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Systems Approaches to Biology and Disease Enable Translational Systems Medicine

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Genomics, Proteomics & Bioinformatics 2012年第4期10卷 181-185页

作者： leroy hood Qiang Tian Institute for Systems Biology SeattleWA 98109-5234USA

The development and application of systems strategies to biology and disease are transforming medical research and clinical practice in an unprecedented rate. In the foreseeable future, clinicians, medical researchers, and ultimately the consumers and patients will be increasingly equipped with a deluge of personal health information, e.g., whole genome sequences, molecular profiling of diseased tissues, and periodic multi-analyte blood testing of biomarker panels for disease and wellness. The convergence of these practices will enable accurate prediction of disease susceptibility and early diagnosis for actionable preventive schema and personalized treatment regimes tailored to each individual. It will also entail proactive participation from all major stakeholders in the health care system. We are at the dawn of predictive, preventive, personalized, and participatory （P4） medicine, the fully implementation of which requires marrying basic and clinical researches through advanced systems thinking and the employment of high-throughput technologies in genomics, pro- teomics, nanofluidics, single-cell analysis, and computation strategies in a highly-orchestrated discipline we termed translational systems medicine.

关键词： Systems biology P4 medicine Family genome sequencing Targeted proteomics Single-cell analysis

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Organotypic Models for Functional Drug Testing of Human Cancers

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Biomedical Engineering Frontiers 2023年第1期4卷 103-112页

作者： Yu Ling Huang Lindsay K.Dickerson Heidi Kenerson Xiuyun Jiang Venu Pillarisetty Qiang Tian leroy hood Taranjit S.Gujral Raymond S.Yeung Division of Human Biology Fred Hutchinson Cancer CenterSeattleWAUSA Department of Surgery University of WashingtonSeattleWAUSA National Research Center for Translational Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Institute for Systems Biology Phenome Health InstituteSeattleWAUSA

In the era of personalized oncology,there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual *** ideal assay will serve as a diagnostic companion to inform the oncologist of the various treatments that are sensitive and insensitive,thus improving outcome while minimizing unnecessary toxicities and *** date,no such platform exists for clinical use,but promising approaches are on the horizon that take advantage of improved techniques in creating human cancer models that encompass the entire tumor microenvironment,alongside technologies for assessing and analyzing tumor *** review summarizes a number of current strategies that make use of intact human cancer tissues as organotypic cultures in drug sensitivity testing.

关键词： Cancer horizon Human

Human Gut Microbiota and Gastrointestinal Cancer

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 33-49页

作者： Changting Meng Chunmei Bai Thomas D. Brown leroy E. hood Qiang Tian Institute for Systems Biology Seattle WA 98109 USA Department of Oncology Peking Union Medical College Hospital Beijing 100730 China Swedish Cancer Institute Seattle WA 98104 USA P4 Medicine Institute Seattle WA 98109 USA

Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts to understand various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways. Further studies have suggested that the microbiota and their associated metabolites are not only closely related to carcinogenesis by inducing inflammation and immune dysregulation, which lead to genetic instability, but also inter- fere with the pharmacodynamics of anticancer agents. In this article, we mainly reviewed the influ- ence of gut microbiota on cancers in the gastrointestinal （GI） tract （including esophageal, gastric, colorectal, liver, and pancreatic cancers） and the regulation of microbiota by diet, prebiotics, pro- biotics, synbiotics, antibiotics, or the Traditional Chinese Medicine. We also proposed some new strategies in the prevention and treatment of GI cancers that could be explored in the future. We hope that this review could provide a comprehensive overview of the studies on the interactions between the gut microbiota and GI cancers, which are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention, diagnosis, and treatment.

关键词： Inflammation Immune regulation Microbial metabolites Carcinogenesis Traditional ChineseMedicine

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From Phage lambda to human cancer： endogenous molecular-cellular network hypothesis

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Frontiers of Electrical and Electronic Engineering in China 2013年第1期8卷 32-49页

作者： Gaowei Wang Xiaomei Zhu leroy hood Ping Ao Ministry of Education Key Laboratory of Systems Biomedicine Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China State Key Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute Shanghai Jiao Tong University School of Medicine Shanghai 200032 China GenMath Corp. Seattle WA 98105 USA Institute for Systems Biology Seattle WA 98103 USA Department of Physics Shanghai Jiao Tong University Shanghai 200240 China

Experimental evidences and theoretical analyses have amply suggested that in cancer genesis and progression genetic information is very important but not the whole. Nevertheless, ＂cancer as a disease of the genome＂ is still currently the dominant doctrine. With such a background and based on the fundamental properties of biological systems, a new endogenous molecular-cellular network theory for cancer was recently proposed by us. Similar proposals were also made by others. The new theory attempts to incorporate both genetic and environmental effects into one single framework, with the possibility to give a quantitative and dynamical description. It is asserted that the complex regulatory machinery behind biological processes may be modeled by a nonlinear stochastic dynamical system similar to a noise perturbed Morse-Smale system. Both qualitative and quantitative descriptions may be obtained. The dynamical variables are specified by a set of endogenous molecular-cellular agents and the structure of the dynamical system by the interactions among those biological agents. Here we review this theory from a pedagogical angle which emphasizes the role of modularization, hierarchy and autonomous regulation. We discuss how the core set of assumptions is exemplified in detail in one of the simple, important and well studied model organisms, Phage lambda. With this concrete and quantitative example in hand, we show that the application of the hypothesized theory in human cancer, such as hepatocellular carcinoma （HCC）, is plausible, and that it may provide a set of new insights on understanding cancer genesis and progression, and on strategies for cancer prevention, cure, and care.

关键词： Phage Lambda Intrinsic State Adaptive Landscape Regulatory Machinery Genetic Switch

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超越疾病,实现科学保健

空中英语教室（高级版．彭蒙惠英语） 2021年第12期 14-15,40,41页

作者： leroy hood 徐佩仪(译) 不详

这次新冠疫情让疾病显得更加危险,同时也凸显出“整体健康”在预防疾病与优化医疗上的关键性。我们了解这一点,因为新冠肺炎对慢性病患者与生活方式不健康者的影响格外严重,身为在医学、工程学、遗传学最尖端领域工作了数十载的科学家,... 详细信息

这次新冠疫情让疾病显得更加危险,同时也凸显出“整体健康”在预防疾病与优化医疗上的关键性。我们了解这一点,因为新冠肺炎对慢性病患者与生活方式不健康者的影响格外严重,身为在医学、工程学、遗传学最尖端领域工作了数十载的科学家,我努力想赋予身心整体健康所应得的科学严谨与迫切性。在极小化疾病、延长生命长度与强化生命品质方面,没有医生、政策或突破性药物能像“整体健康”这么有效。

关键词：慢性病患者整体健康尖端领域预防疾病极小化工程学遗传学生命品质

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生物技术和未来的医学

遗传工程 1984年第2期 46-50页

作者： leroy hood M.Hunkapiller 沈菲

八十年代看来是生物技术的时代。近来生物技术的惊人进展为解决医学、农业、能源和化学合成的基础和应用问题提供了广阔的天地。本文将讨论生物技术的两个领域—重组DNA技术和微量化学仪器以及它们对未来医学的影响。

关键词： DNA 限制性人类遗传病人类基因超微量化学核酸内切限制酶干扰素基因信息基因基因指纹图谱胎儿细胞羊膜穿刺术生物技术合成仪医学现代医药学