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肺动脉高压患者脂肪酸代谢异常与右心室脂毒性的关系

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中华高血压杂志 2016年第4期24卷 399-399页

作者： Brittain EL Talati M Fessel JP Zhu H Penner N Calcutt MW West J Funke M lewis gd Gerszten RE Hamid R Pugh ME Austin ED Newman JH Hemnes AR 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,应用无创成像检测PAH患者及对照人群脂肪酸代谢途径不同阶段的特点。与对照组比较,PAH患者循环游离脂肪酸和长链酰基肉碱水平升高;右心室长链脂肪酸增加,长链酰基肉碱显著减少。

关键词：脂肪酸代谢长链酰基肉碱肺动脉高压右心室脂毒性长链脂肪酸动物实验模型右心衰竭三酰甘油水平脂肪变性

GEANT4 simulation study of over-response phenomenon of fiber x-ray sensor

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Chinese Physics B 2021年第4期30卷 633-639页

作者： Bin Zhang Tian-Ci Xie Zhuang Qin Hao-Peng Li Song Li Wen-Hui Zhao Zi-Yin Chen Jun Xu Elfed lewis Wei-Min Sun Key Laboratory of In-fiber Integrated Optics Ministry of EducationHarbin Engineering UniversityHarbin 150001China Electronic Engineering College Ministry of EducationHeilongjiang UniversityHarbin 150001China Comprehensive Cancer Center First Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Comprehensive Cancer Center Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Optical Fiber Sensors Research Centre University of LimerickCastletroyLimerickIreland

The purpose of this article is to explore the cause of the over-response phenomenon of fiber x-ray *** sensor is based on a length of PMMA fiber,whose end is filled with the scintillation material gd_(2)O_(2)S:*** Monte Carlo simulation software GEANT4 uses the phase space file provided by the International Atomic Energy Agency(IAEA),by irradiating the fiber x-ray sensor in the water phantom,counting the fluorescence signal of the optical fiber x-ray sensor after propagation through the *** addition,the number of Cerenkov photons propagating through the fiber is also *** this article with previous research,we believe that one of the reasons for the over-response of the fiber x-ray sensor is the non-linear response of the deposition energy of the scintillator to the *** establishing a region of interest and counting the x-rays in this region,the simulation results show that the counted number of x-rays that may affect the fiber x-ray sensor is the biggest in the area of interest at a water depth of 5 *** result is close to the maximum dose point of the experimental and simulated percentage depth dose(PDD) curve of fiber x-ray ***,the second reason of the over-response phenomenon is believed to be fact that the inorganic materials such as gd_(2)O_(2)S:Tb have larger effective atomic numbers,so the fiber x-ray sensors will cause more collisions with x-ray in a low energy region of 0.1 MeV-1.5 MeV.

关键词： fiber x-ray sensors over-response percentage depth dose(PDD) Monte Carlo(MC)simulation

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光纤X射线传感器剂量衰减的仿真研究

传感器与微系统 2024年第9期43卷 19-22页

作者：封勇贺泊杨浩杰耿涛 lewis Elfed 孙伟民青岛市黄岛区人民医院山东青岛266400 哈尔滨工程大学纤维集成光学教育部重点实验室黑龙江哈尔滨150001 利默里克大学光纤传感器研究中心爱尔兰利默里克V94 T9PX

光纤X射线传感器由于其可实现实时在线剂量测量的特点而引起了广泛的关注。实验中采用gd_(2)O_(2)S︰Tb作为闪烁体材料,利用蒙特卡罗仿真方法计算了两种嵌入不同尺度闪烁材料的光纤X射线传感器所导致的剂量衰减。并探讨了射野大小、水... 详细信息

光纤X射线传感器由于其可实现实时在线剂量测量的特点而引起了广泛的关注。实验中采用gd_(2)O_(2)S︰Tb作为闪烁体材料,利用蒙特卡罗仿真方法计算了两种嵌入不同尺度闪烁材料的光纤X射线传感器所导致的剂量衰减。并探讨了射野大小、水深和闪烁体体积对剂量扰动的影响。结果表明:嵌入长7 mm,直径0.7 mm闪烁体的光纤X射线传感器在光纤后部表现出显著的剂量衰减,范围为深度5~10 mm。而嵌入长2 mm,直径0.4 mm闪烁体的光纤X射线传感器的剂量衰减被限制在光纤内部。光纤传感器的剂量衰减量与闪烁体的体积、射野大小和水深等因素有关,其中闪烁体的体积为主要影响因素。为了减少由于传感器带来的剂量衰减,在制作过程中应该限制嵌入光纤传感器内部的闪烁体体积。

关键词：放疗光纤X射线传感器剂量扰动蒙特卡洛仿真

Gadolinium enhanced MRI in patients with left ventricular apical ballooning syndrome implicates myocarditis as an etiology

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World Journal of Cardiovascular Diseases 2013年第1期3卷 118-125页

作者： Andrew O. Maree Christian Witzke Godtfred Holmvang Gregory D. lewis Hani Jneid Lindsay B. Reardon Nadeem Afridi Marc J. Semigran G. William Dec Harry C. Lowe Igor F. Palacios Cardiology Section Department of Medicine Waterford Regional Hospital Waterford Ireland.

Aims: Left ventricular apical ballooning syndrome (LVABS) is a clinical condition of unknown etiology, characterized by acute onset of atypical apical wall motion and absence of coronary artery disease. Gadolinium-enhanced cardiac magnetic resonance imaging (gd-MRI) may be used to identify patients with myocarditis. Using cardiac MRI, we evaluated whether acute myocarditis may be an etiology that underlies LVABS. Methods and Results: Consecutive patients who presented with LVABS during a three-year period were included. Demographic data was recorded and echocardiography, coronary angiography, and hemodynamic assessment performed. gd-MRI was performed in all patients. The study was deemed consistent with myocarditis when global myocardial to skeletal muscle enhancement ratio was ≥3.5. Regional gd-MRI analysis was also performed. Patients (n = 11) were female (100%) and of mean age 72 years (72 ± 11). Preceding febrile illness occurred in 4 (36.3%) and leukocytosis in 6 (54.4%) patients. Initial mean left ventricular ejection fraction (41% ± 12%) improved (70.2% ± 8%) upon follow-up (39 ± 43 days). Global MRI analysis was positive in 5/11 (45.5%) (mean relative enhancement ratio 4.8 ± 1.4). Regional MRI analysis was positive in 4/6 further patients (overall: 9/11 (82%)). Conclusions: Gadolinium enhanced MRI imaging in LVABS implicates myocarditis as a possible etiology. Regional MRI analysis adds sensitivity to global cardiac MRI evaluation.

关键词： Left Ventricular Apical Ballooning Syndrome Gadolinium-Enhanced Cardiac Magnetic Resonance Imaging Myocarditis Catecholamine