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Identification of crystal symmetry from noisy diffraction patterns by a shape analysis and deep learning

npj Computational Materials 2020年第1期6卷 35-45页

作者： leslie ching ow tiong Jeongrae Kim Sang Soo Han Donghun Kim Computational Science Research Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

The robust and automated determination of crystal symmetry is of utmost importance in material characterization and *** studies have shown that deep learning(DL)methods can effectively reveal the correlations between X-ray or electron-beam diffraction patterns and crystal *** their promise,most of these studies have been limited to identifying relatively few classes into which a target material may be *** the other hand,the DL-based identification of crystal symmetry suffers from a drastic drop in accuracy for problems involving classification into tens or hundreds of symmetry classes(e.g.,up to 230 space groups),severely limiting its practical usage.

关键词： symmetry crystal limiting

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Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues

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Bone Research 2020年第3期8卷 286-299页

作者： Jiajia Xu Dongqing Li ching-Yun Hsu Ye Tian Leititia Zhang Yiyun Wang Robert J.Tower leslie Chang Carolyn A.Meyers Yongxing Gao Kristen Broderick Carol Morris Jody E.Hooper Sridhar Nimmagadda Bruno Peault Aaron W.James Departments of Pathology Johns Hopkins UniversityBaltimore 21205 MDUSA Department of Microbiology Wuhan University School of Basic Medical of ScienceWuhanHubeiP.R.China Department of Oral and Maxillofacial Surgery School of StomatologyChina Medical UniversityShenyangLiaoningP.R.China Departments of Orthopaedics Johns Hopkins UniversityBaltimore 21205 MDUSA Departments of Plastic Surgery Johns Hopkins UniversityBaltimore 21205 MDUSA Departments of Autopsy Service Johns Hopkins UniversityBaltimoreMD 21205USA Departments of Radiology and Radiological Science bonBaltimore 21205 MDUSA UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center Los AngelesCA 90095USA Center for Cardiovascular Science and MRC Center for Regenerative Medicine University of EdinburghEdinburghUK

Human osteogenic progenitors are not precisely defined,being primarily studied as heterogeneous multipotent cell populations and termed mesenchymal stem cells(MSCs).Notably,select human pericytes can develop into bone-forming ***,we sought to define the differentiation potential of CD146 f human pericytes from skeletal and soft tissue sources,with the underlying goal of defining cell surface markers that typify an osteoblastogenic ***146+CD31~CD45_pericytes were derived by fluorescence-activated cell sorting from human periosteum,adipose,or dermal *** CD146+CD31—CD45 cells retained canonical features of pericytes/*** pericytes demonstrated a striking tendency to undergo osteoblastogenesis in vitro and skeletogenesis in vivo,while soft tissue pericytes did not *** analysis revealed higher CXCR4 signaling among periosteal pericytes in comparison to their soft tissue counterparts,and CXCR4 chemical inhibition abrogated ectopic ossification by periosteal ***,enrichment of CXCR4+pericytes or stromal cells identified an osteoblastic/non-adipocytic precursor *** sum,human skeletal and soft tissue pericytes differ in their basal abilities to form *** exists in soft tissue pericytes,however,and CXCR4+pericytes represent an osteoblastogenic,non-adipocytic cell ***,enrichment for CXCR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering.

关键词： CD146 CXCR4 pericyte

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TEC KINASE SIGNALING IN T CELLS IS REGULATED BY PHOSPHATIDYLINOSITOL 3-KINASE AND THE TEC PLECKSTRIN HOMOLOGY DOMAIN

TEC KINASE SIGNALING IN T CELLS IS REGULATED BY PHOSPHATIDYL...

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The 4th Asian-Pacific Organization for Cell Biology Congress Cell Biology in the Post-Genomic Era

作者： Wen-Chin Yang Keith A.ching Constantine D.Tsoukas leslie J.Berg Institute of Bio-Agricultural Sciences Academia SinicaTaipei 115 Department of Biology and Molecular Biology Institute San Diego State UniversitySan DiegoCA 92121 University of Massachusetts Medical School Department of Pathology 55 Lake Avenue NorthWorcesterMA 01655

Tec, the prototypical member of the Tec family of tyrosine kinases, is abundantly expressed in T cells and other hemopoietic cell types. Although the functions of Itk and Txk have recently been investigated, little is...

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达格列净对肾脏葡萄糖动力学的影响

达格列净对肾脏葡萄糖动力学的影响

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中华医学会第十二次全国内分泌学学术会议

作者： RA DeFronzo M.Hompesch S.Kasichayanula X.Liu Y.Hong M.Pfister LA Morrow BR leslie DW Boulton A.ching SC Griffen University of Texas Health Science Center San AntonioTXUSA

目的:达格列净(DAPA)是一种选择性的SGLT2抑制剂,通过促进尿糖排泄改善2型糖尿病(T2D)中的高血糖。本研究(NCT01165268)考察了DAPA对肾脏葡萄糖动力学的影响。方法:在年龄、BMI、性别和种族匹配的12名健康对照(HbA1c 5.5%,41岁,27 kg/m,...

目的:达格列净(DAPA)是一种选择性的SGLT2抑制剂,通过促进尿糖排泄改善2型糖尿病(T2D)中的高血糖。本研究(NCT01165268)考察了DAPA对肾脏葡萄糖动力学的影响。方法:在年龄、BMI、性别和种族匹配的12名健康对照(HbA1c 5.5%,41岁,27 kg/m,7男/5女)和12名2型糖尿病(HbA1c 6.5%,53岁,30 kg/m,7男/5女)受试者中,根据肾脏病膳食改良试验公式计算,所有受试者肾

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