检索结果-南通市图书馆

Retinoic acid signaling acts as a rheostat to balance Treg function

Cellular & Molecular Immunology 2022年第7期19卷 820-833页

作者： Govindarajan Thangavelu Gabriela Andrejeva sara Bolivar-Wagers sujeong Jin Michael C.Zaiken Michael Loschi Ethan G.Aguilar scott N.Furlan Chrysothemis C.Brown Yu-Chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey R.Hill David H.Munn Robert Zeiser leslie s.kean Jeffrey C.Rathmell Hongbo Chi Randolph J.Noelle Bruce R.Blazar Department of Pediatrics Center for ImmunologyUniversity of MinnesotaMinneapolisMNUSA Center for Immunobiology Vanderbilt University Medical CenterNashville TNUSA Department of Pediatrics University of WashingtonSeattleWAUSA Fred Hutchinson Cancer Research Center SeattleWAUSA Howard Hughes Medical Institute Immunology Program and Ludwig CenterSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Microbiology and Immunology.Geisel school of Medicine at Dartmouth Norris Cotton Cancer CenterLebanonUSA Department of Immunology Queensland Institute of Medical Research(QIMR)Berghofer Medical Research Institute and School of MedicineUniversity of QueenslandBrisbaneQLDAustralia Departmentof Dermatology School of MedicineUniversity of California DavisSacramentoCAUSA Division of Hematology/Oncology Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Georgia Cancer Center Augusta UniversityAugustaGAUSA Department of Haematology Oncology and Stem Cell TransplantationFaculty of MedicineFreiburg University Medical CentreFreiburgGermany Boston Children's Hospital and the Dana-Farber Cancer Institute BostonMAUSA Department of Immunology St.Jude Children's ResearchHospitalMemphisTNUSA

Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory *** certain inflammatory conditions,Tregs can lose their lineage stability and *** studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and ***,it is unknown how RA receptor signaling in Tregs influences these processes in ***,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T *** the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased CD25 expression,sTAT5 pathway activation,mTORC1 signaling and supersuppressor ***,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic *** function was observed when wild-type mice were treated with a pharmacologic pan-RAR ***,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and *** loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive *** mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA *** findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner.

关键词： Retinoic acid Tregulatory cells Autoimmunity Metabolism mTORC1 sTAT5

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Add-on Renewables Aim to Decrease Impact and Increase Benefits

引用

Engineering 2024年第6期37卷 10-12页

作者： Mitch leslie senior Technology Writer

In the south Boulder Canal near Denver,CO,UsA,turbine blades that resemble the mixers used to stir cake batter in kitchens(Fig.1)spin in the rushing water[1].Each of the turbines,manufactured by Emrgy of Atlanta,GA,UsA,generates up to 25 kW of electricity for the area’s grid[2].In an orchard in southern Italy,an arcade of solar panels stands above rows of citron trees,which are valuable for the essential oils in their fruits[3].The solar panels not only produce electricity for local homes,but also protect the trees from the sun,reducing their water use by 70%[3].These are two examples of a clean energy trend:integrating power-generation with other *** the approach called agrivoltaics,for example,farmers and ranchers grow crops or raise livestock around and beneath solar panels(Fig.2)[4].Experts hope that such add-on strategies can spare farmland,cut the environmental costs of clean energy development,supply extra income to landowners,and furnish other benefits[5,6].

关键词： income beneath integrating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Is There a Bright Future for solar Power from space?

引用

Engineering 2024年第2期33卷 9-11页

作者： Mitch leslie senior Technology Writer

Late in the evening of May 22,2023,a team of researchers at the California Institute of Technology(Caltech)in Pasadena,CA,UsA,measured a faint beam of microwaves emanating from a solar-powered satellite 550 km *** send signals to Earth all the time,but this occasion was *** satellite car-ried a unique transmitter developed by the Caltech researchers,a 30 cm by 30 cm array of polyimide and copper designed to be lightweight and *** that transmitter,the satellite became the first spacecraft to direct solar power captured in space to the Earth’s surface.

关键词： Earth solar lightweight

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

seasonal changes in Hermit Thrush (Catharus guttatus) song syntax

引用

Avian Research 2024年第2期15卷 172-179页

作者： sean P.Roach Luke C.McLean Jeff W.MacLeod leslie s.Phillmore Psychology Department University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Department of Psychology and Neuroscience Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In many songbird species,birdsong features phonological syntax,meaning that the units within their vocal se-quences are ordered in a non-random way that adheres to a *** such syntactical patterns have been richly described in many species,comparatively little is known about how those patterns contribute to song achieving its important *** each of song’s main functions,territorial defense and mate attraction,evidence of a role for syntax is *** species for which syntax has been thoroughly described is the Hermit Thrush(Catharus guttatus),which presents song types from their repertoires in a semi-predictable order and,in doing so,rapidly cycle up and down the frequency *** objective of the present study was to explore the importance of song syntax in the Hermit Thrush through a within-subject examination of how measures of syntax,such as the predictability of song type order within song sequences,shift over the breeding *** hypothesized that,if such syntactical characteristics are important to breeding behaviour,they would be most prominent at the start of the breeding season when activity associated with territory establishment and mate attraction is most *** revealed that,as predicted,the rigidness of song type ordering within se-quences was highest at the start of the season and declined *** song type sequences were most predictable at the vitally important early part of the breeding season fit our hypothesis that this aspect of song syntax is important to song’s functions related to territory establishment and/or mate *** work will clarify whether that role relates to one of song’s two main functions or serves song transmission in some broader way.

关键词： Birdsong Hermit Thrush seasonal change stereotypy syntax

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

引用

Asian Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed s.Goolam Don Perera Ryan Downey scott leslie Peter Grimison Henry Woo Peter Ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQR]240-315)*** blood loss was 100(IQR 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQR 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： Retroperitoneal lymph node dissection Robotic surgery Testicular cancer Retroperitoneal node dissection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人工智能或将引发科学革命

引用

Engineering 2024年第4期35卷 4-6页

作者： Mitch leslie senior Technology Writer

A drug developer trying to devise a new cancer treatment,a virologist investigating how a virus invades cells,an evolutionary biologist probing the effects of mutations on an organism’s fitness—these are just some of the scientists who need to know the three-dimensional structures of specific ***,deducing a protein’s shape through experiments is laborious and costly[1].

关键词：人工智能 cancer treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

引用

Acta Pharmaceutica sinica B 2024年第4期14卷 1525-1541页

作者： Qi shang Wandong Liu Faith leslie Jiapei Yang Mingmei Guo Mingjiao sun Guangji Zhang Qiang Zhang Feihu Wang school of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China school of Basic Medical sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Blood-stasis-toxin syndrome of Zhejiang Province Hangzhou 310053China Department of Chemical and Biomolecular Engineering Whiting School of Engineeringthe Johns Hopkins UniversityBaltimoreMD 21218USA Traditional Chinese Medicine“Preventing Disease”Wisdom Health Project Research Center of Zhejiang Hangzhou 310053China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.

关键词： Chinese herbal medicines Nano-formulation Activeingredients Drug delivery Cancer immunotherapy Innate immune system Adaptive immune system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rigidity symmetry Line for Thermodynamic Fluid Equations-of-state

引用

Journal of Modern Physics 2024年第5期15卷 613-633页

作者： leslie V. Woodcock Department of Physics University of Algarve Faro Portugal

We report progress towards a modern scientific description of thermodynamic properties of fluids following the discovery (in 2012) of a coexisting critical density hiatus and a supercritical mesophase defined by percolation transitions. The state functions density ρ(p,T), and Gibbs energy G(p,T), of fluids, e.g. COsub>2sub>, Hsub>2sub>O and argon exhibit a symmetry characterised by the rigidity, ω = (dp/dρ)sub>Tsub>, between gaseous and liquid states along any isotherm from critical (Tsub>csub>) to Boyle (Tsub>Bsub>) temperatures, on either side of the supercritical mesophase. Here, using experimental data for fluid argon, we investigate the low-density cluster physics description of an ideal dilute gas that obeys Dalton’s partial pressure law. Cluster expansions in powers of density relate to a supercritical liquid-phase rigidity symmetry (Rs) line (ω = ρsub>rssub>(T) = RT) to gas phase virial coefficients. We show that it is continuous in all derivatives, linear within stable fluid phase, and relates analytically to the Boyle-work line (BW) (w = (p/ρ)sub>Tsub> = RT), and to percolation lines of gas (PB) and liquid (PA) phases by: ρsub>BWsub>(T) = 2ρsub>PAsub>(T) = 3ρsub>PBsub>(T) = 3ρsub>Rssub>(T)/2 for T Tsub>Bsub>. These simple relationships arise, because the higher virial coefficients (bsub>nsub>, n ≥ 4) cancel due to clustering equilibria, or become negligible at all temperatures (0 T Tsub>Bsub>)sub> sub>within the gas phase. The Boyle-work line (p/ρsub>BWsub>)sub>Tsub> is related exactly at lower densities as T → Tsub>Bsub>, and accurately for liquid densities, by ρsub>BWsub>(T) = −(bsub>2sub>/bsub>3sub>)sub>Tsub>. The Rs line, ω(T) = RT, defines a new liquid-density ground-state physical constant (ρsub>Rssub>(0) = (2/3)ρsub>BWsub>(0) for argon). Given the gas-liquid rigidity symmetry, the entire thermodynamic state functions below Tsub>Bsub> are obtainable from bsub>2sub>(T). A BW

关键词： Liquid-state Theory Cluster Physics Percolation Lines Fluid Thermodynamics Boyle Line Rigidity-symmetry Line

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

引用

Advances in Atmospheric sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE leslie A.KING Noel KEENLYsIDE François COUNILLON Brynhildur DAVIÐsDÓTTIR Níels EINARssON sergey GULEV Ke FAN Torben KOENIGK James R.MCGOODWIN Marianne H.RAsMUssON shuting YANG Institute of Arctic and Alpine Research(INsTAAR) University of ColoradoBoulder CO 80303USA stefansson Arctic Institute AkureyriÍS-600Iceland Royal Roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen Environmental and Remote sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland shirshov Institute of Oceanology Moscow 117218Russia Moscow state University Moscow 11991Russia Chinese Academy of sciences Beijing 100045China swedish Meteorological and Hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient sustainable societies-ARCPATH(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, Russia, China, the United states, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ARCPATH made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATH was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATH served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

synthesizing molecularly imprinted polymer beads for the purification of vitamin E

引用

Particuology 2021年第4期19卷 10-18页

作者： Youhong Zhang Yinpei Zhua leslie s.Loo Jianguo Yin kean Wang school of Environmental Ecology and Biological Engineering Wuhan Institute of TechnologyWuhan 430205PR China Key Laboratory for Green Chemical Process of Ministry of Education Wuhan Institute of TechnologyWuhan 430205PR China singapore Institute of Technology 10 Dover Drive138683 Singapore Jiangsu Xixin Vitamin Co. Ltd.Jiangsu 223600PR China Center for Catalysis and separation(CeCAs) Chemical Engineering DepartmentKhalifa University of Science&TechnologyAbu DhabiUnited Arab Emirates

Molecularly imprinted polymer(MIP)beads imprinted with vitamin E(V_(E))were synthesized via a two-step swelling polymerization method,using methacrylic acid(MAA)and other functional monomers together with polystyrene(Ps)microspheres as the *** initial trials,different functional monomers were assessed,along with a variety of solvents and imprinting *** MIP_(MAA) sample exhibited the highest performance and was characterized and also assessed with regard to V_(E) adsorption under various experimental *** material exhibited reasonably good sphericity,porosity and stability,along with an excellent adsorption capacity of 46 mg/*** was much higher than the value for the corresponding non-imprinted polymer made with the same monomer,and 20%higher than that for an acrylamide-based MIP synthesized using a precipitation polymerization *** core-shell structured MIP_(MAA) also demonstrated fast adsorption kinetics,a low pressure drop and good reusability in fixed bed *** V_(E) adsorption equilibrium,selectivity,kinetics,thermodynamics and regeneration capacity of this material were also examined and are reported herein.

关键词： Vitamin E α-Tocopherol MIP Molecularly imprinting Adsorption separation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：