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在经皮球囊二尖瓣成形术中非侵入性评估二尖瓣面积:实时3D超声心动图的作用

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 32-33页

作者： Zamorano J. perez de isla L. 高登峰

In the last decade, multiple studies depicted discrepancies between mitral valvular orifice area(MVA) measurements obtained with the pressure half-time(PHT) method and invasive methods during the immediate post-percutaneous mitral valvuloplasty(PMV) period. Our aim was to assess the accuracy of Real-Time 3D echo(RT3D) to measure the MVA in the immediate post-PMV period. The invasively determined MVA was used as the gold standard. We studied 29 patients with rheumatic mitral stenosis from two centres(27 women; mean age 48.2±11.3 years), all of which had underwent PMV. MVA was calculated before and after PMV using the PHT method, 2D echo planime try, RT3D echo planimetry and invasive determination (Gorlin’s method). The RT3D MVA assessment showed a better agreement with the invasively derived MVA before and in the immediate post-PMV period (Bland-Altman analysis: Average difference between both methods and limits of agreement: 0.01(-0.31 to 0.33) cm2 and -0.12(-0.71 to 0.47) cm2) before and immediately after the PMV, respectively. RT3D is a feasible and accurate technique for measuring MVA in patients with RMVS. It has the best agreement with the invasively determined MVA, particularly in the immediate post-PMV period.

关键词：二尖瓣面积超声心动图瓣口面积金指标面积法

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首次心肌梗死前二尖瓣反流对预后的影响

世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 47-47页

作者： Zamorano J. perez de isla L. Oliveros L. 郭战宏 Echocardiogr./Cardiovasc. I. L. Hospital Clinico San Carlos Plaza de Cristo Rey 28040 Madrid Spain

Aims Mitral regurgitation(MR) following an acute myocardial infarction(AMI) confers an adverse prognosis during long term follow- up. There are no studies evaluating the influence of pre- AMI MR in the short- and long- term prognosis of such patients. Our aim was to assess the prognostic value of pre- AMI MR in the short and long- term follow- up of patients who suffered a first AMI and to assess its influence on left ventricular haemodynamics. Methods and results Sixty- eight consecutive patients with a first AMI and an echocardiographic study before AMI(ded in the study. The pre- AMI echo was performed for various reasons. Of these 68 patients, 42 had pre- AMI MR(Group 1) and 26 showed no pre- AMI MR(Group 2). The presence of degenerative changes at the level of the mitral valve was confirmed in all cases. Patients with any other cause of MR were excluded. Clinical and echocardiographic variables for both phases(pre- AMI and post- AMI) were analysed and patients were followed up. Mean age was 75.5± 9.5 years; there were 38 males(55.9% ). There were no statistical differences in baseline clinical variables between the groups, except for the presence of pre- AMI atrial fibrillation, which was more frequent in Group 1(21.4 vs. 0% ; P=0.01 ). After AMI, only end- diastolic left ventricular diameter was significantly larger in Group 1(54.9± 4.7 vs. 48.1± 5.6 mm; Pdence interval): 3.8(1.1- 13.1); P=0.037]. Conclusion The present study shows that the presence of pre- AMI MR is an independent prognostic marker among those patients suffering a first AMI.

关键词：二尖瓣反流超声检查超声心动图血流动力学预后预测中位生存时间临床参数预后指标四分位数多变量分析

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首次非ST段抬高型急性冠状动脉综合征后功能性二尖瓣反流的预后意义

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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 24-24页

作者： perez de isla L. Zamorano J. Quezada M. 韩瑞娟 Instituto Cardiovascular Echocardiographic Laboratory Hospital Clnico San Carlos Plaza Cristo Rey 28040 Madrid Spain

目的:急性心肌梗死(AMI)后发生二尖瓣反流(MR)已被公认为是一种常见的并发症,其对存活率的负面影响已有观察。然而,关于非ST段抬高型急性冠状动脉综合征(NSTSEACS)后发生MR的资料少见。本研

关键词：急性冠状动脉综合征预后意义 LVEF ST

Cell Stress by Phosphate of Two Protozoa Tetrahymena thermophila and Tetrahymena pyriformis

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Advances in Bioscience and Biotechnology 2017年第12期8卷 451-462页

作者： Papa Daouda Mar Bouchra El Khalfi Jose Roman perez-Castineira Aurelio Serrano Abdelaziz Soukri Laboratory of Physiopathology Genetics Molecular and Biotechnology(PGMB)Faculty of Sciences Ain ChockUniversity Hassan Ⅱ of CasablancaCasablancaMorocco Instituto de Bioquímica Vegetal y Fotosíntesis CSIC-Universidad de SevillaCentro de Investigaciones Científicas“Isla de la Cartuja”SevillaSpain

Phosphorus is one of the bioelements most needed as a compound cell by living organisms. Phosphorus is involved in several pathologies: in human with bone and kidney diseases, in mammals with metabolism disorder (glucose, insulin···), in microorganisms whose phosphorus is involved in cell growth. Phosphorus has various forms including pyrophosphate, a by-product of multiple pathways of biosynthesis. Enzymes that hydrolyze pyrophosphate are called inorganic pyrophosphatases (PPases). Two major types of inorganic pyrophosphatases are distinguished: the soluble pyrophosphatases (sPPases) and the membrane pyrophosphatases (mPPases or H+/Na+-PPases). They play a key role in the control of intracellular inorganic pyrophosphate level and produce an important ions gradient (H+ or Na+) to the cells. In this work, we primarily focused on the physiological study in a phosphate-poor medium of two models Tetrahymena thermophile and Tetrahymena pyriformis, following the mobility, the growth and the morphology of cells. Secondly, we evaluated the enzymatic activity of soluble and membrane pyrophosphatases in both species grown in the same complex medium. A decrease of cell growth is correlated with unusual morphologies and different mobility in the stress medium. The measurement of soluble and membrane inorganic pyrophosphatases activities also shows a decrease which illustrates the lack of phosphate found in the stress medium. deficiency of phosphate is a limiting factor for protozoan growth. These results indicate that Tetrahymena can be used as a model of cellular stress and consists of a target to study inorganic pyrophosphatases for a better understanding of phosphate cycle in higher organisms.

关键词： Phosphorus Pyrophosphatases NBRIP Tetrahymena

Inorganic Pyrophosphatases:Study of Interest

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Advances in Bioscience and Biotechnology 2017年第10期8卷 388-397页

作者： Mar Papa Daouda El Khalfi Bouchra perez-Castineira Jose Roman Serrano delgado Aurelio Soukri Abdelaziz Laboratory of Physiopathology Genetics Molecular and Biotechnology(PGMB)Faculty of Sciences Ain ChockUniversity Hassan Ⅱ of CasablancaCasablancaMorocco Instituto de Bioquímica Vegetal y Fotosíntesis CSIC-Universidad de SevillaCentro de Investigaciones Científicas“Isla de la Cartuja”SevillaSpain

Inorganic pyrophosphatases are enzymes that catalyze the hydrolysis of inorganic pyrophosphate to orthophosphate. These enzymes are divided into two groups: the soluble pyrophosphatases and the membrane pyrophosphatases. They vary in structure and each has a determined catalysis mechanism. Soluble pyrophosphatases are ubiquitous enzymes and play a key role in regulating the rate of pyrophosphate and balance in this sense, the biosynthetic reactions. Membrane pyrophosphatases are ion pumps, producing a proton or sodium gradient, and provide critical energy reserves to organisms, especially during stress conditions. Several studies have shown that these enzymes are involved in numerous disorders (diseases, fault cell growth···). However they are potential targets for the development of agents against parasites. This article consists of a description of the different types, structures, catalytic properties of inorganic pyrophosphatases and their involvement in cellular metabolism.

关键词： Pyrophosphatases Structure Catalytic Activity Phylogeny Pathology

急性心肌梗死后参数成像定量心肌声学造影识别心肌顿抑

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 28-28页

作者： Serra V. perez de isla L. Ferro M. P. J. Zamorano 杨海涛 Instituto Cardiovascular Hospital Clnico San Carlos Madrid Spain Dr.

Microvascular integrity demonstrated by myocardial contrast echocardiography(MCE) predicts functional recovery after an acute myocardial infarction(AMI). Recently, parametric imaging-based quantitative MCE has been developed. Our aim was to assess the usefulness of parametric imaging-based quantitative MCE parameters to predict the functional recovery of akinetic segments after primary percutaneous transluminal coronary angioplasty(PTCA). Fifty-three consecutive patients with a first AMI were enrolled. They underwent primary PTCA. Standard echocardiography and real-time MCE were performed. Qualitative analysis and parametric imaging-based quantitative parameters were measured offline by different blinded investigators. Dobutamine stress echocardiography was performed 1 month later. A new standard echocardiogram to assess the functional status of the akinetic segments and coronary angiography to evaluate the presence of restenosis at the level of the culprit lesion were performed 6 months later. The mean patient age was 62.9±14 years, and 42 were men(79%); 170 segments were akinetic. Of these, 105(62%) recovered their function. The best parameter to predict functional recovery was the myocardial blood flow velocity(β). These results were better than those obtained using dobutamine stress echocardiography and qualitative MCE to predict functional recovery. In conclusion, parametric imaging-based quantitative MCE is an accurate diagnostic tool to detect stunned myocardium after AMI. Its diagnostic accuracy in predicting the functional recovery of akinetic segments after primary PTCA is better than the accuracy of dobutamine stress echocardiography and qualitative MCE.

关键词：心肌声学造影急性心肌梗死心肌顿抑负荷超声心动图心肌节段冠状动脉造影再狭窄多巴酚丁胺心肌血流功能恢复情况

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