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Microenvironment & Microecology Research 2023年第2期5卷 13-23页

作者： lester raymundo dominguez huarcaya María Fernanda dominguez Ríos Faculty of Pharmacy and Biochemistry National University of San MarcosLima 03Peru Pontifical Catholic University of Peru Lima 03Peru

The highest rates of morbidity and impairment related to gastrointestinal difficulties are associated with depression,which is associated with the highest rates of all mental *** has been demonstrated that the composition of an individual's gut microbiome plays a significant part in determining that person's risk of developing *** to the hypothesis known as the gut-brain axis,there may be a connection between the intestinal microbial system and the *** recent years,it has been common practice to treat disorders by concentrating on the bacteria that are found in the digestive tract(for instance,by making use of probiotics)and incorporating the gut-brain axis *** research revealed a remarkable association between the composition of the bacteria in the stomach and the incidence of *** in the structure of the microbiota system in the gut could possibly have direct and special impacts on the rise in the prevalence of *** study investigated the mechanisms underlying the two-way communication in the gut-brain axis,including the current techniques of relieving symptoms and antidepressant medicines that are related to gut *** increase in the amount of research into the medical potential of probiotics has led to a rapid expansion of the field of probiotics over the past few *** preclinical and clinical studies have established that the therapeutic effects of probiotics-mediated microbiota remodeling near the microbiota-gut-brain axis(MGBA)are *** studies were conducted near one ***,the potential effects of probiotics on numerous mental illnesses,which have been proved in vivo and in vitro research,have set the ground for the translation of preclinical models to humans,which is still in its infancy.

关键词： depression probiotics gut-brain axis gut microbiota

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The role of microglia in depression

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Microenvironment & Microecology Research 2023年第3期5卷 10-15页

作者： lester raymundo dominguez huarcaya María Fernanda dominguez Ríos Faculty of Pharmacy and Biochemistry National University of San MarcosLima 01Peru Faculty of Psychology Pontifical Catholic University of Peru1801 Universitaria AvenueSan MiguelLima 32Peru.

According to studies,neuroinflammation is increasingly being linked to the development of major depressive disorder(MDD).In response to inflammatory stimuli,brain microglia,which are immune cells,can change into reactive *** of this,microglia play an essentiall role in the early stages of *** have shown that microglia are able to detect infected or damaged cells,which then activates a cytotoxic response that further exacerbates the harm to brain *** has been proven that microglia are quite good at recognizing infections and damaged ***,on the other hand,have been found to respond in a number of ways to injury and may even help regenerate damaged *** activation of microglia has been observed in persons with *** in neuroplasticity have been linked to depression,and recent studies show that this may be related to changes in microglia shape and function brought on by either excessive inflammatory activity or the natural aging *** the phenotype of microglia by regulation of inflammatory pathways may be necessary for harnessing neuroinflammation in *** research has linked several microglial phenotypes to individual metabolic pathways,showing that energy metabolism plays a pivotal role in coordinating microglial *** this study,we investigate whether or not traditional pro-inflammatory,anti-inflammatory,and metabolic pathways in microglia can be used as novel therapeutic routes for regulating neuroinflammation in brain *** focus of this essay is on MDD,although we will also discuss related mental health issues.

关键词： anti-inflammatory pathway major depressive disorder metabolic pathway microglia microglial pathways as therapeutic targets neuroinflammation pro-inflammatory pathway

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