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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu Congnuan Liu Song Hao Lee lewis sze chun choi Michael T.Wilson Dirk U.Pfeiffer Yun Young Go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina Center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina College of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

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Osteopontin is a biomarker for early autoimmune uveoretinitis

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Neural Regeneration Research 2022年第7期17卷 1604-1608页

作者： Jeongtae Kim Meejung Ahn Yuna choi Jiyoon chun Kyungsook Jung Akane Tanaka Hiroshi Matsuda Taekyun Shin Department of Anatomy Kosin University College of MedicineBusanRepublic of Korea Department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea Functional Biomaterials Research Center Korea Research Institute of Bioscience and BiotechnologyJeonbukRepublic of Korea Laboratory of Comparative Animal Medicine Division of Animal Life ScienceInstitute of AgricultureTokyo University of Agriculture and TechnologyTokyoJapan

Osteopontin(OPN)is an extracellular matrix protein with a diverse range of functions,including roles in cell adhesion,migration,and immunomodulation,which are associated with the modulation of neuroinflammation in the central nervous *** present study was performed to evaluate the involvement of OPN in the eyes of an experimental autoimmune uveoretinitis(EAU)*** EAU model was developed by immunization of lewis rats with interphotoreceptor retinoid-binding *** results showed the OPN level was remarkably upregulated in the eye of EAU rats on day 9 *** level of CD44,a ligand of OPN,was increased in the ciliary body of EAU ***,OPN was also detected in the ciliary body and activated microglia/macrophages in the EAU *** results suggest that OPN was significantly upregulated in the eyes of EAU rats,and that it may be useful as an early biomarker of ocular autoimmune *** animal experiments were approved by the Institutional Animal Care and Use Committee of Jeju National University(approval No.2020-0012)on March 11,2020.

关键词： CD44 ciliary body experimental autoimmune uveoretinitis macrophage Müller cell osteopontin photoreceptor cell retina

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Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials

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Cancer Communications 2022年第2期42卷 179-183页

作者： Sung Hwan Lee Yun Seong Jeong Sunyoung Lee Bo Hwa Sohn Ho Kyoung Hwang Gi Hong choi Chang Moo Kang Jin Sub choi Woo Jung Lee Jae-Ho Cheong Hee Jin Jang Ahmed Kaseb lewis Roberts Sun Young Yim Yun Shin chun Ju-Seog Lee Department of Systems Biology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Republic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryCHA Bundang Medical CenterCHA UniversitySeongnam 13496Republic of Korea Department of GI Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoul 03722Republic of Korea Division of Thoracic Surgery Michael E.DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030USA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902USA Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841Republic of Korea Department of Surgery The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)*** two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes.

关键词： therapeutic subtypes prognosis

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