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Association between Life’s Essential 8 and Cerebral Small Vessel Disease

Stroke & Vascular Neurology 2024年第5期9卷 481-489页

作者： Dandan Liu Xueli Cai Yingying Yang Suying Wang lerong mei Jing Jing Shan Li Mengxing Wang Yun Chen Xia Meng Tiemin Wei Yongjun Wang Yilong Wang Yuesong Pan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijingPeople's Republic of China Department of Neurology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Lishui Clinical Research Center for Neurological Diseases The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Cerebrovascular Research Lab The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Department of Cardiology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina

Background Given that associations of Life’s Essential 8(LE8)and cerebral small vessel disease(CSVD)or its imaging markers were unclear,we examined relationship between *** The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events *** calculated the total LE8 score,medical LE8 score and behavioural score,and categorised them into low(10)was allocated one *** on modified total CSVD score(0–6 points),WMH or CMB was modified to three grades,and BG-EPVS(N>20)was allocated one *** Among 3061 participants in this study,1424(46.5%)were *** LE8 score was associated with lower total CSVD score(moderate vs low:cOR 0.78,95%CI 0.63 to 0.96;high vs low:cOR 0.44,95%CI 0.33 to 0.59),and the medical score was inversely related to the total CSVD ***,the medical score was inversely related to odds of WMH(p<0.05),modified WMH(p<0.05),lacunes(p<0.05)or BG-EPVS(p<0.05),and the behavioural score were inversely related to the odds of lacunes and *** Higher LE8 score which indicates better cardiovascular status was associated with lower burden of CSVD and its MRI *** studies are needed to examine the causality.

关键词： cerebral behaviour Essential

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Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease:a population-based study

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Stroke & Vascular Neurology 2023年第5期8卷 413-423,I0031-I0050页

作者： Yu Tian Xueli Cai Yijun Zhou Aoming Jin Suying Wang Yingying Yang lerong mei Jing Jing Shan Li Xia Meng Tiemin Wei Tao Liu Yongjun Wang Yuesong Pan Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Neurology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Cerebrovascular Research Lab The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Department of Cardiology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina

Objective This study aims to investigate the associations of glymphatic system with the presence,severity and neuroimaging phenotypes of cerebral small vessel disease(CSVD)in a community-based *** This report included 2219 community-dwelling people aged 50-75 years who participated in the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events *** diffusivity along perivascular spaces based on diffusion tensor imaging(DTI-ALPS index)was measured to assess glymphatic *** presence and severity of CSVD were estimated using a CSVD score(points from 0 to 6)and a modified CSVD score(points from 0 to 4),which were driven by 4 neuroimaging features of CSVD,including white matter hyperintensity(WMH),enlarged perivascular spaces(EPVS),lacunes,cerebral *** atrophy(BA)was also *** or ordinal logistic regression analyses were carried out to investigate the relationships of DTI-ALPS index with *** The mean age was 61.3(SD 6.6)years,and 1019(45.9%)participants were *** average DTI-ALPS index was 1.67±*** in the first quartile(Q1)of the DTI-ALPS index had higher risks of the presence of CSVD(OR 1.77,95%CI 1.33 to 2.35,p<0.001),modified presence of CSVD(odds ratio(OR)1.80,95%CI 1.38 to 2.34,p<0.001),total burden of CSVD(common OR(cOR)1.89,95%CI 1.43 to 2.49,p<0.001)and modified total burden of CSVD(cOR 1.95,95%CI 1.51 to 2.50,p<0.001)compared with those in the fourth quartile(Q4).Additionally,individuals in Q1 of the DTI-ALPS index had increased risks of WMH burden,modified WMH burden,lacunes,basal ganglia-EPVS and BA(all p<0.05).Conclusion A lower DTI-ALPS index underlay the presence,severity and typical neuroimaging markers of CSVD,implying that glymphatic impairment may interact with CSVD-related pathology in the general ageing population.

关键词： cerebral lymphatic severity

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PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)-a population-based prospective cohort study: rationale, design and baseline participant characteristics

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Stroke & Vascular Neurology 2021年第1期6卷 145-151页

作者： Yuesong Pan Jing Jing Xueli Cai Yilong Wang Suying Wang Xia Meng Chunlai Zeng Jiong Shi Jiansong Ji Jinxi Lin Lingchun Lyu Zhe Zhang lerong mei Shiping Li Shan Li Wanlin Zhu Hao Li Tiemin Wei Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Neurology Lishui HospitalZhejiang University School of MedicineLishuiChina Cerebrovascular Research Lab Lishui HospitalZhejiang University School of MedicineLishuiChina Department of Cardiology Lishui HospitalZhejiang University School of MedicineLishuiChina Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Lishui HospitalZhejiang University School of MedicineLishuiChina

Background and purpose Cardiovascular diseases and dementia are two major diseases in the *** is associated with future vascular events and cognitive *** PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events(PRECISE)study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive *** Between May 2017 and September 2019,the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in *** are collected in face-to face interviews at baseline,2-year and 4-year follow-up *** MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 ***/cerebrovascular events and cognitive assessment will be prospectively collected after the *** and urine samples were collected and biomarkers were tested at *** A total of 3067 subjects were enrolled,among which 53.5%were female with an average age of 61.2±6.7 *** them,2.8%,8.1%,43.1%and 21.6%had a history of stroke,coronary heart diseases,hypertension and diabetes mellitus,*** The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging *** from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment.

关键词： prospective Blood PRECIS

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心脑血管疾病高危人群首发缺血性脑卒中的影响因素分析

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护理与康复 2021年第11期20卷 1-6页

作者：宋佳梅乐荣李珊陈美芬丽水市中心医院浙江丽水323000

目的分析心脑血管疾病高危人群首发缺血性脑卒中的影响因素。方法选取心脑血管疾病高危人群655例,按照是否首次发生缺血性脑卒中分为脑卒中组和非脑卒中组,采用一般情况调查表、半定量食物频率问卷、国际体力活动问卷、一般键康问卷、Mo... 详细信息

目的分析心脑血管疾病高危人群首发缺血性脑卒中的影响因素。方法选取心脑血管疾病高危人群655例,按照是否首次发生缺血性脑卒中分为脑卒中组和非脑卒中组,采用一般情况调查表、半定量食物频率问卷、国际体力活动问卷、一般键康问卷、Morisky服药依从性量表、慢性病自我效能量表对两组进行分析。采用单因素分析、多元Logistic回归分析探讨心脑血管疾病高危人群首发缺血性脑卒中的影响因素。结果多元Logistic回归分析显示,膳食纤维(OR=0.333,95%CI=0.232~0.647)、胆固醇摄入(OR=3.535,95%CI=2.965~11.012)、体力活动(OR=0.100,95%CI=0.012~0.818)、服药依从性(OR=0.250,95%CI=0.102~0.337)和自我效能(OR=0.731,95%CI=0.604~0.884)是心脑血管疾病高危人群首发缺血性脑卒中的影响因素(P<0.05)。结论心脑血管疾病高危人群的服药依从性、生活方式、自我效能与首发缺血性脑卒中相关,医护人员应加强心脑血管疾病高危人群的健康宣教指导。

关键词：心脑血管疾病高危人群脑卒中影响因素

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