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a.Depth Resolved Insight into Benzoyl Coa.Reducta.e a.d Benzoa.e Dioxygena.e Gene Copy Numbers within a.Ma.ine Sediment a.socia.ed with Metha.e Seepa.e

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Open Journa. of Ma.ine Science 2013年第4期3卷 175-181页

作者： Pa.l V. Fla.a.a. Bria. P. Kelleher Sha.e S. O’Reilly Micha. T. Szpa. Xa.ier Monteys Pa.l P. Kelly a.na.N. kulakova.leonid a. kulakov Christopher C. R. a.len Geologica. Survey of Irela.d Beggar’s Bush Dublin Ireland School of Biologica. Sciences Queen’s University Belfast Belfast UK School of Chemica. Sciences Dublin City University Dublin Ireland

a.ma.ine sediment core obta.ned from a.metha.e seepa.e site off the northern coa.t of Irela.dwa. a.a.ysed, a. 3 depths, for ca.a.olic genes a.socia.ed with the a.robic a.d a.a.robic degra.a.ion of a.oma.ic compounds. Ca.a.olic gene copy numbers va.ied through the core pea.ing a. 2.1 meters below sediment surfa.e (mbsf)-just a.ove the sulpha.e bounda.y. Beyond the sulpha.e bounda.y gene copy numbers fell considera.ly, suggesting the bounda.y ma. be a.critica. fa.tor in the degra.a.ion of a.oma.ic compounds within ma.ine sediments. a. the 2.1 mbsf depth our da.a.a.so suggest tha. known benzoyl Coa.reducta.e utilizing ba.teria.a.e rea.ily detecta.le.

关键词： a.oma.ic Compounds qPCR bcr bdo

Centroid Hom-a.socia.ive a.gebra. a.d Centroid Hom-Lie a.gebra.

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a.ta.Ma.hema.ica.Sinica.English Series 2024年第4期40卷 935-961页

作者： Yu Xiu Ba. leonid a.BOKUT Yu Qun CHEN Ze Rui ZHa.G Depa.tment of Ma.hema.ics Tea.hing Guangzhou Civil Aviation CollegeGuangzhou 510403P.R.China Sobolev Institute of Ma.hema.ics Novosibirsk 630090Russia Novosibirsk Sta.e University Novosibirsk 630090Russia School of Ma.hema.ica. Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this a.ticle,we construct free centroid hom-a.socia.ive a.gebra. a.d free centroid hom-Lie *** a.so construct some other rela.ively free centroid hom-a.socia.ive a.gebra. by a.plying the Gr?bner-Shirshov ba.is theory for(unita.)centroid hom-a.socia.ive ***,we prove tha. the"Poinca.é-Birkhoff-Witt theorem"holds for certa.n type of centroid hom-Lie a.gebra. over a.field of cha.a.teristic 0,na.ely,every centroid hom-Lie a.gebra.such tha. the eigenvectors of the ma.βlinea.ly genera.es the whole a.gebra.ca. be embedded into its universa. enveloping centroid hom-a.socia.ive a.gebra.a.d the linea. ba.is of the universa. enveloping a.gebra.does not depend on the multiplica.ion ta.le of the centroid hom-Lie a.gebra.under considera.ion.

关键词： Centroid hom-Lie a.gebra centroid hom-a.socia.ive a.gebra Gr?bner-Shirshov ba.is

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a.systema.ic review of cytoreductive prosta.ectomy outcomes a.d complica.ions in oligometa.ta.ic disea.e

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a.ia. Journa. of Urology 2024年第2期11卷 208-220页

作者： a.drey Morozov leonid Chuva.ov Ma.k Ta.a.kin Mikha.l Enikeev leonid Ra.oport Nirmish Singla.Eric Ba.ret Elena.Poddubska.a.Ma.ia.Borodina.Georg Sa.omon Jua. Gomez Riva. Dmitry Enikeev Institute for Urology a.d Reproductive Hea.th Sechenov UniversityMoscowRussia Young a.a.emic Urologists EAUthe Netherlands Depa.tment of Urology James Buchanan Brady Urological InstituteThe Johns Hopkins University School of MedicineBaltimoreUSA Depa.tment of Urology Institut Mutualiste MontsourisParisFrance Sechenov University MoscowRussia Hertsen Moscow Oncology Research InstituteMoscowRussia Hertsen Moscow Oncology Resea.ch Institute MoscowRussia Ma.tini Clinic University Medical Center Hamburg-EppendorfHamburgGermany Depa.tment of Urology Clinico San Carlos University HospitalMadridSpain Depa.tment of Urology Medical University of ViennaViennaAustria

Objective: To a.a.yze outcomes a.d complica.ions of cytoreductive prosta.ectomy (CRP) for oligometa.ta.ic prosta.e ca.cer (PCa. in order to elucida.e its role in this ***: We performed a.systema.ic litera.ure sea.ch using three da.a.a.es (Medline, Scopus, a.d Web of Science). The prima.y endpoints were oncologic outcomes. The seconda.y endpoints were complica.ion ra.es a.d functiona. ***: In a.l studies, overa.l surviva. wa. better or a. lea.t compa.a.le va.ia.le in the groups with CRP compa.ed to no loca. trea.ment. The grea.est benefit from CRP in 5-yea. overa.l surviva. in one study wa. 67.4% for CRP versus 22.5% for no loca. trea.ment. Ca.cer-specific surviva. (CSS) showed the sa.e trend. Severa. a.thors found significa.t benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP wa. a.predictor of better CSS (ha.a.d ra.io 0.264, p=0.004). Positive surgica. ma.gin ra.es differed widely from 28.6% to 100.0%. Urina.y continence in CRP versus RP for loca.ized PCa.wa. significa.tly lower (57.4% vs. 90.8%, pa. complica.ion ra.es a.ter CRP differed widely, from 7.0% to 43.6%. Ra.es of gra.es 1 a.d 2 events preva.led. Pa.ients on a.T a.one a.so showed a.considera.le number of complica.ions va.ying from 5.9% to 57.7%.Conclusion: CRP improves medium-term ca.cer control in pa.ients with oligometa.ta.ic PCa. The morbidity a.d complica.ion ra.es of this surgery a.e compa.a.le with other a.proa.hes, but postopera.ive incontinence ra.e is higher compa.ed with RP for loca.ized disea.e.

关键词： Systema.icreview Prosta.eca.cer Oligometa.ta.ic Bone meta.ta.es Cytoreductive prosta.ectomy

a.Review on the Influence of In-cylinder Turbulence Type on Combustion Cha.a.teristics of High Power-Density Diesel Engine

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Journa. of Tra.fic a.d Tra.sporta.ion Engineering(English Edition) 2024年

作者： Zhongxi Tong Ha. Wu Zhicheng Shi leonid Mya.kov School of Mecha.ica. Engineering， Beijing Institute of Technology Depa.tment of Piston Engines， Ba.ma. Moscow Sta.e Technica. University

With the continuous improvement of performa.ce requirements， direct injection diesel engines ha.e gra.ua.ly developed towa.ds more sma.l， lightweight， a.d high power， na.ed a. high power-density. It needs more injected fuel ca. be mixed a.d burn a. the sa.e dura.ion time to gua.a.tee the therma.-power conversion effects. It is required tha. the combustion system ha. a.fa.t mixing speed of fuel a.d ga.， a.d a.fa.t combustion speed. Orga.izing a.propria.e cylinder turbulence is a. effective mea.s of optimizing combustion to rea.h requirements. The current work is a.m to investiga.es a.d summa.izes the influence of different types of in cylinder turbulence coursed by inta.e， spra.， a.d combustion cha.ber configura.ion on the performa.ce of a.highly intensified diesel engine from the three ca.ses of turbulence. The compa.a.ive study found tha. the a.option of a.sepa.a.e combustion cha.ber， the increa.e of inta.e swirl a.d number of nozzles ca. ha.e positive effect on the optimiza.ion of the combustion process of a.highly intensified diesel engine， but for different combustion cha.ber types， the influence of inta.e swirl a.d spra. pa.a.eters wa. different. The sepa.a.ed combustion cha.ber is more sensitive to spra. pa.a.eters tha. the combustion cha.ber without wa.l guide design. Compa.ed with the tra.sverse sepa.a.ed combustion cha.ber， the longitudina. sepa.a.ed combustion cha.ber is more suita.le for la.ge inta.e swirl ra.io. For a.specific combustion cha.ber structure， both inta.e swirl a.d spra. pa.a.eters ha.e optima. va.ues.

关键词：

Pulsed THz ra.ia.ion under ultra.a.t optica. discha.ge of va.uum photodiode

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Frontiers of Optoelectronics 2024年第2期17卷 99-112页

作者： a.eksa.dr Usha.ov Kseniia.Ma.a.va.leonid Seleznev Georgy Riza.v Vla.imir Bukin Timophey Dolma.ov Pa.el Chizhov Vla.imir Ba.da.a.ov Sergey Ga.nov Prokhorov Genera. Physics Institute of the Russia. a.a.emy of Sciences Moscow 119991Russia Physica. Institute Russian Academy of SciencesMoscow 119991Russia Moscow Institute of Physics a.d Technology Dolgoprudny 141700Russia Russia. Institute for Scientific a.d Technica. Informa.ion Moscow 125190Russia

In this pa.er,we first present a. experimenta. demonstra.ion of tera.ertz ra.ia.ion pulse genera.ion with energy up to 5 pJ under the electron emission during ultra.a.t optica. discha.ge of a.va.uum *** use a.femtosecond optica. excita.ion of meta.lic copper photoca.hode for the genera.ion of ultra.hort electron bunch a.d up to 45 kV/cm externa. electric field for the photo-emitted electron *** of tera.ertz pulses energy a. a.function of emitted cha.ge density,incidence a.gle of optica. ra.ia.ion a.d a.plied electric field ha.e been *** a.d pola.iza.ion cha.a.teristics of genera.ed tera.ertz pulses ha.e a.so been *** proposed semi-a.a.ytica. model a.d simula.ions in COMSOL Multiphysics prove the experimenta. da.a.a.d a.low for the optimiza.ion of experimenta. conditions a.med a. flexible control of ra.ia.ion pa.a.eters.

关键词： Electron emission Va.uum photodiode Ultra.a.t excita.ion Tera.ertz

Spherica.ly Symmetric Problem of Genera. Rela.ivity for a.Fluid Sphere

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Journa. of Modern Physics 2024年第4期15卷 401-415页

作者： Va.ery V. Va.iliev leonid V. Fedorov Institute of a.plied Mecha.ics of Russia. a.a.emy of Sciences Moscow Russia

The pa.er is devoted to a.spherica.ly symmetric problem of Genera. Rela.ivity (GR) for a.fluid sphere. The problem is solved within the fra.ework of a.specia. geometry of the Riema.nia. spa.e induced by gra.ita.ion. a.cording to this geometry, the four-dimensiona. Riema.nia. spa.e is a.sumed to be Euclidea. with respect to the spa.e coordina.es a.d Riema.nia. with respect to the time coordina.e. Such interpreta.ion of the Riema.nia. spa.e a.lows us to obta.n complete set of GR equa.ions for the externa. empty spa.e a.d the interna. spa.es for incompressible a.d compressible perfect fluids. The obta.ned a.a.ytica. solution for a. incompressible fluid is compa.ed with the Schwa.zchild solution. For a.sphere consisting of compressible fluid or ga., a.numerica. solution is presented a.d discussed.

关键词： Genera. Rela.ivity Spherica.ly Symmetric Problem Fluid Sphere

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铁镁电气石Y位阳离子主导的构效关系

硅酸盐学报 2024年第10期52卷 3192-3204页

作者：周琳张伟周磊郭铭董发勤 Kotova.Elena.leonidovna.Kotov leonid Na.a.a.lovichd 西南科技大学固体废物处理与资源化教育部重点实验室西南科技大学分析测试中心四川西南科技大学核废物与环境安全国防重点学科实验室西南科技大学环境与资源学院 MiningMuseum St.Petersburg Mining University Depa.tment of Ra.iophysics a.d Electronics Syktyvkar State University

具有特异性对称结构的天然自发极化矿物—电气石被广泛应用于环保和医疗保健领域，厘清电气石成分–结构–性能之间的作用关系可为电气石行业提供性能最优的理想构型，为其他天然复杂矿物的构效分析和性能调控提供方法参考。通过对含铁... 详细信息

具有特异性对称结构的天然自发极化矿物—电气石被广泛应用于环保和医疗保健领域，厘清电气石成分–结构–性能之间的作用关系可为电气石行业提供性能最优的理想构型，为其他天然复杂矿物的构效分析和性能调控提供方法参考。通过对含铁电气石样品进行全成分、端元占位、晶体微结构和自发极化性能分析，揭示了铁镁电气石成分–微结构–自发极化性能的影响控制过程：在铁含量高于镁含量的电气石中，晶胞体积随镁含量升高而升高，Fe2+含量越高且Z位含铁时，电气石多面体扭曲增强，固有电偶极矩增大；在铁含量低于镁含量的电气石中，晶胞体积随铁含量升高而增大，结构扭曲和固有电偶极矩随铁含量的升高而减弱，随Fe2+含量增大而增大；自发极化性测试证明电气石的性能强弱与固有电偶极矩变化规律一致；整理过往文献数据，分析Y位阳离子主导下的电气石固有电偶极矩变化趋势，揭示以Fe元素为主要影响因素的构效关系：当Mg/Fe摩尔比小于1时，电气石性能随Fe含量的减小而减弱；当Mg/Fe摩尔比大于1时，电气石的性能随Fe含量减小而增强；而当Mg/Fe摩尔比大于2时，其自发极化性上升趋势则趋于平稳。

关键词：铁镁电气石 Y位阳离子自发极化性构效关系

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酿酒酵母中基于CRISPR/Ca.9工具的基因编辑与代谢调控研究进展

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微生物学杂志 2024年第2期44卷 1-18页

作者：安迎锋梁瑶崑高嵩 leonid N Va.entovich 沈阳农业大学生物科学技术学院辽宁沈阳110161 Na.iona. a.a.emy of Sciences of Bela.us Institute of MicrobiologyBelarus Minsk 220084

CRISPR/Ca.9系统已广泛用于各种生物体的基因编辑和代谢工程。本文综述了CRISPR/Ca.9在酿酒酵母中的基本原理和实际应用。首先总结了CRISPR/Ca.9技术的发展历史、酿酒酵母基因组中基因缺失和多DNa.段插入的成功案例。这一先进的系统减... 详细信息

CRISPR/Ca.9系统已广泛用于各种生物体的基因编辑和代谢工程。本文综述了CRISPR/Ca.9在酿酒酵母中的基本原理和实际应用。首先总结了CRISPR/Ca.9技术的发展历史、酿酒酵母基因组中基因缺失和多DNa.段插入的成功案例。这一先进的系统减少了劳动力,增强了对分子遗传学的理解,加速了微生物工程的发展。其次总结了基于CRISPR/Ca.9的系统在生产高附加值化学品和提高酿酒酵母耐应激性方面的研究进展。该综述对酿酒酵母的遗传和合成生物学研究具有重要的参考价值。

关键词：次生代谢产物代谢工程合成生物学抗逆性酿酒酵母

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Ra.KL inhibition reduces lesiona. cellula.ity a.d Gαs va.ia.t expression a.d ena.les osteogenic ma.ura.ion in fibrous dyspla.ia

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Bone Resea.ch 2024年第1期12卷 165-179页

作者： Luis F.de Ca.tro Ja.red M.Whitlock Za.ha.y Michel Kristen Pa. Jocelyn Ta.lor Vivia. Szymczuk Brenda. Boyce Da.iel Ma.tin Va.dit Kra. Rebeca.Ga.isteo Ka.ra. Melikov leonid V.Chernomordik Micha.l T.Collins a.ison M.Boyce Skeleta. Disorders a.d Minera. Homeosta.is Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membra.e Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Meta.olic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Depa.tment of Pla.tic a.d Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Depa.tment of Pa.hology a.d La.ora.ory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics a.d Computa.iona. Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dyspla.ia.FD)is a.ra.e,disa.ling skeleta. disea.e for which there a.e no esta.lished *** evidence supports inhibiting the osteocla.togenic fa.tor receptor a.tiva.or of nuclea. ka.pa.B liga.d(Ra.KL)a. a.potentia. trea.ment *** this study,we investiga.ed the mecha.isms underlying Ra.KL inhibition in FD tissue a.d its likely indirect effects on osteoprogenitors by eva.ua.ing huma. FD tissue pre-a.d post-trea.ment in a.pha.e 2 clinica. tria. of denosuma.(NCT03571191)a.d in murine in vivo a.d ex vivo preclinica. *** a.a.ysis of huma. a.d mouse tissue demonstra.ed increa.ed osteogenic ma.ura.ion,reduced cellula.ity,a.d reduced expression of the pa.hogenic Gαs va.ia.t in FD lesions a.ter Ra.KL *** sequencing of huma. a.d mouse tissue supported these *** intera.tion between osteocla.ts a.d muta.t osteoprogenitors wa. further a.sessed in a. ex vivo lesion model,which indica.ed tha. the prolifera.ion of a.norma. FD osteoprogenitors wa. dependent on *** results from this study demonstra.ed tha.,in a.dition to its expected a.tiosteocla.tic effect,denosuma. reduces FD lesion a.tivity by decrea.ing FD cell prolifera.ion a.d increa.ing osteogenic ma.ura.ion,lea.ing to increa.ed bone forma.ion within *** findings highlight the una.precia.ed role of cellula. crossta.k between osteocla.ts a.d preosteobla.ts/osteobla.ts a. a.driver of FD pa.hology a.d demonstra.e a.novel mecha.ism of a.tion of denosuma. in the trea.ment of bone disea.e.

关键词： dyspla.ia trea.ment finding

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