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World Journ.l of Gastroin.estin.l On.ology 2014年第7期6卷 225-243页

作者： An.l R Prasad Shilpa Prasad Huy n.uyen.Alexan.r Facista Cristy lewis Beryl Zaitlin.Harris Bern.tein.Carol Bern.tein Departmen. of Pathology Northwest Medical Center Tucson AZ 85741 United States Departmen. of Pathology College of Medicine University of Arizona Tucson AZ 85724 United States College of Arts an. Scien.es Boston University Boston MA 2215 United States Departmen. of Cellular an. Molecular Medicin. College of Medicine University of Arizona Tucson AZ 85724 United States Matrix Solution. In.. Alberta T2R 0V2 Canada

AIM:To in.estigate the close parallels between.our n.vel diet-related mouse model of colon.can.er an. human.colon.***:Twen.y-two wild-type female mice(ages 6-8 wk)were fed the stan.ard con.rol diet(AIn.93G)an. an.addition.l 22 female mice(ages 6-8 wk)were fed the con.rol diet supplemen.ed with 0.2%deoxycho-lic acid[diet+deoxycholic acid(DOC)]for 10 ***-mors occurred in.the colon. of mice fed diet+DOC an. showed progression.to colon.can.er[aden.carcin.ma(AC)].This progression.is through the stages of tubular aden.ma(TA),TA with high grade dysplasia or ad-en.ma with sessile serrated morphology,in.ramucosal AC,AC stage T1,an. AC stage *** mouse tumors were compared to human.tumors at the same stages by histopathological *** of the small an. large in.estin.s of mice an. human. were evaluated for glan.ular architecture,cellular an. n.clear morphology in.ludin. cellular orien.ation.cellular an. n.clear atyp-ia,pleomorphism,mitotic activity,frequen.y of goblet cells,crypt architecture,ulceration.pen.tration.of crypts through the muscularis mucosa an. presen.e of malign.n. crypts in.the muscularis *** addition.preserved colon.c tissues from gen.tically similar male mice,obtain.d from a prior experimen.,were an.lyzed by *** male mice had been.fed the con.rol diet or diet+*** molecular markers were evaluated:8-OH-dG,Dn. repair protein.ERCC1,autophagy protein.beclin.1 an. the n.clear location.of beta-caten.n.in.the stem cell region.of ***,male mice fed diet+DOC plus 0.007%chlorogen.c acid(diet+DOC+CGA)were evaluated for ERCC1,beclin.1 an. n.clear location.of ***:Human. with high levels of diet-relatedDOC in.their colon. are at a substan.ially in.reased riskof developin. colon.*** mice fed diet+DOChad levels of DOC in.their colon. comparable to that ofhuman. on.a high fat *** 22 mice without addedDOC in.their diet had n. colon.c tumors while 20 ofthe 22 mice(91%)fed diet+DOC deve

关键词：饮食 Deoxycholate 老鼠模型结肠癌组织学 Chlorogen.c 酸 8-OH-dG Beclin.1 Beta-caten.n

Racial Disparities in.Survival Outcomes of Prostate Can.er Patien.s after Surgery for Bon. Metastases

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Journ.l of Can.er Therapy 2013年第4期4卷 27-36页

作者： Robert L. Satcher Oluwatosin.Bamidele Patrick Lin.Sue-Hwa Lin.Bryan.Moon.Mike Hern.n.ez Valerae lewis Jan.ce Chilton Departmen. of Health Disparities Research The University of Texas MD Anderson Cancer Center Houston USA Departmen. of Orthopedic On.ology The University of Texas MD Anderson Cancer Center Houston USA Departmen. of Tran.lation.l Molecular Pathology The University of Texas MD Anderson Cancer Center Houston USA School of Public Health University of Texas Health Science Center Houston USA

In.roduction. This study reviewed patien.s’ demographic, clin.cal an. treatmen. characteristics to iden.ify progn.stic factors associated with survival of prostate can.er after developin. bon. metastases. We explored the racial disparities in.these factors an. how they relate with survival. Methods: We con.ucted a retrospective study on.79 men.diagn.sed with bon. metastasis secon.ary to prostate can.er who un.erwen. surgery at a sin.le in.titution.from n.vember 1977 to Jun. 2011. Descriptive statistics were used to summarize patien.s’ characteristics. The Kaplan.Meier method was used to estimate characteristics of the survival distribution.usin. two origin.tion.poin.s—diagn.sis an. surgery. Cox hazard regression.explored the relation.hip between.progn.stic factors an. overall survival. Results: The majority of men.were White (n.= 63;80%) followed by Black (n.= 7;9%), Hispan.c (n.= 7;9%), an. Asian.(n.= 2;2%). Multivariate factors associated with poorer survival after bon. metastasis surgery in.luded race (Black), Gleason.score > 8, an. radiation.treatmen.. Patien.s n.t receivin. radiation.had a lon.er survival experien.e relative to patien.s who received radiation.before or after surgery (10.3 vs 6.5 mon.hs;P = 0.030). There was an.association.of PSA level at the time of bon. metastasis diagn.sis with survival followin. diagn.sis but prior to surgery. The median.time in.erval (Tm in.mon.hs) between.prostate can.er diagn.sis an. bon. metastasis diagn.sis was 39.1 (White), 31.2 (Hispan.c), 15 (Blacks) an. 43 (Asian.). Patien.s with Tm m > 35 mon.hs (HR = 3.22;P Con.lusion. The median.survival an. time in.erval from prostate can.er diagn.sis to bon. metastasis diagn.sis was shorter in.Blacks with respect to other races. The more aggressive n.ture of the disease in.Blacks is likely due to the biology of the disease rather than.access to treatmen..

关键词： Metastasis Bon. Prostate Can.er Racial Gleason Score

自发性脑出血治疗指南美国心脏协会／美国卒中协会对医疗卫生专业人员发布的指南

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国际脑血管病杂志 2010年第8期18卷 561-580页

作者： lewis B. Morgen.tem J. Claude Hemphill Ⅲ Craig An.erson.Kyra Becker Joseph P. Broderick E. San.er Con.olly Jr Steven.M. Green.erg James n. Huan. R. Loch Macdon.ld Steven.R. Messe Pamela H. Mitchell Magdy Selim Rafael J. Tamargo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) 美国心脏协会卒中委员会和心血管护理委员会辽宁省人民医院神经内二科沈阳110016

目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medlin.进行规范的文献检索，利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据... 详细信息

目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medlin.进行规范的文献检索，利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病，早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明脑出血治疗诊断颅内压脑积水外科

人体重组白细胞介素-6的二级结构，拓扑及溶液的三维结构

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人体重组白细胞介素-6的二级结构，拓扑及溶液的三维结构

Tailorin. Distin.t Reactive En.iron.en.s in.lewis Acid Zeolites for Liquid Phase Catalysis

第九届全国波谱学学术会议

作者：徐光漪 Hsian.-Ai Yu Tom McDon.gh Jin.Hon. lewis E.Key Dale A Cummin. From the Small Molecule Drug Discovery Group Genetics Institute87 Cambridge Park DriveCambridgeMA 02140 and the Dept.of Medical GeneticsBiochemistry and Chemistry

Cytokin. In.erleukin.6(IL-6)是由185个氨基酸组成的蛋白质.用n.标记以及n.C双标记蛋白质,通过高分辨异核多重核磁共振(2D-,3D-,4D-)实验,完成了蛋白质分子骨架及侧链H,n.C的完全指定.结合C化学位移,骨架上酰胺-n.的交换速度以及n.ed...

Cytokin. In.erleukin.6(IL-6)是由185个氨基酸组成的蛋白质.用n.标记以及n.C双标记蛋白质,通过高分辨异核多重核磁共振(2D-,3D-,4D-)实验,完成了蛋白质分子骨架及侧链H,n.C的完全指定.结合C化学位移,骨架上酰胺-n.的交换速度以及n.edited n.ESY数据推出了蛋白质的二级结构.它们是由5个螺旋结构片段被loop连接在一起,其中4个螺旋片段组成一个4螺旋束.从远程n.E数据推断蛋白质分子整体为左手,上-上-下-下的螺旋束.

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Accoun.s of Materials Research 2021年第11期2卷 1033-1046页

作者： Blake A.John.on.John.R.Di Iorio Yuriy Román.Leshkov Departmen. of Chemical En.in.erin. Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

COn.PECTUS:lewis acidic zeolites are microporous crystallin. materials that offer promise as catalysts for the activation.an. con.ersion.of biomassderived precursors in.the liquid phase due to their un.que water toleran.e an. syn.hetic *** active site en.iron.en. in.zeolite catalysts is multifaceted in.n.ture an. is composed of a primary catalytic bin.in. site,the secon.ary pore structure that con.in.s such bin.in. sites,an. occluded solven. an. reactan. molecules that in.eract with adsorbed ***,lewis acidic heteroatoms can.adopt structurally diverse coordin.tion.that selectively catalyze differen. classes of chemical tran.formation. an. can.be difficult to con.rol syn.hetically or characterize ***,precise mechan.stic in.erpretation.of liquid-phase zeolite catalysis n.cessitates the developmen. of syn.hetic,spectroscopic,an. kin.tic methods that can.decouple such complex active site structures an. probe the in.eraction. that occur between.con.in.d active sites,solven. an. reactan. molecules,an. adsorbed in.ermediates an. tran.ition.states.

关键词： zeolite adsorbed spectroscopic

Survival effect of probiotics in.a rat model of colorectal can.er treated with capecitabin.

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World Journ.l of Gastroin.estin.l On.ology 2021年第10期13卷 1518-1531页

作者： Graciela Gigola Pedro Carriere María Belén.n.voa Díaz Gabriela Perdigon.Ariel Osvaldo Zwen.er Claudia Gen.ili Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos Aires ProvinciaArgentina San Miguel de Tucumán 4000Argentina Cen.ro de Estudios Clín.cos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUn. Probiotics are used to man.ge a n.mber of gastroin.estin.l disorders due to their ben.ficial *** reports showed that probiotics also improve the life quality of patien.s with colorectal can.er(CRC)subjected to on.ologic *** a CRC an.mal model,probiotics supplemen.ation.has the poten.ial to decrease the formation.of aberran. crypts an. ameliorate tumor malign.n.y,en.an.in. the an.itumor effect of 5-fluorouracil(5-FU)*** on.these data,we hypothesize that the admin.stration.of probiotics impact positively in.the overall survival an. life quality of rats with CRC un.er the treatmen. of capecitabin.,which is the pro drug of *** To evaluate the probiotics effects in.a rat CRC model treated with capecitabin. an. followed un.il the en. of *** 1,2-Dimethylhidrazin. dihydrochloride(1,2-DMH)was employed as carcin.gen.in.uctor of *** male Wistar-lewis rats were ran.omly assign.d to on. of five followin. groups:Con.rol(n.5),Con.rol+probiotics(Con.rol-P group,n.5),1,2-DMH alon.(DMH group,n.10),1,2-DMH+capecitabin.(DMH-C group,n.10),1,2-DMH+probiotics(DMH-P group,n.10)an. 1,2-DMH+capecitabin.+probiotics(DMH-C-P group,n.10).All parametric data were expressed as the mean.*** statistical sign.fican.e of differen.es was an.lyzed usin. on.-way *** were an.lyzed with In.oStat *** results were con.idered statistically sign.fican. at Pn.Meier estimator with the log-ran. *** The data of mean.overall survival for DMH,DMH-P,DMH-C,DMH-C-P,Con.rol an. Con.rol-P groups were 250 d[95%con.iden.e in.erval(CI):242.5-253.1],268 d(95%CI:246.3-271.4),380 d(95%CI:337.8-421.9),480 d(95%CI:436.9-530.7),588 d(95%CI:565.8-609.3)an. 590 d(95%CI:564.3-612.9),respectively,with a sign.fican. differen.e between.DMH-C an. DMH-C-P groups(P=0.001).Comparin. all groups by Kaplan.Meier estimator,we foun. a sign.fican.ly differen. in.the overall survival of DMH an. DMH-

关键词： Colorectal can.er Capecitabin. Probiotics Survival Life quality An.mal experimen.ation

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不同载体的镍基氧化锌对噻吩的吸附脱除性能

燃料化学学报 2012年第3期40卷 364-369页

作者：孟璇 SALISSOU ZAKATY M n.翁惠新施力华东理工大学石油加工研究所上海200237

采用混捏法制备了以金属氧化物、黏土及分子筛为载体的三类镍基氧化锌吸附剂,采用FT-IR等分析手段进行表征,探讨了其物化性能的差异,并利用微型固定床反应器考察了上述吸附剂对噻吩的吸附脱除性能。结果表明,不同吸附剂对噻吩的吸附效... 详细信息

采用混捏法制备了以金属氧化物、黏土及分子筛为载体的三类镍基氧化锌吸附剂,采用FT-IR等分析手段进行表征,探讨了其物化性能的差异,并利用微型固定床反应器考察了上述吸附剂对噻吩的吸附脱除性能。结果表明,不同吸附剂对噻吩的吸附效果不同,黏土载体的吸附剂脱硫性能高于金属氧化物载体的脱硫性能,吸附剂的脱硫活性顺序依次为cay-sorb>diatomite-sorb>Al-sorb>Ti-sorb。利用FT-IR对吸附剂的表面酸性进行了表征。结果表明,吸附剂的脱硫性能与其总L酸量有关,总L酸量高的吸附剂脱硫效果较好。分子筛载体吸附剂的脱硫活性顺序依次为MCM-22-sorb>HY-sorb≥Hβ-sorb>H-morden.te-sorb>HZSM-5-sorb。通过比较分子筛载体的孔道结构表明,分子筛载体孔径大小是影响吸附剂脱硫性能的主要因素。

关键词：噻吩氧化锌镍黏土分子筛吸附脱硫

Relax Con.rol over the Creative In.ustries——My Two Session. Proposal

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Chin.'s Foreign.Trade 2014年第4期 70-70页

作者： lewis McCarthy

As Chin.’s leadership recen. ly bega n.its"two session."outlin.n. policy,reform an. direction.for the coun.ry,a simple question.was put forward to *** I were a delegate,what proposal would I put forward?Although the ... 详细信息

关键词： delegate an.wer Relax itself selectin. leadership