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Plasma Scien.e an. Techn.logy 2009年第2期11卷 187-193页

作者： J.O.KAMGAn. M.n.ITALI J.-M.HERRY M.-n.BELLOn.FOn.AIn. J.-L.BRISSET R.BRIAn.ET Laboratory of In.erfacial Electrochemistry an. An.lytical Chemistry University of Rouen In.A(n.tion.l In.titute for Agricultural Research) UMR 763 Bio-adhesion and Hygiene of Materials AgroParisTech UMR 763 Bio-adhesion and Hygiene of Materials AgroParisTech UMR763 Bio-adhesion and Hygiene of Materials

This study addressed the effects of treatmen. with glidin. discharge plasma on.the surface properties of solid materials, as well as the con.equen.es con.ern.n. adheren.e of a model bacterium. As evaluated by con.act an.les with selected liquids, plasma treatmen. caused an.in.rease in.surface hydrophilicity an. in.the lewis acid-base compon.n.s of the surface en.rgy of all materials tested. These modification. were more marked for low den.ity polyethylen. an. stain.ess steel than.for polytetrafiuoroethylen.. After treatmen., the hydrophilicity of the materials remain.d relatively stable for at least 20 days. Moreover, an.lysis of the topography of the materials by atomic force microscopy revealed that the roughn.ss of both polymers was reduced by glidarc plasma treatmen.. As a result of all these modification., solid substrates were activated towards micro-organ.sms an. the adheren.e of S. epidermidis, a n.gatively charged lewis-base an. mildly hydrophilic strain.selected as the model, was in.reased in.almost all the cases tested.

关键词： glidin. arc plasma surface en.rgy properties polymers stain.ess steel surface hydrophilicity atomic force microscopy

Cross-section.l study to determin. viral hepatitis kn.wledge in.differen. urban.population. in.Brazil

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World Journ.l of Hepatology 2018年第11期10卷 867-876页

作者： Helen. Medin. Cruz Jakelin. Ribeiro Barbosa Jeová Ken. Baima Colares An.on.o Hen.ique Almeida de Moraes n.to Maria de Fátima Leal Alen.ar Fran.isco In.cio Bastos Jurema Corrêa da Mota Filipe An.bal Carvalho-Costa Claudia Alexan.ra Pon.es Ivan.es Lia Laura lewis-Ximen.z Livia Melo Villar Laboratory of Viral HepatitisOswaldo Cruz In.titute Fiocruz Rio de Janeiro 21040360 Brazi Postgraduate Program in.Pathology Federal University of Ceará Fortaleza Ceará 60020181 Brazil Postgraduate Program in.Medical Scien.es University of Fortaleza Ceará 60430160 Brazil Laboratory of In.ovation. in.Therapies Teaching and Bioproducts Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazil In.titute of Commun.cation.an. Scien.ifc In.ormation.an. Techn.logy for Health Oswaldo Cruz Foundation Rio de Janeiro 21040900 Brazil Laboratory of Epidemiology an. Molecular Systematics Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040900 Brazil Orien.ation.an. Coun.ellin. Cen.re Curitiba Paraná 80810070 Brazil

AIM To evaluate viral hepatitis kn.wledge amon. in.ividuals from differen. resource areas an. health con.ition. to iden.ify possible *** A cross-section.l, descriptive study was carried out amon. 447 in.ividuals from five distin.t population. in.Brazil: Southeast Viral Hepatitis Ambulatory(n.= 100), South(n.= 89) an. n.rtheast(n.= 114) Health Cen.er, Southeast(n.= 77) an. n.rtheast(n.= 67) low resource areas. All in.ividuals an.wered a question.aire assessin. sociodemographic characteristics an. viral hepatitis awaren.ss. The perception.was scored based on.the average n.mber of correct an.wers of all participan.s an. categorized as "low"(0-28 correct an.wers) or "desirable"(29-46 correct an.wers). Association. between.sociodemographic characteristics an. perception.were also *** A low level of kn.wledge was observed in.in.ividuals from n.rtheast Health Cen.er, n.rtheast an. Southeast low resource areas while desirable kn.wledge was observed in.in.ividuals from Viral Hepatitis Ambulatory an. South Health Cen.er. Accordin. to sociodemographic characteristics, desirable scores were more common.amon. those with secon.ary education.47.1%), those who declared themselves as white(46.3%), an. those who lived in.houses with three in.ividuals(25.5%). Multivariate an.lysis showed an.association.between.viral hepatitis perception.an. type of population. COn.LUSIOn.The results demon.trated high level of kn.wledge amon. study participan.s from health clin.cs from the Southeast region.of Brazil an. the importan.e of education.programs in.in.reasin. the level of kn.wledge in.low resource areas.

关键词： Viral hepatitis Kn.wledge Perception Urban.population Brazil

Morphin. has laten. deleterious effects on.the ven.ilatory respon.es to a hypoxic challen.e

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Open.Journ.l of Molecular an. In.egrative Physiology 2013年第3期3卷 166-180页

作者： Walter J. May Ryan.B. Gruber Joseph F. Discala Veljko Puskovic Fraser Hen.erson.Jr. Lisa A. Palmer Stephen.J. lewis Pediatric Respiratory Medicin. University of Virginia School of Medicine Charlottesville USA Division.of Biology Galleon Pharmaceuticals Horsham USA

The aim of this study was to determin. whether morphin. depresses the ven.ilatory respon.es elicited by a hypoxic challen.e (10% O2, 90% n.) in.con.cious rats at a time when.the effects of morphin. on.arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradien. an. min.te ven.ilation.(Vm) had completely subsided. In.vehicle-treated rats, each episode of hypoxia stimulated ven.ilatory fun.tion.an. the respon.es gen.rally subsided durin. each n.rmoxic period. Morphin. (5 mg/kg, i.v.) in.uced an.array of depressan. effects on.ABG chemistry, A-a gradien. an. Vm (via decreases in.tidal volume). Despite resolution.of these morphin.-in.uced effects, the first episode of hypoxia elicited substan.ially smaller in.reases in.Vm than.in.vehicle-treated rats, due main.y to smaller in.reases in.frequen.y of breathin.. The pattern.of ven.ilatory respon.es durin. subsequen. episodes of hypoxia an. n.rmoxia chan.ed substan.ially in.morphin.-treated rats. It is eviden. that morphin. haslaten. deleterious effects on.ven.ilatory respon.es elicited by hypoxic challen.e.

关键词： Morphin. Hypoxia Min.te Ven.ilation Arterial Blood Gas Chemistry Con.cious Rats

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加密货币:达成共识的协议

数学译林 2021年第3期40卷 209-219,199页

作者： An.rew lewis-Pye 张翰文(译) 赵振江(校) 伦敦经济学院不详

比特币[n.08]作为一种货币,其新颖特点是去中心化(decen.ralised),也就是说,在不使用中央银行或任何中央控制点的情况下运行,然而,除了作为货币之外,像比特币这样的加密货币实际上是在去中心化用户网络上达成共识的协议.尽管货币流通是... 详细信息

比特币[n.08]作为一种货币,其新颖特点是去中心化(decen.ralised),也就是说,在不使用中央银行或任何中央控制点的情况下运行,然而,除了作为货币之外,像比特币这样的加密货币实际上是在去中心化用户网络上达成共识的协议.尽管货币流通是这种协议一个可能的应用,人们还在考虑其他可能的应用.

关键词：去中心化用户网络中央银行比特币加密货币控制点货币流通协议

环境空气污染与老年人中的抑郁症状:波士顿MOBILIZE研究结果

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环境与职业医学 2014年第9期31卷 671-671页

作者： Yi Wan. Melissa n. Eliot Petros Koutrakis Alexan.ros Gryparis Joel D. Schwartz Bren. A. Coull Murray A. Mittleman.William P. Milberg lewis A. Lipsitz Gregory A. Wellen.us

[背景]暴露于空气污染特别是来源于交通的空气污染与不良的认知结局有关联,但它与抑郁症状间的关联尚不清楚。[目的]研究波士顿地区732名≥65岁[均数±标准差:(78.1±5.5)岁]的成人中暴露于空气和交通污染与出现抑郁症状之间的关联。[方... 详细信息

[背景]暴露于空气污染特别是来源于交通的空气污染与不良的认知结局有关联,但它与抑郁症状间的关联尚不清楚。[目的]研究波士顿地区732名≥65岁[均数±标准差:(78.1±5.5)岁]的成人中暴露于空气和交通污染与出现抑郁症状之间的关联。[方法]使用经修订的流行病学研究中心抑郁量表(CESD-R)进行家庭入户访问,对抑郁症状进行评估。估计住宅与最近的主要道路的距离,作为长期暴露于交通污染的标志物,并取每次评估前两周之的平均值评估大气细颗粒物(PM2.5)、硫酸盐、炭黑(BC)、超细颗粒和气态污染物的短期暴露。用广义估计方程估计CESD-R评分≥16与暴露的优势比(OR),模型中调整了潜在的混杂因素。在敏感性分析中,把CESD-R评分作为连续结局变量,把年均住宅BC作为长期暴露于交通污染的替代标志物。[结果]未发现证据表明长期暴露于交通污染或污染物水平的短期变化与抑郁症状呈正相关。[结论]在美国大都市区的老年人群中,未发现环境空气污染与抑郁症状间存在关联的证据,符合目前美国监管标准。

关键词：环境空气污染 MOBILIZE 交通污染波士顿地区超细颗粒广义估计方程大都市区结局变量气态污染物敏感性分析

2型糖尿病患者胰岛素治疗与患结直肠癌风险的相关性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 31-32页

作者： Hen.essy S. lewis J.D. 王志宇

Backgroun. &Aims: En.ogen.us hyperin.ulin.mia in.the con.ext of type 2 diabetes mellitus is poten.ially associated with an.in.reased risk of colorectal can.er. We aimed to determin. whether in.ulin.therapy might in.rease the risk of colorectal can.er amon. type 2 diabetes mellitus patien.s. Methods: We con.ucted a retrospective cohort study amon. all patien.s with a diagn.sis of type 2 diabetes mellitus in.the Gen.ral Practice Research Database from the Un.ted Kin.dom. We excluded patien.s with n.er free database follow up after the diabetes diagn.sis as well as those in.ulin.users who developed colorectal can.er after n.ulin.therapy. The remain.n. in.ulin.users an. the n.n.n.ulin.usin. type 2 diabetic patien.s were followed for the occurren.e of colorectal can.er. Hazard ratios (HR) were determin.d in.Cox proportion.l hazard an.lysis. A n.sted case con.rol study was con.ucted to perform multivariable an.lysis an. to determin. a duration.respon.e effect. Results: The in.iden.e of colorectal can.er in.in.ulin.users (n.= 3160) was 197 per 100,000 person.years, compared with 124 per 100,000 person.years in.type 2 diabetes mellitus patien.s n.t receivin. in.ulin.(n.= 21 ,758). The age an. sex adjusted HR of col orectal can.er associated with ≥1 year of in.ulin.use was 2.1 (95%CI: 1.2-3.4, P=0.005). The positive association.stren.then.d after adjustin. for poten.ial con.oun.ers. The multivariable odds ratio associated with each in.remen.al year of in.ulin.therapy was 1.21 (95%CI: 1.03-1.42, P = 0.02). Con.lusion.: Chron.c in.ulin.therapy sign.fican.ly in.reases the risk of colorectal can.er amon. type 2 diabetes mellitus patien.s.

关键词：结直肠癌高胰岛素血症研究数据库患病风险病例对照研究回顾性队列研究比值比多变量分析干扰因素内源

The Effect of the Oxygen.Preadsorption.on.the Adsorption.of n.tric Oxide on.Mo (111)

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Chemical Research in.Chin.se Un.versities 1993年第3期9卷 214-219页

作者： WAn. Guo-Jia (Departmen. of Chemistry, Jilin.Un.versity, Chan.chun. 130023)K. B. lewis an. G. A. Somorjai(Materials an. Molecular Research Division.Lawren.e Berkeley Laboratory an. Departmen. of Chemistry, Un.versity of Californ.a Berkeley, Californ.a, 94720, U. S. A. )

The adsorption.of n.tric oxide adsorption.on.clean.Mod(111), Mo(111)/O2-(4×4), Mo(111)/O2-(1×3), Mo(111)/O2-(112) facets an. Mo(111) oxide surfaces was studied. Mass 28 (n.) desorption.spectra show two high temperature peaks at approximate 1030 (β1) an. 1200K (β2). For n. exposures less than.0. 1 L on.y the ft peak was observed. At higher exposures, the ft peak appeared an. small amoun.s of n.O as well as n. desorbed. The preadsorption.of oxygen.blocked the β2 desorption.partially on.the (4×4) an. (1×3) surfaces an. fully on.the (112) facet an. oxide surfaces. In.addition. the β1 desorption.peak shifted to higher temperatures with in.reasin. oxygen.preexposure.

关键词： Adsorption n.tric、oxide Oxygen.preadsorption

用in.liximab治疗女阴Crohn.

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 36-36页

作者： Preston.P.W. Hudson.n. lewis F.M. 冯义国 Departmen. of Dermatology Worcestershire Royal Hospital Charles Hastings WayWorcester WR5 1DD United Kingdom Dr.

An.i-tumour n.crosis factor-α therapy of Crohn. s disease (CD) with in.liximab has proved a major advan.e in.the treatmen. of patien.s with difficult disease. We report our experien.e of the use of in.liximab in.a patien. with recalcitran. vulval CD. The in.roduction.of in.liximab has improved disease con.rol, although a search for an.optimum remittive dosin. schedule is on.oin..

关键词： in.liximab Crohn. 女阴抗肿瘤坏死因子

Experimen.al Study of the An.itumor Activity of Polymetalacrylates again.t An.mal Tran.plan.able Tumors

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Journ.l of Can.er Therapy 2010年第2期1卷 59-65页

作者： Larisa A. Ostrovskaya M. G. Voron.ov D. B. Korman.M. M. Fomin. n. V. Bluhterova V. A. Rikova K. A. Abzaeva L. V. Zhilitskaya A.E. Favorsky Irkutsk In.titute of Chemistry Siberian Branch of the Russian Academy of Sciences Irkutsk Russia n.M. Eman.el In.titute of Biochemical Physics Russian Academy of Sciences Russian Moscow

The an.itumor activity of the fourteen.polymetalacrylates again.t two models of murin. solid tumors (lewis lun. carcin.ma an. Acatol aden.carcin.ma) as well as the acute toxicity of these compoun.s has been.studied. It was shown.that polyacrylates of n.ble metals (argen., aurum, platin.m), n.mely argacryl (М = Ag), auracryl (М = Au) an. platacryl (М = Pt) were the most effective agen.s amon. tested compoun.s again.t studied tumors. Thus, the tumor growth in.ibitory effect of argacryl again.t lewis lun. carcin.ma was equal to 90%, the life-span.of treated by this compoun. an.mals has in.reased on.50% in.comparison.with con.rol. Auracryl in.uced the in.ibition.of the lewis lun. carcin.ma an. Acatol aden.carcin.ma developmen. on.60 an. 65%, correspon.in.ly an. the in.reasin. of the mean.life-span.of an.mals with lewis lun. carcin.ma on.20% in.comparison.with con.rol. Platacryl in.ibited the growth of lewis lun. carcin.ma on.40% in.reasin. the mean.life-span.of an.mals on.25% in.comparison.with con.rol. In.this way it was established that argacryl is the agen. with the stron.est an.itumor activity amon. studied polymetalacrylates. On.the basis of obtain.d data it seems possible to con.ider polymetalacrylates as a group of agen.s with the poten.ial an.itumor activity suitable for the further deep experimen.al in.estigation.

关键词： Polymetalcrylates An.itumor Activity Tran.plan.able Tumors of An.mals

Iden.ification.of n.w gen.tic risk factors for prostate can.er

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Asian.Journ.l of An.rology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin.Al Olama Sarah K. Jugurn.uth Shan. Mulhollan. Dan.el A. Leon.amomlert Stephen.M. Edwards Jon.than.Morrison.Helen.I. Field Melissa C. Southey Gian.uca Severi Jen.y L. Don.van.Freddie C. Hamdy David R Dearn.ley Ken.eth R. Muir Charmain. Smith Melisa Bagn.to Audrey T. Ardern.Jon.s Aman.a L. Hall Lyn.e T. O＇Brien.Beatrice n. Gehr-Swain.Rosemary A. Wilkin.on.An.ela Cox Sarah lewis Paul M. Brown.Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatan.n.n.Sarah L. Bryan. The UK Gen.tic Prostate Can.er Study Collaborators British Association.of Urological Surgeon.＇ Section.of On.ology an. The UK ProtecT Study Collaborators Alan.Horwich Robert A. Huddart Vin.en. S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan.Thompson.Tim Christmas Chris Ogden.Cyril Fisher Charles Jameson.Colin.S. Cooper Dallas R. En.lish John.L. Hopper David E. n.al Douglas E Easton.Rosalin. A. Eeles Section.of Can.er Gen.tics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Can.er Epidemiology Cen.re The Cancer Council Victoria Carlton VIC 3053 Australia Cen.re for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Can.er Research UK Gen.tic Epidemiology Un.t University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Departmen. of On.ology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Gen.tic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Departmen. of Social Medicin. University of Bristol Bristol BS8 2PR UK Academic Urology Un.t University of Sheffield Sheffield SIO 2JF UK The Royal Marsden.n.S Foun.ation.Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK Un.versity of n.ttin.ham Medical School Queens Medical Centre Nottingham NG7 2UH UK In.titute for Can.er Studies University of Sheffield Sheffield SIO 2RX UK Surgical On.ology （Uro-On.ology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in.the Supplemen.ary n.te on.in. Ka Shing Centre Cambridge CB2 ORE UK Can.er Research UK Cambridge Research In.titute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is eviden.e that a substan.ial part of gen.tic predisposition.to prostate can.er （PCa） may be due to lower pen.tran.e gen.s which are foun. by gen.me-wide association.studies. We have recen.ly con.ucted such a study an. seven.n.w region. of the gen.me lin.ed to PCa risk have been.iden.ified. Three of these loci con.ain.can.idate susceptibility gen.s： MSMB, LMTK2 an. KLK2/3. The MSMB an. KLK2/3 gen.s may be useful for PCa screen.n., an. the LMTK2 gen. might provide a poten.ial therapeutic target. Together with results from other groups, there are n.w 23 germlin. gen.tic varian.s which have been.reported. These results have the poten.ial to be developed in.o a gen.tic test. However, we con.ider that marketin. of tests to the public is premature, as PCa risk can.n.t be evaluated fully at this stage an. the appropriate screen.n. protocols n.ed to be developed. Follow-up validation.studies, as well as studies to explore the psychological implication. of gen.tic profile testin., will be vital prior to roll out in.o healthcare.

关键词： prostate can.er gen.tics susceptibility loci Sn.s relative risks