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Ga.trointestina. microbiome a.d Helicoba.ter pylori:Era.ica.e,lea.e it a. it is,or ta.e a.persona.ized benefit-risk a.proa.h?

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World Journa. of Ga.troenterology 2022年第7期28卷 766-774页

作者： Sta.isla. Sitkin leonid La.ebnik Elena.a.a.ueva.Svetla.a.Kononova.Timur Va.hitov Depa.tment of Interna. Disea.es Gastroenterology and DieteticsNorth-Western State Medical University Named After I.I.MechnikovSt.Petersburg 191015Russia Non-Infectious Disea.e Meta.olomics Group Institute of Experimental MedicineSt.Petersburg 197376Russia Epigenetics a.d Meta.enomics Group Institute of Perinatology and PediatricsAlmazov National Medical Research CentreSt.Petersburg 197341Russia Depa.tment of Outpa.ient Thera.y A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Institute of Protein Resea.ch Russian Academy of SciencesPushchinoMoscow region 142290Russia

Helicoba.ter pylori(***)is genera.ly rega.ded a. a.huma. pa.hogen a.d a.cla.s 1 ca.cinogen,etiologica.ly rela.ed to ga.tric a.d duodena. ulcers,ga.tric ca.cer,a.d mucosa.a.socia.ed lymphoid tissue ***,*** ca. a.so be rega.ded a. a.commensa. *** other pa.hogenic/opportunistic ba.teria.*** coloniza.ion in infa.cy is fa.ilita.ed by T helper type 2 immunity a.d lea.s to the development of immune *** ga.tric mucin glyca.s,which a.e a. importa.t pa.t of the inna.e a.d a.a.tive immune system,media.e the a.hesion of *** to the surfa.e of the ga.tric epithelium,contributing to successful *** ma. ha.e beneficia. effects on the host by regula.ing ga.trointestina.(GI)microbiota.a.d protecting a.a.nst some a.lergic a.d a.toimmune disorders a.d infla.ma.ory bowel *** potentia. protective role a.a.nst infla.ma.ory bowel disea.e ma. be rela.ed to both modula.ion of the gut microbiota.a.d the immunomodula.ory properties of *** inverse a.socia.ion between *** a.d some potentia.ly proinfla.ma.ory a.d/or proca.cinogenic ba.teria.ma. suggest it regula.es the GI *** of *** ca. ca.se va.ious a.verse effects a.d a.ter the GI microbiota.lea.ing to short-term or long-term ***,studies ha.e shown tha. ga.tric a.tinoba.teria.decrea.e a.ter *** era.ica.ion,Proteoba.teria.increa.e during short-term follow-up a.d then return to ba.eline levels,a.d Enteroba.teria.ea. a.d Enterococcus increa.e in the short-term a.d interim *** ga.tric mucosa. ba.teria.a.tinomyces,Gra.ulica.ella.Pa.vimona.,Peptostreptococcus,Prevotella.Rothia.Streptococcus,Rhodococcus,a.d La.toba.illus)ma. contribute to preca.cerous ga.tric lesions a.d ca.cer itself a.ter *** *** era.ica.ion ca. a.so lea. to dysbiosis of the gut microbiota.with increa.ed Proteoba.teria.a.d decrea.ed Ba.teroidetes a.d *** increa.e in gut Proteoba.teria.ma. c

关键词： Helicoba.ter pylori Era.ica.ion Ga.trointestina. microbiota Dysbiosis Fucosyla.ed glyca. Infla.ma.ory bowel disea.e

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Cha.a.teriza.ion of a. infectious pa.crea.ic necrosis virus from ra.nbow trout fry(Onhorhynchus mykiss) in West Ukra.ne

引用

Virologica.Sinica 2015年第3期30卷 231-233页

作者： Yuriy P Rud Ma.ia.I Ma.strenko leonid P Bucha.skiy La.ora.ory of Biotechnology in a.ua.ulture Institute of Fisheries of the National Academy of Agrarian Sciences of Ukraine Depa.tment of Molecula. Biology Biotechnology and Biophysics Institute of High Technologies Taras Shevchenko National University of Kyiv La.ora.ory of Physico-Chemica. Biology ESC Institute of BiologyTaras Shevchenko National University of Kyiv

Dea. Editor,a.ua.ic birna.iruses a.e a.group within the fa.ily Birna.irida. tha. comprise isola.es from fish a.d shellfish from both fresh-a.d sea.a.er(Woo a.d Bruno,1999).Members of the fa.ily Birna.irida. a.e icosa.edra. viruses a.proxima.ely 60 nm in dia.eter composed of five polypeptides a.d two segments of double-stra.ded RNa.Dixon et a..,2008).In this report,a. a.ua.ic birna.irus wa. isola.ed from ra.nbow trout fry,Onhorhynchus myki-

关键词： trout shellfish infectious Dixon isola.es Bruno a.ua.ic stra.ded fresh comprise

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Ba.ic forma.ion mecha.isms of La.e Doroninskoye soda.wa.er, Ea.t Siberia. Russia

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a.ta.Geochimica 2018年第4期37卷 546-558页

作者： Svetla.a.V. Borzenko leonid V. Za.a.a.La.isa.I. Usma.ova Institute of Na.ura. Resources Ecology and Cryology of Siberian Branch of Russian Academy of Sciences ChitaRussia 672049 Tomsk Depa.tment of the Trofimuk Institute of Petroleum-Ga. Geology a.d Geophysics of Siberia. Bra.ch of the Russia. a.a.emy of Sciences Tomsk Russia 634050

The prima.y scientific goa. of studying sa.t la.es is to better understa.d the forma.ion of sma.l continenta.- type hydrogeochemica. systems. Ma.y scientists ha.e a.tributed the meta.orphism of the chemica. composition of sa.t la.es to the eva.ora.ive concentra.ion of wa.er. How- ever, the forma.ion of soda.wa.er is inconsistent with this hypothesis. Thus, a.a.yzing intra.a.ina. biochemica. pro- cesses a.d wa.er--rocks intera.tions during the eva.ora.ive concentra.ion of wa.er a.lows us to understa.d the ma.or mecha.isms of the forma.ion a.d evolution of wa.er com- positions. Therefore, the a.m of this pa.er is to identify the key processes involved in the forma.ion of the chemica. composition of the wa.er in La.e Doroninskoye. a. a.a.ysis of the distribution of ma.or components shows tha. Na., HCO3-, CO32-, a.d C1- a.e domina.t in this wa.er. High concentra.ions of these elements a.e the result of eva.ora.ive wa.er concentra.ion. Ca.cium, ma.nesium, a.d pota.sium a.e not a.cumula.ed beca.se the wa.er is sa.ura.ed in min- era.s conta.ning these elements. The ma.n ba.rier to the growth of the sulfa.e content of wa.er is sulfa.e reduction. This process a.so contributes to the a.ditiona. reproduction of ca.bon dioxide, which rea.ts with the products of the hydrolysis of a.uminosilica.es OH- to form HCO3- a.d CO32-, thus further contributing to the na.ura. processes of soda.forma.ion.

关键词： Sa.ine la.e Sulfa.e reduction Thermodyna.ic equilibrium

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Bila.ered semiconductor gra.hene na.ostructures with periodica.ly a.ra.ged hexa.ona. holes

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Na.o Resea.ch 2015年第4期8卷 1250-1258页

作者： Dmitry G. Kva.hnin Peter Va.cso Liubov Yu. a.tipina.Geza.I. Ma.k La.zlo P. Biro Pa.el B. Sorokin leonid a. Chernoza.onskii Ema.uel Institute of Biochemica. Physics 4 Kosigina Street Moscow 119334 Russia Institute of Technica. Physics a.d Ma.eria.s Science Research Centre for Natural Sciences H- 1525 Budapest P.O. Box 49 Hungary Technologica. Institute of Superha.d a.d Novel Ca.bon Ma.eria.s 7a Centralnaya Street Troitsk Moscow 142190 Russia

We present a.theoretica. study of new na.ostructures ba.ed on bila.ered gra.hene with periodica.ly a.ra.ged hexa.ona. holes （bila.ered gra.hene a.tidots）. Our a. initio ca.cula.ions show tha. fa.rica.ion of hexa.ona. holes in bigra.hene lea.s to connection of the neighboring edges of the two gra.hene la.ers with forma.ion of a.hollow ca.bon na.ostructure sheet which displa.s a.wide ra.ge of electronic properties （from semiconductor to meta.lic）, depending on the size of the holes a.d the dista.ce between them. The results were a.ditiona.ly supported by wa.e pa.ket dyna.ica. tra.sport ca.cula.ions ba.ed on the numerica. solution of the time-dependent Schr/Sdinger equa.ion.

关键词： ga.hene a.tidots electronic properties DFT

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Ocea. stra.ifica.ion a.d sea.ice cover in Ba.ents a.d Ka.a.sea. modula.e sea.a.r metha.e flux:sa.ellite da.a

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a.va.ces in Pola. Science 2021年第2期32卷 118-140页

作者： leonid YURGa.OV Dustin Ca.ROLL a.drey PNYUSHKOV Igor POLYa.OV Hong ZHa.G University of Ma.yla.d Ba.timore County(ret) BaltimoreMDUSA Moss La.ding Ma.ine La.ora.ories San JoséState UniversityCAUSA Interna.iona. a.ctic Resea.ch Center University of Alaska FairbanksAKUSA Jet Propulsion La.ora.ory California Institute of TechnologyCAUSA

The diverse ra.ge of mecha.isms driving the a.ctic a.plifica.ion a.d globa. clima.e a.e not completely understood a.d,in pa.ticula.,the role of the greenhouse ga. metha.e(CH4)in the a.ctic wa.ming rema.ns *** sources of metha.e a. the ocea. sea.ed in the Ba.ents Sea.a.d other pola. regions a.e well ***,some of those publica.ions suggest tha. negligible a.ounts of metha.e fluxed from the sea.ed enter the a.mosphere,with roughly 90%of the metha.e consumed by *** in situ observa.ions a.e ta.en during summer,which is fa.ora.le for collecting da.a.but a.so cha.a.terized by a.stra.ified wa.er *** present perennia. observa.ions of three Therma. IR spa.e-borne spectrometers in the a.ctic between 2002 a.d *** to estima.es derived from the da.a.synthesis ECCO(Estima.ing the Circula.ion a.d Clima.e of the Ocea.),in the ice-free Ba.ents Sea.the stra.ifica.ion in winter wea.ens a.ter the summer strong *** convection,storms,a.d turbulent diffusion mix the full-depth wa.er ***4 excess over a.control a.ea.in North a.la.tic,mea.ured by three sounders,a.d the ocea.ic Mixed La.er Depth(MLD)both ma.imize in winter.a.significa.t sea.ona. increa.e of sea.a.r excha.ge in ice-free sea. is *** a.plitude of the sea.ona. metha.e cycle for the Ka.a.Sea.significa.tly increa.ed since the beginning of the *** ma. be expla.ned by a.decline of ice concentra.ion *** a.nua. CH4 emission from the a.ctic sea. is estima.ed a. 2/3 of la.d *** Ba.ents/Ka.a.sea. contribute between 1/3 a.d 1/2 into the a.ctic sea. a.nua. emission.

关键词： sa.ellite da.a greenhouse ga.es metha.e Therma. IR(TIR) a.ctic

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Lea.ning to Genera.e Posters of Scientific Pa.ers by Proba.ilistic Gra.hica. Models

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Journa. of Computer Science & Technology 2019年第1期34卷 155-169页

作者： Yu-Ting Qia.g Ya.-Wei Fu Xia. Yu Ya.-Wen Guo Zhi-Hua.Zhou leonid Siga. Na.iona. Key La.ora.ory for Novel Softwa.e Technology Nanjing UniversityNanjing 210046China School of Da.a.Science Fudan UniversityShanghai 200433China Disney Resea.ch Pittsburgh Pittsburgh 15241U.S.A.

Resea.chers often summa.ize their work in the form of scientific *** provide a.coherent a.d efficient wa. to convey core idea. expressed in scientific *** a.good scientific poster,however,is a.complex a.d time-consuming cognitive ta.k,since such posters need to be rea.a.le,informa.ive,a.d visua.ly *** this pa.er, for the first time,we study the cha.lenging problem of lea.ning to genera.e posters from scientific *** this end,a.da.a.driven fra.ework,which utilizes gra.hica. models,is ***,given content to displa.,the key elements of a.good poster,including a.tributes of ea.h pa.el a.d a.ra.gements of gra.hica. elements,a.e lea.ned a.d inferred from *** the inference sta.e,the ma.imum a.posterior (Ma.)estima.ion fra.ework is employed to incorpora.e some design *** order to bridge the ga. between pa.el a.tributes a.d the composition within ea.h pa.el,we a.so propose a.recursive pa.e splitting a.gorithm to genera.e the pa.el la.out for a.*** lea.n a.d va.ida.e our model,we collect a.d relea.e a.new benchma.k da.a.et,ca.led NJU-Fuda. Pa.er-Poster da.a.et,which consists of scientific pa.ers a.d corresponding posters with exha.stively la.elled pa.els a.d *** a.d qua.tita.ive results indica.e the effectiveness of our a.proa.h.

关键词： gra.hica. design la.out a.toma.ion proba.ilistic gra.hica. model

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In situ high-pressure nuclea. ma.netic resona.ce crysta.logra.hy in one a.d two dimensions

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Ma.ter a.d Ra.ia.ion a. Extremes 2021年第6期6卷 94-103页

作者： Thoma. Meier a.ena.a.la.dukova.Floria. Trybel Dominique La.iel Ta.a.uki Ishii Sa.a.a.Kha.da.kha.va.Na.a.ia.Dubrovinska.a.leonid Dubrovinsky Center for High Pressure Science a.d Technology a.va.ced Resea.ch BeijingChina Ba.erisches Geoinstitut University of BayreuthBayreuthGermany Depa.tment of Physics Chemistry and Biology(IFM)Linkoping UniversitySE-58183 LinkopingSweden Ma.eria. Physics a.d Technology a. Extreme Conditions Laboratory of CrystallographyUniversity of BayreuthBayreuthGermany

Recent developments in in situ nuclea. ma.netic resona.ce(NMR)spectroscopy under extreme conditions ha.e led to the observa.ion of a.wide va.iety of physica. phenomena.tha. a.e not a.cessible with sta.da.d high-pressure experimenta. ***,inherent di-or qua.rupola. line broa.ening in dia.ond a.vil cell(Da.)-ba.ed NMR experiments often limits deta.led investiga.ion of loca. a.omic structures,especia.ly if different pha.es or loca. environments ***,we describe our progress in the development of high-resolutionNMRexperiments in Da.s using one-a.d two-dimensiona. homonuclea. decoupling experiments a. pressures up to the mega.a. *** this technique,spectra. resolutions of the order of 1 ppm a.d below ha.e been a.hieved,ena.ling high-pressure structura. *** exa.ples a.e presented tha. demonstra.e the wide a.plica.ility of this method for extreme conditions resea.ch.

关键词： NMR extreme dimensions

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POSSIBLE　HYDROGEOCHEMICa.　PRECONDITIONS　FOR　Ka.HIN－BECK　DISEa.E　IN　TRa.SBa.Ka.IA

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Chinese Geogra.hica. Science 1995年第2期5卷 185-192页

作者： Za.a.a.leonid Va.ilevich(Chita.Institute of Na.ura. Resources, 672014 Chita. Russia. Chita.Institute of Na.ura. Resources Chita Russia

In the ba.in of the a.ur River a. the territory of Russia. in the northern regions of China.a.d Korea.the ostea.-a.ticula.e disea.e of people a.d a.ima.s, well known a. Ka.hin-Beck disea.e is sprea.. a.out 20 hypotheses ha. been suggested for expla.ning the disea.e ca.ses. some of them a.e briefly introduced. The hydrogeochemica. resea.ches in Tra.sba.ka.ia. Russia. showed tha. na.ura. wa.er of the endemic a.ea. ha.e severa. fea.ures in chemica. *** of them a.e considered by existing hypotheses a. the ca.ses of the *** do not concern the possible etiologic fa.tors of the disea.e for the present. The a.thor exa.ines these fea.ures respectively.

关键词： Ka.hin-Beck disea.e ca.ses. endemic disea.e Tra.sba.ka.ia of Russia

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Cytomorphologica. a.d genetic indica.ors in the ea.ly ontogenesis of the wild a.d fa.med broa. whitefish(Coregonus na.us)

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渔业学报（英文） 2023年第3期8卷 261-266页

作者： a.eksa.dr Selyukov Oksa.a.Zhigileva.leonid Shuma. Svetla.a.Selyukova.Vera.Bogda.ova Tyumen Sta.e University Institute of BiologyPirogov Street 3Tyumen625043Russia St.Petersburg Bra.ch of the a.l-Russia. Resea.ch Institute of Fisheries a.d Ocea.ogra.hy(St.Petersburg Bra.ch of VNIRO) St.Petersburg199155Russia

The qua.ita.ive a.d qua.tita.ive composition of primordia. germ cells(PGCs)a.d the genetic va.ia.ility of embryos of the Coregonus na.us from the Ob river ba.in a.d domestica.ed popula.ion breeding outside the na.ura. a.ea. wa. *** the broa. whitefish,typica.,binuclea.,polymorphic nuclei cells,a. well a. PGCs represented prima.y gonocytes during embryogenesis in *** ha.ching la.va. PGCs mitoses were noted only in domestica.ed *** genetic va.ia.ility of embryos of the broa. whitefish wa. studied by polymera.e cha.n rea.tion of inter simple sequence repea.s(ISSR-PCR).The high polymorphism of the broa. whitefish cultured popula.ion wa. *** proportion of polymorphic ba.ds wa. 89.4%,Nei’s genetic diversity wa. *** of the domestica.ed broa. whitefish did not a.fect the overa.l level of polymorphism of neutra. DNa.*** findings suggest the preserva.ion of cytomorphologica. a.d genetic diversity in *** embryo from different sources.

关键词： Broa. whitefish Domestic brood stock Wild popula.ion Embryogenesis Genetic polymorphism Primordia. germ cells

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Combined Sa.-SHa. prediction of Ea.th Orienta.ion Pa.a.eters since 2012 till 2017

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Geodesy a.d Geodyna.ics 2018年第6期9卷 485-490页

作者： leonid Zotov Xueqing Xu Yonghong Zhou a.ka.iy Skoroboga.ov Sternberg a.tronomica. Institute of Lomonosov Moscow Sta.e University Moscow 119992 Russia Sha.gha. a.tronomica. Observa.ory Chinese Academy of Sciences Shanghai 200030 China Na.iona. Resea.ch University Higher School of Economics Russia

a. the pa.ticipa.ts of Ea.th Orienta.ion Pa.a.eters Combina.ion of Prediction Pilot Project(EOPC PPP),Sternberg a.tronomica. Institute of Moscow Sta.e University(Sa.) a.d Sha.gha. a.tronomica. Observa.ory(SHa.) ha.e a.cumula.ed ～1800 da.s of Ea.th Orienta.ion Pa.a.eters(EOP) predictions since2012 till 2017, which were up to 90 da.s into the future, a.d ma.e by four techniques: a.to-regression(a.), lea.t squa.es colloca.ion(LSC), a.d neura. network(NNET) foreca.ts from Sa., a.d lea.t-squa.es plus a.to-regression(LS+a.) foreca.t from SHa.. The predictions were fina.ly combined into Sa.SHa. COMB EOP prediction. In this work we present five-yea. rea.-time sta.istics of the combined prediction a.d compa.e it with the uncerta.nties of IERS bulletin a.predictions ma.e by USNO.

关键词： EOP prediction Error estima.ion Combined foreca.t Pola. motion UT1-UTC

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