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Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective

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World journal of Gastrointestinal Endoscopy 2023年第6期15卷 458-468页

作者： Mike T Wei Margaret j Zhou Andrew A Li Andrew Ofosu joo Ha Hwang shai Friedland Department of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCA 94306United States Department of Gastroenterology University of Cincinnati College of MedicineCincinnatiOH 45267United States

BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence *** submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the *** To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for *** The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and ***-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential ***≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were *** primary outcome was recurrence on *** A total of 376 patients and 428 polyps were *** polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(Pjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic *** found factors including resection by ESD,en bloc removal,and use of circumferentia

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Recurrence Colonoscopy Polypectomy

“绿色发展”的深层次逻辑与可行性路径——基于空间正义视角的探讨

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北京理工大学学报（社会科学版） 2017年第1期19卷 28-34页

作者：张晒东南大学公共管理系南京210096

伴随着中国经济建设与生态(环境)之间矛盾的日益突出,中国政府选择了"绿色发展"的理念。中国推行"绿色发展"是修复和维护"空间正义"的必然选择———这是中国"绿色发展"的深层次逻辑。根据"绿色发展"的深层次逻辑,"绿色发展"必须要在"... 详细信息

伴随着中国经济建设与生态(环境)之间矛盾的日益突出,中国政府选择了"绿色发展"的理念。中国推行"绿色发展"是修复和维护"空间正义"的必然选择———这是中国"绿色发展"的深层次逻辑。根据"绿色发展"的深层次逻辑,"绿色发展"必须要在"空间正义"的框架内及其主导下展开——守住空间中各事物之间的界限,即根据各事物的固有属性及其意义划清其空间界限并守住其界限;发挥再分配的调节与救助作用,即通过经济援助和技术援助来帮助落后国家和地区改善生产方式和提高发展水平,通过税收和财政转移支付帮助处于贫困状态尤其是濒临"绝望交易"的民众提高生活能力和改善生活水平;引导大众的"绿色发展"行为,即通过选择性激励来引导民众践行"绿色发展"理念。

关键词：人与自然绿色发展空间正义空间限界

Evaluation of computer aided detection during colonoscopy among Veterans:Randomized clinical trial

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Artificial Intelligence in Medical Imaging 2023年第1期4卷 1-9页

作者： Mike T Wei Yu Chen Susan Y Quan jennifer Y Pan Robert j Wong shai Friedland Department of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCA 94305United States Department of Gastroenterology and Hepatology Veterans Affairs Palo Alto Health Care SystemPalo AltoCA 94305United States

BACKGROUND There has been significant interest in use of computer aided detection(CADe)devices in colonoscopy to improve polyp detection and reduce miss *** To investigate the use of CADe amongst *** Between September 2020 and December 2021,we performed a randomized controlled trial to evaluate the impact of *** at Veterans Affairs Palo Alto Health Care System presenting for screening or low-risk surveillance were randomized to colonoscopy performed with or without *** outcomes of interest included adenoma detection rate(ADR),adenomas per colonoscopy(APC),and adenomas per *** addition,we measured serrated polyps per colonoscopy,non-adenomatous,non-serrated polyps per colonoscopy,serrated polyp detection rate,and procedural *** A total of 244 patients were enrolled(124 with CADe),with similar patient characteristics(age,sex,body mass index,indication)between the two *** of CADe was found to have decreased number of adenomas(1.79 vs 2.53,P=0.030)per colonoscopy compared to without *** was no significant difference in number of serrated polyps or non-adenomatous non-serrated polyps per colonoscopy between the two ***,use of CADe was found to have lower ADR(68.5%vs 80.0%,P=0.041)compared to without use of *** polyp detection rate was lower with CADe(3.2%vs 7.5%)compared to without CADe,but this was not statistically significant(P=0.137).There was no significant difference in withdrawal and procedure times between the two groups or in detection of adenomas per extraction(71.4%vs 73.1%,P=0.613).No adverse events were *** While several randomized controlled trials have demonstrated improved ADR and APC with use of CADe,in this RCT performed at a center with high ADR,use of CADe was found to have decreased APC and *** studies are needed to understand the true impact of CADe on performance quality among endoscopists as well as determine criteria for endoscopis

关键词： Colonoscopy Colorectal cancer prevention Artificial intelligence Computer aided detection Adenoma detection rate

以嵌入式自主提升再分配能力:国家介入共同富裕的优先逻辑和实现路径

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理论月刊 2024年第11期 24-34,159页

作者：张晒安徽大学社会与政治学院政治学系

实现全体人民共同富裕需要强大的国家再分配能力。国家再分配能力在很大程度上取决于国家所掌握的财富与资源的数量,以及国家运用其所掌握的财富与资源对社会进行有效调节的能力,而后者主要受制于国家隔离性与国家嵌入性两个关键因素。... 详细信息

实现全体人民共同富裕需要强大的国家再分配能力。国家再分配能力在很大程度上取决于国家所掌握的财富与资源的数量,以及国家运用其所掌握的财富与资源对社会进行有效调节的能力,而后者主要受制于国家隔离性与国家嵌入性两个关键因素。国家隔离性与国家嵌入性皆弱或者错位,均会导致国家再分配能力不足。增强国家再分配能力,需要让代表国家隔离性的国家自主与代表国家嵌入性的国家与社会合作维持平衡,即国家要树立严正形象并营造亲和力,要遇事有担当并争取社会支持,要勇于负责并善于合理分责。

关键词：共同富裕国家与社会嵌入式自主再分配能力

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共同富裕取得实质性进展的共同责任体系及其运行机制

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理论月刊 2022年第5期 32-41页

作者：张晒安徽大学社会与政治学院安徽合肥230601

共同富裕不是同步富裕、同等富裕,是共同而有差别的富裕。社会合力的作用可以推进共同而有差别的富裕。社会合力的凝聚根本上取决于共同责任。共同责任是共同而有差别的责任,包括政府正当调配责任、企事业单位基础性增长责任、富裕阶层... 详细信息

共同富裕不是同步富裕、同等富裕,是共同而有差别的富裕。社会合力的作用可以推进共同而有差别的富裕。社会合力的凝聚根本上取决于共同责任。共同责任是共同而有差别的责任,包括政府正当调配责任、企事业单位基础性增长责任、富裕阶层人道回馈责任、中等收入群体包容互助责任、相对贫困群体主体内生责任。五个主体的共同而有差别的责任集成共同责任体系。共同责任体系不会自动运转生效,必须进行“制度化”,即需要构建共同责任体系的运行机制。共同责任体系的运行机制包括动员机制、协商机制、监督机制、激励机制。

关键词：共同富裕实质性进展共同责任责任集成责任制度化

The miR166-SIHB15A regulatory module controls ovule development and parthenocarpic fruit set under adverse temperatures in tomato

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Molecular Plant 2021年第7期14卷 1185-1198页

作者： Christian Clepet Ravi Sureshbhai Devani Rachid Boumlik Yanwei Hao Halima Morin Fabien Marcel Marion Verdenaud Brahim Mania Gwilherm Brisou Sylvie Citerne Gregory Mouille jean-Christophe Lepeltier shai Koussevitzky Adnane Boualem Abdelhafid Bendahmane Institute of Plant Sciences Paris-Saclay INRAECNRSUniversite Paris-SaclayOrsay 91405France HM Clause Mas Saint-PierreQuartier La GalineSaint-Remy de Provence 13210France Hazera Seeds Ltd Berurim M.P.Shikmim 7983700Israel lnstitut jean-Pierre Bourgin INRAEVersaillesFrance Present address:Key Laboratory of Horticultural Crop Biology and Germplasm Innovation in South China College of HorticultureSouth China Agricultural UniversityGuangzhou 510642China

Fruit set is inhibited by adverse temperatures,with consequences on *** isolated a tomato mutant producing fruits under non-permissive hot temperatures and identified the causal gene as SIHB15A,belonging to classⅢhomeodomain leucine-zipper transcription ***15A,loss-of-function mu-tants display aberrant ovule development that mimics transcriptional changes occurring in fertilized ovules and leads to parthenocarpic fruit set under optimal and non-permissive temperatures,in field and greenhouse *** cold growing conditions,SIHB15A is subjected to conditional haploinsufficiency and recessive dosage sensitivity controlled by microRNA 166(miR166).Knockdown of SIHB15A alleles by miR166 leads to a continuum of aberrant ovules correlating with parthenocarpic fruit *** with this,plants harboring an Slhb15a-miRNA166-resisiant allele developed normal ovules and were unable to set parthenocarpic fruit under cold *** affinity purification sequencing and RNA-sequencing analyses revealed that SIHB15A is a bifunctional transcription factor expressed in the ovule ***15A binds to the promoters of auxin-related genes to repress auxin signaling and to the promoters of ethylene-related genes to activate their expression.A survey of tomato genetic biodiversity identified pat and pat-1,two historical parthenocarpic mutants,as alleles of *** together,our findings demonstrate the role of SIHB15A as a sentinel to prevent fruit set in the absence of fertilization and provide a mean to enhance fruiting under extreme temperatures.

关键词： parthenocarpy dosage sensitivity HD-Ziplll miRNA166 heat stress cold stress

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降低苎麻纱毛羽的技术措施

毛纺科技 2012年第7期40卷 8-11页

作者：赵筛喜泰州职业技术学院江苏泰州225300

研究络筒、浆纱工序减少31.3 tex麻纱毛羽的措施。运用对比试验的方法,对络筒速度、络筒张力、毛羽消除器、双浸双压上浆工艺、上浆率、回潮率、浆料配方、湿分绞根数等工艺因素进行研究,并优选出合理的工艺参数。试验结果表明:络筒速... 详细信息

研究络筒、浆纱工序减少31.3 tex麻纱毛羽的措施。运用对比试验的方法,对络筒速度、络筒张力、毛羽消除器、双浸双压上浆工艺、上浆率、回潮率、浆料配方、湿分绞根数等工艺因素进行研究,并优选出合理的工艺参数。试验结果表明:络筒速度越大,毛羽越多;络筒张力过大或过小都不利于降低纱线毛羽;选用低黏度成膜性好的浆料,采用"高浓度、低回潮、高上浆、双浸双压、湿分绞"的工艺路线,能显著降低麻纱毛羽,并把布机断头率降低到0.6根/(台.h)以下。

关键词：苎麻纱络筒浆纱毛羽工艺

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苎麻织物的设计与生产

毛纺科技 2007年第11期35卷 36-39页

作者：赵筛喜泰州职业技术学院江苏泰州225300

系统介绍了苎麻织物的设计和生产过程。通过市场调研、理论分析和对比试验分析,设计出一款纯麻织物,优选出合理的浆纱、织造等工序的工艺参数,并在实际应用中产生良好的效果,织机运转效率达到91%,入库一等品率达到99%。实践证明:合理的... 详细信息

系统介绍了苎麻织物的设计和生产过程。通过市场调研、理论分析和对比试验分析,设计出一款纯麻织物,优选出合理的浆纱、织造等工序的工艺参数,并在实际应用中产生良好的效果,织机运转效率达到91%,入库一等品率达到99%。实践证明:合理的浆纱工艺配方、布机上机工艺和较高的织造温湿度控制是取得良好质量的前提。

关键词：苎麻工艺生产

用羟基磷灰石纳米粒作内耳基因治疗新载体的体内外研究

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中华耳鼻咽喉头颈外科杂志 2008年第1期43卷 51-57页

作者：孙虹蒋明朱晒红中南大学湘雅三医院耳鼻咽喉头颈外科学教研室长沙410013 中南大学粉末冶金国家重点实验室

目的研制羟基磷灰石（hydroxyapatite，HAT）纳米粒，评价其作为新的内耳基因转染载体的可能性。方法用化学共沉淀-水热合成法制备HAT载体。经DNA电泳做不同pH值和HAT含量的DNA结合实验，了解HAT纳米粒对DNA的结合和保护作用；用四甲基... 详细信息

目的研制羟基磷灰石（hydroxyapatite，HAT）纳米粒，评价其作为新的内耳基因转染载体的可能性。方法用化学共沉淀-水热合成法制备HAT载体。经DNA电泳做不同pH值和HAT含量的DNA结合实验，了解HAT纳米粒对DNA的结合和保护作用；用四甲基偶氮唑盐法观察HAT纳米粒对宫颈癌上皮Hela细胞的毒性；用Hela细胞和小鼠耳蜗原代螺旋神经节细胞做神经营养素3（neurotrophin 3，NB）体外转染实验（绿色荧光蛋白基因荧光显微镜法）及NB的蛋白印迹分析，观察HAT介导的NB基因对活细胞的体外转染能力和基因表达情况；经实验性兴奋性耳毒性损伤豚鼠的耳蜗外淋巴腔灌注HAT纳米载体-含增强型绿色荧光蛋白（enhanced green fluorescent protein，EGFP）质粒载体-NT3基因复合物（HAT—pEGFPC2-NT3），用免疫组化（二氨基联苯胺法）观察NT3在耳蜗的表达，以了解HAT纳米载体在活体动物耳蜗介导基因转染的能力。结果含量250．0μg／ml，pH值3～7是这种长约40～50nm的短棒状HAT纳米粒能完全结合重组质粒pEGFPC2-NT3的最低含量混悬液和最佳pH环境，并可有效保护基因不被核酸酶（DNase Ⅰ）破坏。四甲基偶氮唑盐法观察HAT纳米粒从62．5μg／ml至500．0μg／ml4种混悬液对Hela细胞存活率无明显影响，细胞形态无变化。EGFP荧光显微镜观察显示，HAT纳米载体对Hela细胞的基因转染率为15．7％±2．6％（-↑x±s）；将HAT—pEGFPC2-NT3转染培养的小鼠耳蜗神经元，也可见明显的EGFP表达。NT3免疫组化显示，向实验性兴奋性耳蜗损害豚鼠的耳蜗外淋巴腔灌注HAT—pEGFPC2-NT3，可见活体耳蜗神经元内有明显的NT3蛋白表达。结论HAT纳米粒不仅可介导NT3基因的体外转染，而且可介导其耳蜗活体转染；尽管转染率有待提高，但由于没有病毒载体转染造成的生物威胁，仍不失为一种很有研究价值的非病毒型内耳基因治疗载体。

关键词：基因疗法药物载体羟基磷灰石类耳蜗