hospitalier Universitaire(CHU)Sainte-JustineMontréalH3T 1C5Canada Centre de Psycho-Oncologie(CPO) CHU Sainte-JustineMontréalH3T 1C5Canada École de Travail Social UniversitéLavalQuébecG1V 0A6Canada Département de Pédiatrie Universitéde MontréalMontréalH3T 1C5Canada Département de Pédiatrie Générale CHU Sainte-JustineMontréalH3T 1C5Canada Centre mère-enfant Soleil CHU de Québec-UniversitéLavalQuébecG1V 4G2Canada CHU de Québec-UniversitéLaval QuébecG1V 4G2Canada Patient Partenaire CHU Sainte-JustineMontréalH3T 1C5Canada Département d’Hémato-OncologIe CHU Sainte-JustineMontréalH3T 1C5Canada

In pediatric advanced cancer,i.e.,when cancer-targeted treatments are not effective,care provided to patients is of palliative *** aims at limiting symptoms and optimizing quality of life(QoL).To orient care,it is necessary to know and measure what is really important for young ***,tools are still scarce in this *** aim of this paper is to describe the development process of a new QoL assessment method,the Advance QoL *** is specifically designed for the clinical context of pediatric advanced *** previous studies carried out by our team identified seven important QoL domains for this *** developed a tool named Advance QoL—parent/caregiver version.A current study aims to develop self-reported versions of the Advance QoL for children(8-12 years)and adolescents(13-18 years)with advanced *** the very near future,the Advance QoL tool will be available in three versions(parents/caregivers,children,and adolescents)ready to be tested in validation *** assessment of the QoL of young people with cancer is a central process in defining targets for care and should be carried out throughout the trajectory,including when cancer is at an advanced stage,i.e.,when no standard treatment options are available.

关键词： Pediatric cancer advanced cancer palliative care quality of life measures

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Effect of synthesis variables of plasma synthesized polymers on growth of HepG2 cells

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BIOCELL 2017年第2期41卷 41-43页

作者： ELIZABETH PEREZ-TEJADA JUAN mORALES-CORONA LUIS ERNESTO gomez-QUIROZ mARIA CONCEPCIONGUTIERREZ-RUIZ ROBERTO OLAYO Departamento de Química.Universidad Autónoma metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Ciencias de la Salud.Universidad Autónoma metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Física.Universidad Autónoma metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaMéxicoD.F.CP 09340 CECyT No.8 Instituto Politécnico NacionalAve.de las Granjas 618Jardín AzpeitiaAzcapotzalcoCDMXCP 02530

Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both *** were polymerized on glass substrates under the same reaction *** of allylamine was also studied at different operating *** thin polymer films were used as culture surfaces for HepG2 cells,a cell line derived from a human *** proliferation,differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis,the physicochemical characteristics obtained and the performance as substrates for the cellular growth.

关键词： Hepatocytes Pyrrole Allylamine Plasma Polymerization

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Variability of the useful life of reservoirs in tropical locations:A case study from the Burdekin Falls Dam, Australia

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International Journal of Sediment Research 2018年第2期33卷 93-106页

作者： michelle Cooper Stephen E.lewis Thomas C.Stieglitz Scott G.Smithers College of Scilence and Engineering James Cook University Centre for Tropical Water ε Aquatic Ecosystem Research TropWATER James Cook University

Large dam construction for irrigation, hydropower, water supply, and flood control in tropical to subtropical areas increased markedly after 1950. many of the dams built during this period have filled with sediment and no longer perform to their original design specifications; in many cases, forecast dam life was greatly overestimated. This study investigates the useful life of Burdekin Falls Dam(BFD), northeastern Australia and compares the findings with other tropical reservoirs. Using two independent methods it is estimated that between 61 and 65 million m3 of sediment has been deposited in the reservoir over the 24 years of operation through 2011. This sediment volume equates to an average of0.15% of capacity lost per year since construction was completed. If current sediment loads/climate regimes persist, reservoir capacity will be reduced by 50% after 345 years. However, the useful life of the BFD reduces to just 276 years when drawdown data are considered; these data show reservoir use would be affected once 40% of storage was filled with sediment, with a 60% drawdown return period of 1 in 15 years. When compared to similar large tropical to sub-tropical reservoirs, the BFD has a slightly longer reservoir useful life than dams in India and a much longer half-life than for both similar-sized and larger dams in China, Brazil, and Iran. Properties of the BFD that promote a longer useful life include a lower trap efficiency, relatively low annual sediment load delivered to the reservoir, limited sediment deposition behind the dam wall(and uniform distribution of deposited sediment), and the export of highly turbid annual floodwaters before settling and deposition of any remaining sediment within the reservoir.

关键词： Reservoir half-life Lake Dalrymple Sediment trapping Trap efficiency Tropical reservoir Useful life

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Changes in symmetry of anterior chamber following routine cataract surgery in non-glaucomatous eyes

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Eye and Vision 2019年第1期6卷 148-155页

作者： Hanbin Lee Ieva Zukaite Valerie Juniat maria E.Dimitry Amanda lewis mayank A.Nanavat Presentations:The early results of this study were presented at the British Society for Refractive Surgery Congress BirminghamUnited KingdomMarch 2015 and the annual meeting of the Royal College of Ophthalmologist in May 2016

Background:To assess minimum and maximum changes in anterior chamber dimensions following routine cataract surgery in non-glaucomatous ***:Forty-two eyes(42 participants)underwent routine cataract surgery with same surgeon and were assessed preoperatively,1,3,6 and 12 months *** outcome measure:Angle-to-angle diameter(AAD)(at 0-180°,45-225°,90-270°,135-315°),Anterior-chamber-angle(ACA)(at 0°,45°,90°,135°,180°,225°,270° and 315°)and central anterior chamber depth(ACD)at all *** outcome measures:relationship to axial length(AL).Results:The mean AAD and ACA increased post-operatively in all meridians at all visits *** 12 months,there was a maximum change in AAD in horizontal meridian(506.55±468.71μm)and least in vertical meridian(256.31±1082.3μm).The mean percentage increase in ACA postoperatively was least at 90o(5%increase compared to 29–35%elsewhere).Central ACD deepened at all postoperative visits and this did not change over 12 *** was no correlation between AAD,ACA and ACD with AL at any ***:The AAD,ACA and ACD increases following cataract surgery in non-glaucomatous eyes,but at 12 months increase in AAD is least in vertical compared to horizontal ***,ACA was narrower(only 5%increase)superiorly compared to elsewhere(29–35%increase in ACA).This may have implications with regards to surgeries performed in the anterior chamber and corneal endothelial cell loss.

关键词： Anterior chamber depth Anterior chamber angle Angle to angle diameter

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mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2019年第9期14卷 1626-1634页

作者： Edwin E. Reza-Zaldivar mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-mercado Sergio Sandoval-ávila Ulises gomez-Pinedo Ana L. márquez-Aguirre Estefanía Vázquez-méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre Unidad de Evaluation Preclinica Unidad de Biotecnologia Medica y FarmaceuticaCentro de Investigation y Asistencia en Tecnologia y Diseno del Estado de JaliscoGuadalajaraMexico Regenerative medicine Unit Neuroscience InstituteDepartment of Neurosurgery and NeurologyIdlSSC Health Research Institute of the Hospital Clinico San CarlosMadridSpain

Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive *** purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s ***’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus *** water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after ***,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAm *** showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem *** findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s *** procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval *** 2016-011)on April 25,2016.

关键词： Alzheimer’s disease neurodegenerative disease cognitive impairment memory Alzheimer’s disease mouse model mesenchymal stem cell exosomes neurogenesis cognitive improvement cell-free therapy neural regeneration

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Survival of Seedlings of Native Woody Species in the Rehabilitation of Gold mined-Site within a Three Years Old Acacia mangium Willd Plantation of St. Elizabeth-mahdia, Guyana

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Journal of Environmental Science and Engineering(B) 2023年第3期12卷 133-145页

作者： Susy lewis Lawrence lewis Ryan Dey Lecturer 11 Forestry DepartmentFaculty of Agriculture and ForestryUniversity of GuyanaTurkeyen CampusGeorgetown 101110Guyana Senior Planning Officer Guyana Forestry Commission1 Water StreetKingstonGeorgetown 101110Guyana

Active restoration is a critical component of biodiversity conservation for degraded tropical forest ecosystems caused by artisanal gold mining, and the success of restoration is dependent on native species selection. However, significant knowledge gaps exist regarding when and where to plant trees. This article reports on a revegetation trial undertaken in St Elizabeth, mahdia, Guyana, to assess the survival and RGR (Relative Growth Rate) of three native woody trees and shrubs planted within three years old Acacia mangium Willd trees pruned and unpruned blocks. ANOVA (Analysis of Variance) for a completely randomized block design with four blocks, two pruned and two unpruned, within A. mangium plots. Biochar treatment was added to the plants during transplanting. Thirty-six (36) wildlings of Humiria balsamifera (Aublet.) (Tauroniro), Goupia glabra Aublet (Kabukalli), and Vismia guianensis (Aublet.) Choisy (Bloodwood) were collected and raised in a tree nursery for two weeks. The native plants were transplanted 3 m apart, survival observations and each seedling’s initial height and diameter were measured and recorded. After the experiment, 13% of seedlings from a population of 720 had died, with the highest mortality being experienced at the 92 days of the experiment (t ≤ 122 days). While the overall survival rates were high, emphasizing the importance of field trials on native and exotic species in different environments is essential to fill the knowledge gaps on suitable species for restoration in degraded areas with other land use histories.

关键词： Artisanal gold mining native species survival Acacia mangium diameter growth rate.

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Investigation of Coronavirus Deposition in Realistic Human Nasal Cavity and Impact of Social Distancing to Contain COVID-19:A Computational Fluid Dynamic Approach

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Computer modeling in Engineering & Sciences 2020年第12期125卷 1185-1199页

作者： mohammad Zuber John Valerian Corda milad Ahmadi BSatish Shenoy Irfan Anjum Badruddin Ali E.Anqi Kamarul Arifin Ahmad S.m.Abdul Khader Leslie lewis mohammad Anas Khan Sarfaraz Kamangar Department of Aeronautical&Automobile Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal576104India Department of mechanics of Solids Surfaces and SystemsFaculty of Engineering TechnologyUniversity of TwenteEnschede7522The Netherlands mechanical Engineering Department College of EngineeringKing Khalid UniversityAbha61421Saudi Arabia Department of Aerospace Engineering Universiti Putra MalaysiaSerdang43400Malaysia Department of mechanical and manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal576104India Department of Paediatrics Kasturba Medical College&HospitalManipal576104India Department of mechanical Engineering Jamia Millia IslamiaDelhi110025India

The novel coronavirus responsible for COVID-19 has spread to several countries within a considerably short *** virus gets deposited in the human nasal cavity and moves to the lungs that might be *** per safety guidelines by theWorld Health Organization(WHO),social distancing has emerged as one of the major factors to avoid the spread of ***,different guidelines are being followed across the countries with regards to what should be the safe ***,the current work is an attempt to understand the virus deposition pattern in the realistic human nasal cavity and also to find the impact of distance that could be termed as a safety *** study is performed usingComputationalFluid Dynamics as a solution tool to investigate the impact of COVID-19 deposition(i)On a realistic 3D human upper airway model and(ii)2D social distancing protocol for a distance of 0.6,1.2,1.8,and 2.4 *** results revealed that the regional deposition flux within the nasal cavity was predominantly observed in the external nasal cavity and nasopharyngeal *** flushing of these regions with saltwater substitutes can limit contamination in healthy *** safe distancing limit estimated with 1 m/s airflow was about 1.8 *** extensive deposition was observed for distances less than 1.8 m in this study,emphasizing the fact that social distancing advisories are not useful and do not take into account the external dynamics associated with airflow.

关键词： COVID-19 upper respiratory tract virus deposition social distancing

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Widespread glacier advances across the Tian Shan during marine Isotope Stage 3 not supported by climate-glaciation simulations

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Fundamental Research 2023年第1期3卷 102-110页

作者： Qing Yan lewis A.Owen Chuncheng Guo Zhongshi Zhang Jinzhe Zhang Huijun Wang Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of meteorological Disaster/Collaborative Innovation Center on Forecast and Evaluation of meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Department of marine Earthand Atmospheric ScienceNorth Carolina State UniversityRaleighNC 27695United States NORCE Norwegian Research Centre Bjerknes Centre for Climate ResearchBergenNorway Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan 430074China

Whether there were more extensive glaciations during the marine Isotope Stage(mIS)3 relative to mIS 2 across the Tian Shan in Central Asia is intensely debated because of the uncertainty in chronological data and fully understanding the driving *** help resolve the ongoing debate,we assess the climate sensitivity of the glaciers and reconstruct the extent of glaciation during mIS 2 and 3 across the Tian Shan,using a glacier-resolving(250×250 m)ice sheet model asynchronously coupled with a global climate *** results demonstrate that the equilibrium-line altitude(ELA)over the Tian Shan decreases by∼180 m for every 1°C cooling under a modern precipitation regime,but precipitation reduction greatly lowers the sensitivity of the glaciers to temperature decrease(e.g.,the effect of 2°C cooling is broadly offset by a 50%decrease in precipitation).Under the modeled colder/drier-than-present climate,the model predicts an ELA depression(∆ELA)of∼75 m(162 m)over the Tian Shan during mIS 3 interstadials(stadials).The extent of mIS 3 glaciation is much smaller than that during mIS 2(i.e.,∆ELA=∼726 m).The more extensive glaciation during mIS 2 is largely attributed to the enhanced summer ***,through a site-to-site model-data comparison,we find that the closest match between the modeled glacier margin and the locations of the glacial deposits previously argued to be mIS 3 is generally achieved under mIS 2 climatic *** results suggest more extensive glacier advances over the Tian Shan during mIS 2 than mIS 3 on a regional scale,although mIS 3 glaciation may still occur in individual glacier *** pattern suggests general synchronicity with the timing of maximum Northern Hemisphere ice sheets during the last glacial,which should be further tested in a multimodel framework in the future.

关键词： Glacier modeling Glacier sensitivity mIS 3 mIS 2 Tian Shan Paleoclimate modeling

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