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The Global Stratotype Section and Point （GSSP） for the base of the Katian Stage of the Upper Ordovician Series at Black Knob Ridge, Southeastern Oklahoma, USA

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Episodes 2007年第4期30卷 258-270页

作者： Daniel Goldman Stephen A. leslie jaak Nōlvak Seth Young Stig M. Bergstroem Warren D. Huff Department of Geology University of Dayton 300 College Park Dayton Ohio 45469 USA Deparment of Geology and Environmental Science James Madison University MSC 6903 Harrisonburg VA 22807 USA Institute of Geology at Tallinn University of Technology Ehitajate tee 5 19086 Tallinn Estonia School of Earth Sciences Division of Geological Sciences The Ohio State University 155 S. Oval Mall Columbus Ohio 43210 USA Department of Geology University of Cincinnati Cincinnati Ohio 45221 USA.

The Global Boundary Stratotype Section and Point （GSSP） for the Katian Stage of the Upper Ordovician Series is defined as the 4.0 m-level above the base of the Bigfork Chert in the Black Knob Ridge section, southeastern Oklahoma. This point in this section is coincident with the first appearance of the graptolite Diplacanthograptus caudatus, which has proved to be a reliable datum for precise worldwide correlation. The FAD ofD. caudatus occurs very near the first occurrences of the graptolites D. lanceolatus, *** americanus, Orthograptus pageanus, O. quadrimucronatus, Dicranograptus hians, and Neurograptus margaritatus. This rapid succession of fossil species appearance events provides a secure basis for identification of the base of the Katian Stage of the Upper Ordovician Series and for its global chronostratigraphic correlation.

关键词：层形断面奥陶纪俄克拉荷马州美国地质特点

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不同程度慢性牙周炎患者病情的二年自然进展

中华口腔医学杂志 2004年第3期39卷 193-196页

作者：欧阳翔英曹采方 Henry Liu 胡文杰 j leslie Winston 北京大学口腔医学院牙周科 100081 Procter and Gamble Company

目的　观察不同程度慢性牙周炎的自然进展规律。方法　纵向观察 16 9例轻、中、重度慢性牙周炎患者在 2年中的疾病自然进展 ,检查除第三磨牙外的全口牙 ,每颗牙 6个位点 ,以探诊深度、附着丧失为指标 ,两次检查之间附着丧失加重≥ 3mm... 详细信息

目的　观察不同程度慢性牙周炎的自然进展规律。方法　纵向观察 16 9例轻、中、重度慢性牙周炎患者在 2年中的疾病自然进展 ,检查除第三磨牙外的全口牙 ,每颗牙 6个位点 ,以探诊深度、附着丧失为指标 ,两次检查之间附着丧失加重≥ 3mm的牙位定为活动性进展。结果　活动性发生率依基线时疾病的轻、中、重程度而逐渐增高 ,按位点活动性的发生率分别为 0 14 %、0 39%及0 73% ,按个体活动性的发生率分别为 15 5 6 %、2 9 89%及 4 3 2 4 % ,差异有统计学意义。结论　重度牙周炎患者是牙周破坏活动性进展的高危人群。

关键词：慢性牙周炎病情自然进展诊断治疗

Structural and biomechanical characterizations of acellular porcine mitral valve scaffolds:anterior leaflets,posterior leaflets,and chordae tendineae

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Engineered Regeneration 2022年第4期3卷 374-386页

作者： Bo Wang leslie N.Sierad jeremy j.Mercuri Agneta Simionescu Dan T.Simionescu Lakiesha N.Williams Ryan Vela Pietro Bajona Matthias Peltz Sharan Ramaswamy Yi Hong jun Liao Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010United States joint Department of Biomedical Engineering Medical College of Wisconsin and Marquette UniversityMilwaukeeWI 53226United States Department of Bioengineering Clemson UniversityClemsonSC 29634United States Department of Biomedical Engineering Florida International UniversityMiamiFL 33174United States Department of Biomedical Engineering University of FloridaGainesvilleFL 32611United States Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical CenterDallasTX 75390United States Allegheny Health Network-Drexel University College of Medicine PittsburghPA 15212United States

Mitral valve(MV)tissue engineering is still in its early stage,and one major challenge in MV tissue engineering is to identify appropriate scaffold *** the potential of acellular MV scaffolds being demonstrated recently,it is important to have a full understanding of the biomechanics of the native MV components and their acellular *** this study,we have successfully characterized the structural and mechanical properties of porcine MV components,including anterior leaflet(AL),posterior leaflet(PL),strut chordae,and basal chordae,before and after *** DNA assay showed more than 90%reduction in DNA content,and Griffonia simplicifolia(GS)lectin immunohistochemistry confirmed the complete lack of porcine𝛼-Gal antigen in the acellular MV *** the acellular AL and PL,the atrialis,spongiosa,and fibrosa trilayered structure,along with its ECM constitutes,i.e.,collagen fibers,elastin fibers,and portion of GAGs,were ***-theless,the ECM of both AL and PL experienced a certain degree of disruption,exhibiting a less dense,porous ECM *** overall anatomical morphology of the strut and basal chordae were also maintained af-ter decellularization,with longitudinal morphology experiencing minimum disruption,but the cross-sectional morphology exhibiting evenly-distributed porous *** the acellular AL and PL,the nonlinear anisotropic biaxial mechanical behavior was overall preserved;however,uniaxial tensile tests showed that the removal of cellular content and the disruption of structural ECM did result in small decreases in maximum tensile modulus,tissue extensibility,failure stress,and failure strain for both MV leaflets and chordae.

关键词： Mitral valve tissue engineering Heart valve biomechanics Valve leaflets Chordae tendineae Decellularization

Gastric food retention at endoscopy is associated with severity of liver cirrhosis

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World journal of Hepatology 2019年第11期11卷 725-734页

作者： David B Snell Shirley cohen-Mekelburg Russell Weg Gaurav Ghosh Adam P Buckholz Amit Mehta Xiaoyue Ma Paul j Christos Arun B jesudian Division of Gastroenterology and Hepatology New York UniversityNew YorkNY 10016United States Division of Gastroenterology and Hepatology University of MichiganAnn ArborMI 48109United States Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14642United States Department of Medicine NewYork-Presbyterian Hospital/Weill Cornell MedicineNew YorkNY 10065United States Division of Gastroenterology&Hepatology Weill Cornell MedicineNew YorkNY 10021United States Division of Biostatistics and Epidemiology Department of Healthcare Policy and ResearchWeill Cornell MedicineNew YorkNY 10065United States

BACKGROUND Gastrointestinal symptoms are prevalent in patients with *** patients have a known predilection to delayed gastric emptying compared to those without ***,the contributing factors have not been fully *** gastric food on esophagogastroduodenoscopy(EGD)has been used as a surrogate marker for delayed gastric emptying with reasonably high ***,we hypothesize that the frequency of retained gastric food contents at EGD will be higher in a cirrhotic population compared to a control population without liver ***,we hypothesize that increased frequency of gastric food contents will be associated with increased severity of *** To determine the relative frequency of delayed gastric emptying among cirrhotics as compared to non-cirrhotics and to identify associated *** performed a retrospective case-control study of cirrhotic subjects whounderwent EGD at an academic medical center between 2000 and 2015. Threehundred sixty-four patients with confirmed cirrhosis, who underwent a total of1044 EGDs for the indication of esophageal variceal screening or surveillance,were identified. During the same period, 519 control patients without liverdisease, who underwent a total of 881 EGDs for the indication of anemia, wereidentified. The presence of retained food on EGD was used as a surrogate fordelayed gastric emptying. The relative frequency of delayed gastric emptyingamong cirrhotics was compared to non-cirrhotics. Characteristics of patients withand without retained food on EGD were compared using univariable andmultivariable logistic regression analysis to identify associated ***, 40 (4.5%) patients had evidence of retained food on EGD. Cirrhotics weremore likely to have retained food on EGD than non-cirrhotics (9.1% vs 1.4%, P <0.001). Characteristics associated with retained food on univariable analysisincluded age less than 60 years (12.6% vs 5.2%, P =

关键词： Child-Pugh Cirrhosis Endoscopy Gastric emptying Motility

The Transradial Approach for Cardiac Catheterization and Percutaneous Coronary Intervention:A Review

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Cardiovascular Innovations and Applications 2016年第B5期1卷 301-310页

作者： Dhaval Pau Nileshkumar j.Patel Nish Patel Mauricio G.cohen Department of Medicine Staten Island University HospitalStaten IslandNYUSA Cardiovascular Division and Elaine and Sydney Sussman Cardiac Catheterization Laboratory University of Miami Miller School of MedicineMiamiFLUSA

Cardiac catheterization and percutaneous coronary intervention play an important role in the management of coronary artery *** the transfemoral approach has been the traditionally dominant method,there has been an increased utilization of the transradial *** observational studies and randomized clinical trials have shown fewer bleeding complications,reduced morbidity and mortality,improved quality of life,and better economic outcomes when the transradial approach is utilized when compared to the transfemoral *** its many benefits,utilization of this approach in certain countries including the United States has been less than optimal due to a lower adoption rates mostly driven by lack of training opportunities and decreased awareness of clinical benefits of the transradial *** this review,the history,observational trends,efficacy,and technical aspects of transradial cardiac catheterization and percutaneous coronary intervention are discussed.

关键词： transradial vascular access cardiac catheterization percutaneous coronary intervention

The COVID-19 Pandemic and Higher Education: Common Interdisciplinary Issues and Lessons Learned

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Open journal of Nursing 2020年第12期10卷 1195-1208页

作者： Paula R. Klemm Donna Ruelens-Trinkaus leslie M. Allshouse Patricia j. Barnard School of Nursing University of Delaware Newark USA Department of Medical & Molecular Sciences University of Delaware Newark USA

Background: Coronavirus-19 (COVID-19) dramatically impacted institutions of higher education. The effect was acute in the practice disciplines such as medicine, medical laboratory science, and nursing. The purpose is to describe how an interdisciplinary team, led by nursing faculty, adapted to the changes driven by COVID-19 and the lessons that were learned for nursing and other disciplines in higher education. Method: The interdisciplinary group created a comprehensive list which captured the impact of COVID-19 on their academic disciplines. Similarities and differences between the disciplines regarding faculty experiences, teaching, and responding to student concerns were discovered. Results: Collective review resulted in the identification of four inclusive thematic categories and several sub-categories. These were: academic considerations (didactic, lab, clinical), perceptions (faculty, student), ethical considerations, and social determinants affecting the learning environment. Lessons Learned: This project utilized an innovative interdisciplinary approach to identify common COVID-19 effects on higher education. Conclusions: Nursing and other health-related disciplines should pursue interdisciplinary collaboration to address common academic issues that arise during the COVID.

关键词： COVID-19 Higher Education Academic Issues Interdisciplinary Collaboration Lessons Learned

Oncomorphic <i>TP</i>53 Mutations in Gynecologic Cancers Lose the Normal Protein:Protein Interactions with the microRNA Microprocessing Complex

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journal of Cancer Therapy 2014年第6期5卷 506-516页

作者： Pavla Brachova Samuel R. Mueting Eric j. Devor Kimberly K. leslie Department of Obstetrics and Gynecology University of Iowa Iowa City USA Department of Pediatrics University of Iowa Iowa City USA

Mutations in the tumor suppressor TP53 occur in almost all advanced ovarian cancers and in many advanced serous endometrial cancers. Mutations in TP53 can alter the function of the p53 protein, and some mutations result in a mutated protein with oncogenic activity. Previously referred to as gain of function (GOF) p53 proteins, we now term these “oncomorphic” mutations to better describe their function as oncogenes. We reviewed the data from The Cancer Genome Atlas (TCGA) and demonstrate that of the patients diagnosed with endometrial cancer that harbor TP53 mutations, approximately 30% of these mutations are oncomorphic. In ovarian cancer, approximately 20% are oncomorphic. The wild type (WT) p53 protein transactivates genes and micro-RNAs (miRNAs) necessary in the response to cellular stress, which turn off growth and induce apoptosis. In addition to direct transcriptional activation, WT p53 also acts through protein:protein interactions with Drosha and the miRNA processing complex to mediate rapid, enhanced processing of a subset of anti-growth miRNAs. We validated the interaction of WT p53 with the Drosha complex in the cell line UCI-107. We observed that miRNAs that inhibit the expression of oncogenes were induced. Specifically, some miRNAs were induced very rapidly over minutes, consistent with enhanced processing, while others required hours, consistent with transcriptional activation. In contrast, the most common oncomorphic TP53 mutations failed to interact with the Drosha complex and lost the ability to rapidly induce the miRNAs which inhibit oncogene expression. These studies highlight one mechanism underlying the oncomorphic properties of specific TP53 mutations: loss of the enhanced processing of anti-proliferative miRNAs.

关键词： TP53 p53 miRNA Drosha Oncomorphic TP53 Gain of Function

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利用单一的和集合的方法预告区域预报技巧

气象科技 1991年第6期19卷 35-42页

作者： LANCE M.leslie GREG j.HOLLAND 史凤苓澳大利亚墨尔本气象研究中心局

本文利用平均海平面气压的模式预报误差(MFE)的3个预告因子研究了预告澳大利亚有限区域模式36小时预报技巧的可能。两个预告因子使用单一预报:其中1个以对于初始分析和预报的MFE的统计回归为基础;另1个因子利用了预报的持续性程度。第3... 详细信息

本文利用平均海平面气压的模式预报误差(MFE)的3个预告因子研究了预告澳大利亚有限区域模式36小时预报技巧的可能。两个预告因子使用单一预报:其中1个以对于初始分析和预报的MFE的统计回归为基础;另1个因子利用了预报的持续性程度。第3个因子应用了与其它NWP中心的预报集合偏差。根据5个月的逐日36小时预报,发现了上述预告因子与MFE的相关系数分别是0.58、0.18和0.40。用最佳线性方法把上述3个因子组合后与MFE的相关系数增加到0.71。用两个月的独立资料集进一步对组合因子进行试验,得出的相关系数是0.67。因此,把这种方法应用于独立的和非独立的资料中,可以解释MFE方差的近50％。这证明了这种方法对于在总体上鉴别模式预报好坏有业务应用价值。澳大利亚东南部的实例研究,进一步证明了这些预告因子在整个预报区域中可以相当好地鉴别预报技巧。

关键词：区域预报有限区域模式模式预报预报区资料集海平面气压可预报性预报误差相关系数数值天气预报

Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues

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Bone Research 2020年第3期8卷 286-299页

作者： jiajia Xu Dongqing Li Ching-Yun Hsu Ye Tian Leititia Zhang Yiyun Wang Robert j.Tower leslie Chang Carolyn A.Meyers Yongxing Gao Kristen Broderick Carol Morris jody E.Hooper Sridhar Nimmagadda Bruno Peault Aaron W.james Departments of Pathology Johns Hopkins UniversityBaltimore 21205 MDUSA Department of Microbiology Wuhan University School of Basic Medical of ScienceWuhanHubeiP.R.China Department of Oral and Maxillofacial Surgery School of StomatologyChina Medical UniversityShenyangLiaoningP.R.China Departments of Orthopaedics Johns Hopkins UniversityBaltimore 21205 MDUSA Departments of Plastic Surgery Johns Hopkins UniversityBaltimore 21205 MDUSA Departments of Autopsy Service Johns Hopkins UniversityBaltimoreMD 21205USA Departments of Radiology and Radiological Science bonBaltimore 21205 MDUSA UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center Los AngelesCA 90095USA Center for Cardiovascular Science and MRC Center for Regenerative Medicine University of EdinburghEdinburghUK

Human osteogenic progenitors are not precisely defined,being primarily studied as heterogeneous multipotent cell populations and termed mesenchymal stem cells(MSCs).Notably,select human pericytes can develop into bone-forming ***,we sought to define the differentiation potential of CD146 f human pericytes from skeletal and soft tissue sources,with the underlying goal of defining cell surface markers that typify an osteoblastogenic ***146+CD31~CD45_pericytes were derived by fluorescence-activated cell sorting from human periosteum,adipose,or dermal *** CD146+CD31—CD45 cells retained canonical features of pericytes/*** pericytes demonstrated a striking tendency to undergo osteoblastogenesis in vitro and skeletogenesis in vivo,while soft tissue pericytes did not *** analysis revealed higher CXCR4 signaling among periosteal pericytes in comparison to their soft tissue counterparts,and CXCR4 chemical inhibition abrogated ectopic ossification by periosteal ***,enrichment of CXCR4+pericytes or stromal cells identified an osteoblastic/non-adipocytic precursor *** sum,human skeletal and soft tissue pericytes differ in their basal abilities to form *** exists in soft tissue pericytes,however,and CXCR4+pericytes represent an osteoblastogenic,non-adipocytic cell ***,enrichment for CXCR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering.

关键词： CD146 CXCR4 pericyte