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Hepatocellular carcinoma in the setting of interferon-free treatment for chronic HCV hepatitis - experience of a single center

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Hepatoma Research 2018年第1期4卷 21-30页

作者： Elena Laura Iliescu Adriana Mercan-Stanciu letitia toma Elena Simona Ioanitescu Radu Dumitru Daniel Rusie Department of Internal Medicine II Fundeni Clinical InstituteBucharest 022328Romania Department of Interventional Radiology Fundeni Clinical InstituteBucharest 022328Romania Department of General Surgery Clinical Emergency HospitalBucharest 014461Romania

Aim: This study aims to analyze the particularities of hepatitis C induced hepatocellular carcinoma (HCC), developed during or after treatment with direct-acting antivirals. Methods: We conducted an observational prospective study on 278 patients, who underwent treatment for hepatitis C related liver cirrhosis and respectively for F3 chronic hepatitis C. Liver status was assessed using biological parameters and imagistic evaluation (ultrasonography, computed tomography scan, magnetic resonance imaging). Results: The follow-up time was 14 months. Before therapy, 69.3% of the cirrhotic patients and 26.7% of those with F3 degree of liver fibrosis had high levels of alpha-fetoprotein, with no imagistic evidence of HCC. During treatment, HCC was confirmed in 5 patients, 2 of them presenting portal vein thrombosis (PVT). Antiviral therapy was not interrupted. Two patients developed HCC at the end of treatment, while 4 of them were diagnosed with HCC after three months of ending the treatment. Excepting the ones with PVT, all patients underwent trans-arterial chemoembolization. Conclusion: All patients acquired sustained virological response. The screening for HCC should not be stopped after achievement of sustained virological response. Patients who develop HCC after antiviral treatment often need to be evaluated by magnetic resonance imaging in order to detect the extensionof the disease.

关键词： Hepatitis C virus direct-acting antiviral therapy hepatocellular carcinoma trans-arterial chemoembolization

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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabeth M.Whitley letitia E.Bible Philip A.Efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p values<0.05(*).Results:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(p<0.0001),lower hemoglobin(p<0.0001),and enlarged spleen to body weight ratios(p=0.004).Both LCHS and PT demonstrated suppression of CFU-E and BFU-E growth compared to naive(p<0.03,p<0.01).Plasma G-CSF was elevated in PT compared to both na?ve and LCHS(p<0.0001,p=0.02).LCHS and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

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Psychosocial stress and liver disease status

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World Journal of Gastroenterology 2009年第24期15卷 2980-2986页

作者： Cristin Constantin Vere Costin Teodor Streba letitia Maria Streba Alin Gabriel Ionescu Felix Sima 1st Department of Internal Medicine Emergency County Hospital of Craiova University of Medicine and Pharmacy of Craiova 3rd Department of Internal Medicine "Filantropia" University Hospital of Craiova

"Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma.

关键词： Stress Chronic viral hepatitis Cirrhosis Carcinoma Hepatocellular Liver pathology

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Focus on alcoholic liver disease:From nosography to treatment

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World Journal of Gastroenterology 2014年第25期20卷 8040-8047页

作者： letitia Adela Maria Streba Cristin Constantin Vere Costin Teodor Streba Marius Eugen Ciurea Internal Medicine-Medical Semiology University of Medicine and Pharmacy of Craiova 200639 Craiova Romania Research Center of Gastroenterology and Hepatology of Craiova University of Medicine and Pharmacy of Craiova200639 CraiovaRomania University of Medicine and Pharmacy of Craiova 200639 Craiova Romania

Abusive alcohol intake currently ranks as a major cause of liver disease, and is associated with significant mortality worldwide. Alcoholic liver disease(ALD) generically defines liver abnormalities ranging from liver steatosis to the end-stages of disease such as liver cirrhosis. Information regarding the precise incidence and prevalence of ALD is still limited by a lack of large population-based studies and by the absence of large systematic reviews of all epidemiological data available. However, existing collected data show an overall increase in the number of alcohol abusers and alcoholrelated liver disease. The burden exerted on medical systems worldwide is significant, with hospitalization and management costs rising constantly over the years. A great number of all cirrhosis-related deaths in Europe and a significant percentage worldwide areassociated with alcohol consumption. The main possible risk factors for ALD are the amount and duration of alcohol abuse, patterns of drinking and the type of alcoholic beverage consumed. However, ALD does not progress to cirrhosis in all patients, therefore a series of additional factors are implicated. Even though insufficiently studied, genetic factors are generally regarded as highly important, and the presence of comorbidities and dietary habits seem to play a role in disease onset and progression. This lack of clear pathophysiological data further translates in the absence of definite treatment for ALD and shall prove challenging in the coming years. In this article, we aimed to briefly review epidemiologic data on the burden of ALD, risk factors, clinical and nosographic as well as therapeutic aspects of this disease. Without attempting to be exhaustive, this short topic highlight emphasizes each point and may serve as a general guidance tool in the complicated literature related to ALD.

关键词： Alcoholic liver disease Epidemiology Risk factors Diagnosis Treatment

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New Episode in PV Trade Dispute

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China International Business 2012年第12期 46-47页

作者： letitia CHENG

China has lodged a complaint with the World Trade Organization （WTO） about European Union（EU） subsidies for photovoltaic （PV） products. The case, launched by China＇s Ministry of Commerce （MOFCOM） on November 5, focuses on subsidies granted by Italy and Greece. According to the law in the two countries, electricity is entitled to certain subsidies if the power is generated by PV installations with the main components produced within the EU or the European Economic Area.

关键词：贸易争端世界贸易组织欧洲联盟发电装置组成部分补贴 WTO 商务部

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When Publishing Meets Digitalization

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China International Business 2013年第5期 44-46页

作者： letitia CHENG

Interview with Shen Lijun, Vice President of the Foreign Language Teaching and Research PressWith so many readers turning away from print books and to electronic devices, traditional publishers may be feeling the pressure of the digital age. Shen Lijun, vice president of the Foreign LanguageTeaching and Research Press （＇FLTRP） calls for the ~ght att^itu^e to embrace the changes brought by digitalization.

关键词：数字化时代传统出版电子设备外语教学出版社外交部 ATT ITU

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Welcome to the American Footbal

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China International Business 2013年第5期 36-37页

作者： letitia CHENG

Interview with Nathan Jones, China Federation of American Football representative of the InternationalIn the sports sector at the 2nd China （Beijing） International Fair for Trade in Services （CIFTIS）, there will be several overseas delegates attending the International Sports Service Trade Forum and Sports ServiceExhibition. One of the organizations represented is the International Federation of American Football （IFAF）, which is planning to introduce a brand new sports programme for Chinese youngsters.

关键词：足球体育节目美国国际贸易服务贸易博览会中国青少年

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A New Deal for Movies

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China International Business 2012年第4期 38-40页

作者： letitia CHENG

On the screen, Tom Cruise is run- ning through a sandstorm in Dubai： it＇s Mission Impossible：Ghost Protocol. As the hero desperately climbs the outside of the Burj Khalifa tower with fancy gloves and thrilling iumps, Xiao Dong, a student in Tianjin, is watching. The 19-year-old is a Hollywood movie fan, and rarely misses the latest blockbuster.

关键词：电影沙尘暴好莱坞迪拜屏幕

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Henan One of the Biggest Provinces Finally Takes off--Crouching Tiger in the Central Plains

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China International Business 2011年第12期 57-60页

作者： letitia CHENG

Historically called ＂the Central Plains＂, Henan Province is considered the birthplace of the Chinese civilization and the Chinese nation. With rich culture and natural resources, Henan Province has nurtured generations of outstanding people, and remains a big province of population, culture, tourism, agriculture and economy in China.

关键词：河南省中原起飞文化资源中华民族自然资源虎发祥地

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A Dream of Stone

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China International Business 2013年第5期 40-41页

作者： letitia CHENG

Interview with Zhang Baogui, General Manager of Baogui Artificial Stone Art, Science and Technology Co. LtdBaogui Artificial Stone Art, Science and Technology Co. Ltd. is based in Habatun, in the Changping district of Beijing. It＇s a remote village, some 40 kilometers from the city centre. The company uses cement, stone powder and other waste building materials to make sculptures.

关键词：人造石张宝贵总经理昌平区北京市市中心废弃物艺术

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