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Factors associated with change in frailty scores and long-term outcomes in older adults with coronary artery disease

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journal of Geriatric Cardiology 2021年第3期18卷 196-203页

作者： S.Michael Gharacholou joshua P.Slusser Ryan j.Lennon Carolyn R.Flock leslie T.Cooper Patricia A.Pellikka jorge Brenes Salazar Mandeep Singh Department of Cardiovascular Medicine Mayo ClinicJacksonvilleFLUSA Department of Cardiology Mayo Health SystemLa CrosseWIUSA Department of Biostatistics Mayo ClinicRochesterMNUSA Department of Cardiovascular Medicine Mayo ClinicRochesterMNUSA

OBjECTIVE Older adults with coronary artery disease(CAD)are at risk for ***,little is known regarding transition in frailty measures over time or its impact on *** sought to determine the association of temporal change in frailty with long-term outcome in older adults with *** We re-assessed for phenotypic frailty using the Fried index(0=not frail;1−2=pre-frail;≥3 frail)in a cohort of CAD patients≥65 years old at 2 time points 5 years *** associated with frailty worsening were assessed with scatterplots and outcomes estimated using the Kaplan-Meier *** models were used to assess the risk of worsening frailty on *** There were 45 subjects that completed both baseline and 5-year Fried frailty *** age was 74.6±5.9 and 30(67%)were *** incidence increased over time:baseline(3%frail,37%pre-frail);5 years(10%frail,40%pre-frail).Baseline factors were not predictors of worsening frailty score,while both slower walk time(r=0.46;P=0.004)and diminishing grip strength(r=−0.39;P=0.01)were associated with worsening frailty *** follow-up(median 5.2 years),long-term major adverse cardiac event(MACE)free survival(P=0.12)or hospitalization(P=0.98)was not different for those with worsening frailty score(referent:improved/unchanged frailty).Frailty worsening had a trend towards increased risk of MACE(HR=1.86;95%CI:0.65−5.27,P=0.25).CONCLUSIONS Frailty transitions,specifically,declines in walk time and grip strength,were strongly associated with worsening frailty score in a cohort of older adults with CAD than were baseline indices,though frailty change status was not independently associated with MACE outcomes.

关键词： coronary unchanged score

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Computer-aided sperm analysis： a useful tool to evaluate patient＇s response to varicocelectomy

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Asian journal of Andrology 2017年第4期19卷 449-452页

作者： julia I Ariagno Gabriela R Mendeluk Maria j Furlan M Sardi P Chenlo Susana M Curi Mercedes N Pugliese Herberto E Repetto Mariano cohen Clinical Biochemistry Department Male Fertility Laboratory Faculty of Pharmacy and Biochemetry University of Buenos Aires Argentina Urology Department "Jose de San Martin" Clinical Hospital University of Buenos Aires Buenos Aires Argentina (CP1120)

Preoperative and postoperative sperm parameter values from infertile men with varicocele were analyzed by computer-aided sperm analysis （CASA） to assess if sperm characteristics improved after varicocelectomy. Semen samples of men with proven fertility （n = 38） and men with varicocele-related infertility （n = 61） were also analyzed. Conventional semen analysis was performed according to WHO （2010） criteria and a CASA system was employed to assess kinetic parameters and sperm concentration. Seminal parameters values in the fertile group were very far above from those of the patients, either before or after surgery. No significant improvement in the percentage normal sperm morphology （P = 0. 10）, sperm concentration （P = 0.52）, total sperm count （P = 0.76）, subjective motility （%）（P = 0.97） nor kinematics （P = 0.30） was observed after varicocelectomy when all groups were compared. Neither was significant improvement found in percentage normal sperm morphology （P = 0.91）, sperm concentration （P =0. 10）, total sperm count （P = 0.89） or percentage motility （P = 0.77） after varicocelectomy in paired comparisons of preoperative and postoperative data. Analysis of paired samples revealed that the total sperm count （P = 0.01） and most sperm kinetic parameters： curvilinear velocity （P = 0.002）, straight-line velocity （P = 0.0004）, average path velocity （P = 0.0005）, linearity （P = 0.02）, and wobble （P = 0.006） improved after surgery. CASA offers the potential for accurate quantitative assessment of each patient＇s response to varicocelectomy.

关键词： computer-assisted semen analysis male infertility semen analysis varicocele varicocelectomy

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Galaxy formation in the reionization epoch as hinted by WideField Camera 3 observations of the Hubble Ultra Deep Field

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Research in Astronomy and Astrophysics 2010年第9期10卷 867-904页

作者： Hao-jing Yan Rogier A. Windhorst Nimish E Hathi Seth H. cohen Russell E.Ryan Robert W. O＇Connell Patrick j. McCarthy Center for Cosmology and AstroParticle Physics The Ohio State University 191 West Woodruff Avenue Columbus OH 43210 USA School of Earth and Space Exploration Arizona State University Tempe AZ 85287 USA Department of Physics ＆ Astronomy University of California Riverside CA 92521 USA Department of Physics University of California One Shields Avenue Davis CA 95616 USA Astronomy Department University of Virginia P.O. Box 3818 Charlottesville VA 22903 USA Observatories of the Carnegie Institution of Washington 813 Santa Barbara Street Pasadena CA 91101 USA

We present a large sample of candidate galaxies at z ≈ 7 - 10, selected in the Hubble Ultra Deep Field using the new observations of the Wide Field Camera 3 that was recently installed on the Hubble Space Telescope. Our sample is composed of 20 z850-dropouts （four new discoveries）, 15 Y105-dropouts （nine new discoveries） and 20 j125-dropouts （all new discoveries）. The surface densities of the Z850-dropouts are close to what was predicted by earlier studies, however, those of the Y105- and j125-dropouts are quite unexpected. While no Y105- or j125-dropouts have been found at AB ≤ 28.0 mag, their surface densities seem to increase sharply at fainter levels. While some of these candidates seem to be close to foreground galaxies and thus could possibly be gravitationally lensed, the overall surface densities after excluding such cases are still much higher than what would be expected if the luminosity function does not evolve from z ～ 7 to 10. Motivated by such steep increases, we tentatively propose a set of Schechter function parameters to describe the luminosity functions at z ≈8 and 10. As compared to their counterpart at z ≈ 7, here L^＊ decreases by a factor of ～ 6.5 and Ф^＊ increases by a factor of 17-90. Although such parameters are not yet demanded by the existing observations, they are allowed and seem to agree with the data better than other alternatives. If these luminosity functions are still valid beyond our current detection limit, this would imply a sudden emergence of a large number of low-luminosity galaxies when looking back in time to z ≈ 10, which, while seemingly exotic, would naturally fit in the picture of the cosmic hydrogen reionization. These early galaxies could easily account for the ionizing photon budget required by the reionization, and they would imply that the global star formation rate density might start from a very high value at z ≈ 10, rapidly reach the minimum at z≈ 7, and start to rise again towards z ≈ 6. In this scenario, the maj

关键词： cosmology observations -- cosmology early universe -- galaxies evolution -- galaxies luminosity function, mass function -- infrared galaxies

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THE DECLINE AND FALL OF CONSUMER SOCIETY? IMPLICATIONS FOR THEORIES OF MODERNIZATION

THE DECLINE AND FALL OF CONSUMER SOCIETY? IMPLICATIONS FOR T...

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作者： MAURIE j.cohen Program in Science Technologyand SocietyNew Jersey Institute of TechnologyUniversity Heights

Four decades have passed since modernization theorists first gave serious consideration to a transition from consumerism to post-consumerism. The intervening years have given rise to committed efforts in the United States and other affluent countries to reinforce the preconditions of consumer society through the deregulation of key economic sectors, the liberalization of international trade, and the reassertion of military power abroad. Enthusiasm for renewing these interventions now seems to be waning amid protracted difficulties restoring customary increments of economic growth. The prevailing situation, combined with a reversal of once favorable trends with respect to demography, household income, political capacity, and resource availability, suggests that the pillars of consumerist lifestyles are coming under increasing strain and new routines are beginning to develop.

关键词： IMPLICATIONS FOR THEORIES OF MODERNIZATION THE DECLINE AND FALL OF CONSUMER SOCIETY

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Le Corbusier, 1887-1965

Le Corbusier, 1887-1965

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作者： jean-Louise cohen.

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败血性休克的治疗

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国外医学（流行病学．传染病学分册） 1992年第3期19卷 123-125页

作者： cohen j 胡林华

本文复习败血性休克的重要治疗进展,包括对大剂量类固醇的评价,以及针对内毒素核心糖脂及肿瘤坏死因子的治疗.

关键词：败血性休克

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人文社会与医学：UIC临床医学基要课程

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复旦教育论坛 2010年第2期8卷 88-92页

作者：曾勇 Dale Lorens Maureen Valaski leslie j.Sandlow 复旦大学上海医学院医学教育研究室中国 200032 伊利诺伊大学芝加哥校区医学院美国芝加哥60612

本文介绍了伊利诺伊大学芝加哥校区的整合式课程"临床医学基要"(Essentials of Clinical Medicine,ECM)的历史、课程目标、内容和教学安排、学生课业评价、课程管理与改进、课程的效果和主要特点等。该课程将医学人文社会知识技能与临... 详细信息

本文介绍了伊利诺伊大学芝加哥校区的整合式课程"临床医学基要"(Essentials of Clinical Medicine,ECM)的历史、课程目标、内容和教学安排、学生课业评价、课程管理与改进、课程的效果和主要特点等。该课程将医学人文社会知识技能与临床问诊、查体和临床决策紧密联系起来,运用讲座、小组学习、工作坊、医院见习与实习多种教学方法,注重学生从"做中学",注重自我教育与反思,注重团队合作与教学相长,教学效果良好。

关键词：伊利诺伊大学芝加哥校区临床医学基要人文社会科学临床医学

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Three-dimensional fuzzy graphene ultra-microelectrodes for subcellular electrical recordings

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Nano Research 2020年第5期13卷 1444-1452页

作者： Sahil K.Rastogi jacqueline Bliley Laura Matino Raghav Garg Francesca Santoro Adam W.Feinberg Tzahi cohen-Karni Department of Biomedical Engineering Carnegie Mellon UniversityPittsburghPA15213USA Center for Advanced Biomaterials for Healthcare Istituto Italiano di TecnologiaNaples80125Italy Department of Chemical Materials and Industrial Production EngineeringUniversity of Naples Federico IINaples80125Italy Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPA15213USA

Microelectrode arrays(MEAs)have enabled investigation of cellular networks at sub-millisecond temporal ***,current MEAs are limited by the large electrode footprint since reducing the electrode’s geometric area to sub-cellular dimensions leads to a significant increase in impedance thus affecting its recording *** report a breakthrough ultra-microelectrodes platform by leveraging the outstanding surface-to-volume ratio of nanowire-templated out-of-plane synthesized three-dimensional fuzzy graphene(NT-3DFG).The enormous surface area of NT-3DFG leads to 140-fold reduction in electrode impedance compared to bare Au microelectrodes,thus enabling scaling down the geometric size by 625-fold to ca.2µm×2µ*** out-of-plane morphology of NT-3DFG leads to a tight seal with the cell membrane thus enabling recording of electrical signals with high signal-to-noise ratio(SNR)of>*** work highlights the possibility to push the limits of the conventional MEA technology to enable electrophysiological investigation at sub-cellular level without the need of any surface *** presented approach would greatly impact our basic understanding of signal transduction within a single cell as well as complex cellular assemblies.

关键词： microelectrode array ultra-microelectrodes electrical recordings biocompatible hybrid-nanomaterial 3D graphene cardiomyocytes

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From the epididymis to the egg： participation of CRISP proteins in mammalian fertilization

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Asian journal of Andrology 2015年第5期17卷 711-715,I0005页

作者： Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora j cohen Patricia S Cuasnicu Instituto de Biologi y Medicina Experimental (IByME-CONICET) Buenos Aires C1428ADN Argentina

Mammalian fertilization is a complex process that involves different steps of interaction between the male and female gametes. In spite of its relevance, the molecular mechanisms underlying this process still remain to be elucidated. The present review describes the contribution of our laboratory to the understanding of mammalian fertilization using Cysteine-Rlch Secretory Proteins （CRISP） as model molecules. Substantial evidence obtained from in vitro assays and knockout models shows that epididymal CRISP1 associates with the sperm surface with two different affinities during maturation, and participates in the regulation of signaling pathways during capacitation as well as in both sperm-zona pellucida interaction and gamete fusion. These observations can be extended to humans as judged by our findings showing that the human homolog of the rodent protein （hCRISP1） is also involved in both stages of fertilization. Evidence supports that other members of the CRISP family secreted in the testis （CRISP2）, epididymis （CRISP3-4） or during ejaculation （CRISP3） are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. Together, our observations indicate that CRISP proteins accompany spermatozoa along their transit through both the male and female reproductive tracts. We believe these results not only contribute to a better mechanistic understanding of fertilization but also support CRISP proteins as excellent candidates for future research on infertility and contraception.

关键词： Cysteine-Rlch Secretory Proteins epididymal proteins fertilization sperm

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The association between weight stability and parenteral nutrition characteristics and survival in patients with colorectal cancer

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Gastroenterology Report 2019年第6期7卷 419-425,I0002页

作者： Wenli Liu Aiham Qdaisat Eric Lee jason Yeung Khanh Vu jun-Zhong Lin Todd Canada Shouhao Zhou Lorenzo cohen Eduardo Bruera Sai-Ching j.Yeung Department of Palliative Rehabilitation and Integrative MedicineThe University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Emergency Medicine The University of Texas MD Anderson Cancer CenterHoustonTXUSA McGovern Medical School HoustonTXUSA Biomedical Science Texas A&M UniversityCollege StationTXUSA Department of General Internal Medicine The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China Division of Pharmacy The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Public Health Sciences Pennsylvania State University School of MedicineHersheyPAUSA Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Objective:Knowledge about the impact of metabolic disturbances and parenteral nutrition(PN)characteristics on the survival of cancer patients receiving PN is *** aimed to assess the association between clinical and PN characteristics and survival in colorectal-cancer patients receiving PN ***:Our study included 572 consecutive colorectal-cancer patients who had received PN support between 2008 and *** characteristics,body mass index,weight,medical/surgical history,indication for PN,PN data and survival were *** between clinical and PN characteristics and survival were analysed with important confounding ***:The final cohort included 437 evaluable patients,with a mean age of 57 ***-one percent of the study population had advanced stage of colorectal *** weight(weight change≥2.5%)prior to PN initiation[hazard ratio(HR)=1.41,P=0.023]was adversely associated with survival after adjusting for multiple factors including cancer *** obstruction(HR=1.75,P=0.017)as a PN indication was associated with worse survival when compared with without bowel *** PN amino acid by ideal body weight(g•kg^(-1))(HR=0.59,P=0.029)was associated with longer survival,whereas a higher percentage of non-PN intravenous calories(HR=1.04,P=0.011)was associated with shorter survival independently of confounding ***:Body mass index and weight stability can be useful nutritional indices for survival prediction in cancer patients receiving *** planning should take into account of non-PN calories to achieve optimal energy support and *** research is needed to define optimal PN amino-acid requirement and energy balance.

关键词： BMI weight loss non-parenteral calorie energy balance parenteral nutrition

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