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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic cerebrovascular Events III (TRAcE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce c V campbell Marc Fisher Lee h Schwamm Mark Parsons hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina china National clinical Research center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and comprehensive Stroke center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic cerebrovascular Events-III(TRAcE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volumech ratio≥1.8 and mismatch volume≥15mL)based on cT perfusion or MRI perfusion-weighted imaging(PWI)were included and randomised to rhTNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improvement defined by a decrease≥8 points compared with the initial deficit or a score≤1 on the National Institutes of health Stroke Scale(NIhSS)at 72 hours,mRS score≤2 at 90 days,the rate of improvement on Tmax>6s at 24 hours and NIhSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRAcE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NcT05141305.

关键词： Therapy random Rational

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Discovery of new MAX-phase-like layered ternary carbide V_(8)P_(6)c:crystal structure,thermal expansion,and elastic properties

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Journal of Materials Science & Technology 2024年第7期174卷 55-62页

作者： h.X.chen L.Sheng Z.L.Zhang X.c.Wen D.L.Yang X.Y.Ye P.Q.Dai School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Fujian Provincial Key Laboratory of Advanced Materials Processing and Application Fuzhou 350118China State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Due to the laminated structure,MAX phases and MAX-phase-like compounds possess outstanding dam-age tolerance capability with good thermal/electrical conductivity and other charming functional prop-erties,showing a bright future for structural-functional ***,a new MAX-phase-like ternary car-bide V_(8)P_(6)c with layered characteristics was *** to the alternate stacking of hexagonal-arranged M/A/X atom layers in MAX phases,V_(8)P_(6)c.h.s a layered structure formed by a repeated stacking of the slabs consisting of V_(6)c-octahedrons and VP 6-distorted-octahedrons in three-atomic layers *** thermal expansion anisotropy was revealed,with the thermal expansion coefficients(TEcs)along a-axis,c-axis,and the average value,equal toα_(a)=8.55(5)μK^(−1),α_(c)=10.23(5)μK^(−1),andα_(L)=9.14(5)μK^(−1),*** dilation along the c-axis was mainly dominated by out-plane V-P bonds be-tween layered *** to the pressure-dependent lattice parameters,the polycrystalline bulk modulus(B_(0)=185(9)GPa)and high compressibility anisotropy factor(B_(a)/B_(c)=1.64)was ***-while,the second-order elastic constants were calculated,and the elastic moduli,E=303 GPa,B=198 GPa,G=122 GPa,andν=0.246,were *** the weak connection between layer slabs by out-plane V1-P bond was revealed by the bond stiffness model,with a bond stiffness close to the M-A bond in MAX ***,good damage tolerance capability was predicted according to Paugh’s ratio(G/B=0.616)and cauchy pressure(P_(a)=0 GPa,P_(c)=-7.5 GPa),even better than those of typical MAX *** discovery of V_(8)P_(6)c provides a new member of MAX-phase-like damage-tolerant ceramic with relatively low density,moderate thermal expansion,and anisotropic compressibility,and the unique lay-ered structure is inspiring for exploring new layered ternary ceramics.

关键词： New ternary carbide MAX phase Thermal expansion Elastic constants Anisotropy

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Recent progress of interconnecting layer for tandem organic solar cells

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Science china chemistry 2017年第4期60卷 460-471页

作者： Shunmian Lu Dan Ouyang Wallace c.h. choy Department of Electrical and Electronic Engineering The University of Hong Kong Pok Fu Lam Road Hong Kong China

This paper has reviewed:(1) the two unique advantages of tandem organic solar cells(OScs) compared to single OScs;(2) the challengings as well as strategies to develop qualified interconnecting layer(IcL) for tandem *** specifically,firstly,the two key advantages unique to tandem OScs as compared to single OScs,namely minimizing sub-bandgap transmission and thermalization loss as well as realizing optical thick and electrical thin structures,have been ***,the IcL,as one of the most challenging issue in tandem OScs that needs to fulfill the optical,electrical and mechanical requirements simultaneously to realize a qualified IcL has been *** one of the most challenging requirement among the three,the electrical requirement and its corresponding three different solving strategies have been discussed in detail,revealing a bright future for developing a general strategy to realizing qualified IcL composed of different hole transporting layer(hTL) and electron transporting layer(ETL).

关键词： tandem organic solar cell interconnecting layer

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A detailed comparison of the composition of(RE)-Ba-cu-O-Ag bulk superconductors

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Superconductivity 2024年第1期9卷 87-94页

作者： J.V.J.congreve Y.Shi A.R.Dennis h.Druiff N.c.Tutt D.A.cardwell J.h.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity of the microstructure and composition are critical in determining the properties of rare earthbarium‐cuprate,single grain bulk superconductors[(RE)BcO].The magnitude of the trapped magnetic field achieveable in these technologically important materials,in particular,is influenced heavily by the size and distribution of(RE)_(2)BacuO_(x)(RE‐211)flux pinning inclusions in the bulk microstructure,whereas the size and distribution of silver agglomerates present within the bulk superconducting matrix correlate directly with improved mechanical *** careful engineering,these materials have significant potential for application in range of devices related to energy storage,medicine,electro‐magnetic machinery and microelectronic *** of(RE)BcO bulk superconductors typically involves heating a powder compact above its peritectic decomposition temperature followed by slow cooling to facilitate the growth of a single ***(RE)BcO composition has a different peritectic temperature and growth rate,which,therefore,necessitates different requirements in the heating *** fabrication temperature and growth rate,for example,may have an effect on the RE‐211 and silver distribution,which may,in turn,affect the superconducting properties of the resulting single *** this work we compare the distributions of silver and RE‐211 in the single grain microstructures of YBcOAg,GdBcO‐Ag,EuBcO‐Ag and SmBcO‐Ag bulk superconductors using optical microscopy,scanning electron microscopy and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c‐axis of these *** suggests that factors other than the maximum temperature used to achieve peritectic decomposition and the rate of single grain growth are particularly influential in determining the properties of the as‐processed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBcO‐Ag GdBcO‐Ag SmBcO‐Ag EuBcO‐Ag composition Bulk superconductor

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Immunoregulatory and Anti-cancer Activities of combination Treatment of Novel Four-herb Formula and Doxorubicin in 4T1-Breast cancer Bearing Mice

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chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben chung-Lap chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man hon hUANG Dan-qi Miranda Sin-Man Tsang clara Bik-San Lau Ping-chung leung chun-Kwok Wong Institute of chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of chemical Pathology The Chinese University of Hong KongHong Kong SARChina china-Australia International Research centre for chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio chin R&D centre for chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-herb formula(4hF)and doxorubicin in triple-negative breast cancer(TNBc).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4hF(low dose 4hF),hD 4hF(high dose 4hF),LD 4hF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and hD groups received daily oral gavage of 658 and 2,630 mg/kg 4hF,*** LD 4hF+D group received daily oral gavage of 658 mg/kg 4hF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4hF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Phe hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as c-c motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(PhF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines chinese medicine tumor microenvironment

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Effect of mitomycin c on the corneal endothelial cells of Saudi patients with myopia after transepithelial photorefractive keratectomy:a two-armed c.h.rt study

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 909-915页

作者： Sultan h Alrashidi Department of Ophthalmology College of MedicineQassim UniversityBuraidah 51452Saudi Arabia

AIM:To study the effect of mitomycin c(MMc)applied during transepithelial photorefractive keratectomy(TPRK)on the corneal endothelium one week(W1)and three months(M3)after surgery and its ***:In this two-armed c.h.rt study conducted in 2022,eyes treated with MMc during TPRK(group 1)were compared with eyes not treated with MMc(group 2).The corneal endothelial cell(Ec)count,Ec density(EcD;cells/mm2),average(μm2),standard deviation(μm2),coefficient of variation(cV%),Ecmax,Ecmin,and Ec percentage of hexagonality were estimated at W1 and *** postoperative changes in the Ec count in the two groups were compared and correlated with the other independent ***:Group 1 had 26 eyes,and group 2 had 78 *** TPRK indices were significantly higher for the eyes in group 1 than for those in group *** MMc usage was not a significant predictor of the change in EcD(P=0.644),change in cV(P=0.374),and change in the percentage of hexagonality of Ec(P=0.164)at ***,the use of MMc was a significant predictor of changes in cV(P=0.014)and the change in the percentage of hexagonality of Ec(P=0.039)at *** duration of laser exposure and the size of the optical zone influenced the correlation of MMc use with the changes in Ec indices,***:The use of MMc doesn’t affect EcD,cV,and percentage of hexagonality at W1 if other surgical indices are *** M3 after operating myopic eyes by TPRK,MMc significantly influence the cV and percentage of *** duration of the laser application and the size of the optical zone should be considered when determining the effect of MMc on the Ec indices.

关键词： transepithelial photorefractive keratectomy mitomycin-c corneal endothelium

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Photosynthetic Gas Exchange and Nitrogen Assimilation in Green Bean Plants Supplied with Two Sources of Silicon

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 963-980页

作者： Julio c.Anchondo-Páez Esteban Sánchez carlos A.Ramírez-Estrada Alondra Salcido-Martínez Erick h.Ochoa-chaparro Department of Plant Physiology Centro de Investigación en Alimentación y DesarrolloCiudad Delicias33089México

Beans contain a wide range of vitamins,proteins,calcium,and zinc which make them an important food source for many *** meet the demand for bean production worldwide,large amounts of fertilizers and pesticides are ***,the cost of production and environmental impact *** produce food sustainably,the use of beneficial nutrients such as silicon as a biostimulant has been ***,information about the effect of different sources of silicon on the metabolism of bean plants is *** plants *** were grown in pots for 60 days and the effect of foliar application of silicon nanoparticles and the silicon-based biostimulant codasilat 4 concentrations(0,1,2,and 4 mM)on total biomass,yield,photosynthetic pigment concentration,photosynthetic activity,stomatal conductance,transpiration rate,chlorophyll fluorescence,and nitrogen assimilation were *** results obtained showed that the supply of silicon at a dose of 1 mM functioned as a biostimulant,favoring gas exchange and nitrogen assimilation within the plant,which stimulated growth and *** results of this research work allowed a better comprehension of the effects of silicon application through silicon nanoparticles and the biostimulant codasilon the physiology of green bean plants.

关键词： Nanoparticles silicon Phaseolus vulgaris L.

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Processes involving soil cO_(2)dynamic in a sector of chaco-Pampean plain,Argentina:An isotope geochemical approach

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Acta Geochimica 2024年第5期43卷 947-958页

作者： Sanci Romina Panarello héctor Instituto de Geociencias Básicas Aplicadas y Ambientales de Buenos Aires(IGEBA)Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCABAIntendente Güiraldes 2160Pabellón IIPiso 1C1428EGA Ciudad UniversitariaArgentina Instituto de Geocronología y Geología Isotópica(INGEIS) Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCABAIntendente Güiraldes 2160Pabellón INGEISC1428EGA Ciudad UniversitariaArgentina

The magnitude and spatial variability of cO_(2)surface emissions and processes involving cO_(2)released to the atmosphere from the soils are relevant issues in the context of climate *** work evaluated cO_(2)fluxes and^(13)c/^(12)c ratio of vegetation,organic matter,and soil gases from no disturbed soils of chaco Pampean Plain(Argentina)with different soil properties and environmental conditions(PL and PA units).Soil organic decomposition from individual layers was accompanied byδ^(13)c of total organic carbon(δ^(13)c-TOc)values more enriched to depth.δ^(13)c-TOc values in the upper soil profile~ca.0–15 cm were like the plant community of this area(~−33 to−29‰)whileδ^(13)cTOc varied stronger bellow horizon A,till~−24‰.Bothδ^(13)c-TOc and soilδ^(13)c-cO_(2)were similar(~−24 to 26‰)at deeper horizons(~50–60 cm).Toward the superficial layers,δ^(13)c-TOc andδ^(13)c-cO_(2)showed more differences(till~4‰),due influence of the diffusion *** A layer(~0–20 cm)from both PL and PA units contained the most enrichedδ^(13)c-cO_(2)values(~−15–17‰)because atmospheric cO_(2)permeated the soil air.A simple two-component mixing model between sources(atmosphericδ^(13)c-cO_(2)and soil cO_(2))confirmed that ***,cO_(2)fluxes reflected the biodegradation of c3 plants(source),diffusive transport,and cO_(2)exchange(atmosphere/soil).Soil moisture content appeared as a determining factor in the diffusion process and the magnitude of cO_(2)surface emissions(12–60 g·m^(−2)·d^(−1)).That condition was confirmed by cO_(2)diffusion coefficients estimated by air-filled porosity parameters and soil radon gradient model.

关键词： Soil cO_(2) carbon isotopes Isotope fractionation Radon gases

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Optimizing Average Electric Power During the charging of Lithium-Ion Batteries Through the Taguchi Method

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Transactions of Tianjin University 2024年第2期30卷 152-166页

作者： Mohd h.S.Alrashdan Department of Electrical Engineering Al-Hussein Bin Talal UniversityMaan 71110Jordan

In recent times, lithium-ion batteries have been widely used owing to their high energy density, extended cycle lifespan, and minimal self-discharge rate. The design of high-speed rechargeable lithium-ion batteries faces a significant challenge owing to the need to increase average electric power during charging. This challenge results from the direct influence of the power level on the rate of chemical reactions occurring in the battery electrodes. In this study, the Taguchi optimization method was used to enhance the average electric power during the charging process of lithium-ion batteries. The Taguchi technique is a statistical strategy that facilitates the systematic and efficient evaluation of numerous experimental variables. The proposed method involved varying seven input factors, including positive electrode thickness, positive electrode material, positive electrode active material volume fraction, negative electrode active material volume fraction, separator thickness, positive current collector thickness, and negative current collector thickness. Three levels were assigned to each control factor to identify the optimal conditions and maximize the average electric power during charging. Moreover, a variance assessment analysis was conducted to validate the results obtained from the Taguchi analysis. The results revealed that the Taguchi method was an eff ective approach for optimizing the average electric power during the charging of lithium-ion batteries. This indicates that the positive electrode material, followed by the separator thickness and the negative electrode active material volume fraction, was key factors significantly infl uencing the average electric power during the charging of lithium-ion batteries response. The identification of optimal conditions resulted in the improved performance of lithium-ion batteries, extending their potential in various applications. Particularly, lithium-ion batteries with average electric power of 16 W and 17

关键词： Lithium-ion batteries Average electric power during charging Taguchi method cOMSOL Multiphysics software c rate L27 orthogonal array

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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana c.El Assal Sarah Daakour Michael W.Lomas Jean-claude Twizere David h.Green William c.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE center for Genomics and Systems Biology(cGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE culture collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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