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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： lewis a hall Duncan Loader Santiago Gouveia Marta Burak James halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail David C Bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

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The Roles of Different CLE Domains in Arabidopsis CLE Polypeptide Activity and Functional Specificity

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Molecular Plant 2010年第4期3卷 760-772页

作者： Ling Meng Kenneth C. Ruth Jennifer C. Fletcher lewis Feldman Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Plant Gene Expression Center USDA-UC Berkeley 800 Buchanan Street Albany CA 94710 USA

The CLE （CLVATA3/ESR-related） family of plant polypeptide signaling molecules shares a conserved 14-aminoacid （aa） motif, designated the CLE motif, which recent studies suggest is sufficient for CLE function in vitro. In this study, we report that Arabidopsis CLE proteins can function in a tissue-specific manner and confirm some CLE factors can act through different receptors. Using domain swapping, we show for the first time that the CLE motif likely determines much of the functional tissue-specificity of the proteins in planta. However, we also provide evidence in support of the new view that sequences outside the CLE motif （14 aa） contribute to CLE function and functional specificity in vivo. Additionally, we report that deletion of the putative signal peptide from different CLE proteins completely inactivates CLE function in vivo, whereas exchanging the CLE signal peptides with a conventional signal peptide from a rice glycine-rich cell wall protein also influences CLE function. We thus propose that the CLE motif itself determines its functional tissue-specificity by dic- tating the direct recognition and interaction of each CLE peptide with its optimal receptor（s）, whereas the receptor（s） may be available in a tissue-specific manner. On the other hand, the sequences outside the CLE motif may influence CLE function by affecting the processing of CLE peptides, resulting in a change in the availability and/or abundance of CLE peptides in specific tissues and/or cells.

关键词： Arabidopsis cell signaling CLE meristem polypeptide protein domain.

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世界显微外科大师——朱莉娅·卡利波利图·特尔齐斯

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中华显微外科杂志 2023年第1期46卷 C1-2-C1-14页

作者：弗吉尼亚州诺福克市奥尔尼路刘易斯大厅700号东弗吉尼亚医学院外科研究中心2055室邮编23501

位于宾夕法尼亚州瑞丁的阿尔布莱特学院为我提供了一个绝佳的接触生物学的环境。为贴补部分学费,我在比较解剖学实验室找到了助手的工作。周末时,我在格林教授的指导下开展了一个利用青蛙坐骨神经模型进行神经再生研究的项目。此外,这2...

位于宾夕法尼亚州瑞丁的阿尔布莱特学院为我提供了一个绝佳的接触生物学的环境。为贴补部分学费,我在比较解剖学实验室找到了助手的工作。周末时,我在格林教授的指导下开展了一个利用青蛙坐骨神经模型进行神经再生研究的项目。此外,这2年也是十分令人难忘的,我与生物学专业的其他学生和脊椎动物学家霍尔博士一起到过很多洞穴开展研究,研究内容是给蝙蝠扎上标记来研究它们的迁徙行为。

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Human epidermal growth factor receptor-2 in oesophageal cancers:An observational study

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World Journal of Gastroenterology 2012年第44期18卷 6447-6451页

作者： Hazem Al-Momani Rachel Barnes Ahmed El-Hadi Rachit Shah Wyn G lewis Paul Edwards Department of Surgery Nevill Hall HospitalAbergavenny NP7 7EGWalesUnited Kingdom Department of Surgery University Hospital of WalesCardiff CF14 4XWUnited Kingdom

AIM:To determine the incidence of human epidermal growth factor receptor 2(HER2) over expression in oesophageal ***:A retrospective study,of one hundred consecutive cases of endoscopic histological samples of oesophageal cancers from a single British cancer network were *** cases were diagnosed between April 2007 and June ***2 over expression was assessed using immunohistochemistry,those that scored "0" and "+1" were considered "negative" for HER2;those that scored "+3" were considered "Positive".Cases that were scored "+2" on immunohistochemistry further went on to have HER2 gene analysis using the Ventana HER brightfield dual-colourin situ hybridisations(HER B DISH) assay and either came back to be positive or negative for HER2 over *** survival was measured from date of histological diagnosis until date of death.93% of the cases were followed up till five years or death,and all were followed up till two *** of gastro-oesophageal junctional tumours were ***:The median age of our sample was 66 years(range:38-91 years).Eighty one were male and 19 ***-one of the cases were adenocarcinoma of the oesophagus and the rest were cases of squamous cell *** anatomical distribution of the tumours was;upper oesophagus 2,middle oesophagus 11,and 87 were in the lower *** resection was completed in 15 cases;seven cases had attempted surgical resections,i.e.,open and close,33 patients received definitive chemo-radiation and 52 had palliative ***-five of the cancers showed evidence of HER2 over expression,all were *** the 25 cases that showed evidence of HER2 over expression,21(84%) were located in the lower third of the *** staging,24 out of the 25 HER2 positive cases were at stage 3 or more(13 at stage 3 and 11 at stage 4),For HER2 negative cases 37 were at stage 3 and 32 were staged as stage *** out of twenty five cases(68%) with HER

关键词： Oesophageal adenocarcinoma, Human epi-dermal growth factor receptor 2, Immunohistochemis-try Dual-colour in situ hybridisations Trastuzumab

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Vegetated Systems for Non-Point Source Pollution Control

Vegetated Systems for Non-Point Source Pollution Control

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国际农业工程大会

作者： Stacy lewis Hutchinson Ph.D.Assistant Professor Kansas State University 147 Seaton hall Manhattan KS 66506

Nonpoint source pollution is the leading cause of water quality problems in the United States, and its reduction is a major challenge facing society today. Since the approval of the Clean Water Act of 1972, the United States has made great advances in reducing point source pollution from industrial and municipal wastewater systems. Unfortunately, not enough has been done to control nonpoint source or diffuse pollution, resulting in approximately 40% of rivers, lakes, and estuaries being unfit for fishing and swimming. As of 1998 over 290,000

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Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

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炎症性肠病患者脱髓鞘病变的风险增加

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 27-28页

作者： Gupta G. Gelfand J.M. lewis J.D. 孟欣颖 Center for Clinical Epidemiology and Biostatistics University of Pennsylvania 720 Blockley Hall 423 Guardian Drive Philadelphia PA 19104-6021 United States Dr.

Background & Aims: Reports of multiple sclerosis (MS), demyelination, and optic neuritis (ON) associated with anti-tumor necrosis factor α therapy resulted in warnings on prescribing instructions for infliximab, etanercept, and adalimumab. However, the underlying relationship between IBD and these neurologic conditions has not been established. Methods: We performed a retrospective cohort study and a retrospective cross-sectional study using 1988 to 1997 data from the General Practice Research Database. A total of 7988 Crohn’ s disease and 12,185 ulcerative colitis patients were matched for age, sex, and primary care practice to 80,666 randomly selected controls. In the cohort study, incident cases of MS, demyelination, and/or ON (MS/D/ON) had to occur at least 1 year after registration with the physician and after the diagnosis of IBD. In the cross-sectional study, the diagnosis of MS/D/ON could either precede or follow the IBD diagnosis. Results: In the cohort study, the incidence of MS/D/ON was higher in patients with Crohn’ s disease and ulcerative colitis compared with their matched controls, reaching statistical significance for ulcerative colitis (ulcerative colitis incidence rate ratio [IRR], 2.63; 95% confidence interval, 1.29-5.15;Crohn’ s disease IRR, 2.12; 95% confidence interval, .94-4.50). In the cross-sectional study, MS/D/ON was more prevalent in patients with Crohn’ s disease and ulcerative colitis compared with their matched controls (Crohn’ s disease odds ratio, 1.54; 95% confidence interval, 1.03-2.32; ulcerative colitis odds ratio,1.75; 95% confidence interval, 1.28-2.39). Conclusions: Demyelinating diseases occur more commonly among patients with IBD than among non-IBD patients. Future studies should clarify whether treatment with tumor necrosis factor α blockers results in further increased incidence of MS/D/ON among IBD patients.

关键词：炎症性肠病脱髓鞘病变溃疡性结肠炎克罗恩病依那西普研究数据库多发性硬化横向研究队列研究

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A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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凯斯宾王子第二章尘封的宝库

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时代英语（高二版） 2019年第5期 4-10页

作者： C.S.刘易斯吴民(译) 不详

第二章尘封的宝库“这不像是个花园。”苏珊想了想说,“这更像是个城堡,如果没错的话,我们现在所在的位置应该是城堡的某个院落。”“还真别说,是有那么点像。”彼得说,“看,那是残存的塔楼,可是只剩下一小段楼梯了,本来沿着那楼梯可以... 详细信息

第二章尘封的宝库“这不像是个花园。”苏珊想了想说,“这更像是个城堡,如果没错的话,我们现在所在的位置应该是城堡的某个院落。”“还真别说,是有那么点像。”彼得说,“看,那是残存的塔楼,可是只剩下一小段楼梯了,本来沿着那楼梯可以直接通往塔顶的。你们再看那些又宽又平缓的台阶,一直通往门廊,那门准是通往大厅去的。”“看上去可真有些年头了。”爱德蒙感慨道。

关键词：王子凯斯城堡楼梯苏珊

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《黎明踏浪号》第四章(中)

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时代英语（高三版） 2020年第1期 4-6页

作者： C.S.刘易斯任显楷(译) 不详

卫队长打呵欠之际,波恩爵士立马高声喊道:“为国王陛下三呼'万岁'!”那些卫兵,除了记得“美酒一桶”,别的什么也没闹明白。不过既然有酒喝,他们自然也就加入了欢呼的人群。凯斯宾随后命令自己带来的人待在内院里,只挑了四名最得力的随从... 详细信息

卫队长打呵欠之际,波恩爵士立马高声喊道:“为国王陛下三呼'万岁'!”那些卫兵,除了记得“美酒一桶”,别的什么也没闹明白。不过既然有酒喝,他们自然也就加入了欢呼的人群。凯斯宾随后命令自己带来的人待在内院里,只挑了四名最得力的随从,加上波恩爵士和德瑞尼亚,走进诚堡的大厅。

关键词：德瑞尼亚爵士

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