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Cyanide-bridged single molecule magnet based on a manganese(Ⅲ) complex with TTF-fused Schiff base ligand

2001年中国中西医结合皮肤性病学术会议

作者： Chang Heng-leong M.d.

A multicenter,investigator-blinded,reference-controlled study has been conducted in four hospitals in Taiwan fromMay to October *** primary objective of this study was to evaluate the safety and efficacy of differin（adapalene）Gel,0.1％compared to Retin-A Gel,0.025％applied once daily to the face for 12 weeks in subjects withacne vugaris.

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Science China Chemistry 2015年第4期58卷 650-657页

作者： Long Cui Feifei Zhu Chanel F.leong Jing Ru Feng Gao deanna M.d’Alessandro Jinglin Zuo State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing National Laboratory of Microstructures Nanjing University School of Chemistry The University of Sydney

Reaction of [Mn（TTF-salphen）][OAc] （TTF-salphen2=2,2＇-（（2-（4,5-bis（methylthio）-1,3-dithiol-2-ylidene）-1,3-benzodithiole- 5,6-diyl）bis（nitrilomethylidyne）bis（pbenolate）dianion） and the cyanometalate building blocks [n-Bu4N][（Tp）Fe（CN）3] （Tp =Tris（pyrazolyl）hydroborate） or [n-Bu4N][Ru（salen）（CN）2] （salen2 =N,N＇-ethylenebis（salicylideneimine）dianion） resulted in the formation of two redox-active complexes, the dinuclear heterometallic complex [（Tp）Fe（CN）3Mn（TTF-salphen）＇CH3OH] （1） and the one dimensional complex [Ru（salen）（CN）2Mn（TTF-salphen）]n （2）. Both complexes were characterized by X-ray crystallography and solid state electrochemistry, in addition to static and dynamic magnetic measurements. Antiferromagnetic couplings are found to be operative between metal ion centers bridged by cyanide in both complexes. Complex 1 exhibited field-induced SMM behavior with an energy barrier of 13.8 K. The introduction of the redox-active TTF unit into cyanidebridged complexes with interesting magnetic properties renders them promising candidates for the construction of new hybrid inorganic-organic materials.

关键词： cyanide complexes single molecule magnets tetrathiafulvalene multifunctional materials

Application of proteomics in environmental science

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Frontiers of Environmental Science & Engineering 2009年第4期3卷 393-403页

作者： Xiaona CHU Jiangyong HU Say leong ONG Center for Water Research division of Environmental Science and Engineering National University of Singapore10 Kent Ridge CrescentSingapore 119260Singapore

Proteomics involves the separation of proteins,identification of the amino acid sequence of the interested or target proteins,study of the function of the proteins,modification,structure and ultimate assignments to functional pathways in the *** proteomic investigations have contributed greatly to human diseases studies,new drugs discovery researches,and environmental science in recent *** article provides a review on the development of the main proteomic technologies,including both the gel based and non-gel based technologies,and their applications in environmental *** technologies have been utilized in the environmental stresses studies to analyze the induction or reduction of proteins at expression level and identify the target proteins to investigate their function in response to environmental stresses,such as high or low pH,oxidation stress,and toxic *** protein responses are also helpful to understand the mechanisms of some cellular activities and the functions of some proteins.

关键词： proteomics environmental stress two dimensional(2d)gel electrophoresis mass spectrometry

收缩压变异及平均心率与心血管病高危患者的认知功能障碍相关

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中华高血压杂志 2015年第1期23卷 72-72页

作者：赵狄练桂丽 Bhm M Schumacher H leong d Mancia G Unger T Schmieder R Custodis F diener HC Laufs U Lonn E Sliwa K Teo K Fagard R Redon J Sleight P Anderson C O'donnell M Yusuf S

收缩压升高与认知功能减退及伴随而来的痴呆有关。但心率、随诊间心率变异、随诊间收缩压变异的影响仍未明确。在单用替米沙坦或与雷米普利联用全球终点试验和替米沙坦用于治疗对血管紧张素转换酶抑制剂不耐受的心血管病患者的随机评估... 详细信息

收缩压升高与认知功能减退及伴随而来的痴呆有关。但心率、随诊间心率变异、随诊间收缩压变异的影响仍未明确。在单用替米沙坦或与雷米普利联用全球终点试验和替米沙坦用于治疗对血管紧张素转换酶抑制剂不耐受的心血管病患者的随机评估研究中,根据收缩压均值、随诊间收缩压变异（变异系数=标准差/均值×100%）、平均心率、随诊间心率变异评估之前无认知功能障碍的24593例患者。

关键词：收缩压变异平均心率替米沙坦心血管病患者变异系数雷米普利评估研究状态量 ahead 叠加效应

Understanding the role of PIN1 in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第45期22卷 9921-9932页

作者： Chi-Wai Cheng Ka-Wai leong Eric Tse department of Medicine The University of Hong Kong Queen Mary Hospital

PIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline(p Ser/Thr-Pro) in proteins. PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine/threonine phosphorylation. Through this phosphorylation-dependent prolyl isomerization, PIN1 fine-tunes the functions of key phosphoproteins(e.g., cyclin d1, survivin, β-catenin and x-protein of hepatitis B virus) that are involved in the regulation of cell cycle progression, apoptosis, proliferation and oncogenic transformation. PIN1 has been found to be over-expressed in many cancers, including human hepatocellular carcinoma(HCC). It has been shown previously that overexpression of PIN1 contributes to the development of HCC invitro and in xenograft mouse model. In this review, we first discussed the aberrant transcription factor expression, miR NAs dysregulation, PIN1 gene promoter polymorphisms and phosphorylation of PIN1 as potential mechanisms underlying PIN1 overexpression in cancers. Furthermore, we also examined the role of PIN1 in HCC tumourigenesis by reviewing the interactions between PIN1 and various cellular and viral proteins that are involved in β-catenin, NOTCH, and PI3K/Akt/mT OR pathways, apoptosis, angiogenesis and epithelial-mesenchymal transition. Finally, the potential of PIN1 inhibitors as an anti-cancer therapy was explored and discussed.

关键词： Phosphorylation Hepatocellular carcinoma PIN1 Isomerization Hepatocarcinogenesis

Selective enriching of trionic emission in a WS2-ZnO hybrid through type-Ⅱ band alignment

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Science China(Information Sciences) 2023年第6期66卷 63-70页

作者： Jin Feng leong Kim Yong LIM Xiao WU Qinghua XU Chorng Haur SOW Eng Tuan POH department of Physics National University of Singapore department of Chemistry National University of Singapore

Strategies to modulate the exciton dynamics in ultrathin two-dimensional(2d)semiconductors have always been an integral component in the bid towards improved optoelectronics and quantum photonic devices. The capability to non-destructively tune the relaxation dynamics, valley polarization, binding energies, and population ratio of various excitonic species has been well-sought for advanced *** the rationale design of a WS2-ZnO hybrid platform, we present a distinct increment in the trion-toexciton ratio for WS2emission across a patterned heterostructure. The shift in dominant excitonic species arose due to the efficient charge segregation at the spatially confined interface of the type-Ⅱ *** to the charge transfer process, the resultant emission profile presents up to four times amplification in the trion-to-exciton ratio, with temperature variable trion binding energies up to 59 meV. Since trions possess non-zero charge and spin degrees of freedom, the provision of a higher density of trions with increased binding stability would encourage new opportunities for reproducible optoelectronics and quantum emitters.

关键词： heterostructure trions type-II band alignment

Thermodynamic and kinetics of hydrogen photoproduction enhancement by concentrated sunlight with CO_(2) photoreduction by heterojunction photocatalysts

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Energy and AI 2021年第4期6卷 14-20页

作者： Ziyu Liu Teng Yi Chenxu Huang Kwang-leong Choy Chaozong Liu School of Medical Science and Engineering Beihang UniversityChina Centre for Materials Research University College LondonUK National Institude of defense Science and Technology China Northwest Institute of Mechanical&Electrical Engineering China

For achieving water splitting into hydrogen under sunlight for practical applications,the high efficiencies of the photoreduction of CO_(2) over TiO_(2)/Fe3O4 photocatalysts combined with hydrogenation of water splitting over Pt/TiO_(2) were investigated by practical concentrated solar energy compared with Hg lamp and Xe *** on AI analysis on the influence factors,the key parameters for TOC concentration were photocatalysts,Na2CO3 concentration and radiation intensity while the key parameters for hydrogen production were photocatalysts,radiation intensity,and TOC ***,the mechanism of concentrated sunlight effects has been discussed from the view of thermodynamics and *** concentrated sunlight provides a simultaneous supply of sufficient electron–hole pairs and thermal *** to hydrogen and CO_(2) reduction are both enhanced in concentrated sunlight due to endothermal *** changes the internal electric field of p-n junction of in different possible ways,and thus composite photocatalysts with favorable formation of p-n junctions would enhance the charge separation by internal electric ***,photocatalysts are beneficial for providing more excited electrons at a time for achieving CO_(2) photoreduction at the surface region of the particles with higher density of radiation by concentrated solar ***,products from CO_(2) photoreduction,acting as sacrificial electron donors,improved hydrogen evolution in solar-mediated water splitting for prohibiting reverse reactions.

关键词： Concentrated sunlight Hydrogen evolution CO_(2)photoreduction p-n junction Thermodynamics and kinetics

Presentation matters： Identity of gold nanocluster capping agent governs intracellular uptake and cell metabolism

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Nano Research 2014年第6期7卷 805-815页

作者： Chor Yong Tay Yong Yu Magdiel Inggrid Setyawati Jianping Xie david Tai leong department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 28 Medical Drive Singapore 117456 Singapore

Au nanoclusters （AuNCs） hold tremendous potential to be employed in a wide variety of biological applications. despite the rapid development in the field of NCs synthesis, a comprehensive understanding of how cells interact with this class of ultra-small nanoparticles （〈2 nm） having defined sizes and surface chemistry, remains poorly understood. In this study, we show that the choice of the surface ligand used to protect AuNCs can significantly perturb cellular uptake and intracellular redox signaling. A panel of monodisperse, atomically precise AuNCs with different core Au atom number （i.e., Auls, Au18 and Au25） protected with either mercaptopropionic acid （MPA） or glutathione （GSH） capping agent were synthesized and their effects on the generation of intracellular reactive oxygen species （ROS）, cytotoxicity and genotoxicity of the NCs were assessed. Both mitochondrial superoxide anion （O2^-） and cytoplasmic ROS were found to be higher in cells exposed to MPA but not GSH capped AuNCs. The unregulated state of intracellular ROS is correlated to the amount of internalized AuNCs. Interestingly, MPA-AuNCs induction of ROS level did not lead to any detrimental cellular effects such as cell death or dNA damage. Instead, it was observed that the increase in redox status corresponded to higher cellular metabolism and proliferative capacity. Our study illustrates that surface chemistry of AuNCs plays a pivotal role in affecting the biological outcomes and the new insights gained will be useful to form the basis of defining specific design rules to enable rational engineering of ultra-small complex nanostructures for biological applications.

关键词： nanotechnology nanobiology gold nanoclusters reactive oxygen species surface chemistry

Feasibility of Integrating Bimetallic Au-Ag Non-Alloys Nanoparticles Embedded in Reduced Graphene Oxide Photodetector

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Photonic Sensors 2023年第3期13卷 23-36页

作者： Nurul Syazwani ROHIZAT Muhammad Nur Syafiq MOHAMAd ISMAIL Muhammad Aiman Saufi AHMAd FAHRI Chee leong TAN Rozalina ZAKARIA Photonics Research Center Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia School of Electronic and Optical Engineering and College of Microelectronics Nanjing University of Posts and TelecommunicationsNanjing 210023China

To coordinate the resonant wavelength of the plasmonic nanoparticles(NPs),the emission band of the reduced graphene oxide(rGO)photodetector at the NIR-region is crucial for the optimal plasmon-enhanced luminescence in the *** contrast to monometallic NPs,where limits the dimensions and extended resonant wavelength,we integrated an Au-Ag bimetallic NPs(BMNPs)to enable resonance tuning at the longer wavelength at the excitation source of 785 *** features showed an increase in radiative recombination rates as well as the quantum yield efficiency of the *** BMNPs were produced from the dewetting process of 600℃and 500℃,both at 1 min after the deposition thickness layer of Au(8 nm)and Ag(10 nm)on the Si substrate using the electron-beam evaporation *** BMNPs-rGO photodetector exhibited the responsivity of 2.25 A·W^(–1),Jones of specific detectivity of 2.45×10^(11)Jones,and external quantum efficiency(EQE)of 356%.The rise time and fall time for the photodetector were 32 ns and 186 ns,*** work provided an essential information to enable the versatile plasmon-enhanced application in 2-dimensional(2d)material optoelectronic devices.

关键词： Au-Ag bimetallic nanoparticles rGO photodetector

Anti-migratory and increased cytotoxic effects of novel dual drug-loaded complex hybrid micelles in triple negative breast cancer cells

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Nano Research 2015年第8期8卷 2533-2547页

作者： Rajaletchumy Veloo Kutty Chor Yong Tay Chen Siew Lim Si-Shen Feng david Tai leong department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive Singapore 117585 Singapore International Joint Cancer Institute The Second Military Medical University 800 Xiang Yin Road Shanghai 200433 China NUS Graduate School for Integrative Science and Engineering National University of Singapore 28 Medical Drive Singapore 117456 Singapore

A polymer-based nanocarrier was developed for the co-delivery of epigenetic and chemotherapeutic drugs. The sterically stabilized hybrid micelle system uses micelles composed of d-a-tocopheryl polyethylene glycol 1000 succinate （vitamin E TPGS or TPGS） and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[methoxy（polyethylene glycol）-2000] （dSPE-PEG2000）. In this study, suberoylanilide hydroxamic acid （SAHA） and paclitaxel were used as model drugs for combination chemotherapy to enhance therapeutic efficiency in targeting mesenchyme-like triple negative breast cancer （TNBC） cells. Combination therapy of paclitaxel and SAHA in a dual drug micelle system, （P ＋ S）mic, exhibited an IC50 value of 0.52 μg/mL, which is about 5.91-fold more cytotoxic than the mere combination of free drugs （P ＋ S）. Furthermore, the （P ＋ S）mic formulation was far more effective at inhibiting cell migration by more than 3.4-fold than the control. Thus, our findings show that the co-delivery of these drugs using the micelle system greatly enhances their therapeutic effect at a lower dosage, thereby minimizing toxicity. In addition, this formulation is proved to be remarkably effective in preventing cell migration at low dosage.

关键词： nanomedicine biomaterials nanobiology biodegradable polymers drug targeting