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rigidity Symmetry Line for thermodynamic Fluid Equations-of-State

Journal of Modern Physics 2024年第5期15卷 613-633页

作者： leslie V. Woodcock Department of Physics University of Algarve Faro Portugal

We report progress towards a modern scientific description of thermodynamic properties of fluids following the discovery (in 2012) of a coexisting critical density hiatus and a supercritical mesophase defined by percolation transitions. the state functions density ρ(p,t), and Gibbs energy G(p,t), of fluids, e.g. CO2, H2O and argon exhibit a symmetry characterised by the rigidity, ω = (dp/dρ)t, between gaseous and liquid states along any isotherm from critical (tc) to Boyle (tB) temperatures, on either side of the supercritical mesophase. Here, using experimental data for fluid argon, we investigate the low-density cluster physics description of an ideal dilute gas that obeys Dalton’s partial pressure law. Cluster expansions in powers of density relate to a supercritical liquid-phase rigidity symmetry (rS) line (ω = ρrs(t) = rt) to gas phase virial coefficients. We show that it is continuous in all derivatives, linear within stable fluid phase, and relates analytically to the Boyle-work line (BW) (w = (p/ρ)t = rt), and to percolation lines of gas (PB) and liquid (PA) phases by: ρBW(t) = 2ρPA(t) = 3ρPB(t) = 3ρrS(t)/2 for t tB. these simple relationships arise, because the higher virial coefficients (bn, n ≥ 4) cancel due to clustering equilibria, or become negligible at all temperatures (0 t tB) within the gas phase. the Boyle-work line (p/ρBW)t is related exactly at lower densities as t → tB, and accurately for liquid densities, by ρBW(t) = −(b2/b3)t. the rS line, ω(t) = rt, defines a new liquid-density ground-state physical constant (ρrS(0) = (2/3)ρBW(0) for argon). Given the gas-liquid rigidity symmetry, the entire thermodynamic state functions below tB are obtainable from b2(t). A BW

关键词： Liquid-State theory Cluster Physics Percolation Lines Fluid thermodynamics Boyle Line rigidity-Symmetry Line

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Isolated Lumbar Extension resistance training Is Effective at Improving Extension Power and Disability in Subjects with Diagnosed Lumbar Multifidus Dysfunction

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Open Journal of therapy and rehabilitation 2024年第3期12卷 245-255页

作者： William roger Peters James thomas Ernest Smith Mario Guiseppe Zotti Adam leslie Lincoln Benjamin James Enser Faculty of Medicine & Health Sciences Bond University Queensland Australia Back Neck Clinic Bundall Queensland Australia Kieser Australia Bundall Queensland Australia

Background: Lumbar multifidus dysfunction is a prevalent cause of disability in individuals with lower back pain. Previous research highlights the benefits of isolated lumbar extension training for non-specific lower back pain, however, studies examining its efficacy in lumbar multifidus dysfunction are lacking. Objective: to evaluate the effectiveness of isolated lumbar extension resistance training on disability and strength in individuals with lumbar multifidus dysfunction. Methods: Subjects underwent a physiotherapy led structured rehabilitation program incorporating isolated lumbar extension. Sessions were conducted twice weekly targeting momentary muscular failure with time under load 90 - 120 seconds and progressions aimed at 5 - 10 lbs increments. Outcomes were assessed using the Oswestry Disability Index and lumbar extension strength testing at baseline and after 12 weeks, with statistical analysis using t-test and chi-squared 2 × 2. results: Forty-five subjects (24 male, 21 female) with a median age of 48 completed the intervention. Improvements were noted in Oswestry Disability Index scores (median pre: 24, post: 15) and maximal lumbar extension strength (median pre: 122 lb, post: 186 lb), with p ≤ 0.05. Overall, 89% showed improvement in disability scores, 67% moved to a better disability category, and 51% saw at least a 50% increase in strength. No significant gender differences were observed. Conclusions: Isolated lumbar extension resistance training is effective at improving extension power and disability in subjects with lumbar multifidus dysfunction.

关键词： Low Back Pain Multifidus Muscle Strength rehabilitation resistance training

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remodeling tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with radiation therapy to Boost Immune response of Castration-resistant Prostate Cancer

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research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan taksim Ahmed Chunsheng He Jeffrey t.Henderson Andrew M.rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical Biophysics and radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (CrPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLMDs) to remodel the tumor immune microenvironment (tIME) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. this study demonstrated that PLMD treatment sensitized hypoxic human and murine CrPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. reoxygenation via PLMDs also polarized hypoxic murine rAW264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine CrPC trAMP-C2 cells. In a syngeneic trAMP-C2 tumor model, intravenous injection of PLMDs suppressed, while radiation alone enhanced recruitment of regulatory t cells and myeloid-derived suppressor cells. Pretreatment with PLMDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor CD8+ t cells and M1 macrophages to tumor sites. taken together, tIME modulation by PLMDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. these results suggest that PLMDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： rAW264.7 alone treatment

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US regulators Clash Over 5G rollout and Aircraft Safety

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Engineering 2022年第8期8卷 6-8页

作者： Mitch leslie 机构不祥

Late in 2021,US wireless companies were set to dramatically increase the performance of their fifth generation(5G)*** they had been offering 5G service since 2019,they were transmitting data in sections of the electromagnetic spectrum that often are no faster than the fourth generation(4G)or that provide restricted coverage[1,2].On 5 December 2021,the two biggest companies,At&t and Verizon,were scheduled to expand into the C-band,a range of mid-band frequencies often dubbed the"sweet spot"for wireless because it combines high speed with broad coverage(Fig.1)[2].

关键词： companies offering faster

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Factors associated with change in frailty scores and long-term outcomes in older adults with coronary artery disease

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Journal of Geriatric Cardiology 2021年第3期18卷 196-203页

作者： S.Michael Gharacholou Joshua P.Slusser ryan J.Lennon Carolyn r.Flock leslie t.coop.r Patricia A.Pellikka Jorge Brenes Salazar Mandeep Singh Department of Cardiovascular Medicine Mayo ClinicJacksonvilleFLUSA Department of Cardiology Mayo Health SystemLa CrosseWIUSA Department of Biostatistics Mayo ClinicRochesterMNUSA Department of Cardiovascular Medicine Mayo ClinicRochesterMNUSA

OBJECtIVE Older adults with coronary artery disease(CAD)are at risk for ***,little is known regarding transition in frailty measures over time or its impact on *** sought to determine the association of temporal change in frailty with long-term outcome in older adults with *** We re-assessed for phenotypic frailty using the Fried index(0=not frail;1−2=pre-frail;≥3 frail)in a cohort of CAD patients≥65 years old at 2 time points 5 years *** associated with frailty worsening were assessed with scatterplots and outcomes estimated using the Kaplan-Meier *** models were used to assess the risk of worsening frailty on *** there were 45 subjects that completed both baseline and 5-year Fried frailty *** age was 74.6±5.9 and 30(67%)were *** incidence increased over time:baseline(3%frail,37%pre-frail);5 years(10%frail,40%pre-frail).Baseline factors were not predictors of worsening frailty score,while both slower walk time(r=0.46;P=0.004)and diminishing grip strength(r=−0.39;P=0.01)were associated with worsening frailty *** follow-up(median 5.2 years),long-term major adverse cardiac event(MACE)free survival(P=0.12)or hospitalization(P=0.98)was not different for those with worsening frailty score(referent:improved/unchanged frailty).Frailty worsening had a trend towards increased risk of MACE(Hr=1.86;95%CI:0.65−5.27,P=0.25).CONCLUSIONS Frailty transitions,specifically,declines in walk time and grip strength,were strongly associated with worsening frailty score in a cohort of older adults with CAD than were baseline indices,though frailty change status was not independently associated with MACE outcomes.

关键词： coronary unchanged score

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基于动力触探的砾性土液化判别方法通用性研究

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岩土工程学报 2016年第1期38卷 163-169页

作者：曹振中刘荟达袁晓铭 t leslie Youd 中国地震局工程力学研究所中国地震局地震工程与工程振动重点实验室黑龙江哈尔滨150080 杨百翰大学土木与环境工程系美国普若佛84602

动力触探是针对砾性土力学性能评价的一种原位测试技术,具有设备简单、操作方便等优势。分别在成都平原和美国Utah地区选取典型砾性土场地,进行中美联合动力触探和有效锤击能量的测试与标定,结果表明:1在成都平原3个砾性土场地获取了中... 详细信息

动力触探是针对砾性土力学性能评价的一种原位测试技术,具有设备简单、操作方便等优势。分别在成都平原和美国Utah地区选取典型砾性土场地,进行中美联合动力触探和有效锤击能量的测试与标定,结果表明:1在成都平原3个砾性土场地获取了中国超重型动力触探1321个重锤锤击能量记录,锤击能量传递系数的平均值约为90%,标准差为7.7%,锤击数离散性受设备操作方法的影响较大;2在美国钻机上安装中国超重型动力触探标准探头,可以有效穿透选取的试验深度为20 m的砾性土场地,并进行分层、力学性能评价;3在美国Echo dam下游坝基上2个砾性土场地获取了美国动力触探1438个重锤锤击记录,锤击能量传递系数约为74%,标准差为8.7%,锤击数离散性受拉绳、钻杆摩擦力的影响较大;4对锤击数进行能量修正之后,以2008年汶川地震砾性土液化为背景、以动力触探锤击数为基本指标的砾性土液化判别方法,具有国际通用的可行性。

关键词：动力触探砾性土液化能量修正判别方法通用性

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Colonic gallstones:a case report

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Hepatobiliary & Pancreatic Diseases International 2007年第3期6卷 324-325页

作者： Zakir K Mohamed Shlok Balupuri leslie H Boobis Sunderland royal Hospital SunderlandUK

BACKGrOUND:Colonic gallstone is an uncommon entity with high morbidity and mortality due to various reasons. It remains a diagnostic challenge because of delayed and non-specific presentations,especially in the elderly population,often with multiple co-morbidities. MEtHOD:We present a case of 81-year-old woman who had a large bowel obstruction due to colonic gallstone. rESULtS:Immediately after a cholecysto-colonic fistula was found by laporotomy,she underwent a single stage enterolithotomy,cholecystectomy and fistula closure. CONCLUSIONS:A single stage enterolithotomy,cholecys- tectomy and fistula closure is ideal for this condition. Various other surgical options in the literature are discussed.

关键词： large bowel obstruction gallstone ileus colonic gallstone

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应用生态环保设计的新一代真空灭弧室

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华东电力 2007年第C期35卷 61-66页

作者： leslie t. Falkingham Martin Schlaug Alstom t&D. UK Alstom t&D. France

介绍ArEVA“VG”新系列真空灭弧室的短路开断性能和外形尺寸最优化，并且从环保的立场出发，通过对设计过程和制造工艺的全面评审，确认其对生态环境的影响也得到了最优化。新型的ArEVA工艺技术减少了制造真空灭弧室所需能源大约40％，... 详细信息

介绍ArEVA“VG”新系列真空灭弧室的短路开断性能和外形尺寸最优化，并且从环保的立场出发，通过对设计过程和制造工艺的全面评审，确认其对生态环境的影响也得到了最优化。新型的ArEVA工艺技术减少了制造真空灭弧室所需能源大约40％，减少原材料消耗约30％。这种工艺技术已经应用于工作电压直到38kV，正常工作电流直到3150A和短路电流直到63kA的新系列真空灭弧室开关装置中。

关键词：真空灭弧室生态环保工艺技术

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德阳松柏村典型液化震害剖析

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岩土工程学报 2012年第3期34卷 546-551页

作者：曹振中李雨润徐学燕 t.leslie Youd 袁晓铭中国地震局工程力学研究所黑龙江哈尔滨150080 河北工业大学土木工程学院天津300401 哈尔滨工业大学土木工程学院黑龙江哈尔滨150001 杨百翰大学土木与环境工程系普若佛84602美国

2008年5月12日中国发生的8.0级汶川大地震中,位于Ⅶ、Ⅷ度交接处的德阳松柏村液化破坏十分明显,喷砂类型丰富,液化伴随大量地裂缝,液化加震现象十分显著,具有典型研究价值。对该村进行了详细的现场测试并与以往液化震害进行了对比分析,... 详细信息

2008年5月12日中国发生的8.0级汶川大地震中,位于Ⅶ、Ⅷ度交接处的德阳松柏村液化破坏十分明显,喷砂类型丰富,液化伴随大量地裂缝,液化加震现象十分显著,具有典型研究价值。对该村进行了详细的现场测试并与以往液化震害进行了对比分析,结果表明:尽管松柏村地表主要喷出物是中砂和粗砂,但实际液化土与喷出物差别显著,主要为砂砾土液化;以往还没有提出过适于工程应用的砂砾土液化判别方法,而超重型动力触探(DPt)具有设备简单、经济实用、测试数据连续的优点,可作为砂砾土液化预测的核心指标;松柏村大量地裂缝现象不是由次断层造成而是由土层液化引起,而液化产生地裂缝的基本条件为地表较平坦(<3%)以及液化土层水平分布不均匀;液化减震的基本条件为上覆非液化层足够厚且较为密实,但定量评价方法还有待进一步研究。

关键词：汶川地震松柏村砂砾土液化地裂缝加震

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砾性土液化评价方法的通用性和可靠性研究

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岩土工程学报 2019年第9期41卷 1628-1635页

作者：曹振中 Kyle M.rollins 袁晓铭 t.leslie Youd Michael talbot Jashod roy Sara Amoroso 桂林理工大学广西岩土力学与工程重点实验室广西桂林541004 杨百翰大学土木与环境工程系美国普若佛84602 中国地震局工程力学研究所中国地震局地震工程与工程振动重点实验室黑龙江哈尔滨150080 美国内政部垦务局美国普若佛84606 意大利国家地质与地球物理研究所意大利拉奎拉8-67100

以2008年汶川地震液化震害调查资料为背景,基于操作性和经济性上具有显著优势的中国动力触探试验(DPt)而提出的砾性土液化评价方法,包括砾性土层液化触发条件以及判别公式(CYY公式),理论上已经得到国内外同行的认可,但其通用性和可靠性... 详细信息

以2008年汶川地震液化震害调查资料为背景,基于操作性和经济性上具有显著优势的中国动力触探试验(DPt)而提出的砾性土液化评价方法,包括砾性土层液化触发条件以及判别公式(CYY公式),理论上已经得到国内外同行的认可,但其通用性和可靠性尚需检验。以5个国家29个历史地震砾性土场地中美联合勘测为基础,研究DPt技术、砾性土层液化触发条件和CYY公式在不同国家、不同地震和不同场地的适用性和可靠性问题,其中,成都平原14个砾性土场地的勘测与数据处理由中方完成,美国、意大利、新西兰、厄瓜多尔等15个砾性土场地的勘测与数据处理由美方rollins教授主导完成,均为新的测试检验点。结果表明:中国动力触探标准探头在不同国家、不同砾性土场地上测试具有可行性,可以有效穿透20 m的砾性土场地,动探击数可作为砾性土液化评价的核心指标,同时亦可扩展到砾性土层的力学性能评价;不同国家、不同砾性土液化场地上,均存在不排水或排水不畅的埋藏条件,符合砾性土层液化触发条件要求;对动力触探击数进行锤击能量、有效上覆压力等修正后,CYY公式在不同国家、不同地震、不同砾性土液化场地的判别成功率约96%,具有较高可靠性。以2008年汶川地震砾性土液化为背景、以动力触探锤击数为基本指标的砾性土液化评价方法,具有国际通用的可行性。

关键词：动力触探试验砂砾土触发条件 CYY公式验证

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