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Synthesis and Optical Properties of Cubic Gold Nanoframes

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Nano Research 2008年第6期1卷 441-449页

作者： leslie Au Yeechi Chen Fei Zhou Pedro H.C.Camargo Byungkwon Lim Zhi-Yuan Li david S.Ginger Younan Xia department of Chemistry University of WashingtonSeattleWashington 98195USA Institute of Physics Chinese Academy of SciencesBeijing 100080China department of Biomedical Engineering Washington UniversitySt.LouisMissouri 63130USA

This paper describes a facile method of preparing cubic Au nanoframes with open structures via the galvanic replacement reaction between Ag nanocubes and AuCl_(2)^(-).A mechanistic study of the reaction revealed that the formation of Au nanoframes relies on the diffusion of both Au and Ag *** effect of the edge length and ridge thickness of the nanoframes on the localized surface plasmon resonance peak was explored by a combination of discrete dipole approximation calculations and single nanoparticle *** their hollow and open structures,the Au nanoframes represent a novel class of substrates for applications including surface plasmonics and surface-enhanced Raman scattering.

关键词： Gold nanostructures galvanic replacement hollow nanostructures localized surface plasmon resonance surface-enhanced Raman scattering

User-Level device drivers： Achieved Performance

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Journal of Computer Science & Technology 2005年第5期20卷 654-664页

作者： Ben leslie Peter Chubb Nicholas Fitzroy-dale Stefan Gotz Charles Gray Luke Macpherson daniel Potts Yue-Ting Shen Kevin Elphinstone Gernot Heiser National ICT Australia and School of Computer Science and Engineering University of New South Wales Sydney 2052 Australia Wilhelm-Schickard-Institute for Computer Science University of Tǖbingen D-72076 Tǖbingen Germany

Running device drivers as unprivileged user-level code, encapsulated into their own process, has often been proposed as a technique for increasing system robustness. However, in the past, systems based on user-level drivers have generally exhibited poor I/O performance. Consequently, user-level device drivers have never caught on to any significant degree. In this paper we demonstrate that it is possible to build systems which employ user-level device drivers, without significant performance degradation, even for high-bandwidth devices such as Gigabit Ethernet.

关键词： device drivers operating systems performance reliability

An immunoglobulin Y that specifically binds to an in silico-predicted unique epitope of Zika virus non-structural 1 antigen

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Asian Pacific Journal of Tropical Medicine 2022年第1期15卷 35-43页

作者： Leonardo A.Guevarra Jr Scott dean P.de Sagon Treena Rica d.Teh Maria Katrina diana MCruz Nikki Cyrill C.Capistrano Austine James Z.StaMaria Laarni Grace M.Corales leslie Michelle M.dalmacio department of Biochemistry and Molecular Biology College of MedicineUniversity of the Philippines ManilaPhilippines department of Biochemistry Faculty of PharmacyUniversity of Santo TomasPhilippines Research Center for Natural and Applied Sciences University of Santo TomasPhilippines

Objective:To identify unique immunogenic epitopes of Zika virus non-structural 1(NS1)antigen and produce immunoglobulin Y(IgY)for potential use in he diagnosis of of Zika virus ***:Immunogenic epitopes were identified using in silico B-cell epitope prediction.A synthetic peptide analog of the predicted epitope was used to induce antipeptide IgY production in hens which was purified using affinity *** of purified IgY and its binding specificity were performed by gel electrophoresis and ELISA,***:Out of the nine continuous epitopes identified,the sequence at position 193-208(LKVREdYSLECdPAVI)was selected and used to produce anti-peptide *** produced IgY was found to bind to the synthetic analog of the Zika virus NS1 immunogenic epitope but not to other flaviviruses and random peptides from other ***:In this study,we identified an immunogenic epitope unique to Zika virus that can be used to develop a serodiagnostic tool that specifically detect Zika virus infection.

关键词： Immunoglobulin Y IgY B-cell epitope prediction Flavivirus Non-structural 1 antigen Zika virus

domestic Water Supply dynamics Using Stable Isotopes δ18O, δd, and d-Excess

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Journal of Water Resource and Protection 2014年第16期6卷 1517-1532页

作者： deborah leslie Kathleen Welch William Berry Lyons School of Earth Sciences The Ohio State University Columbus USA

Surface water is the greatest contributor to many water supplies in urbanized areas. Understanding local water sources and seasonality is important in evaluating water resource management, which is essential to ensure the sustainability of water supplies to provide potable water. Here we describe the municipal water cycle of Columbus, Ohio, USA, using δ18O, δd, and d-excess, and follow water from precipitation through surface reservoirs to a residential tap between May 2010 and November 2011. We show that trends in water isotopic composition of Ohio precipitation have a seasonal character with more negative values during the winter months and more positive values during the summer months. The year of 2011 was the wettest year on record in Central Ohio, with many months having high d-excess values (>+15‰), suggestive of increased moisture recycling, and possibly moisture introduced from more local sources. Tap waters experienced little lag time in the managed system, having a residence time of ~2 months in the reservoirs. Tap waters and reservoir waters preserved the isotopic signal of the precipitation, but the reservoir morphology also influenced the water residence time, and hence, the isotopic relationship to the precipitation. The reservoirs supplied by the Scioto River function like a river system with a fast throughput of water. The other reservoirs display more constant solute concentrations, longer flow-through times, and more lacustrine qualities. This work provides a basic understanding of a regional water supply system in Central Ohio and helps characterize the water flow in the system. These data will provide useful baseline information for the future as urban populations grow and the climate and hydrologic cycle changes.

关键词： Ohio Precipitation Municipal Water Supply Moisture Recycling Reservoir Residence Time

Estimating in building construction 5th ed.

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基于药物体内处置的生物药剂学分类系统在预测药物体内过程中的应用

丛书名：国外大学优秀教材

2004年

作者： Frank R. dagostino leslie Feigenbaum

来源：畅想之星图书光盘版（南... 评论

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中国新药杂志 2014年第16期23卷 1924-1930页

作者：刘维杨丽闫婷婷 leslie Benet 翟所迪北京大学第三医院药剂科北京100191 北京大学药学院药事管理与临床药学系北京100191 加州大学旧金山分校生物工程与药物治疗学系旧金山941430912

"生物药剂学分类系统(biopharmaceutics classification system,BCS)"和"基于药物体内处置的生物药剂学分类系统(biopharmaceutics drug disposition classification system,BddCS)"是两个在欧美药品研发及监管领域使用非常广泛的系统,通过溶解度、渗透性或代谢程度指标,将药物分为简单的4类,即可以对药物的体内过程特点进行预测。本文将详细阐述和比较BCS和BddCS在建立目的、分类标准和应用等方面的特点和差异,并着重介绍不同BddCS分类药物体内过程特点与转运体之间的关系,以及转运体在药物吸收、分布、代谢和排泄过程中的作用。

关键词：基于药物体内处置的生物药剂学分类系统新药预测

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应用生态环保设计的新一代真空灭弧室

华东电力 2007年第C期35卷 61-66页

作者： leslie T. Falkingham Martin Schlaug Alstom T&d. UK Alstom T&d. France

介绍AREVA“VG”新系列真空灭弧室的短路开断性能和外形尺寸最优化，并且从环保的立场出发，通过对设计过程和制造工艺的全面评审，确认其对生态环境的影响也得到了最优化。新型的AREVA工艺技术减少了制造真空灭弧室所需能源大约40％，... 详细信息

介绍AREVA“VG”新系列真空灭弧室的短路开断性能和外形尺寸最优化，并且从环保的立场出发，通过对设计过程和制造工艺的全面评审，确认其对生态环境的影响也得到了最优化。新型的AREVA工艺技术减少了制造真空灭弧室所需能源大约40％，减少原材料消耗约30％。这种工艺技术已经应用于工作电压直到38kV，正常工作电流直到3150A和短路电流直到63kA的新系列真空灭弧室开关装置中。

关键词：真空灭弧室生态环保工艺技术

Combination therapy with saxagliptin and vitamin d for the preservation ofβ-cell function in adult-onset type 1 diabetes:a multi-center,randomized,controlled trial

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2354-2362页

作者： Xiang Yan Xia Li Bingwen Liu Jiaqi Huang Yufei Xiang Yuhang Hu Xiaohan Tang Ziwei Zhang Gan Huang Zhiguo Xie Houde Zhou Zhenqi Liu Xiangbing Wang Richard david leslie Zhiguang Zhou National Clinical Research Center for Metabolic diseases Key Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina division of Endocrinology and Metabolism Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVAUSA division of Endocrinology Metabolism and NutritionRutgers University-Robert Wood Johnson Medical SchoolNew BrunswickNJUSA Centre for Immunobiology Blizard InstituteQueen Mary University of LondonLondonUK

disease modifying therapies aiming to preserveβ-cell function in patients with adult-onset autoimmune type 1 diabetes are ***,we conducted a multi-centre,randomized,controlled trial to assess theβ-cell preservation effects of saxagliptin alone and saxagliptin combined with vitamin d as adjunctive therapies in adult-onset autoimmune type 1 *** this 3-arm trial,301 participants were randomly assigned to a 24-month course of the conventional therapy(metformin with or without insulin)or adjunctive saxagliptin or adjunctive saxagliptin plus vitamin d to the conventional *** primary endpoint was the change from baseline to 24 months in the fasting *** secondary endpoints included the area under the concentration-time curve(AUC)for C-peptide level in a 2-h mixed-meal tolerance test,glycemic control,total daily insulin use and safety,*** primary endpoint was not achieved in saxagliptin plus vitamin d group(P=0.18)and saxagliptin group(P=0.26).However,compared with the conventional therapy,2-h C-peptide AUC from 24 months to baseline decreased less with saxagliptin plus vitamin d(-276 pmol/L vs.-419 pmol/L;P=0.01),and not to the same degree with saxagliptin alone(-314 pmol/L;P=0.14).Notably,for participants with higher glutamic acid decarboxylase antibody(GAdA)levels,the decline ofβ-cell function was much lower in saxagliptin plus vitamin d group than in the conventional therapy group(P=0.001).Insulin dose was significantly reduced in both active treatment groups than in the conventional therapy group despite all groups having similar glycemic *** conclusion,the combination of saxagliptin and vitamin d preserves pancreaticβ-cell function in adult-onset autoimmune type 1 diabetes,an effect especially efficacious in individuals with higher GAdA *** results provide evidence for a novel adjunct to insulin and metformin as potential initial treatment for adult-onset type 1 diabetes.(*** identifier:NCT024

关键词： vitamin alone treatment

First Ever documented Total Calcaneus Replacement with 3d Printed Metallic Implant for Chronic Osteomyelitis after a Calcaneal Fracture in a Young, Healthy Individual—A Literature Review and Preliminary Case Report

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Open Journal of Orthopedics 2023年第5期13卷 195-204页

作者： leslie H. Pyle Mica Murdoch Ashley McClain Kyle Yi Town Square Family Foot Care Coralville Iowa USA Broadlawns Medical Center Des Moines Iowa USA

Osteomyelitis of the calcaneus can be a limb threatening diagnosis, which is typically treated with antibiotic therapy with or without partial resection of the bone. Extensive infection of the bone commonly results in limb amputation via transtibial or transfemoral amputation, which can increase morbidity and mortality. This case report involves a 29-year-old male who sustained bilateral calcaneal fracture after a fall, who developed osteomyelitis of the right calcaneus after being treated with internal/external fixation and antibiotic therapy. In order to preserve the limb total calcaneal replacement with 3d printed implant was done.

关键词： Osteomyelitis Calcaneal Replacement 3d Implant Calcaneal Fracture Below Knee Amputation