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Dendrimer nanocarriers drug action: perspective for neuronal pharmacology

Neural Regeneration Research 2015年第7期10卷 1029-1031页

作者： Felipe Vidal leonardo guzman Laboratory of Molecular Neurobiology Department of PhysiologyFaculty of Biological Sciences University of Concepcion

General aspects：Currently,several strategies have been used to overcome common problems found in pharmacological therapies,such as insolubility,reduced bioavailability and low specificity of *** of the most promising alternatives proposed is the use of dendrimeric drug nanocarriers,polymeric chemical structures of diverse nature that contain,transport and deliver the desired drug in biological systems.

关键词： PAMAM perspective for neuronal pharmacology

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Tomato waste as a bioresource for lycopene extraction using emerging technologies

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Food Bioscience 2022年第5期49卷 99-108页

作者： J.Y.M´endez-Carmona J.A.Ascacio-Valdes Olga B.Alvarez-Perez Ayerim Y.Hern´andez-Almanza Nathiely Ramírez-guzman leonardo Sepúlveda Miguel A.Aguilar-Gonz´alez Janeth M.Ventura-Sobrevilla Crist´obal N.Aguilar School of Chemistry Universidad Aut´onoma de CoahuilaSaltilloMexico School of Biological Sciences Universidad Aut´onoma de CoahuilaTorre´onMexico Center for Interdisciplinary Studies and Research Universidad Aut´onoma de CoahuilaSaltillo25280Mexico Center for Research and Advanced Studies of the National Polytechnic Institute Ramos ArizpeCoahuilaMexico School of Health Sciences Universidad Aut´onoma de CoahuilaPiedras NegrasMexico

Background:Tomato is the second most important vegetable around the *** processing of the fruit generates waste such as damaged tomatoes,pulp,skin,seeds,and tomato-derived products that contain valuable biomolecules with functional and technological *** fruit extracts,mainly from waste,possess bioactive molecules,such as lycopene,with important biological applications in some *** and approach:The objective of this review is to analyze,discuss and synthesize the technologies that have been used for the extraction and recovery of the main lycopene present in tomato *** revised methodologies expose valuable results in the number of carotenoids recovered through the application of solvents,microwave-assisted,ultrasound-assisted,enzymatic-assisted,extraction at high pressure,and supercritical ***,the challenges continue concerning the quality of extracted compounds,economic accessibility,industrial reproducibility,and environmental *** findings and conclusions:The tomato waste contains important bioactive molecules,which are of interest in the food,pharmacological,biotechnological,and cosmetic *** information revised in this contribution pretends to support new research lines concerning the formulation of novel tomato waste bio-based functional ***,it is necessary to further analyze the new extraction and recovery conditions to keep the functional properties of this by-product.

关键词： Tomato waste Carotenoids Techniques for extraction Lycopene

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