检索结果-南通市图书馆

Chinese Journal of Chemistry 2023年第21期41卷 2801-2809页

作者： Raffaella Mancuso Alex De Salvo Patrizio Russo Aurelia Falcicchio Nicola Della Ca’ leonardo Pantoja Munoz Bartolo Gabriele Laboratory of Industrial and Synthetic Organic Chemistry(LISOC) Department of Chemistry and Chemical TechnologiesUniversity of CalabriaVia Pietro Bucci 12/C87036 Acavacata di Rende(CS)Italy Institute of Crystallography National Research CouncilVia Amendola122/O70126 BariItaly Department of Chemistry Life Sciences and Environmental Sustainability(SCVSA)University of ParmaParco Area delle Scienze17/A43124 ParmaItaly Department of Natural Sciences Faculty of Science and TechnologyMiddlesex UniversityThe BurroughsNW44BT LondonUK

The PdI_(2)/KI-catalyzed oxidative carbonylation of 4-(2-aminophenyl)-3-yn-1-ols,bearing two potential nucleophilic groups in suitable position selectively leads to dihydrofuroquinolinone derivatives in fair to high yields(60%—89%)and excellent turnover numbers(180—267 mol of product per mol of Pd)over 19 examples,through a mechanistic pathway involving initial O-cyclization followed by *** such process,the selective catalytic construction of two rings and three new bonds is achieved in one synthetic step to afford high value added fused heterocyclic structures starting from readily available materials.

关键词： Carbonylation Cyclization Heterocycles Palladium Polycyclic heterocycles

Investigation of quark distributions in a family of pentaquarks using the Thomas-Fermi quark model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2021年第3期73卷 94-104页

作者： Mohan Giri Suman Baral Gopi Chandra Kaphle Nirmal Dangi Sudip Shiwakoti leonardo Bardomero Paul Lashomb Walter Wilcox Department of Physics Baylor UniversityWacoTX 76798United States of America Everest Institute of Science and Technology KathmanduNP 44618Nepal Central Department of Physics Tribhuvan UniversityKirtipurNP 44600Nepal Neural Innovations LLC LorenaTX 76655United States of America Division of Health Science and Mathematics Niagara County Community CollegeSanbornNY 14132United States of America

Using the Thomas-Fermi quark model,a collective,spherically symmetric density of states is created to represent a gas of interacting fermions with various degeneracies at zero *** a family of pentaquarks,uudcc,color interaction probabilities were obtained after averaging over all the possible *** different functions are developed for light,charm,and anti-charm quarks and are assumed to be linearly related by some proportionality *** patterns of quark distributions are observed while analyzing the quark function consistency conditions for such constants.

关键词： quark models Thomas Fermi models pentaquarks

Forest fire risk indices and zoning of hazardous areas in Sorocaba,Sao Paulo state,Brazil

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2020年第2期31卷 581-590页

作者： leonardo Guimaraes Ziccardi Claudio Roberto Thiersch Aurora Miho Yanai Philip Martin Fearnside Pedro Jose Ferreira-Filho Department of Environmental Dynamics National Institute for Research in Amazonia(INPA)Av.Andre AraujoNo.2936ManausAmazonasCEP 69067-375Brazil Department of Environmental Sciences Federal University of Sao Carlos(UFSCar)SorocabaSao PauloCEP 18052-780Brazil

This study compares the performance of three fire risk indices for accuracy in predicting fires in semideciduous forest fragments,creates a fire risk map by integrating historical fire occurrences in a probabilistic density surface using the Kernel density estimator(KDE)in the municipality of Sorocaba,Sao Paulo state,*** logarithmic Telicyn index,Monte Alegre formula(MAF)and enhanced Monte Alegre formula(MAF+)were employed using data for the period 1 January 2005 to 31 December *** data and numbers of fire occurrences were obtained from the National Institute of Meteorology(INMET)and the Institute for Space Research(INPE),*** performance measures were calculated:Heidke skill score(SS)and success rate(SR).The MAF+index was the most accurate,with values of SS and SR of 0.611%and 62.8%,*** fire risk map revealed two most susceptible areas with high(63 km^2)and very high(47 km^2)risk of fires in the *** of the best risk index and the generation of fire risk maps can contribute to better planning and cost reduction in preventing and fighting forest fires.

关键词： Forest fire risk maps Forest fire protection Monitoring Monte Alegre formula

Endoscopic findings in patients with upper gastrointestinal bleeding clinically classified into three risk groups prior to endoscopy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第32期14卷 5046-5050页

作者： leonardo Tammaro Maria Carla Di Paolo Angelo Zullo Cesare Hassan Sergio Morini SebastianoCaliendo Lorella Pallotta Gastroenterology and DigestiveEndoscopy Ⅱ "San Giovanni Addolorata" Hospital Gastroentero-logy and Digestive Endoscopy "Nuovo Regina Margherita"Hospital

AIM: To investigate in a prospective study whether a simplifi ed clinical score prior to endoscopy in upper gastrointestinal bleeding (UGIB) patients was able to predict endoscopic findings at urgent endoscopy. METHODS: All consecutive UGIB patients referred to a single endoscopic center during a 16 mo period were enrolled. Before endoscopy patients were strati- fied according to a simple clinical score (T-score), including T1 (high-risk), T2 (intermediate-risk) and T3 (low-risk). Endoscopy was performed in all cases within 2 h, and high-risk stigmata were considered for further analysis. RESULTS: Out of the 436 patients included into the study, 126 (29%) resulted to be T1, 135 (31%) T2, and 175 (40%) T3. Overall, stigmata of recent haem-orrhage (SRH) were detected in 118 cases (27%). SRH occurred more frequently in T1 patients than in T2/T3 cases (85% vs 3.2%; χ2 = 304.5309, P < 0.001). Older age (t=3.311; P < 0.01) and presence of comor-bidities (χ2 = 14.7458; P < 0.01) were more frequently detected in T1 than in T2/T3 patients. CONCLUSION: Our simplifi ed clinical score appeared to be associated with the detection of endoscopic findings which may deserve urgent endoscopy. A further,randomised study is needed to assess its accuracy in safely scheduling endoscopy in UGIB patients.

关键词： Upper gastrointestinal bleeding Urgentendoscopy Timing score Endoscopic treatment Oesophageal varices Peptic ulcer

Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第4期11卷 949-957页

作者： Abigail Medford Jonathan Childs Ashleigh Little Sanjukta Chakraborty leonardo Baiocchi Gianfranco Alpini Shannon Glaser Department of Medical Physiology Texas A&M University School of MedicineBryanTXUSA Hepatology Unit University of Tor VergataRomeItaly Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisINUSA

The liver has a vital role in many metabolic and regulatory processes in the *** biliary cholangitis(PBC),previously known as primary biliary cirrhosis,is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial *** this time there is no definitive cure for PBC;however,ursodeoxycholic acid(UDCA)has been shown to reduce injury when administered as the first line of *** therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease ***,a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable *** review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC.

关键词： Cholestatic liver disease Therapeutic approaches Biliary epithelia ursodeoxycholic acid

Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第43期13卷 5731-5735页

作者： leonardo A Sechi Anne Ruehl Niyaz Ahmed Donatella Usai Daniela Paccagnini Giovanna E Felis Stefania Zanetti Department of Biomedical Sciences Microbiology Section University of Sassari Viale S Pietro 43/B Sassari 07100 Italy International Society of Genetic and Evolutionary Microbiology Working Group on Mycobacterial Disease Sassari Italy Department of Human Biology Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan Germany International Society of Genetic and Evolutionary Microbiology Working Group on Mycobacterial Disease Sassari Italy Pathogen Evolution Group Centre for DNA Fingerprinting and Diagnostics Hyderabad India Department of Biomedical Sciences Microbiology Section University of Sassari Viale S Pietro 43/B Sassari 07100 Italy

AIM: To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease. METHODS: In order to establish the role of enteric glial cells during infection with M. avium subspecies paratuberculosis (MAP) in Crohn's disease, Map adhesion experiments on enteric glial cells were performed as well as expression analysis of Map sigma factors during infection. RESULTS: In this study, for the first time, we found a high affinity of MAP to enteric glial cells and we analyzed the expression of MAP sigma factors under different conditions of growth. CONCLUSION: The fact that Map showed a high affinity to the glial cells raises concerns about the complicated etiology of the Crohn's disease. Elucidation of the mechanisms whereby inflammation alters enteric neural control of gut functions may lead to novel treatments for Crohn's disease.

关键词： Mycobacterium avium subspecies Paratuber-culosis Enteric glial cells Inflammatory bowel diseases Crohn's disease Sigma factors expression

Non-invasive diagnosis of liver fibrosis in chronic hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第11期20卷 2854-2866页

作者： leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon Roberto José de Carvalho-Filho Gastroenterology Division Department of Internal MedicineFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil Gastroenterology Division Department of MedicineFederal University of Sao PauloSao PauloSP 04023-900Brazil

Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision *** liver biopsy has been considered the gold standard for staging liver fibrosis,it is an invasive technique and subject to sampling errors and significant intra-and inter-observer *** the last decade,several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection,with variable *** the clear advantage of being noninvasive,a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver *** addition,these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional ***,in general,these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic *** methods are either serum markers(usually combined in a mathematical model)or imaging modalities that can be used separately or combined in algorithms to improve *** this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C,their advantages,limitations and application in clinical practice.

关键词： Liver fibrosis Liver cirrhosis Hepatitis C Diagnosis Elasticity imaging techniques

Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2019年第7期11卷 421-430页

作者： JoséBraganca Joao AndréLopes leonardo Mendes-Silva Joao Miguel Almeida Santos Department of Biomedical Sciences and Medicine University of AlgarveFaro 8005-139Portugal Centre for Biomedical Research(CBMR) University of AlgarveFaro 8005-139Portugal

Induced pluripotent stem cells(iPSC)technology has propelled the field of stem cells biology,providing new cells to explore the molecular mechanisms of pluripotency,cancer biology and aging.A major advantage of human iPSC,compared to the pluripotent embryonic stem cells,is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human *** addition,iPSC can be generated from somatic cells harvested from normal individuals or patients,and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible *** these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells,these cells hold an immense potential for cell-based therapies,and for the discovery of new or personalized pharmacological treatments for many ***,we review some of the current challenges and concerns about iPSC *** introduce the potential held by iPSC for research and development of novel health-related *** briefly present the efforts made by the scientific and clinical communities to create the necessary guidelines and regulations to achieve the highest quality standards in the procedures for iPSC generation,characterization and long-term ***,we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells.

关键词： Induced pluripotent stem cells Reprogramming Cell-based therapy Stem cell banking Disease modelling

Effects of laser surface melting on crystallographic texture, microstructure, elastic modulus and hardness of Ti-30Nb-4Sn alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2020年第2期30卷 392-404页

作者： leonardo FANTON Nelson Batista de LIMA Emilio Rayon ENCINAS Vicente Amigo BORRAS Conrado Ramos Moreira AFONSO Joao Batista FOGAGNOLO School of Mechanical Engineering University of CampinasRua Mendeleyev200CEP 13083-860CampinasSPBrazil Instituto de Pesquisas Energéticas e Nucleares Av.Prof.Lineu Prestes2242CEP 05508-000São PauloSPBrazil Institut de Tecnologia de Materials Universitat Politècnica de ValènciaCamino de Veras/nCódigo Postal 46022ValenciaSpain Department of Materials Engineering Federal University of São CarlosRodovia Washington LuísKm 235CEP 13565-905São CarlosSPBrazil

The biocompatibility of orthopedic implants is closely related to their elastic modulus and surface *** objective of this study was to determine the effects of cold rolling,recrystallization and laser surface melting(LSM)on the microstructure and mechanical properties of a biphase(α″+β)Ti-30Nb-4Sn alloy.X-ray diffraction(XRD)texture analysis of the cold-rolled substrate revealed the[302]α″//ND texture component,while analysis of the recrystallized substrate showed the[302]α″//ND and[110]α″//ND ***β-phase texture could not be directly measured by XRD,but the presence of the[111]β//ND texture component was successfully predicted by considering the orientation relationship between theα″andβ*** measurements showed that the elastic modulus of the cold-rolled substrate(63GPa)was lower than that of the recrystallized substrate(74GPa).Based on the available literature and the results presented here,it is suggested that this difference is caused by the introduction of crystal defects during cold *** combined nanoindentation/EBSD analysis showed that the nanoindentation results are not affected by crystal *** of the deformed alloy produced changes in hardness,elastic modulus and crystallographic texture similar to those produced by recrystallization heat treatment,creating a stiffness gradient between surface and substrate.

关键词： titanium alloy cold rolling laser surface melting recrystallization crystallographic texture stiffness-graded material

Second Generation Nitrogen Doped Titania Nanoparticles:A Comprehensive Electronic and Microstructural Picture

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国化学:英文版 2014年第12期32卷 1195-1213页

作者： Francesca Spadavecchia Michele Ceotto leonardo Lo Presti Chiara Aieta Iolanda Biraghi Daniela Meroni Silvia Ardizzone Giuseppe Cappellettia Dipartimentodi Chimica Universitàdegli Studidi MilanoVia Golgi 1920133 MilanoItaly Consorzio Interuniversitario Nazionaleperla Scienzaela Tecnologiadei Materiali(INSTM) Via Giusti 950121 FirenzeItaly Istitutodi Scienzee Tecnologie Molecolari Italian CNRVia Golgi 1920133 MilanoItaly Center for Materials Crystallography Aarhus UniversityLangelandsgade 1408000 AarhusDenmark

A state-of-the-art overview of N-dopant characterizations in nano-TiO_(2)second-generation photocatalysts is *** related literature is very rich and sometimes offers contrasting *** we critically discuss up-to-date literature results and our own findings,as retrieved by several experimental(BET,HR-TEM,XPS,DRS,HR-XRPD,EXAFS,electrochemical tools)and theoretical(periodic DFT)*** intent is to pull together outcomes from very different and complementary sources to make an as much as possible coherent picture of the morphological,electrochemical and electronic properties of N-TiO_(2)*** is commonly accepted that critical issues to be considered in the design of high-performing N-TiO_(2)photocatalysts are synthetic strategy,defect concentration and chemical nature of the lattice point *** focus on the latter two issues,with emphasis on sol-gel prepared materials,according to the specific area of expertise of our *** problem of the chemical nature of guest N species into the lattice is crucial,as substitutional(N_(s))or interstitial(N_(i))nitrogen place their valence states just above the valence band or deeper into the band ***,we show how synergism among experimental and theoretical techniques is decisive to disentangle structural,electronic and morphological effects in complex N-doped TiO_(2)matrices.

关键词： point defects flatband potential photovoltage photocurrent DFT calculations