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The differential genetic signatures related to climatic landscapes for jaguars and pumas on a continental scale

Integrative Zoology 2021年第1期16卷 2-18页

作者： Marina ZANIN Noa GONZALEZ-BORRAJO Cuauhtémoc CHÁVEZ Yamel RUBIO Bart HARMSEN Claudia KELLER Pablo VILLALVA Ana Carolina SRBEK-ARAUJO leonora pires costa Francisco PALOMARES Biology Department Federal University of MaranhãoSão LuísBrazil Departamento de Biologia de la Conservación Estación Biológica de DoñanaSevillaSpain Departamento de Ciencias Ambientales Universidad Autónoma MetropolitanaMexico CityMexico Escuela de Biologia Universidad Autónoma de SinaloaCuliacánMexico Panthera New YorkUSA Biodiversity Coordination Amazon Research InstituteManausBrazil Biology Department Vila Velha UniversityVila VelhaBrazil Biological Sciences Department Federal University of Espírito SantoVitóriaBrazil

Modern and paleoclimate changes may have altered species dynamics by shifting species’niche suitability over space and *** analyze whether the current genetic structure and isolation of the two large American felids,jaguar(Panthera onca)and puma(Puma concolor),are mediated by changes in climatic suitability and connection routes over modern and paleoclimatic *** estimate species distribution under 5 climatic landscapes(modern,Holocene,last maximum glaciations[LMG],average suitability,and climatic instability)and correlate them with individuals’genetic isolation through causal modeling on a resemblance *** species exhibit genetic isolation patterns correlated with LMG climatic suitability,suggesting that these areas may have worked as“allele refuges.”However,the jaguar showed higher vulnerability to climate changes,responding to modern climatic suitability and connection routes,whereas the puma showed a continuous and gradual transition of genetic *** differential responsiveness to climate change,both species are subjected to the climatic effects on genetic configuration,which may make them susceptible to future climatic changes,since these are progressing faster and with higher intensity than changes in the ***,the effects of climatic changes should be considered in the design of conservation strategies to ensure evolutionary and demographic processes mediated by gene flow for both species.

关键词： causal modeling climatic landscape ecological niche modeling gene flow linear mixed model

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An illustrated checklist of macrofaunal molluscs from soft-sediments of the Abrolhos Parcel(northeastern,Brazil)with 15 new records

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Journal of Oceanology and Limnology 2021年第2期39卷 671-682页

作者： Flávia Maria Pereira da costa Ana Maria Setubal pires-VANIN Departamento de Oceanografi a Biológica Instituto Oceanográfi coUniversidade de São PauloSão Paulo 05508-120Brazil

Comprehensive understanding of marine biodiversity is essential for conservation,especially for vulnerable *** this paper,we implemented and illustrated a checklist of molluscs from the Abrolhos Parcel,Brazil,the most important coralline area in South Atlantic *** list features 100 species belonging to 4 classes and 85 genera,of which 15 are new records for Bahia State,northeast *** results highlight the potential for new records in the *** species came from 54 unconsolidated sediment samples collected from the bottom of the reef with a 0.042-m^(2) van Veen *** the listed species,Curveulima sp.,Notarchus *** Guyanella clenchi are new records for the South Atlantic,while Caecum metamorphosicum,Eratoidea janeiroensis,Volvarina serrei,Solemya notialis,Solariorbis shimeri,and Amphithalamus glabrus are endemic to Brazilian waters.A comparison of our results with those obtained in other reef environments indicates that the Abrolhos Parcel has a rich malacofauna and suggests that many more species can still be found with more samplings.

关键词： Bivalvia Gastropoda micromolluscs Scaphopoda Solenogastres southwest Atlantic

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GO FAIR Brazil:A Challenge for Brazilian Data Science

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Data Intelligence 2020年第1期2卷 238-245,316,317页

作者： Luana Sales Patricia Henning Viviane Veiga Maira Murrieta costa Luis Fernando Sayao Luiz Olavo Bonino da Silva Santos Luis Ferreira pires Instituto Brasileiro em Informacao em Ciencia e Tecnologia Rio de Janeiro-RJ22290-160Brazil Universidade Federal do Estado do Rio de Janeiro Rio de Janeiro-RJ22290-240Brazil Fundacao Oswaldo Cruz Rio de Janeiro-RJ21040-900Brazil Ministerio da Ciencia TecnologiaInovacoes e ComunicacoesEsplanada dos MinisteriosBloco R-BrasiliaDFCEP 70067-900Brazil Comissao Nacional de Energia Nuclear Rua Gal.Severianon 90 Bairro:BotafogoCEP 22290-901-Rio de JaneiroBrazil GO FAIR International Support&Coordination Office(GFISCO) Leiden 2333 AAThe Netherlands University of Twente Enschede 7522 NHThe Netherlands

The FAIR principles,an acronym for Findable,Accessible,Interoperable and Reusable,are recognised worldwide as key elements for good practice in all data management *** understand how the Brazilian scientific community is adhering to these principles,this article reports Brazilian adherence to the GO FAIR initiative through the creation of the GO FAIR Brazil Office and the manner in which they create their implementation *** contextualise this understanding,we provide a brief presentation of open data policies in Brazilian research and government,and finally,we describe a model that has been adopted for the GO FAIR Brazil implementation *** Brazilian Institute of Information in Science and Technology is responsible for the GO FAIR Brazil Office,which operates in all fields of knowledge and supports thematic implementation ***,GO FAIR Brazil-Health is the first active implementation network in operation,which works in all health domains,serving as a model for other fields like agriculture,nuclear energy,and digital humanities,which are in the process of adherence *** report demonstrates the strong interest and effort from the Brazilian scientific communities in implementing the FAIR principles in their research data management practices.

关键词： FAIR principles GO FAIR GO FAIR Brazil Open Science Research data

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Therapeutic Approaches to Post-Mastectomy Pain Syndrome

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Journal of Biosciences and Medicines 2023年第12期11卷 304-317页

作者： Vanessa Ferreira Dias Duarte Da costa Giovanna Schwarz Mazzucca Carlos Augusto pires Zerbini Oscar César pires Camila Dos Santos Leite Laboratory of Pharmacology and Physiology Department of Medicine Taubaté University Taubaté Brazil

Background: Breast cancer is increasingly common in society and post-mastectomy pain is a striking condition associated with surgery, both intra and postoperatively. The post-mastectomy syndrome is characterized by the persistence of pain for more than 3 months after the procedure. It is mostly of neuropathic origin and is highly refractory to treatments, which vary from clinical to surgical measures and alternative techniques. In this context, it is essential to understand the possible approaches to these patients. Objective: Understand alternatives for pain management in patients undergoing mastectomy, especially in those in whom pain persists for more than 3 months. Methods: Systematic literature review, conducted in the Virtual Health Library databases includes: Lilacs, SciELO, Medline, PubMed and Cochrane between 2018 and 2023, restricted to articles in English with the descriptors: Mastectomy, chronic Pain, Nerve Blocks and Breast Cancer. 317 articles were found involving the descriptors presented, all in English. After reading the abstracts, 28 articles were selected. Results: This review analyzed 28 scientific studies that rigorously met the previously established characteristics in the sample selection. The synthesis included the following aspects: author/year of publication, article title, objective, type of study and database. Conclusion: It was concluded that, according to the analyzed studies, post-mastectomy pain is a problem that has increased its incidence and that needs the attention of health professionals. The use of antineuropathic medications, nerve blocks, fat grafting, lymph node transplantation, therapy, physical activity and acupuncture are some examples of therapeutic approaches for these women. Therefore, the team must assist the patients, seeking to provide a better prognosis, quality of life and comfort.

关键词： Mastectomy Chronic Pain Nerve Blocks Breast Cancer

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Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells

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Cellular & Molecular Immunology 2015年第3期12卷 384-386页

作者： Liana Verinaud Luidy Kazuo Issayama Fabio Zanucoli Ana Carolina de Carvalho Thiago Alves da costa Rosaria Di Gangi Amanda pires Bonfanti Isadora Tassinari Ferreira Alexandre Leite Rodrigues de Oliveira Dagmar Ruth Stach Machado Rodolfo Thome Department of Structural and Functional Biology Institute of Biology University of Campinas SP Brazil

Tolerogenic dendritic cells （DCs） are widely studied for their possible use in the treatment of inflammatory disorders, such as autoimmune diseases. One of the obstacles for the use of this cell-based therapy is the characterization of drugs that are able to modulate DCs. We have previously shown that chloroquine （CQ）, an antimalarial agent, has the ability to modulate DCs towards a tolerogenic phenotype.1 These tolerogenic DCs are able to suppress the development of experimental autoimmune encephalomyelitis （EAE）, a T cell-driven mouse model of human multiple sclerosis. In addition, several studies have proposed that nitric oxide （NO） plays a major role in the dif- ferentiation of regulatory T cells （Tregs） and the suppression of Thl/Th17 cells.2＂3 However, little is known about the role of DC-derived NO in the modulation of inflammatory auto- immune responses. Thus, we aimed to evaluate whether NO plays a role in the tolerogenic activity of CQ-treated DCs （CQ- DCs）. We found that CQ induces DC production of NO and expression of indoleamine 2,3-dioxygenase （IDO）, as well as inducible nitric oxide syrtthase （iNOS）.

关键词： suppressive activity tolerogenic

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Tracheal Intubation Difficulties: Systematic Literature Review

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Journal of Biosciences and Medicines 2022年第5期10卷 95-104页

作者： Vanessa Ferreira Dias Duarte da costa Mariana Ronchesel Barauna Camila dos Santos Leite Oscar César pires Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil

Background: Tracheal intubation is a common procedure in medical practice, being performed mainly in surgical centers and emergencies in trauma patients. Objective: This systematic literature review aims to understand the main difficulties and complications related to tracheal intubation. Methods: Systematic literature review, conducted in the Virtual Health Library databases between 2016 and 2021, restricted to articles in English and Portuguese with the descriptors: Airway, Difficult intubation, and Complications. After reading the abstracts, 34 articles were found, and, after reading them, 9 articles were selected. Results: This review analyzed 9 scientific studies that rigorously met the previously established characteristics in the sample selection. The synthesis included the following aspects (author/year of publication, article title, objective, type of study, and database. Discussion: Several factors that influence the success of intubation were identified, such as technical, professional, and patient issues. In addition, measures to minimize the risks involving the procedure were highlighted. Conclusion: Tracheal intubation is a common procedure in surgical centers and emergencies. However, its risks, while low, should not be ignored. Unsuccessful procedures can occur and have consequences for the patient, such as trauma to the upper airway.

关键词： Airway Difficult Intubation Complications

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Effect of Corrosion Inhibitor Used in Surface Treatment on the Anticorrosive Performance of an Epoxy Paint System

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Materials Sciences and Applications 2016年第10期7卷 593-609页

作者： Jorge Felipe Ramos Pontes Elber Vidigal Bendinelli Cristina da costa Amorim Marcos Martins de Sá Alberto pires Ordine Cepel-Electric Energy Research Center Corrosion Laboratory Rio de Janeiro Brazil

The mechanism of corrosion is mainly sustained by an electrochemical process, in which anodic and cathodic reactions take place, keeping their kinetics alive by electrons and ions fluxes. Several specific conditions can accelerate corrosion processes. When studying anticorrosive coatings, one of them is the contamination of metallic surface by soluble salts prior to coating, leading to premature failure of the paint system due to corrosion between the metallic surface and the coating. So the surface preparation step prior to coating is a procedure of great importance to the coating anticorrosive performance. The aim of this step is to clean the surface by removing visible and non-visible contaminants. Usually, wet abrasive blasting methods are the most efficient ones to achieve the latter objective, because they may clean the surface, create a surface roughness and also remove the non-visible contaminants, as they use water as a media. On the other hand, evaporation of water after blasting may create flash rust and to avoid this, it is common to use corrosion inhibitors in the water of wet blasting methods. In this paper, the use of sodium tetraborate (borax) as a corrosion inhibitor in wet abrasive blasting is discussed. Electrochemical measurements and mass loss tests show that a borax content of 1% in a saline solution has the best inhibitory action over carbon steel and zinc surfaces, allowing postponing for the painting step some time. However, residual borax left on the surface generated blistering and corrosion under coating, during accelerated corrosion test in a humidity condensation chamber. Electrochemical impedance spectroscopy confirmed that borax accelerated the permeation of water through the coating, downgrading the anticorrosive performance of the paint system.

关键词： Wet Abrasive Blasting Corrosion Inhibitor Borax Epoxy Paint System

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Functional and Structural Arterial Vessel Features of Female Patients with Stable Dermatomyositis and Antisynthetase Syndrome

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Open Journal of Rheumatology and Autoimmune Diseases 2019年第3期9卷 101-110页

作者： Rafael Giovani Misse Isabela Bruna pires Borges Valéria Aparecida costa Hong Luiz Aparecido Bortolotto Samuel Katsuyuki Shinjo Division of Rheumatology Faculdade de Medicina FMUSP Universidade de Sao Paulo Sao Paulo SP Brazil (BR) Hypertension Unit Instituto do Cora&#231 o Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo SP Brazil (BR)

Introduction: Dermatomyositis (DM) and antisynthetase syndrome (ASS) show a high frequency of metabolic syndrome, which can be preceded by endothelial dysfunction and arterial stiffness. To date, only one study has evaluated these vessel parameters in DM, and no study of ASS exists. Therefore, the aim of the study was to assess the structural and functional arterial of arterial vessels in DM and ASS. Methods: This cross-sectional study enrolled 21 adult female patients (14 DM and 7 ASS) who were age-, gender- and ethnicity-matched to 12 healthy individuals. Patients using lipid lowering agents or prednisone at doses ≥ 0.25 mg/kg/day, and patients with uncontrolled systemic arterial hypertension, diabetes mellitus, cardiac insufficiency, and disease activity were excluded. Arterial stiffness was evaluated using carotid-femoral pulse wave velocity (PWV), and endothelial function was evaluated using dependent flow-mediated dilatation (FMD) of the brachial artery. Results: The mean age of patients with DM or ASS were 45.4 ± 8.6 and 44.0 ± 6.1 years, respectively (P = 1.000), and patients were predominantly of white ethnicity. Six DM patients and three ASS patients had systemic arterial hypertension, whereas 9 DM patients and six ASS patients had dyslipidemia. Endothelial baseline diameter, hyperemia diameter and FMD values were similar among the three groups (P > 0.05). Moreover, the median FMD values were also similar between the patients with DM and patients with ASS [8.3% (4.5% - 10.9%) vs. 6.0% (−1.8% - 8.2%);P = 0.585]. The PWV values were comparable among the three groups (P = 0.253). In addition, no difference was observed between patients with DM and patients with ASS (7.4 ± 0.8 m/s vs. 7.4 ± 0.9 m/s;P = 1.000). Conclusions: Despite the high prevalence of dyslipidemia and systemic arterial hypertension, our female patients with stable DM and ASS had FMD and PWV values comparable to those of the control group.

关键词： Arterial Stiffness Atherosclerosis Endothelial Dysfunction Systemic Autoimmune Myopathies

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Approach to Pain in Endometriosis Patients: Systematic Literature Review

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Journal of Biosciences and Medicines 2022年第11期10卷 1-27页

作者： Vanessa Ferreira Dias Duarte da costa Maria Eduarda Pazini Modesto Gonçalves Camila dos Santos Leite Oscar César pires Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil

Background: Endometriosis is a gynecological, multifactorial condition that affects women’s life quality, especially due to the pain inherent to it. Pain is caused by physical and psychological aspects;therefore, several factors must be analyzed, aiming to treat the whole. Conventional, drug or surgical treatments are the most used;however, the search for alternative therapeutic methods is growing. Objective: To analyze the approach to pain in women with endometriosis, seeking a better understanding of the pathophysiological mechanisms of this disease, its impact on life quality, as well as the means of treatments in use and innovations in this field. Methods: Systematic literature review, conducted in the Virtual Health Library databases between 2010 and 2021, restricted to articles in English and Portuguese with the descriptors: Endometriosis, Pain, and Treatment. After reading the abstracts, 197 articles were found, and, after reading them, 59 articles were selected. Results: This review analyzed 59 scientific studies that rigorously met the previously established characteristics in the sample selection. The synthesis included the following aspects: author/year of publication, article title, objective, type of study and database. Related factors such as acute or chronic pain, late diagnosis, discrediting symptomatic complaints and trivialization by health professionals have a profound impact on the physical and mental health of women with endometriosis. On the other hand, there are several classes of drugs, surgical procedures, and alternative therapies available for pain management. Conclusion: Given the context addressed, a certain need is suggested for health professionals to better understand the disease and adopt new behaviors or improve existing ones, such as reception, active listening, early diagnosis and comprehensive and individualized treatment. In addition, further studies are needed regarding alternative therapies, seeking to expand the scientific ev

关键词： Endometriosis Pain Treatment

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Effects of Exercise Training on Endothelial Function,Arterial Structure,and Physical Conditioning in Patients with Systemic Autoimmune Myopathies:A Case Series Study

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Open Journal of Rheumatology and Autoimmune Diseases 2019年第2期9卷 57-68页

作者： Rafael Giovani Misse Isabela Bruna pires Borges Alexandre Moura dos Santos Diego Sales de Oliveira Jean Marcos de Souza Bruno Gualano Valéria Aparecida costa Hong Luis Aparecido Bortolotto Samuel Katsuyuki Shinjo Faculdade de Medicina FMUSP Universidade de Sao Paulo SP Brazil Hypertension Unit Instituto do Coracao Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo SP Brazil

Introduction. Exercise training has been effective in improving endothelial function and decreasing arterial stiffness in several systemic autoimmune diseases. However, to date, no studies have assessed patients with systemic autoimmune myopathies (SAM). Methods. Five female patients with definite SAM (3 dermatomyositis and 2 polymyositis) who underwent a 12-week, twice-a-week, exercise training program were assessed prospectively. The following parameters were assessed: endothelial function measured by flow-mediated dilatation (FMD), carotid femoral by pulse wave velocity (PWV), disease status by International Myositis Assessment & Clinical Studies Group (IMACS) set score, the ventilatory anaerobic threefold (VAT), respiratory compensation point (RCP), maximum effort (ME), maximal oxygen uptake (VO2max) measured by ergospyrometer, and strength and muscle function. Results. Mean age of the patients and duration of disease were 43.9 and 10.5 years, respectively. The median FMD and PWV were 10.2% and 7.1 m/s. After exercise training, important FMD reduction was observed in 4 out of 5 patients, whereas the PWV parameters decreased in only 2 out of 5 patients. The exercise training was safe, without clinical intercurrences or disease relapses. Moreover, an increase in strength and functionality was observed. Concerning aerobic capacity, there was a decrease in the VAT and an increase in ME, without al-terations in the maximum oxygen consumption. Conclusions. In general, exercise training does not alter endothelial function and PWV values, but improves muscle strength and function and also, does not lead to disease reactivation (Clinical Trials (NCT03092167)).

关键词： Dermatomyositis Endothelial Function Exercise Polymyositis Pulse Wave Velocity

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