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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 27-27页

作者： Hamid n.A. Mitchell R.D. Mocroft P. 陈云春 Department of neurosurgery Queen ElizMabeth edical CentreUniversity Hospital BirminghamBirmingham B152THUnited Kingdom

Objectives: To define the role of magnetic resonance imaging(MRI) and intraope rative electrophysiological recording in targeting the subthalamic nucleus (STn) in Parkinson’s disease and to determine accuracy of electrode placement. Patie nts and methods: We implanted 54 electrodes into the STn in 27 patients. Target planning was done by coordinate guidelines and visualising the STn on MRI and de fined in relation to the mid-point of the AC-PC line. Intraoperative microelec trode recording was used. We adjusted electrode positions for placement in the c entre of the STn electrical activity and verified this on postoperative MRI in 1 6 cases, which were fused to the preoperative images to measure actual error in electrode placement in the three axes. Results: Based on coordinate calculation and MRI localisation, the mean of the target was 11.5 mm lateral,2.5 mm posterio r and 4.1 mm inferior to the mid-point of the AC-PC line. Fifty good electroph ysiological recordings of the STn (average length 4.65 mm) were achieved and tar get point adjusted in 90%of lead placements. The mean of the final target after electrophysiological correction was 11.7 mm lateral,2.1 mm posterior, and 3.8 m m inferior to the mid-point. The distance from the centre of the electrode arte fact to the final target used after electrophysiological recording on the fused images was 0.48 mm, 0.69 mm, and 2.9 mm in the x, y, and zaxes, respectively. no postoperative MRI related complication was observed. Conclusion: Both direct vi sualisation of the STn on MRI and intraoperative electrophysiological recording are important in defining the best target. Individual variations exist in the lo cation of the STn target. Fewer tracks were required to define STn activity on t he side operated first. Our current stereotactic method of electrode placement i s relatively accurate.

关键词：丘脑底核脑深部刺激 MRI 电极位置帕金森病电生理 inferior placement 定位点 intraoperative

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茶碱对支气管哮喘患者肺功能及IL-17、CRP的影响

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国际呼吸杂志 2015年第17期35卷 1289-1291页

作者：钟冰周传麟王学亮王丽娜谢淑奇卞明菊刘爱文济南市第五人民医院呼吸内科 250000

目的观察茶碱对支气管哮喘（简称哮喘）患者肺功能及IL-17、C反应蛋白（CRP）的影响。方法将120例哮喘患者随机分为对照组和治疗组各60例。对照组予以沙美特罗氟替卡松50／250μg每日2次吸入治疗；治疗组在对照组治疗基础上加用茶碱缓... 详细信息

目的观察茶碱对支气管哮喘（简称哮喘）患者肺功能及IL-17、C反应蛋白（CRP）的影响。方法将120例哮喘患者随机分为对照组和治疗组各60例。对照组予以沙美特罗氟替卡松50／250μg每日2次吸入治疗；治疗组在对照组治疗基础上加用茶碱缓释片（0．1g每日2次口服）。2组治疗前均行肺功能及血IL-17、CRP检测。4周后复测肺功能及IL-17、CRP。结果治疗前2组肺功能及血IL-17、CRP比较差异无统计学意义（P〉0．05）；治疗后肺功能：FEV1％pred、FEV1／FVC、最大呼气流速％pred均改善，但2组间改善率比较，差异无统计学意义（P〉0．05），用力呼出气量为25％～75％肺活量时的平均流量（FEF25％-75％）占预计值百分比及FEF25％-75％／FVC明显高于对照组（P〈0．01），治疗组血IL-17、CRP水平下降高于对照组（P〈0．01）。结论茶碱能更好的控制哮喘患者的小气道功能及气道炎症，并改善气道高反应性。

关键词：支气管哮喘茶碱肺功能白介素17 C反应蛋白

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Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Assessment of Lung Cancer Risk on the Basis of a Biomarker P...

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2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： sun,nan Florence,Guida Bantis,LeonidasE. Muller,DavidC. Li,Peng Taguchi,Ayumu Dhillon,Dilsher kundnani,DeepaliL. Patel,nikulJ. Yan,Qingxiang Byrnes,Graham Moons,karelG.M. Tj?nneland,Anne Panico,Salvatore Claudia ,Agnoli Vineis,Paolo Palli,Domenico Bueno-de-Mesquita,Bas Peeters,PetraH. Agudo,Antonio Huerta,JoseM. Dorronsoro,Miren Barranco,MiguelRodriguez Ardanaz,Eva Travis,RuthC. Byrne,karlSmith Boeing,Heiner Steffen,Annika kaaks,Rudolf Hüsing,Anika Trichopoulou,Antonia Lagiou,Pagona LaVecchia,Carlo Severi,Gianluca Boutron-Ruault,Marie-Christine Sandanger,TorkjelM. Weiderpass,Elisabete n?st,ThereseH. Tsilidis,kostas Riboli,Elio Grankvist,kjell Johansson,Mikael Goodman,GaryE. Feng,Ziding Brennan,Paul Johansson,Mattias Hanash,Samir M. The University of Texas MD Anderson Cancer Center Genetic Epidemiology Group International Agency for Research on Cancer Department of Biostatistics The University of Texas MD Anderson Cancer Center Department of Epidemiology and Biostatistics Imperial College London School of Public Health Laboratory of Population Health Max Planck Institute for Demographic Research Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Environment and Radiation Section International Agency for Research on Cancer Department of Epidemiology Julius Center for Health Sciences and Primary CareUniversity Medical Center Unit of Diet Genesand EnvironmentDanish Cancer Society Research Center Department of Clinical Medicine and Surgery Federico Ⅱ University Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Molecular and Genetic Epidemiology Unit Human Genetics Foundation Cancer Risk Factors and Life-Style Epidemiology Unit Cancer Research and Prevention Institute-Istituto per lo Studio ela Prevenzione Oncologica Department for Determinants of Chronic Diseases National Institute for Public Health and the Environment Unit of nutirition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of OncologyBellvitge Institute for Biomedical Research (IDIBELL)L’Hospitalet de Llobregat Department of Epidemiology Murcia Regional Health Council Biomedical Research Institute of Murcia(IMIB-Arrixaca) Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP) Public Health Direction and Biodonostia Research Institute-CIBERESP Escuela Andaluza de Salud Pública Instituto de Investigación Biosanitaria Hospitales Universitarios de Granada/Universidad de Granada Epidemiology Preventionand Promotion Health ServiceNavarra Public Health Institute Instituto de Investigación Sanitaria de navarra (IdiSnA) Navarra Institute for Health Research Cancer Epidemiology Unit Nuffield Department of Population HealthUniversity of Oxford Department of Epidemi

IMPORTAnCE:There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of ***:To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.

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