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Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal damage

中国药理学与毒理学杂志 2013年第3期 492-493页

作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale THURMAN HU Li-ping QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI lew kinter Nigel BARRASS Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK Global Safety Assessment AstraZeneca R&D BostonMAUSA

OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney *** Study #1,11 monkeys(2-3 /sex /group) were given vehicle or imipenem(180 mg·kg-1,iv infusion once daily for 7 d) and urine was collected on days xxxxx for biomarker *** Study #2,24 monkeys(3 /sex /group) were given of vehicle or imipenem(45,90 or 180 mg·kg-1,iv infusion once daily for 7 d).The following endpoints were assessed in both studies: clinical observations,body weight,food consumption,haematology,coagulation,blood chemistry,urine analysis,imipenem concentration /toxicokinetics (TK) and gross and microscopic *** Study #1: Imipenem causes minor body weight loss,increased urea and creatinine,and decreased phosphate in *** total protein and bilirubin were observed in the *** effects were progressive and most pronounced at days 7 and *** and relative kidney weights were increased in both *** histopathological findings were present in kidneys of the dosed monkeys,consisting of minimal to moderate tubular necrosis /degeneration /*** biomarkers(α-1 and β-2 microglobulin,clusterin,Tamm-Horsfall protein and vascular endothelial growth factor) increased progressively and significantly from day 2 onward and preceded notable changes in urinalysis or plasma chemistry on day 7 or 8,*** #2: There were similar findings to Study #1 in the 180 mg·kg-1 imipenem treatment *** total bilirubin and decreased of phosphate in plasma and an increase of urinary urobilinogen /ketones were observed in a dose related *** to imipenem 〔Cmax and AUC(0-3 h) 〕increased in proportion from 45-90 mg·kg-1 but more than in proportion from 90-180 mg·*** The no observed adverse effect level(NOAEL) for the imipenem induced kidney injury was identified as 90 mg·*** increases of five urinary biomark

关键词： imipenem toxicity biomarkers renal damage

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Spin-based magnetic random-access memory for high-performance computing

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National Science Review 2024年第3期11卷 20-23页

作者： Kaiming Cai Tianli Jin Wen Siang lew School of Physics Huazhong University of Science and Technology Interuniversity Microelectronics Centre(IMEC) School of Physical and Mathematical Sciences Nanyang Technological University

Memory serves as a critical component in today's electronic systems for data storage and processing. In traditional computer architectures, the logic and memory units are physically separated, due to the performance gap in operational speed and capacity among memories, resulting in the fundamental limitation of the von Neumann computers.

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Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential biomarkers of renal toxicity

Evaluation of cisplatin-induced toxicity in cynomolgus macaq...

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作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale THURMAN QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI lew kinter Nigel BARRASS Global Safety Assessment Centre for Drug Safety Evaduation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park

OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans. Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney *** In study #1,6 monkeys(1/sex/group) were given a single *** of cisplatin(1.25,2.5 and 5 mg·kg~(-1)) and were terminated for necropsy on day 7 *** Study #2,36 monkeys(3/sex/group) were given a single iv infusion of vehicle or cisplatin(2.5 mg·kg~(-1)) and then they were terminated for necropsy on days 2,5,10 or 21,respectively, *** following endpoints were assessed in both studies:clinical observations,body weight,food consumption, haematology,coagulation,blood chemistry,urine analysis,cisplatin concentration/toxicokinetics(TK) and gross and microscopic *** of biomarkers for drug-induced kidney injury(DIKI) was confined to Study #*** Study #1:A single intravenous administration of cisplatin induced occasional vomiting,decreased motor activity, reduced food consumption and minor body weight loss at the highest dose(5 mg·kg~(-1)).Urea and creatinine were markedly increased,plasma electrolytes showed dose-related alterations and blood and proteins were found in the urine. The high dose animals had reduced urine *** weights were increased following 2.5 and 5 mg·kg~(-1) and there were progressive renal histopathological *** to cisplatin〔C_(max) and AUC_((0-24))〕increased slightly more than in proportion to the dose of cisplatin across the dose *** #2:One male dosed at 2.5 mg·kg~(-1) cisplatin was prematurely terminated on day *** other animals survived to their scheduled *** evaluation demonstrated that kidney lesions progressed with *** chemistry results indicated that 7 out of 24 animals treated with cisplatin had moderatel

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Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential biomarkers of renal toxicity

Evaluation of cisplatin-induced toxicity in cynomolgus macaq...

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2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans. Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney *** In study #1,6 monkeys(1/sex/group) were given a single *** of cisplatin(1.25,2.5 and 5 mg·kg) and were terminated for necropsy on day 7 *** Study #2,36 monkeys(3/sex/group) were given a single iv infusion of vehicle or cisplatin(2.5 mg·kg) and then they were terminated for necropsy on days 2,5,10 or 21,respectively, post - *** following endpoints were assessed in both studies:clinical observations,body weight,food consumption, haematology,coagulation,blood chemistry,urine analysis,cisplatin concentration/toxicokinetics(TK) and gross and microscopic *** of biomarkers for drug-induced kidney injury(DIKI) was confined to Study #*** Study #1:A single intravenous administration of cisplatin induced occasional vomiting,decreased motor activity, reduced food consumption and minor body weight loss at the highest dose(5 mg·kg).Urea and creatinine were markedly increased,plasma electrolytes showed dose-related alterations and blood and proteins were found in the urine. The high dose animals had reduced urine *** weights were increased following 2.5 and 5 mg·kg and there were progressive renal histopathological *** to cisplatin[C and AUC(04))]increased slightly more than in proportion to the dose of cisplatin across the dose *** #2:One male dosed at 2.5 mg·kg cisplatin was prematurely terminated on day *** other animals survived to their scheduled *** evaluation demonstrated that kidney lesions progressed with *** chemistry results indicated that 7 out of 24 animals treated with cisplatin had moderately to markedly increased urea and

关键词： cisplatin renal toxicity biomarkers

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Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal damage

Evaluation of imipenem toxicity in cynomolgus macaques inclu...

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作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale THURMAN HU Li-ping QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI lew kinter Nigel BARRASS Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica Global Safety Assessment AstraZeneca R&D Alderley Park

OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney *** Study #1,11 monkeys(2 -3/sex/group) were given vehicle or imipenem(180 mg·kg~(-1),iv infusion once daily for 7 d) and urine was collected on days xxxxx for biomarker *** Study #2,24 monkeys(3/sex/group) were given of vehicle or imipenem(45,90 or 180 mg·kg~(-1),iv infusion once daily for 7 d).The following endpoints were assessed in both studies:clinical observations,body weight, food consumption,haematology,coagulation,blood chemistry,urine analysis,imipenem concentration/toxicokinetics (TK) and gross and microscopic *** Study #1:Imipenem causes minor body weight loss,increased urea and creatinine,and decreased phosphate in *** total protein and bilirubin were observed in the urine. These effects were progressive and most pronounced at days 7 and *** and relative kidney weights were increased in both *** histopathological findings were present in kidneys of the dosed monkeys,consisting of minimal to moderate tubular necrosis/degeneration/*** biomarkers(α-1 andβ-2 microglobulin,clusterin, Tamm-Horsfall protein and vascular endothelial growth factor) increased progressively and significantly from day 2 onward and preceded notable changes in urinalysis or plasma chemistry on day 7 or 8,*** #2:There were similar findings to Study #1 in the 180 mg·kg~(-1) imipenem treatment *** total bilirubin and decreased of phosphate in plasma and an increase of urinary urobilinogen/ketones were observed in a dose related *** to imipenem〔C_(max) and AUC_(0-3h)〕increased in proportion from 45 -90 mg·kg~(-1) but more than in proportion from 90-180 mg·kg~(-1). CONCLUSION The no observed adverse effect level(NOAEL) for the imipenem induced kidney injury was identified as 90 mg·kg~(-1).Early increases of five ur

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Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential biomarkers of renal toxicity

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中国药理学与毒理学杂志 2013年第3期 466-466页

作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale THURMAN QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI lew kinter Nigel BARRASS Centre for Drug Safety Evaduation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK Global Safety Assessment AstraZeneca R&D BostonMAUSA

OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and *** studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney *** In study #1,6 monkeys(1 /sex /group) were given a single *** of cisplatin(1.25,2.5 and 5 mg·kg-1) and were terminated for necropsy on day 7 *** Study #2,36 monkeys(3 /sex /group) were given a single iv infusion of vehicle or cisplatin(2.5 mg·kg-1) and then they were terminated for necropsy on days 2,5,10 or 21,respectively,*** following endpoints were assessed in both studies: clinical observations,body weight,food consumption,haematology,coagulation,blood chemistry,urine analysis,cisplatin concentration /toxicokinetics(TK) and gross and microscopic *** of biomarkers for drug-induced kidney injury(DIKI) was confined to Study #*** Study #1: A single intravenous administration of cisplatin induced occasional vomiting,decreased motor activity,reduced food consumption and minor body weight loss at the highest dose(5 mg·kg-1).Urea and creatinine were markedly increased,plasma electrolytes showed dose-related alterations and blood and proteins were found in the *** high dose animals had reduced urine *** weights were increased following 2.5 and 5 mg·kg-1 and there were progressive renal histopathological *** to cisplatin〔Cmax and AUC(0-24) 〕increased slightly more than in proportion to the dose of cisplatin across the dose *** #2: One male dosed at 2.5 mg·kg-1 cisplatin was prematurely terminated on day *** other animals survived to their scheduled *** evaluation demonstrated that kidney lesions progressed with *** chemistry results indicated that 7 out of 24 animals treated with cisplatin had moderately to markedly inc

关键词： cisplatin renal toxicity biomarkers

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Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal damage

Evaluation of imipenem toxicity in cynomolgus macaques inclu...

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2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney *** Study #1,11 monkeys(2 -3/sex/group) were given vehicle or imipenem(180 mg·kg,iv infusion once daily for 7 d) and urine was collected on days xxxxx for biomarker *** Study #2,24 monkeys(3/sex/group) were given of vehicle or imipenem(45,90 or 180 mg·kg,iv infusion once daily for 7 d).The following endpoints were assessed in both studies:clinical observations,body weight, food consumption,haematology,coagulation,blood chemistry,urine analysis,imipenem concentration/toxicokinetics (TK) and gross and microscopic *** Study #1:Imipenem causes minor body weight loss,increased urea and creatinine,and decreased phosphate in *** total protein and bilirubin were observed in the urine. These effects were progressive and most pronounced at days 7 and *** and relative kidney weights were increased in both *** histopathological findings were present in kidneys of the dosed monkeys,consisting of minimal to moderate tubular necrosis/degeneration/*** biomarkers(α-1 andβ-2 microglobulin,clusterin, Tamm-Horsfall protein and vascular endothelial growth factor) increased progressively and significantly from day 2 onward and preceded notable changes in urinalysis or plasma chemistry on day 7 or 8,*** #2:There were similar findings to Study #1 in the 180 mg·kg imipenem treatment *** total bilirubin and decreased of phosphate in plasma and an increase of urinary urobilinogen/ketones were observed in a dose related *** to imipenem [C and AUC(0-3h))) increased in proportion from 45 -90 mg-kg but more than in proportion from 90-180 mg·kg. CONCLUSION The no observed adverse effect level(NOAEL) for the imipenem induced kidney injury was identified as 90 mg·*** increases of five urinary biomarkers of kidney toxicit

关键词： imipenem toxicity biomarkers renal damage

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Electron push-pull effects induced performance promotion in covalent organic polymer thin films-based memristor for neuromorphic application

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Chinese Chemical Letters 2024年第5期35卷 227-231页

作者： Panke Zhou Hong Yu Mun Yin Chee Tao Zeng Tianli Jin Hongling Yu Shuo Wu Wen Siang lew Xiong Chen State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350116China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Covalent organic polymer(COP)thin film-based memristors have generated intensive research interest,but the studies are still in their ***,by controlling the content of hydroxyl groups in the aldehyde monomer,Py-COP thin films with different electronic push-pull effects were fabricated bearing distinct memory performances,where the films were prepared by the solid-liquid interface method on the ITO substrates and further fabricated as memory devices with ITO/Py-COPs/Ag *** Py-COP-1-based memory device only exhibited binary memory behavior with an ON/OFF ratio of 1:10^(1.87).In contrast,the device based on Py-COP-2 demonstrated ternary memory behavior with an ON/OFF ratio of 1:10^(0.6):10^(3.1) and a ternary yield of 55%.The ternary memory mechanism of the ITO/Py-COP-2/Ag memory device is most likely due to the combination of the trapping of charge carriers and conductive ***,the Py-COPs-based devices can successfully emulate the synaptic potentiation/depression behavior,clarifying the programmability of these devices in neuromorphic *** results suggest that the electronic properties of COPs can be precisely tuned at the molecular level,which provides a promising route for designing multi-level memory devices.

关键词： Covalent organic polymers Push-pull effects Multi-level memory Memristor

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插电式混动车在中国驶入快车道

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商业周刊（中文版） 2024年第4期 36-38页

作者： Linda lew Chunying Zhang Jinshan Hong 融汐(译) 不详

●随着中国电动汽车市场总体增长放缓,价格较为便宜、也可使用汽油的车型开始流行山姆·钟(Sam Zhong)最近开始挑选自己的第一辆车。他试驾了很多款汽油车和少量的纯电动车型,最终选定了比亚迪的插电式混合动力车“秦”。这款车总价不... 详细信息

●随着中国电动汽车市场总体增长放缓,价格较为便宜、也可使用汽油的车型开始流行山姆·钟(Sam Zhong)最近开始挑选自己的第一辆车。他试驾了很多款汽油车和少量的纯电动车型,最终选定了比亚迪的插电式混合动力车“秦”。这款车总价不到10万元人民币(约合1.39万美元),符合他的预算;可以在电池驱动的电机和传统内燃机之间切换的能力意味着,他可以在日常通勤时省钱,而长途旅行时却不用担心充电问题。

关键词：长途旅行电池驱动纯电动车汽油车比亚迪电动汽车增长放缓插电式混合动力车

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Synthesis and electrochemical properties of dual doped spinels LiNi_xAl_yMn_(2-x-y)O_4 via facile novel chelated sol–gel method as possible cathode material for lithium rechargeable batteries

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Journal of Energy Chemistry 2017年第1期26卷 101-114页

作者： R.Thirunakaran Gil Hwan lew Won-Sub Yoon CSIR-Central Electrochemical Research Institute Sungkyunkwan University Department of Energy Science

LiMnOand LiNiAlyMnO（x= 0.50;y = 0.05-0.50） powders have been synthesized via facile solgel method using Behenic acid as active cheiating *** synthesized samples are subjected to physical characterizations such as thermo gravimetric analysis（TG/DTA）,X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FT-IR）,field-emission scanning electron microscopy（FESEM）,transmission electron microscopy（TEM） and electrochemical studies viz.,galvanostatic cycling properties,electrochemical impedance spectroscopy（EIS） and differential capacity curves（dQ/dE）.Finger print XRD patterns of LiMnOand LiNiAlMnOfortify the high degree of crystallinity with better phase *** images of the undoped pristine spinel illustrate uniform spherical grains surface morphology with an average particle size of 0.5 μm while Ni doped particles depict the spherical grains growth（50nm） with ice-cube surface *** images of the spinel LiMnOshows the uniform spherical morphology with particle size of（100 nm） while low level of Al-doping spinel（LiNio.5Alo.05Mn1.45O4） displaying cloudy particles with agglomerated particles of（50nm）.The LiMnOsamples calcined at 850℃ deliver the discharge capacity of 130 mAh/g in the first cycle corresponds to 94%coiumbic efficiency with capacity fade of 1.5 mAh/g/cycle over the investigated 10 *** all four dopant compositions investigated,LiNiAlMnOdelivers the maximum discharge capacity of 126 mAh/g during the first cycle and shows the stable cycling performance with low capacity fade of 1 mAh/g/cycle（capacity retention of 92%） over the investigated 10 *** impedance studies of spinel LiMnOand LiNiAlMnOdepict the high and low real polarization of 1562 and 1100 Ω.

关键词： Multi-doping Sol–gel method Behenic acid Differential capacity Spinel cathode

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