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Engineering 2018年第2期4卷 30-35页

作者： Zackery B. Morris Stephen M. Malone Abigail R. cohen Marc j. Weissburg Bert Bras George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology Atlanta GA 30332-0405 USA School of Biological Sciences Georgia Institute of Technology Atlanta GA 30332 USA

Low-impact development （LID） technologies have a great potential to reduce water usage and stormwa- ter runoff and are therefore seen as sustainable improvements that can be made to traditional water infrastructure, These technologies include bioretention areas, rainwater capturing, and xeriscaping, all of which can be used in residential zones, Within the City of Atlanta, residential water usage accounts for 53% of the total water consumption; therefore, residential zones offer significant impact potential for the implementation of LID, This study analyzes the use of LID strategies within the different residen- tial zones of the City of Atlanta from an ecological perspective by drawing analogies to natural ecosys- tems, The analysis shows that these technologies, especially with the addition of a graywater system, work to improve the conventional residential water network based upon these ecological metrics, The higher metric values suggest greater parity with healthy, natural ecosystems.

关键词： Low-impact development Ecological network analysis Residential water consumption

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双波段内置式天线的设计

电子设计技术 2002年第3期 58-58页

作者： leslie j READNG GALTRONICS公司

如果您对内置式天线的物理结构有透彻的了解,而所预期的性能亦与一些基本权限值一致,那么大多数蜂窝电话机都是可以装上内置式天线的。

关键词：天线设计师蜂窝电话双波段振子检流计内置式

Neutrophilic Panniculitis Associated With Myelodysplastic Syndrome/Myeloproliferative Neoplasm:A Case Report and Literature Review

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International journal of Dermatology and Venereology 2023年第3期6卷 168-171页

作者： Alexa j.cohen Laura K.Gleason Safiyyah A.Bhatti Neda Nikbakht Department of Dermatology and Cutaneous Biology Thomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Hematology&Oncology Thomas Jefferson UniversityPhiladelphiaPA 19107USA

Introduction:Neutrophilic panniculitis(NP)is a rare subtype of neutrophilic dermatosis,a group of neutrophilrich inflammatory skin disorders that can present in association with myeloid *** is defined by the presence of a neutrophilic infiltrate in the fat lobules of the subcutis in the absence of either infection or *** herein describe a 65-year-old woman with a recent diagnosis of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome(MDS/MPN)who abruptly developed painful,pruritic nodules consistent with *** presentation:A 65-year-old woman with MDS/MPN presented for evaluation of painful and pruritic nodules on her upper and lower extremities.A biopsy revealed a lobular neutrophilic infiltrate in the subcutis without evidence of microorganisms or *** patient was diagnosed with NP and treated with oral *** 1 month of treatment,she reported complete resolution of the ***:Similar to other neutrophilic dermatoses,NP may arise in association with hematologic malignancies of myeloid origin,such as MDS/MPN.A literature review revealed that most cases of NP associated with MDS occur after the onset of MDS and respond to systemic corticosteroids,not *** should be ruled out before initiating treatment with systemic ***:Although the mechanism is still unknown,it is important for clinicians to be aware that NP is associated with MDS;thus,hematological malignancies should be investigated on diagnosis of *** diagnosed,NP is easily treated and has an excellent response to systemic corticosteroids.

关键词： neutrophilic panniculitis myelodysplastic syndrome neutrophilic dermatoses

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Risk Factors for Failure of OPAT （Outpatient Parenteral Antimicrobial Therapy） in Veterans with Staphylococcus aureus Bacteremia

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journal of Pharmacy and Pharmacology 2016年第6期4卷 241-247页

作者： john j. Veillette leslie Bittner Marion j. Skalweit Usha Stiefel Christopher j. Burant Amy A.Hirsch Sharanie Sims Pharmacy Service Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCDVAMC) Cleveland OH USA Medicine Service LSCDV.4MC Cleveland OH USA Case Western Reserve University School of Medicine Cleveland OH USA Cleveland Geriatric Research Education and Clinical Center (GRECC) LSCDVAMC Cleveland OH USA Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA

To identify risk factors for failure of OPAT （outpatient parenteral antimicrobial therapy） among veterans with SAB （Staphylococcus aureus bacteremia）, a retrospective review was conducted of all patients receiving OPAT for SAB between 01/2011-09/2013 at a large, tertiary-care VA （Veterans＇ Affairs） medical center. Treatment failure was defined as incomplete therapy, therapy extension, infection relapse, or hospital admission or surgical intervention within 60 days of therapy completion. Of 118 SAB patients treated with OPAT, 101 met inclusion criteria. Treatment failure occurred in 36 （35.6%） patients. In multivariate analysis, heart failure （OR 3.67; CI 1.13-12.0）, previous OPAT （OR 14.1; CI 2.02-97.8）, immunosuppression （OR 10.5; CI 1.74-63.3）, and treatment with daptomycin （OR 9.56; CI 1.89-48.4） were independently associated with failure. A trend toward lower failure rates was seen in the community living center, a VA long-term care facility possessing its own infectious diseases consultation service. In veterans with SAB, specific health factors were associated with higher rates of OPAT failure. Given the morbidity and cost of SAB treatment failures, similar analyses may benefit other large OPAT programs to optimize the selection of patients and settings in which successful treatment will most likely occur.

关键词： Risk factors failure OPAT Staphylococcus aureus bacteremia.

Enhanced immuno-detection of shed extracellular domain of HER-2/neu

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Health 2009年第4期1卷 325-329页

作者： Sinang Chourb Brian C. Mackness leslie R. Farris Melisenda j. McDonald 不详

HER-2/neu oncogene is over-expressed and amplified in patients associated with metastatic breast cancer. An increased level (>15 ng/mL) in the shed extracellular domain (sECD-HER 2/neu) is indicative of the potential presence and as-sociated progression of this disease. A fluo-rescent ELISA incorporating the newly devel-oped ALYGNSA antibody-orientation system revealed a 10-fold increase in sensitivity (≤0.63 ng/mL) of sECD-HER 2/neu when compared to a control standard ELISA kit (≤7.5 ng/mL). This enhanced mode of detection has the potential to not only address breast and other cancers per se but also permit an in depth evaluation of “shed extracellular domains”, in general, and the role of these “proteolytic derived factors” in physiological signalling at normal levels.

关键词： HER-2/neu Shed Extracellular Domain C-erbB2 Breast Cancer Marker ELISA Fluorescent immunoassay ALYGNSA

Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke

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Stroke & Vascular Neurology 2021年第2期6卷 238-243页

作者： Simiao Wu Grant Mair Geoff cohen Zoe Morris Anders von Heijne Nick Bradey Lesley Cala Andre Peeters Andrew j Farrall Alessandro Adami Gillian Potter Ming Liu Richard I Lindley Peter A G Sandercock joanna M Wardlaw the IST-3 Collaborative Group Department of Neurology West China HospitalSichuan UniversityChengduSichuanChina Centre for Clinical Brain Sciences The University of EdinburghEdinburghUK Department of Clinical Sciences Danderyd HospitalStockholmSweden Neuroradiology James Cook University HospitalSouth Tees Hospital NHS TrustMiddlesbroughUK Division of Pathology and Laboratory Medicine School of MedicineThe University of Western AustraliaPerthWestern AustraliaAustralia Department of Neurology Cliniques universitaires Saint-LucBruxellesBelgium Stroke Center IRCCS Sacro Cuore Don CalabriaVeronaItaly Department of Neuroradiology Manchester Centre for Clinical NeurosciencesSalford Royal NHS Foundation TrustSalfordUK Westmead Applied Research Centre Westmead Clinical SchoolThe University of SydneySydneyNew South WalesAustralia The George Institute for Global Health NewtownNew South WalesAustralia UK Dementia Research Institute Centre at the University of Edinburgh EdinburghUnited Kingdom 不详

Background Alteplase improves functional outcomes of patients with acute ischaemic stroke,but its effects on symptomatic infarct swelling,an adverse complication of stroke and the influence of CT hyperdense artery sign(HAS)are *** substudy of the Third International Stroke Trial aimed to investigate the association between HAS and symptomatic infarct swelling and effect of intravenous alteplase on this *** We included stroke patients whose prerandomisation scan was non-contrast ***,masked to clinical information,assessed baseline(prerandomisation)and follow-up(24-48 hours postrandomisation)CT scans for HAS,defined as an intracranial artery appearing denser than contralateral *** infarct swelling was defined as clinically significant neurological deterioration≤7 days after stroke with radiological evidence of midline shift,effacement of basal cisterns or uncal *** Among 2961 patients,HAS presence at baseline was associated with higher risk of symptomatic infarct swelling(OR 2.21;95% CI 1.42 to 3.44).Alteplase increased the risk of swelling(OR 1.69;95% CI 1.11 to 2.57),with no difference between patients with and those without baseline HAS(p=0.49).In patients with baseline HAS,alteplase reduced the proportion with HAS at follow-up(OR 0.67;95% CI 0.50 to 0.91),where HAS disappearance was associated with reduced risk of swelling(OR 0.25,95% CI 0.14 to 0.47).Conclusion Although alteplase was associated with increased risk of symptomatic infarct swelling in patients with or without baseline HAS,it was also associated with accelerated clearance of HAS,which in return reduced swelling,providing further mechanistic insights to underpin the benefits of alteplase.

关键词： infarct swelling effect

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网室栽培香蕉耗水特征及合理灌溉水量确定

灌溉排水学报 2008年第5期27卷 37-40页

作者：刘海军黄冠华 j Tanny S cohen 北京师范大学水科学研究院水沙科学教育部重点实验室北京100875 中国农业大学水利与土木工程学院北京100083 Institute of Soil Water and Environmental SciencesAgricultural Research Organization The Volcani Center Bet Dagan 50250 Israel

主要研究网室和不同灌溉水量下香蕉的耗水特征，确定香蕉的作物系数。处理包括大田充分灌溉处理（100％），网室充分灌溉处理（100％）和亏水处理（5S％），香蕉的耗水量（ET）用热消散茎液流法测定。试验结果显示，在3种处理间香蕉叶... 详细信息

主要研究网室和不同灌溉水量下香蕉的耗水特征，确定香蕉的作物系数。处理包括大田充分灌溉处理（100％），网室充分灌溉处理（100％）和亏水处理（5S％），香蕉的耗水量（ET）用热消散茎液流法测定。试验结果显示，在3种处理间香蕉叶面积差异不显著（P〉0．05），网室内香蕉的耗水量比大田降低了44％～55％；网室内2种灌溉水量条件下香蕉蒸散量差异不显著（P〉0．05），说明55％处理灌溉水量已经能够满足香蕉的生长，这个结果也和网室内蒸散量降低值一致。建议当地进行网室内香蕉栽培时，灌溉水量选取大田的一半即可。

关键词：网室香蕉蒸散量茎液流法

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Expression of histone deacetylase (HDAC) family members in bortezomib-refractory multiple myeloma and modulation by panobinostat

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Cancer Drug Resistance 2021年第4期4卷 888-902页

作者： Tiewei Cheng Kendall Kiser leslie Grasse Lakesla Iles Geoffrey Bartholomeusz Felipe Samaniego Robert Z.Orlowski joya Chandra Department of Pediatrics Research University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Experimental Therapeutics University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Lymphoma and Myeloma University of Texas MD Anderson Cancer CenterHoustonTX 77030USA McGovern Medical School University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Epigenetics and Molecular Carcinogenesis University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Aim:Multiple myeloma(MM)is a hematological malignancy of antibody-producing mature B cells or plasma *** proteasome inhibitor,bortezomib,was the first-in-class compound to be FDA approved for MM and is frequently utilized in induction ***,bortezomib refractory disease is a major clinical concern,and the efficacy of the pan-histone deacetylase inhibitor(HDACi),panobinostat,in bortezomib refractory disease indicates that HDAC targeting is a viable ***,we utilized isogenic bortezomib resistant models to profile HDAC expression and define baseline and HDACi-induced expression patterns of individual HDAC family members in sensitive *** cells to better understanding the potential for targeting these ***:Gene expression of HDAC family members in two sets of isogenic bortezomib sensitive or resistant myeloma cell lines was *** cell lines were subsequently treated with HDAC inhibitors:panobinostat or vorinostat,and HDAC expression was ***/Cas9 knockdown and pharmacological inhibition of specific HDAC family members were ***:Interestingly,HDAC6 and HDAC7 were significantly upregulated and downregulated,respectively,in bortezomib-resistant *** was effective at inducing cell death in these lines and modulated HDAC expression in cell lines and patient *** of HDAC7 inhibited cell growth while pharmacologically inhibiting HDAC6 augmented cell death by ***:Our data revealed heterogeneous expression of individual HDACs in bortezomib sensitive *** isogenic cell lines and patient samples treated with *** our findings highlight distinct roles for HDAC6 and HDAC7 in regulating cell death in the context of bortezomib resistance.

关键词： Histone deacetylase bortezomib resistance selective HDAC inhibitors HDAC6 HDAC7

Site-Specific Conjugation of Cell Wall Polyrhamnose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine

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Infectious Microbes & Diseases 2021年第2期3卷 87-100页

作者： Nina j.Gao Satoshi Uchiyama Lucy Pill Samira Dahesh joshua Olson leslie Bautista Shilpa Maroju Aym Berges janet ZLiu Raymond HZurich Nina Mvan Sorge jeff Fairman Neeraj Kapoor Victor Nizet Division of Host-Microbe Systems and Therapeutics Department of PediatricsUC San DiegoLa JollaCaliforniaUSA Vaxcyte Inc.Foster CityCaliforniaUSA Department of Medical Microbiology and Infection Prevention Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Skaggs School of Pharmacy and Pharmaceutical Sciences UC San DiegoLa JollaCaliforniaUSA

Development of an effective vaccine against the leading human bacterial pathogen group A Streptococcus(GAS)is a public health *** species defining group A cell wall carbohydrate(GAC,Lancefield antigen)can be engineered to remove its immunodominant N-acetylglucosamine(GlcNAc)side chain,implicated in provoking autoimmune cross-reactivity in rheumatic heart disease,leaving its polyrhamnose core(GACPR).Here we generate a novel protein conjugate of the GACPR and test the utility of this conjugate antigen in active *** of conjugation to a standard carrier protein,we selected SpyAD,a highly conserved GAS surface protein containing both B-cell and T-cell epitopes relevant to the bacterium that itself shows promise as a vaccine *** was synthesized using the XpressTM cell-free protein expression system,incorporating a non-natural amino acid to which GACpr was conjugated by site-specific click chemistry to yield high molecular mass SpyAD-GACPR conjugates and avoid disruption of important T-cell and B-cell immunological *** conjugated SpyAD-GACPR elicited antibodies that bound the surface of multiple GAS strains of diverse M types and promoted opsonophagocytic killing by human *** immunization of mice with a multivalent vaccine consisting of SpyAD-GACPR,together with candidate vaccine antigens streptolysin O and C5a peptidase,protected against GAS challenge in a systemic infection model and localized skin infection model,without evidence of cross reactivity to human heart or brain tissue *** general approach may allow GAC to be safely and effectively included in future GAS subunit vaccine formulations with the goal of broad protection without autoreactivity.

关键词： group A Streptococcus Streptococcus pyogenes group A carbohydrate Lancefield antigen conjugate vaccine XpressCFTM non-natural amino acids SpyAD Introduction

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小井眼钻井系统使钻速翻一翻

新疆石油科技信息 2000年第3期21卷 28-30页

作者： cohen.,j

介绍了一种可靠的高性能小井眼马达，用它的获得比常规马达快一倍的钻速。这种小井眼钻井系统由一个双倍长的高性能正容积马达与一个嵌有热稳定金刚石切削齿的混合ＰＤＣ钻头组成，分布２个不同实验场所的测试结果。

关键词：钻井速度 PDC钻头小井眼钻井钻井系统