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Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias—the PrePoP guidelines

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Journal of Integrative Medicine 2024年第05期 533-544页

作者： Alexander L.Tournier leoni v.bonamin Susann Buchheim-Schmidt Steven Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria Olga Kokornaczyk Everine B.van de Kraats Jesús Antonio López-Carvallo Papiya Nandy JoséManuel Mazón-Suástegui Fateme Mirzajani Bernard Poitevin Claudia Scherr Karin Thieves Sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern Institute of Integrative Medicine Witten/Herdecke University Homeopathy Research Institute Graduate Program on Environmental and Experimental Pathology Paulista University Department of Medical Science Deutsche Hom?opathie-Union DHU-Arzneimittel GmbH&Co.KG Cherwell Laboratory for Fundamental Research in Homeopathy Society for Cancer Research Hiscia Research Institute Laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de Janeiro World Water Community Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte Centre for Interdisciplinary Research and Education Laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del Noroeste Protein Research Center Shahid Beheshti University Department of Medical Laboratory Science College of ScienceKnowledge University Socie′te′Savante d’Hom′eopathie Sola Salus Institute for Homeopathic Research Scientific Society for Homeopathy

Objective: Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative medicine. The physicochemical properties and biological activity of these preparations are often investigated in preclinical research, yet no guidelines for experimental research currently exist in this area. The present PrePoP guidelines aim to provide recommendations to promote high-quality, statistically sound, and reproducible preclinical research on potentised ***: Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls, sample preparation and handling, and statistics. After three rounds of feedback, a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised ***: We present a series of recommendations on a range of topics including experimental controls,system stability, blinding and randomisation, environmental influences, and procedures for the preparation of potentised samples and controls, and we address some specific challenges of this research ***: This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

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C反应蛋白调节脂蛋白(a)相关冠心病风险:BiomarCaRE项目

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中华高血压杂志（中英文） 2024年第3期32卷 299-299页

作者： Arnold N Blaum C GoBling A Brunner FJ Bay B Ferrario MM Brambilla P Cesana G leoni v Palmieri L Donfrancesco C Padro T Andersson J Jousilahti P Ojeda F Zeller T Linneberg A Soderberg S Iacoviello L Gianfagna F Sans S veronesi G Thorand B Peters A Tunstall-Pedoe H Kee F Salomaa v Schnabel RB Kuulasmaa K Blankenberg S Koenig W Waldeyer C 袁源(译) 郑武洪(审校) 不详

近期研究显示,脂蛋白(a)[lipoprotein(a),Lp(a)]相关心血管疾病风险与机体炎症负荷存在交互作用。本研究旨在探索一般人群中,高敏C反应蛋白(high-sensitive C-reactive protein,hsCRP)能否调节Lp(a)相关冠心病风险。方法:纳入欧洲8项基... 详细信息

近期研究显示,脂蛋白(a)[lipoprotein(a),Lp(a)]相关心血管疾病风险与机体炎症负荷存在交互作用。本研究旨在探索一般人群中,高敏C反应蛋白(high-sensitive C-reactive protein,hsCRP)能否调节Lp(a)相关冠心病风险。方法:纳入欧洲8项基于人群的前瞻性队列研究的71678例参与者数据(基线时65661例未患冠心病/6017例患有冠心病。

关键词：前瞻性队列研究高敏C反应蛋白心血管疾病风险机体炎症冠心病 reactive 交互作用

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IL SITO MESOLITICO SOPRA FIENILE ROSSINO SULL'ALTIPIANO DI CARIDEGHE(Serle-Brescia)

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Natural Disaster Reduction in China 1986年第1期 239-286页

作者： CARLAALBERTAACCORSI MARTABANDINIMAZZANTI PAOLO BIAGI LANFREDO CASTELLETTI MAURO CREMASCHI LAURA leoni MASSIMO PAvARANI Istituto di Botanica dell'Università di Bologna. Istituto di Botanica dell'Università di Bologna. Dipartimento di Archeologia e Filologia Classica dell'Università di Genova. Musei Civici di Como. C.N.R.Centro di Studio per la Stratigrafia e la Petrografia delle Alpi Centrali Milano. Musei Civici di Como. C.N.R.Centro di Studio per la Stratigrafia e la Petrografia delle Alpi Centrali.Milano.

The excavation of the Late Mesolithic site of Sopra Fienile Rossino on the Cariadeghe Upland(***-Northern Italy).***,anthracological and palinologicalThe Mesolithic station Sopra Fienile Rossino is situated at the northern edge of the Cariadeghe karsticupland,some 12 km Northeast of Brescia,at an altitude of 925 m *** excavation of the site was car-ried out in 1970.1979 and *** produced a buried structure containing a《posthole》92 cm deep whichwas elated to 4860±70 bc(Bln-3277).The flint assemblage,almost completely chipped from locally avai-lable raw material,is attributable to the Late Mesolithic Castelnovian *** artefacts recove-red during excavations include subconical narrow bladelet cores,trapezoidal arrowheads and *** stratigraphic sequence shows that the《station》was probably settled between late summerand early spring as shown by the presence of carbonised hazelnut *** location,very close to amiddle altitude pass,might indicate thai hunting activities were practised at the *** and charcoalanalyses demonstrate that a mixed oak wood cover was established during the v millennium bc,in aperiod of slope *** and colluvial phenomena began during the Sub-boreal and Sub-atlan-tic periods being caused by the human impact on the *** area inhabited by the mesolithiccommunities was later settled only during the ⅩⅤ Century AD as revealed by a C14 date obtained frombeech charcoal pieces recovered at-50cm.A more recent occupation is attested by a charcoal pit mainlycomposed of chestnut charcoals discovered at-10cm.

关键词： PIO GI BI Pro Pit Serle-Brescia DEGHE AIP La DI

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