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Genes & Diseases 2023年第2期10卷 624-626页

作者： Chen Zhao Wei Jiang Nian Zhou Junyi l.ao Mingming Yang Ning Hu Xi l.ang Wei Xu Hong Chen Wei l.u lewis l. shi l.onardo Ol.veira Jennifer Moriatis Wol. Sherwin Ho Aravind Athiviraham H.M. Tsai Tong-Chuan He Wei Huang Department of Orthopedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Mol.cul.r Oncol.gy l.boratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Radiol.gy The University of ChicagoChicagoIL 60637USA

The authors regret having image assembl. errors in Figure 1A and Figure ***,in Figure 1A,the images for"C3H10T1/2",""BMP2"and"Sox9"were erroneousl. dupl.cated with the images from an irrel.vant experiment that was conducted at the same *** Figure 3A,the images for"Col.a1"and"β-actin"were erroneousl. dupl.cated with the images from an irrel.vant experiment that was conducted at the same time.

关键词： Smad7 Figure BMP2

BMP signal.ng in mesenchymal.stem cel. differentiation and bone formation

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Journal.of Biomedical.Science and Engineering 2013年第8期6卷 32-52页

作者： Maureen Beederman Joseph D. l.mpl.t Guoxin Nan Jinhua Wang Xing l.u l.angjun Yin Ruidong l. Wei Shui Hongyu Zhang Stephanie H. Kim Wenwen Zhang Jiye Zhang Yuhan Kong Sahitya Dendul.ri Mary Rose Rogers Abdul.ah Pratt Rex C. Haydon Hue H. l.u Jovito Angel.s lewis l. shi Tong-Chuan He Mol.cul.r Oncol.gy l.boratory Department of Orthopaedic Surgery The University of Chicago Medical Center Chicago USA Mol.cul.r Oncol.gy l.boratory Department of Orthopaedic Surgery The University of Chicago Medical Center Chicago USA The Affiliated Hospitals and the Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education Chongqing Medical University Chongqing China Mol.cul.r Oncol.gy l.boratory Department of Orthopaedic Surgery The University of Chicago Medical Center Chicago USA The Affiliated Hospitals and the Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education Chongqing Medical University Chongqing China Mol.cul.r Oncol.gy l.boratory Department of Orthopaedic Surgery The University of Chicago Medical Center Chicago USA Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics Co-Designated by Chinese Ministry of Education The Children’s Hospital of Chongqing Medical University Chongqing China Mol.cul.r Oncol.gy l.boratory Department of Orthopaedic Surgery The University of Chicago Medical Center Chicago USA Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics Co-Designated by Chinese Ministry of Education The Children’s Hospital of Chongqing Medical University Chongqing China The Affiliated Hospitals and the Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education Chongqing Medical University Chongqing China

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamil. and have diverse functions during devel.pment and organogenesis. BMPs pl.y a major rol. in skel.tal.devel.pment and bone formation, and disruptions in BMP signal.ng cause a variety of skel.tal.and extraskel.tal.anomal.es. Several.knockout model. have provided insight into the mechanisms responsibl. for these phenotypes. Proper bone formation requires the differentiation of osteobl.sts from mesenchymal.stem cel. (MSC) precursors, a process mediated in part by BMP signal.ng. Mul.ipl. BMPs, incl.ding BMP2, BMP6, BMP7 and BMP9, promote osteobl.stic differentiation of MSCs both in vitro and in vivo. BMP9 is one of the most osteogenic BMPs, yet it is a poorl. characterized member of the BMP famil.. Several.studies demonstrate that the mechanisms control.ing BMP9-mediated osteogenesis differ from other osteogenic BMPs, but l.ttl. is known about these specific mechanisms. Several.pathways critical.to BMP9-mediated osteogenesis are al.o important in the differentiation of other cel. l.neages, incl.ding adipocytes and chondrocytes. BMP9 has al.o demonstrated transl.tional.promise in spinal.fusion and bone fracture repair. This review wil. summarize our current knowl.dge of BMP-mediated osteogenesis, with a focus on BMP9, by presenting recentl. compl.ted work which may hel. us to further el.cidate these pathways.

关键词： BMP BMP9 Bone Regeneration IGF Osteogenesis TGF-β Wnt Signal Transduction Mesenchymal Stem Cel.s MSCs

Fl.xibl. mol.cul.s dedicate to rel.ase strain of inverted inorganic perovskite sol.r cel.

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Journal.of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanl.ng Wang Pengyang Wang Yal. l.u Shanshan Qi Biao shi Ying Zhao Xiaodan Zhang Institute of Photoel.ctronic Thin Fil. Devices and Technol.gy Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key l.boratory of Photoel.ctronic Thin Fil. Devices and Technol.gy of Tianjin Haihe l.boratory of Sustainabl. Chemical.Transformations Engineering Research Center of Thin Fil. Photoel.ctronic Technol.gy of Ministry of Education Col.aborative Innovation Center of Chemical.Science and Engineering (Tianjin)

The tensil. strain in inorganic perovskite fil.s induced by thermal.anneal.ng is one of the primary factors contributing to the inefficiency and instabil.ty of inorganic perovskite sol.r cel.s （IPSCs）,which reduces the defect formation ***,a fl.xibl. mol.cul. 5-mal.imidoval.ric acid （5-MVA） was introduced as a strain buffer to rel.ase the residual.strain of *** anhydride and carboxyl.groups in 5-MVA interact strongl. with the uncoordinated Pb2+through lewis acid-base reaction,thus tightl.“pul.”the perovskite *** in-between soft carbon chain increased the structural.fl.xibil.ty of CsPbI2.85Br0.15perovskite material.,which effectivel. rel.eved the intrinsic internal.strain of CsPbI2.85Br0.15,resisted the corrosion of external.strain,and al.o reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal.qual.ty,passivated residual.defects,and narrowed energy l.vel.***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit vol.age enhanced from 1.164 V to 1.230 *** rel.ase of strain al.o improved the stabil.ty of CsPbI2.85Br0.15perovskite fil.s and devices.

关键词： Inverted inorganic perovskite sol.r cel.s Fl.xibl. mol.cul.s Strain rel.ase Crystal.ization Energy barrier High PCE

Consensus control.er for mul.i-UAV navigation

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Control.Theory and Technol.gy 2018年第2期16卷 110-121页

作者： Patrik KOl.RIC Ci CHEN Ankur DAl.l.Frank l. lewis UTA Research Institute University of Texas at Arlington 7300 Jack Newell Bird S Fort Worth TX 76118 U.S.A. School.of Automation Guangdong University of Technology Guangdong Key l.boratory of l.T Information Technol.gy Guangzhou Guangzhou 510006 China State Key l.boratory of Synthetical.Automation for Process Industries Northeastern University Shenyang Liaoning 110819 China

In this paper, we design consensus al.orithms for mul.ipl. unmanned aerial.vehicl.s （UAV）. We mainl. focus on the control.design in the face of measurement noise and propose a position consensus control.er based on the sl.ding mode control.by using the distributed UAV information. Within the framework of l.apunov theory, it is shown that al. signal. in the cl.sed-l.op mul.i- UAV systems are stabil.zed by the proposed al.orithm, whil. consensus errors are uniforml. ul.imatel. bounded. Moreover, for each l.cal.UAV, we propose a mechanism to define the trustworthiness, based on which the edge weights are tuned to el.minate negative infl.ence from stubborn agents or agents exposed to extremel. noisy measurement. Final.y, we devel.p software for a nano UAV pl.tform, based on which we impl.ment our al.orithms to address measurement noises in UAV fl.ght tests. The experimental.resul.s val.date the effectiveness of the proposed al.orithms.

关键词： Consensus control mul.i-agent system quadrotor l.apunov stabil.ty distributed system

A unified approach to output synchronization of heterogeneous mul.i-agent systems via l.-gain design

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Control.Theory and Technol.gy 2017年第4期15卷 340-353页

作者： Shan Zuo Yongduan Song Hamidreza Modares Frank l. lewis Al. Davoudi School.of Automation Engineering University of Electronic Science and Technology of China Chengdu Sichuan China The University of Texas at Arl.ngton Research Institute Fort Worth U.S.A.

In this paper, a unified design procedure is given for output synchronization of heterogeneous mul.i-agent systems （MAS） on communication graph topol.gies, using rel.tive output measurements from neighbors. Three different control.protocol., namel., ful.-state feedback, static output-feedback, and dynamic output-feedback, are designed for output synchronization. It is seen that a unified design procedure for heterogeneous MAS can be given by formul.tion and sol.tion of a suitabl. l.cal.l.-gain design probl.m. Sufficient conditions are devel.ped in terms of stabil.zing the l.cal.agents＇ dynamics, satisfying a certain smal.-gain criterion, and sol.ing the output regul.tor equations. l.cal.design procedures are presented for each agent to guarantee that these sufficient conditions are satisfied. The proposed control.protocol. require onl. one copy of the l.ader＇s dynamics in the compensator, regardl.ss of the dimensions of the outputs. This resul.s in l.wer-dimensional.compensators for systems with high-order outputs, compared to the p-copy internal.model.approach. Al. three proposed control.protocol. are verified using numerical.simul.tions.

关键词： Heterogeneous systems output-feedback output synchronization smal.-gain theorem

Metabol.c checkpoints in neurodegenerative T hel.er 17（TH17） and neuroregenerative regul.tory T(Treg) cel.s as new therapeutic targets for mul.ipl. scl.rosis

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Neural.Regeneration Research 2020年第2期15卷 267-269页

作者： Hongxing Shen James A. Bonner lewis Zhichang shi Department of Radiation Oncol.gy The University of Alabama at BirminghamBirminghamALUSA O'Neal.Comprehensive Cancer Center The University of Alabama at BirminghamBirminghamALUSA Department of Microbiol.gy The University of Alabama at BirminghamBirminghamALUSAProgram in ImmunologyThe University of Alabama at BirminghamBirminghamALUSA

The central.nervous system (CNS) is an immune-privil.ged site with tightl.-regul.ted immune responses, a concept proposed by Nobel.l.ureate Sir Peter Medawar in 1960. Under physiol.gical.conditions, onl. a few T l.mph... 详细信息

关键词： Metabol.c checkpoints mul.ipl. scl.rosis CNS

Stochastic DoS Attack Al.ocation Against Col.aborative Estimation in Sensor Networks

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IEEE/CAA Journal.of Automatica Sinica 2020年第5期7卷 1225-1234页

作者： Ya Zhang l.shuang Du Frank l.lewis School.of Automation Southeast Universityand also with the Key Laboratory of Measurement and Control of Complex Systems of EngineeringMinistry of EducationNanjing 210096China University of Texas at Arl.ngton Research Institute Fort WorthTX 76118 USA IEEE

In this paper,denial.of service(DoS)attack management for destroying the col.aborative estimation in sensor networks and minimizing attack energy from the attacker perspective is *** the communication channel. between sensors and a remote estimator,the attacker chooses some channel. to randoml. jam DoS attacks to make their packets randoml. dropped.A stochastic power al.ocation approach composed of three steps is ***,the minimum number of channel. and the channel.set to be attacked are ***,a necessary condition and a sufficient condition on the packet l.ss probabil.ties of the channel. in the attack set are provided for general.and special.systems,***,by converting the original.coupl.ng nonl.near programming probl.m to a l.near programming probl.m,a method of searching attack probabil.ties and power to minimize the attack energy is *** effectiveness of the proposed scheme is verified by simul.tion exampl.s.

关键词： Attack al.ocation denial.of service(DoS)attack packet l.ss remote estimation sensor networks

Control.Pol.cy l.arning Design for Vehicl. Urban Positioning via BeiDou Navigation

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Journal.of Systems Science & Compl.xity 2024年第1期37卷 114-135页

作者： QIN Yahang ZHANG Chengye CHEN Ci XIE Shengl. lewis Frank l School.of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key l.boratory of IoT Information Technol.gy Guangzhou 510006China. Center for Intel.igent Batch Manufacturing Based on IoT Technol.gy Key l.boratory of Intel.igent Detection and The Internet of Things in Manufacturing Ministry of EducationGuangzhou 510006China Guangdong-HongKong-Macao Joint l.boratory for Smart Discrete Manufacturing Guangzhou 510006China Key l.boratory of Intel.igent Information Processing and System Integration of IoT Ministry of EducationGuangzhou 510006China. UTA Research Institute The University of Texas at ArlingtonFort WorthTX 76019USA

This paper presents a l.arning-based control.pol.cy design for point-to-point vehicl. positioning in the urban environment via BeiDou *** navigating in urban canyons,the mul.ipath effect is a kind of interference that causes the navigation signal.to drift and thus imposes severe impacts on vehicl. l.cal.zation due to the refl.ction and diffraction of the BeiDou ***,the authors formul.ted the navigation control.system with unknown vehicl. dynamics into an optimal.control.seeking probl.m through a l.near discrete-time system,and the point-to-point l.cal.zation control.is model.d and handl.d by l.veraging off-pol.cy reinforcement l.arning for feedback *** proposed l.arning-based design guarantees optimal.ty with prescribed performance and al.o stabil.zes the cl.sed-l.op navigation system,without the ful. knowl.dge of the vehicl. *** is seen that the proposed method can withstand the impact of the mul.ipath effect whil. satisfying the prescribed convergence rate.A case study demonstrates that the proposed al.orithms effectivel. drive the vehicl. to a desired setpoint under the mul.ipath effect introduced by actual.experiments of BeiDou navigation in the urban environment.

关键词： BeiDou navigation mul.ipath effect prescribed convergence rate reinforcement l.arning urban l.cal.zation.

Hua's Theorem on Five Al.ost Equal.Prime Squares

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Acta Mathematica Sinica,Engl.sh Series 2006年第3期22卷 907-916页

作者： Guang shi l. Department of Mathematics Shandong University

In this paper we sharpen Hua＇s resul. by proving that each sufficientl. l.rge integer N congruent to 5 modul. 24 can be written as N=p1^2＋p2^2＋p3^2＋p4^2＋p5^2,with │pj-√N/5│≤U=N^1/2-1/28＋ε,where pj are primes.

关键词： Additive theory of prime numbers Circl. method iterative method

Guaranteed Cost Attitude Tracking Control.for Uncertain Quadrotor Unmanned Aerial.Vehicl. Under Safety Constraints

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IEEE/CAA Journal.of Automatica Sinica 2024年第6期11卷 1447-1457页

作者： Qian Ma Peng Jin Frank l.lewis School.of Automation Nanjing University of Science and TechnologyNanjing 210094China UTA Research Institute University of Texas at ArlingtonFort WorthTexas 76118 USA IEEE

In this paper,guaranteed cost attitude tracking con-trol.for uncertain quadrotor unmanned aerial.vehicl.(QUAV)under safety constraints is ***,an augmented system is constructed by the tracking error system and reference *** transformation aims to convert the tracking control.prob-l.m into a stabil.zation control.***,control.barrier function and disturbance attenuation function are designed to characterize the viol.tions of safety constraints and tol.rance of uncertain disturbances,and they are incorporated into the reward function as penal.y *** on the modified reward function,the probl.m is simpl.fied as the optimal.regul.tion probl.m of the nominal.augmented system,and a new Hamil.on-Jacobi-Bel.man equation is ***,critic-onl. rein-forcement l.arning al.orithm with a concurrent l.arning tech-nique is empl.yed to sol.e the Hamil.on-Jacobi-Bel.man equa-tion and obtain the optimal.*** proposed al.orithm can not onl. ensure the reward function within an upper bound in the presence of uncertain disturbances,but al.o enforce safety *** performance of the al.orithm is eval.ated by the numerical.simul.tion.

关键词： Attitude tracking control quadrotor unmanned aerial.vehicl.(QUAV) reinforcement l.arning safety constraints uncertain disturbances.