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Relationship between phase angle,steatosis,and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

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World Journal of Hepatology 2022年第6期14卷 1173-1181页

作者： Sabrina Alves Fernandes Cristiane Valle Tovo AndréLuiz Machado da Silva letícia pereira pinto Randhall B Carteri Angelo A Mattos Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Infectology Service Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Brazil Department of Nutrition Centro Universitário Metodista-IPAPorto Alegre 90420-060Brazil Department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil

BACKGROUND Malnutrition,lipodystrophy,and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus(HIV)infection with or without previous *** a clinical condition can lead to the hypothesis of the presence of hepatic steatosis with possible progression to fibrosis and the risk of hepatocellular ***,a low phase angle(PA),evaluated by bioelectrical impedance analysis(BIA),is an independent prognostic marker of clinical progression and survival in HIV-infected *** To evaluate the relationship between PA and body composition with steatosis and hepatic fibrosis in HIV/hepatitis C virus(HCV)-coinfected *** A retrospective observational study by convenience sampling of coinfected HIV/HCV patients,in which all patients underwent transient elastography(Fibroscan)and BIA ***’s t test was used for group comparisons,and Spearman’s or Pearson’s correlation test was used when *** significance level was set at 5%,and analyses were performed using SPSS version *** Forty-three patients who received antiretroviral therapy met the inclusion criteria,and 23(53.5%)were under treatment with protease inhibitors(PIs).There was no difference in PA between those who used PIs and those who did not(P=0.635).There was no correlation between fibrosis grade and PA(P=0.355)or lean mass(P=0.378).There was a significant inverse correlation between the controlled attenuation parameter(CAP)and lean mass(P=0.378),positive correlation between PA and lean mass(P=0.378),and negative correlation between PA and fatty mass(P=0.378),although the CAP and PA were not *** evaluated by sex,no significant correlations were *** PA determines the muscle function of HIV/HCV-coinfected patients,and the CAP values reinforce the association with lean mass,suggesting that patients require early nutritional interventions.

关键词： Phase angle Bioelectrical impedance Coinfection Human immunodeficiency virus Hepatitis C virus Nutrition

Role of the phase angle in the prognosis of the cirrhotic patient:15 years of follow-up

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World Journal of Methodology 2023年第4期13卷 238-247页

作者： letícia pereira pinto Claudio Augusto Marroni Juliana Czermainski Maria Luiza Fernandes Dahlem Randhall B Carteri Sabrina Alves Fernandes Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Veterinary Medicine Universidade Federal do Rio Grande do SulPorto Alegre 91540-000Brazil Department of Nutrition Centro Universitário Metodista IPAPorto Alegre 90420-060Brazil Department of Nutrition Centro Universitário CesucaCachoerinha 94935-630Brazil

BACKGROUND In 2019,cirrhosis accounted for 2.4%of global *** projection for 2030 is an increase in this *** recent years,hospitalization costs have escalated by 36%for compensated cirrhosis and 24%for decompensated ***,it is necessary to identify a tool capable of predicting the mortality of these patients according to their clinical condition and consequently extending their survival *** studies have shown that the phase angle(PA)can be a feasible method in clinical practice,with the potential to guide assertive patient management in the therapeutic of chronic liver *** To evaluate the prognostic role of PA in cirrhotic patients over a 15-year followup *** Retrospective cohort study with 129 cirrhotic patients of both sexes over 18 years *** of cirrhosis by liver *** first year of data collection was 2007,and data regarding outcomes was collected in *** were gathered from medical records,such as esophageal varices(EV),EV bleeding,ascites,spontaneous bacterial peritonitis(SBP),encephalopathy,laboratory findings and *** cut-off value for the PA was 5.4°,a value described in 2012 by Fernandes et al for 129 patients evaluated in this study and the cut-off points for the Brazilian population presented in percentiles(P),as described by Mattiello et *** mortality was assessed using the PA percentile through Kaplan-Meier curves and multivariate binary logistic regression *** Patients were divided into two groups according to the PA 5.4th(PA>5.4°,n=40;PA≤5.4°,n=89)PA percentile(

关键词： Liver cirrhosis Phase angle Prognosis Liver transplantation Electrical bioimpedance

Temporal and spatial differences in human activities performed in Urban Green Spaces of Vilnius(Lithuania)

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Geography and Sustainability 2024年第2期5卷 302-317页

作者： Luís Valença pinto Carla Sofia Santos Ferreira Paulo pereira Research Centre for Natural Resources Environment and Society(CERNAS) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Polytechnic Institute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green spaces(UGS)are relevant to city well-being,as recognized by the United Nations’Sustainable Development Goals(SDGs).However,few studies have studied the temporal use of *** work assessed the seasonal,weekly,and daily use of three urban green spaces(Vingis Park,Bernardino Garden,and Jomantas Park)in Vilnius(Lithuania).The study is based on an on-site observation-based survey,which recorded users’characteristics,activities,and weather conditions during summer and *** results showed that UGS’s seasonal,weekly,and daily use differed according to park and users’*** with a higher diversity of facilities had a high seasonal difference in the number of observed *** numbers were higher in the summer for activities with children,social activities,sports,and water activities than in the *** Park had the lowest variability in user *** variables were linked to changes in users’*** precipitation and lower temperature were associated with reducing the number of users and the diversity of registered *** of the stationary activities were observed during *** diversity of the observed activities was associated with the available facilities rather than the park *** distribution of stationary activities was spatially correlated with facility/equipment(benches,playgrounds,sports,and fitness equipment)and proximity to water *** results of this study are relevant for UGS design,planning,and management.

关键词： Urban parks Seasonal differences Temporal use Time of day Spatial distribution of UGS users

Challenges in Implementing DVI Best Practice Guidelines Due to the Brumadinho Disaster

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Forensic Medicine and Anatomy Research 2024年第1期12卷 1-12页

作者： Reinaldo Moreira Silva Bruno Diniz Sander Morais Carlos Danilo Ruas Silva Elza Cristina Lopes de Oliveira Fernando pereira Macedo Giovanni Vitral pinto Guadalupe Dell’Arret Coutinho Higgor Gonçalves Dornelas João Luiz Silva Moreira Laila Evangelista de Almeida Fernandes Marcia Lobão Iannini Patrícia Siqueira Valéria Rosalina Dias e Santos Sordaini Maria Caligiorne Instituto de Criminalística Polícia Civil de Minas Gerais Belo Horizonte Brazil

The broke of a tailings dam from Vale S.A. destroyed a gigantic area killing 270 persons in Brumadinho/Brazil. Organizing activities after a mass disaster is a complex process that requires the involvement of many people and resources in the laboratory. To DNA identification of the victims, a daunting work had to be made by DNA laboratory staff in a collaborative effort with many partners. Efforts to implement good practice guidelines in Disaster Victim Identification (DVI) have revealed several important aspects that need to change in the forensic DNA laboratory. This article highlights the challenges of implementing DVI best practice guidelines in resource-poor settings, but with professionals from different sectors engaged in the same goal of briefly identifying victims and helping families and society.

关键词： Disaster Victim Identification DNA Brumadinho

A Novel Approach to Measuring Spatiotemporal Changes in Social Vulnerability at the Local Level in Portugal

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International Journal of Disaster Risk Science 2022年第6期13卷 842-861页

作者： Pedro pinto Santos JoséLuís Zêzere Susana pereira Jorge Rocha Alexandre Oliveira Tavares Centre for Geographical Studies Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Centre for Social Studies Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

Social vulnerability,as one of the risk components,partially explains the magnitude of the impacts observed after a *** this study,a spatiotemporally comparable assessment of social vulnerability and its drivers was conducted in Portugal,at the civil parish level,for three census *** first challenging step consisted of the selection of meaningful and consistent variables over *** were normalized using the Adjusted Mazziotta-Pareto Index(AMPI)to obtain comparable adimensional-normalized values.A joint principal component analysis(PCA)was applied,resulting in a robust set of variables,interpretable from the point of view of their self-grouping around vulnerability drivers.A separate PCA for each census was also conducted,which proved to be useful in analyzing changes in the composition and type of drivers,although only the joint PCA allows the monitoring of spatiotemporal changes in social vulnerability scores and drivers from 1991 to 2011.A general improvement in social vulnerability was observed for *** two main drivers are the economic condition(PC1),and aging and depopulation(PC2).The remaining drivers highlighted are uprooting and internal mobility,and daily *** data proved their value in the territorial,social,and demographic characterization of the country,to support medium-and long-term disaster risk reduction measures.

关键词： AMPI normalization Portugal Social vulnerability Spatiotemporal changes

Urban green spaces accessibility in two European cities:Vilnius(Lithuania)and Coimbra(Portugal)

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Geography and Sustainability 2022年第1期3卷 74-84页

作者： Luís Valença pinto Carla Sofia Santos Ferreira Miguel Inácio Paulo pereira Research Centre for Natural Resources Environment and Society(CERNAS)Polytechnic Institute of CoimbraCoimbra Agrarian Technical SchoolCoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Department of Physical Geography and Bolin Centre for Climate Research Stockholm UniversitySE-10691 StockholmSweden Navarino Environmental Observatory 24001 MessiniaGreece

Urban green spaces(UGS)are essential for human well-being,contributing towards quality of life and promoting social interactions and *** to recreational UGS is key to human well-being in urban ***,there is a lack of works focused on recreational UGS accessibility in cities from different countries,using different types of *** this work,we studied the accessibility to recreational UGS in Vilnius(Lithuania)and Coimbra(Portugal)through four transport modes(foot,bike,bus and car)within 5-and 10-minute *** results showed important differences between *** had higher accessibility to recreational UGS than Coimbra in all transport *** both cities,the accessibility was highest by car and lowest by ***,the percentage of population covered by 5-and 10-minute distance UGS accessibility in Vilnius is higher than in Coimbra,despite the lower population density in Vilnius.A large number of recreational UGS,their geographic distribution,the dispersed population pattern,and the location of several urbanizations near recreational UGS increased the inhabitant’s accessibility to recreational UGS in *** differences in accessibility between cities were mainly attributed to the large number of recreational UGS and higher road network density,cycleways and footways density,and bus lines in Vilnius,compared to *** work identified the areas where recreational UGS accessibility is difficult in using different transport modes and need to be improved in study *** is essential to support urban planners and increase cities’*** findings of this work will be important for the management of the studied urban areas.

关键词： Recreational UGS Accessibility Transport modes Urban planning Well-being

Microstructure and mechanical behavior of similar butt-joints of ZK60 and ZK60-1.5RE magnesium alloys produced by linear friction stir welding

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Journal of Magnesium and Alloys 2021年第5期9卷 1802-1817页

作者： Erenilton pereira da Silva Ricardo Henrique Buzolin Ulises Alfaro Guillermo Requena Haroldo Calvalcanti pinto Institute of Engineering Science and Technology(IECT)Federal University of Vales do Jequitinhonha e Mucuri(UFVJM)JanaúbaMGBrazil Department of Materials Engineering São Carlos School of Engineering(EESC)University of São Paulo(USP)São Carlos-SP CEP 13563-120Brazil Christian Doppler Laboratory for Design of High-Performance Alloys by Thermomechanical Processing Kopernikusgasse 24Graz 8010Austria Institute of Materials Science Joining and Forming at Graz University of Technology opernikusgasse 24/IGraz 8010Austria German Aerospace Center(DLR)Institute of Materials Research Linder HöheCologne 51147Germany RWTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany.

The microstructure and mechanical properties of butt-joints produced by linear friction stir welding of similar plates of as-cast ZK60 and modified ZK60 with 1.5 wt.%RE(ZK60-1.5 RE)are *** thermomechanical affected zone is investigated in both advancing and retrieving sides,and the microstructure is compared to the base metal and the stirred *** backscattered diffraction measurements provide the average microstructural features of the transformed *** mechanical properties are assessed using hardness,tensile testing,and surface residual stress measured using X-ray *** torque and heat input are obtained for the ZK60-1.5 RE compared to the *** thermomechanical affected zone is notably larger for the ZK60 compared to the ZK60-1.5 RE.A gradient microstructure is formed in thermomechanical affected zones where deformed grains are progressively more recrystallised towards the stirred *** is no visible interface between the thermomechanical affected zone and the stirred zone.A fine and partially recrystallised microstructure is formed in the stirred *** retrieving side of the ZK60-1.5 RE has a slightly more refined microstructure compared to the other investigated *** measured with increment in the maximum intensity of the(0001)increases towards to stirred *** formed microstructure is correlated with the role of twinning,recovery,static,and dynamic recrystallisation that can occur during friction stir *** and grains with large misorientation spread are more pronounced in the thermomechanical affected zone and regions towards the base *** low angle grain boundaries are observed towards the stirred *** refined recrystallised grains decorating the grain in the thermomechanical affected zone,a mosaic-like of low and high angle grain boundaries are observed in the stirred *** joints have comparable surface residual *** friction stir welding improved th

关键词： ZK60 Mischmetal FSW Recrystallization Microstructure Thermomechanical

Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo JoséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da Silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini pinto Anete pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil Department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

Maize heat shock proteins-prospection,validation,categorization and in silico analysis of the different ZmHSP families

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Stress Biology 2023年第1期3卷 403-423页

作者： Rubens Diogo-Jr. Edila Vilela de Resende Von Pinho Renan Terassi pinto Lingrui Zhang Jorge Alberto Condori-Apfata Paula Andrade pereira Danielle Rezende Vilela Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN(47907)USA Department of Agriculture Federal University of Lavras(UFLA)LavrasMG(37200-900)Brazil Faculty of Philosophy and Sciences at Ribeirao Preto University of Sao Paulo(USP)Ribeirao PretoSP(14040-901)Brazil Faculty of Engineering and Agricultural Sciences Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas(UNTRM)ChachapoyasAM(01001)Peru

Among the plant molecular mechanisms capable of effectively mitigating the effects of adverse weather conditions,the heat shock proteins(HSPs),a group of chaperones with multiple functions,stand *** a time of full progress on the omic sciences,they look very promising in the genetic engineering field,especially in order to conceive superior genotypes,potentially tolerant to abiotic stresses(AbSts).Recently,some works concerning certain families of maize HSPs(ZmHSPs)were ***,there was still a lack of a study that,with a high degree of criteria,would fully conglomerate *** distinct but complementary strategies,we have prospected as many ZmHSPs candidates as possible,gathering more than a thousand *** detailed data mining,we accounted for 182 validated ones,belonging to seven families,which were subcategorized into classes with potential for functional *** them,we identified dozens of motifs with some degree of similarity with proteins from different kingdoms,which may help explain some of their still poorly understood means of *** in silico and in vitro approaches,we compared their expression levels after controlled exposure to several AbSts’sources,applied at diverse tissues,on varied phenological *** on gene ontology concepts,we still analyzed them from different perspectives of term *** have also searched,in model plants and close species,for potentially orthologous *** all these new insights,which culminated in a plentiful supplementary material,rich in tables,we aim to constitute a fertile consultation source for those maize researchers attracted by these interesting stress proteins.

关键词： Biotechnology Genomics Corn Stress Drought Compendium