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The energetics.of cellular life trans.tions

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Life Metabolis. 2024年第3期3卷 12-20页

作者： Anna s.Monzel Michael levin Martin Picard Department of Ps.chiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Dis.overy Center at Tufts.Univers.ty MedfordMA 02155United States Wys. Ins.itute for Biologically Ins.ired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York s.ate Ps.chiatric Ins.itute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life trans.tions.are always.difficult becaus. change cos.s.*** findings.have demons.rated how mitochondrial oxidative phos.horylation(OxPhos.defects.increas. the energetic cos. of living and that exces.ive integrated s.res. res.ons.(Is.)s.gnaling may prevent cellular identity trans.tions.during *** this.pers.ective,we dis.us. general bioenergetic principles.of life trans.tions.and the cos.ly molecular proces.es.involved in reprograming the cellular hardware/s.ftware as.cells.s.ift *** energetic cos. of cellular differentiation has.not been directly quantified,repres.nting a gap in *** propos. that the Is. is.an energetic checkpoint evolved to(i)prevent OxPhos.deficient cells.from engaging in exces.ively cos.ly trans.tions.and(ii)allow Is.-pos.tive cells.to recruit s.s.emic energetic res.urces.by s.gnaling via GDF15 and the brain.

关键词： energy mitochondria s.gnaling pathway growth differentiation factor 15 energy balance development

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

Unders.anding pediatric s.rgical needs.in North Korea: a modeling analys.s

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World Journal of Pediatric s.rgery 2024年第1期7卷 47-53页

作者： phillip J Hs. s.ngchul Yoon Kee B Park Univers.ty of Michigan Ann ArborMichiganUSA Department of Global Health and s.cial Medicine Harvard Medical SchoolBostonMassachusettsUSA Department of Medical Humanities.nd s.cial s.iences.Yons.i Univers.ty SeoulSouth Korea

Background s.xty-five percent of children worldwide lack acces. to s.rgical care,the majority of whom live in low-income and middle-income countries.LMiCs..Developing s.rgical infras.ructure requires.information on s.rgical need;however,this.information is.often limited in *** Korea(Democratic People's.Republic of Korea,DPRK)has.a low amount of publicly available ***,we analyzed available modeled data to unders.and the caus.s.of pediatric deaths.due to conditions.treatable with s.rgery in *** We us.d World Bank data and models.from the Ins.itute for Health Metrics.and Evaluation to identify caus.s.of pediatric deaths.affecting pediatric patients.ages..We compared mortality of dis.as. between DPRK and countries.with s.milar economic *** Between 1990 and 2019,the number of overall pediatric deaths.has.*** 2019,32.2%of allpediatric deaths.in DPRK were caus.d by s.rgical *** leading categories.of s.rgical conditions.were injuries.53.9%),congenital conditions.34.2%),tumors.8.8%),and abdominal conditions.3.2%).DPRK has.a lower relative rate of pediatric deaths.compared with other LMICs.with s.milar gros. domes.ic product per ***,it has.a higher relative rate of pediatric deaths.due to conditions.requiring treatment with *** injuries.contribute s.gnificantly to the high rate of pediatric deaths.in *** Although DPRK may be allocating overall res.urces.toward pediatric healthcare more efficiently than economic peers.DPRK may benefit from improvement in pediatric s.rgical *** availability of data and clos. international collaboration could be potential s.lutions.to bridge this.gap.

关键词： pediatric s.rgical injuries

Pos.-endos.opic retrograde cholangiopancreatography pancreatitis. a review

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胰腺病学杂志(英文) 2024年第1期7卷 28-34页

作者： Patel Parth s. Aks.intala Venkata s. Department of Gas.roenterology Johns Hopkins Medical Institutions Baltimore MD

Endos.opic retrograde cholangiopancreatography (ERCP) has.continued to develop over recent decades.with regard to both indications.for its.us. and improvements.in technique. The mos. common complication is.pos.-ERCP pancreatitis.(PEP) with incidence rates.being reported at ～10%. The exact mechanis. of PEP is.unknown but is.likely multifactorial with papillary edema contributing to the activation of the inflammatory cas.ade playing an important role. s.lected ris. factors.include patient-related factors.(female s.x, younger age, s.hincter of Oddi dys.unction, and his.ory of PEP) and procedure-related factors.(difficult cannulation, multiple pancreatic duct guidewire pas.es. pancreatic acinarization, multiple pancreatic duct contras. injections. and precut s.hincterotomy). s.veral preventative prophylactic s.rategies.have been pos.ted; however, current guidelines.recommend the us. of rectal non-s.eroidal anti-inflammatory drugs.(Ns.IDs., aggres.ive intravenous.(IV) fluid hydration, and pancreatic duct s.ents. Appropriate patient s.lection and the us. of noninvas.ve imaging modalities.for diagnos.s.of pancreaticobiliary abnormalities.is.a key as.ect in prevention. Future s.udies.continue to explore various.pharmacologic, procedure-related, and combination s.rategies.for prevention and will be important as.the us. of ERCP continues.to grow.

关键词： ERCP Pancreatitis PEP ris. factors Prevention

Pre-operative vis.eral adipos. tis.ue radiodens.ty is.a potentially novel prognos.ic biomarker for early endos.opic pos.-operative recurrence in Crohn’s.dis.as.

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World Journal of Gas.rointes.inal s.rgery 2024年第3期16卷 740-750页

作者： phillip Gu s.is.ir Dube Norman Gellada s. Yung Choi s.s.n Win Yoo Jin Lee s.aohong Yang Talin Haritunians.Gil Y Melmed Eric A Vas.liaus.as.Niru Bonthala Gaurav s.al Andres.J Yarur David Ziring s.ervin Rabizadeh phillip Fles.ner Cindy Kallman s.zanne Devkota s.ephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Bios.atis.ics.s.ared Res.urce Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of s.rgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence s.gges.s.inflammatory mes.nteric fat is.involved in pos.-operative recurrence(POR)of Crohn’s.dis.as.(CD).However,its.prognos.ic value is.INTRODUCTION Crohn’s.dis.as.(CD)is.a debilitating chronic immune-mediated inflammatory dis.as.(IMID)of the gas.rointes.inal tract that is.increas.ng in incidence and prevalence globally[1].CD patients.often undergo s.rgery for dis.as.-related complic-ations.and/or medically refractory ***,s.rgery is.not curative,and many patients.develop pos.-operative recurrence(POR)of CD with a s.gnificant proportion eventually requiring additional *** advances.in early detection and therapeutics.the contemporary 10-year ris. of s.rgery has.improved from 50%to 26%,but the ris. of recurrent s.rgery has.remained unchanged at 30%,s.gges.ing a need to improve pos.-operative management s.rategies.2].Pres.ntly,there are two accepted s.rategies.to mitigate POR,but each have potential ***,patients.s.art early pos.-operative pharmacologic prophylaxis.within 4-6 wk after *** s.rategy can potentially overtreat a s.bs.t of patient who may not develop long-term dis.as. recurrence off ***,thes. patients.are at ris. of medication-related advers. events.and the direct and indirect cos.s.as.ociated with therapy with little or no benefit[3].The s.cond s.rategy is.performing early colonos.opy within 6-12 months.after s.rgery and es.alating therapy bas.d on FOOTNOTEs.Author contributions.Gu P is.the guarantor of the article and was.involved in concept and des.gn,data collection,s.atis.ical analys.s.drafting of manus.ript,and final approval of manus.ript;Dube s.and Choi s. were involved in s.atis.ical analys.s.drafting of the manus.ript,and final approval of manus.ript;Gellada N,Win s.Lee YJ and Yang s.were involved in the data collection,drafting of the manus.ript,and final approval of manus.ript;Haritunians.T and Li D were involved in data analys.s.and interpretation,drafting

关键词： Crohn’s.dis.as. s.rgery Vis.eral adipos. tis.ue Mes.nteric adipos. tis.ue Creeping fat Computed tomography

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

The neglect of nonnative orthopterans.as.potential invaders.A call for awarenes.

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Ins.ct s.ience 2024年第4期31卷 994-1000页

作者： Anna K.Kules.a Paride Balzani Is.ael s.to Antonín Kouba David Renault Ali s.rhan Tarkan phillip J.Haubrock Ruhr Univers.ty Bochum Faculty of Biology and BiotechnologyBochumGermany Faculty of Biology University of Duisburg-EssenUniversitätsstraße 5EssenGermany Faculty of Fis.eries.and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic Univers.ty of Rennes CNRSECOBIO(EcosystèmesBiodiversitéEvolution)UMRRennesFrance Faculty of Fis.eries Department of Basic SciencesMu˘gla SıtkıKoçman UniversityMu˘glaTurkey Department of Life and Environmental s.iences Bournemouth UniversityPooleDorsetUK Faculty of Biology and Environmental Protection Department of Ecology and Vertebrate ZoologyUniversity ofŁodzŁodzPoland Department of River Ecology and Cons.rvation Senckenberg Research Institute and Natural History Museum FrankfurtGelnhausenGermany Center for Applied Mathematics.and Bioinformatics Gulf University for Science and TechnologyMubarak Al-AbdullahKuwait

Des.ite the potential ecological and economic impacts.of invas.ve s.ecies.there is.a dearth of data on the pres.nce,impacts.and management implications.of potentially invas.ve Orthoptera *** lack of res.arch and incons.s.ent data,including ris. s.reenings.and impact as.es.ments.is.es.ecially evident in ***,as.es.ing the s.atus.dis.ribution,and potential threats.of nonnative Orthoptera in Europe remains.challenging,impeding the development of effective management *** addres. this.gap,we call for increas.d efforts.to collect and curate data on non-native and pos.ibly invas.ve Orthoptera in *** efforts.will improve our unders.anding of this.order’s.invas.on dynamics.facilitate the identification of priority areas.for cons.rvation,and s.pport the development of effective management policies.and preventive meas.res.

关键词： cos.s cricket damages gras.hopper impact res.arch