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Use of Intragastral Balloon and Increase in Fertility： Case Report

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 403-409页

作者： Leite leticia Torres Araujo Anna Barbara Ribeiro Souza Luma Lorraine dos Reis Sander Bruno Queiroz Lopes Joanilva Ribeiro Medical school of FAMINAS-BH College of Minas-BHBelo Horizonte 30110012Brazil Bariatric Endoscopy by UFMG Belo Horizonte 30150285Brazil UNIMONTES and Prominas Colleges Montes Claros 39403440Brazil

The IGB （intragastric balloon） is a silicone device, inflated by endoscopy in the gastric cavity, with physiological saline and a blue dye, up to the volume of 700 mL, and used for a maximum of 6 months, It is indicated for patients with BMI〉27 kg/m^2 that have not undergone previous gastric surgery. In obese women there is a decrease in peripheral resistance fertility, and the weight loss achieved in bariatric surgery improves fertility due to reduced subcutaneous fat, with lower insulin resistance. Similar results could be achieved through the use of IGB, a less invasive method. The objective of the article is to report the case of a patient who became pregnant using IGB, considering the hypothesis that the increase in fertility was due to weight loss and/or due to the improvement in the self-esteem （and sexual life） of patient. We selected 13 articles from PubMed, UpToDate, JAMA and a case report. Results： Balloon with drawal occurred on 05/02/16 after positive pregnancy test with final weight 65.5 kg and BMI 25.91 kg/m2. Conclusions： Weight loss actually favors fertility, but self-esteem may have been instrumental in improving the sex life, enabling conception.

关键词： IGB fertility pregnancy obesity.

Silent diabetic nephropathy

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World Journal of Nephrology 2014年第1期3卷 6-15页

作者： Katia López-Revuelta Patricia Pea Galdo Ramona Stanescu leticia Parejo Carmen Guerrero Elia Pérez-Fernández Unidad de Nefrología Hospital Universitario Fundación Alcorcón 28922 Madrid Spain Unidad de AnatomíaPatológica Hospital Universitario Fundación Alcorcón 28922 Madrid Spain Unidad de Investigación Hospital Universitario Fundación Alcorcón 28922 Madrid Spain

AIM： To examine the risk of renal events in patients with biopsy-proven diabetic nephropathy （DN） and its possible associated ***： Clinical and histological data of 60 pa-tients diagnosed with diabetic nephropathy were retro-spectively collected. Patients with evidence or suspicion of other nephropathies were excluded from the study. The fnal event was defned as renal replacement ther-apy （RRT） initiation or progression of chronic kidney disease （CKD）, according to the KDIGO 2012 defnition of a decrease in CKD category and a decrease in GFR of 25% or more. RESULTS： A total of 45 patients with a follow-up of at least 3 mo were included. Most of the patients presented type 2 DM, with a mean age of 58.3 years old. The time of evolution of DM was 9.6 ± 7.8 years, al-though in 13 patients, it was less than 5 years. A total of 62% of patients reached the fnal event in a mean period of 3.4 years （95%CI： 2.1-4.7）, with 21 of them requiring dialysis. The factors that were indepen-dently associated with renal survival were estimated glomerular fltration rate （eGFR） at the time of biopsy, cardiovascular disease （CVD） history and HbA1c less than 7%. Therefore, for each 10 mL/min per 1.73 m2 reduction in eGFR, we obtained a DN progression risk of HR = 2 （1.3-3.0）（P = 0.001）; patients with CVD were at greater risk for DN progression （HR = 2.8, 1.1-7.1, P = 0.032）, and CKD patients with HbA1c 〈 7% demonstrated greater renal risk than patients with HbA1c ≥ 7%, with an HR of 2.9 （1.0-8.4）（P = 0.054）.CONCLUSION： A past history of CVD is a risk fac-tor for DN progression. Levels of HbA1c less than 7% could favor an eGFR decrease in these patients.

关键词： Diabetic nephropathy Predictors of progression Histopathological diagnosis Cardiovascular disease Silent disease

Phase angle through electrical bioimpedance as a predictor of cellularity in inflammatory bowel disease

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Artificial Intelligence in Gastroenterology 2021年第4期2卷 111-123页

作者： Sabrina A Fernandes Carina Rossoni Vivian W Koch Marcello Imbrizi Rosana Evangelista-Poderoso leticia Pereira Pinto Letiia Pereira Pinto Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Institute of Environmental Health(ISAMB) Faculty of MedicineUniversity of LisbonLisbon 1649-028Portugal Gastroenterology Department Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology Department Grupo Hospitalar ConceicaoPorto Alegre 91350-250Brazil Coloproctology Department State University of Campinas(UNICAMP-SP)São Paulo 13056-405Brazil Library Faculty of Medical Sciences State University of Campinas(UNICAMP-SP)São Paulo 13083-887Brazil Department of Surgery State University of Campinas(UNICAMP-SP)and Faculty of Medical Sciences(FCM)São Paulo 13056-405Brazil

It is estimated in Western industrialized countries that inflammatory bowel disease(IBD)has a prevalence of 1 for every 200 *** the past,the fat mass disproportionate increase in relation to the fat-free mass was considered uncommon in patients with IBD,due to the observation of the disease being more common with weight loss and ***,more in-depth investigations demonstrate that the fat/lean mass disproportion stands out both in prevalence in patients with new diagnoses of ulcerative colitis or Crohn's disease as well as a factor of poor prognosis to the natural evolution of the disease or to the therapeutic *** important aspect associated with obesity in IBD is the increased risk of drug clearance[including anti-tumor necrosis factor(TNF)and anti-integrin agents],resulting in short half-life and low trough drug concentrations,since the levels of TNF secreted by adipocytes sequester anti-TNF agents,which could result in suboptimal response to *** view of these characteristic aspects of the inflammatory process of IBD,the identification of cellular functioning is necessary,which can be associated with the staging of the underlying disease,biochemical parameters,and body composition,helping as an indicator for a more accurate clinical and nutritional conduct.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Phase angle Cellularity Bioelectrical impedance

Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test?

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World Journal of Gastroenterology 2015年第12期21卷 3619-3627页

作者： Gregory L Falk John Beattie Alvin Ing SE Falk Michael Magee leticia Burton Hans Van der Wall Sydney Heartburn Clinic Gastroenterology Concord Hospital University of Sydney Macquarie University Sydney Ryde Medical Centre Sydney Department of Respiratory Medicine Concord Hospital the University of Sydney Sydney Heartburn Clinic Gastroenterology Sydney Concord Nuclear Imaging Clinic

AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux ***: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after ***: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux p H studies Oesophageal m

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报警应用电路

电子产品世界 2000年第8期7卷 39-40页

作者： leticia Gomez Diana Pelletier 彭京湘 Motorola公司

引言Motorola公司的MC14600是一款报警应用的通用报警IC,用较少的外部元件很容易配置成各种报警应用电路.例如,MCl4600可用在检测压力和温度变化、液面高度、运动或闯入等系统中.

关键词：报警应用电路专用集成电路振荡器

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巴西南部第三中心早产儿视网膜病变(英文)

国际眼科杂志 2007年第1期7卷 31-35页

作者： Joao Borges Fortes Filho Cristiano Koch Barros Gabriela Unchalo Eckert leticia Procianoy Renato S. Procianoy 巴西Rio grande do sul联邦大学Porto Alegre医院眼科巴西Rio grande do sul联邦大学Porto Alegre医院新生儿科

目的:评估2002-10/2006-10在巴西de Clinicasde Porto Alegre医院出生的所有早产儿的早产儿视网膜病变(ROP)的发生率,其治疗和预后的比率。方法:对323例出生体质量低于或等于1500g或者出生时孕龄等于或者少于32wk的早产儿进行前瞻性队... 详细信息

目的:评估2002-10/2006-10在巴西de Clinicasde Porto Alegre医院出生的所有早产儿的早产儿视网膜病变(ROP)的发生率,其治疗和预后的比率。方法:对323例出生体质量低于或等于1500g或者出生时孕龄等于或者少于32wk的早产儿进行前瞻性队列研究。所有的新生儿都在出生后6wk内进行开睑器开睑,瞳孔散大,间接检眼镜及28D透镜眼底检查,根据疾病的分类进行复查。结果由均数表示,发病率为于95%的可信区间,主要的临床结果为任何分期的ROP发生。结果:新生儿82例发生了ROP,发生率为25.7%。患者中只有17例((5.3%)发生了阈病变,他们的病变都累及后部第II区,需要激光治疗。除了3例经治疗的患儿需要两次激光治疗外,没有一个经过治疗的患儿有I区病变或者严重的后部病变。重复治疗组的1例患儿因发展成为4期ROP而需要行赤道部硅胶带巩膜环扎术。结论:ROP的发生率和阈病变同国际其它的研究结果类似。本研究显示了孕期28wk以内或出生后体重1000g的新生儿高生存率(70.1%)、高视网膜病变发病率和激光治疗的高度必要性。这组患儿需要眼科专家和新生儿专家为发现ROP进行仔细筛查和随访。本组患儿中没有确诊1例有I区后部病变,此点是本研究值得引起注意之处。

关键词：早产防盲早产儿视网膜病变 ROP流行病学 ROP发病率 ROP治疗 ROP结果

Method Optimization Study on Isolation of Volatile Compounds by Headspace Solid-Phase Microextraction (HS-SPME) from Custard Apple (<i>Annona squamosa</i>L.) Pulp.

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Journal of Analytical Sciences, Methods and Instrumentation 2020年第3期10卷 59-77页

作者： Mércia de Sousa Galvão Karen leticia de Santana Juliete Pedreira Nogueira Maria Terezinha Santos Leite Neta Narendra Narain Departament of Food Engineering Federal University of Paraiba Jo&atilde o Pessoa Brazil Laboratory of Flavor and Chromatographic Analysis PROCTA Federal University of Sergipe S&atilde o Cristóvã o Brazil

Aroma is an important quality parameter, which can help in delaying degradative processes and hence understanding the volatile compounds that are part of an aroma is extremely important. Thus, the aim of this study was to isolate the volatile compounds present in custard apple (Annona squamosa L.) pulp by solid-phase microextraction (SPME) technique using 3 different fibers (DVB/CAR/PDMS, PDMS and PDMS/DVB). An experimental design was set up to evaluate the best extraction conditions wherein the variables were extraction temperature (minimum 28°C, maximum 62°C), ionic strength (minimum 0, maximum 30.0%) and sample concentration (min 1, max 99.0%). The separation of volatiles was achieved in chromatographic columns of different polarity (polar and non-polar) while identification of volatile compounds was performed by high resolution gas chromatography system coupled with mass spectrometry. The results obtained using 3 different fibers revealed the isolation of 71 compounds with fiber DVB/CAR/PDMS, while only 30 and 21 compounds were isolated using fibers PDMS/DVB and PDMS, respectively. The major classes of compounds identified were terpenes, esters, alcohols and aldehydes. Optimum conditions for obtaining higher number of volatiles for non-polar column were 45°C for extraction temperature, 15% of sodium chloride and 50% of pulp amount which resulted in isolation of a maximum of 78 peaks.

关键词： Flavor SPME Response Surface Methodology Volatiles Gas Chromatography-Mass Spectrometry

Hypolipidemic Activity of Microwave-Dehydrated Mango (<i>Mangifera indica</i>L.) Powder in Mice Fed a Hypercholesterolemic Diet

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Journal of Biomedical Science and Engineering 2014年第10期7卷 809-817页

作者： Obed Osorio-Esquivel Vianney Cortés-Viguri leticia Garduñ o-Siciliano Alicia Ortiz-Moreno María Elena Sánchez-Pardo Department of Biochemical Engineering National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Department of Physiology National School of Biological Sciences National Polytechnic Institute Mexico City Mexico

The effect of dietary supplementation with mango (Mangifera indica L.) powder obtained by microwave dehydration was studied in normal and hypercholesterolemic mice. The phenolic profiles in methanolic extracts and antioxidant activities were determined using high-performance liquid chromatography and DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis-3-ethyl-benzothiazoline-6-sulphonic acid) assays, respectively. The total phenolic content of microwave-dehydrated mango powder was 1451.7 ± 26.7 μggallic acid equivalents/g dry weight. The main phenolic compounds identified were gallic acid, epicatechin, ferulic acid, and catechin. The anti-oxidant activity was 14.6% higher in microwave-dehydrated mango powder than in conventional mango powder. Mice were fed a hypercholesterolemic diet (1 g cholesterol/100g over 7 days). The hypercholesterolemic mice whose diets were supplemented with microwave-dehydrated mango powder showed a significant decrease (P ≤ 0.05) in total serum cholesterol compared to the hypercholesterolemic mice and the mice fed with conventional dehydrated mango powder. We observed a significant increase (P ≤ 0.05) in HDL-c levels in the microwave-dehydrated mango powder group mice (12.4 ± 1.3 mmol/L) compared to the hypercholesterolemic group (8.6 ± 1.4 mmol/L) and the conventional-dehydrated mango powder group (10.9 ± 1.3 mmol/L). The mice provided with microwave-dehydrated mango powder had significantly lower (P ≤ 0.05) levels of serum LDL-c (36.0%) and total cholesterol (43.3%) compared to the mice in hypercholesterolemic group. Notably, the atherogenic index was 72% lower in the microwave-dehydrated mango powder group compared to the hypercholesterolemic group. These results suggest that the biocompounds, such as polyphenols and dietary fiber, found in mango pulp might improve the lipid profile in mice fed a hypercholesterolemic diet.

关键词： Hypolipidemic Activity Microwave-Dehydrated Mango Powder Hypercholesterolemic Diet Phenolic Profiles

Edge Effects of Oil Pipeline Canopy Openings on Tree Community Structure and Dynamics in a Montane Atlantic Forest

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Journal of Geoscience and Environment Protection 2016年第7期4卷 132-140页

作者： Pablo J. F. Pena Rodrigues leticia R. Melo Rodolfo C. R. de Abreu Mariana A. Iguatemy Instituto de Pesquisas Jardim Botanico do Rio de Janeiro Rio de Janeiro-RJ Brazil

The Atlantic forest has historically been severely deforested, and only fragments currently remain that are subject to a wide variety of anthropogenic impacts, including edge effects that can cause structural and functional degradation. The Tinguá Biological Reserve-RJ comprises approximately 26,000 hectares of well-preserved Atlantic Forest, but it is subject to impacts caused by two canopy openings along oil pipelines. Comparisons were made between pipeline edges and forest interiors to evaluate edge effects on the structure and dynamics of those tree communities. Tree densities were higher along forest edges, apparently increasing over time. Tree basal areas, on the other hand, have decreased along edges due to higher mortality rates. Linear canopy opening edges showed higher densities of small trees, while the interior had more very large trees, indicating changes in successional processes and community structural patterns due to edge effects.

关键词： Fragmentation Disturbance Human-Modified Habitats Linear Canopy Openings Human Impact