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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira leonardo Cardili Venancio Avancini Ferreira alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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Solar-driven CO_(2) conversion to methane and methanol using different nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

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Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo lima Perini lilian D.Moura Torquato Juliana Fde Brito Gustavo A.Andolpho Mateus A.Gonçalves leonardo D.De Angelis Lucas D.Germano Susana I.Córdoba de Torresi Teodorico C.Ramalho Maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(GC-MS)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction DFT calculations

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo leonardo dos Santos Corrêa Amorim leonardo alves mic.li Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

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Stellate ganglion block: what else is necessary to include in the treatment of subarachnoid hemorrhage patients?

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中华神经外科杂志(英文) 2024年第3期10卷 1-4页

作者： Welling leonardo C. Rabelo Nicollas Nunes de Sena Barbosa Mateus Gon?alves Messias Beatriz Rodrigues Pinto Carolina Guimar?es Figueiredo Eberval Gadelha Department of Neurosurgery State University of Ponta Grossa Ponta Grossa PR Brazil Division of Neurosurgery School of Medicine University of S?o Paulo (FMUSP)/Hospital das Clínicas Dr. Enéas de Carvalho Aguiar Street S?o Paulo SP-010 Brazil Department of Neurosurgery Atenas Medical School Passos MG Brazil Department of Neurosurgery Albert Einstein Medical School S?o Paulo SP Brazil

Cerebral vasospasm is determined as a temporary narrowing of cerebral arteries a few days after an aneurysmal subarachnoid hemorrhage. The onset of this vascular event usually evolves with new neurological deficits or progression of ischemic areas. The success of interventions to treat or revert this condition is not satisfying. In addition to cerebral vasospasm, early brain injury plays an important role as a contributor to subarachnoid hemorrhage’s mortality. In this sense, stellate ganglion block appears as an alternative to reduce sympathetic system’s activation, one of the main pathophysiological mechanisms involved in brain injury. Over the past few years, there is growing evidence that stellate ganglion block can contribute to decline patient morbidity from subarachnoid hemorrhage. Is it time to include this procedure as a standard treatment after aneurysm rupture?

关键词： Cerebral vasospasm Subarachnoid hemorrhage Stellate ganglion block

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Predictive modeling for wine authenticity using a machine learning approach

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Artificial Intelligence in Agriculture 2021年第1期5卷 157-162页

作者： Nattane Luíza da Costa leonardo A.Valentin Inar alves Castro Rommel Melgaço Barbos Instituto de Informática Universidade Federal de GoiásGoiânia-GoBrazil Informatics Nucleo Goiano Federal Institute of EducationScience and TechnologyCampus UrutaíRodovia Geraldo Silva Nascimentokm 2.5Zona RuralBloco de InformáticaUrutaíGOBrazil LADAF Department of Food and Experimental NutritionFaculty of Pharmaceutical SciencesUniversity of São PauloAv.Lineu Prestes580B1405508-900 São PauloBrazil

The purpose of this paper is to classify wines from 4 different countries in South *** class of wines is formed by samples considered by experts as representatives of the following commercial categories:“Argentinean Malbec(AM)”,“Brazilian Merlot(BM)”,“Uruguayan Tannat(UT)”and“Chilean Carménère(CC)”.The 83 samples collected were analyzed according to their composition of volatiles,semi-volatiles and phenolic *** built a decision system for classification based on support vector machines(SVM),along with Correlation-based Feature selection(CFS),and RandomForest Importance(RFI),whichmeasures the relative importance of the input ***,we use CFS to select a subset of variables among 190 chemical *** chemicals were selected as correlated to the category and uncorrelated with each ***,these chemical compounds were organized according to the importance ranking given by the RFI and classified with *** study clearly indicated that SVMin combination with feature selection methodswas able to identify the most important chemicals to classify the wine *** the compounds identified in the wine samples,the variable subset defined by the feature selection methods,which were catechin,gallic,octanoic acid,myricetin,caffeic,isobutanol,resveratrol,kaempferol,and ORAC,were able to achieve an accuracy of 93.97%in classifying the commercial categories.

关键词： Wine classification Support vector machines Feature selection South American wines Machine learning

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A perspective on potassic and ultrapotassic rocks:Constraints on the Paleoproterozoic late to post-collisional event in the São Francisco paleocontinent

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Geoscience Frontiers 2022年第5期13卷 242-266页

作者： Samuel Moreira Bersan AndréDanderfer Craig Storey Henrique Bruno Hugo Moreira Francisco Abreu Cristiano Lana leonardo Gonçalves Isabela Nahas Universidade Federal de Ouro Preto Departamento de GeologiaCampus Morro do CruzeiroOuro PretoMG CEP 35400-000Brazil University of Portsmouth School of the EnvironmentGeography and GeosciencesBurnaby BuildingBurnaby RoadPortsmouth PO13QLUK Tektos Research Group UERJ-Rio de Janeiro State UniversityBrazil Sustain Geologia Belo HorizonteBrazil

The late-to post-collisional stage in orogenic systems is characterized by the coeval existence of bimodal potassic to ultrapotassic magmatic activity related to partial melting of an enriched lithospheric mantle together with crustal derived *** this paper,we present new whole rock geochemical analyses combined with zircon and titanite U–Pb and zircon Hf isotopic data from potassic to ultrapotassic rocks from six plutons that occur within the Archean Itacambira-Monte Azul block(BIMA),to discuss their petrogenesis and the tectonic implications for the São Francisco *** new U–Pb ages range from ca.2.06 Ga to 1.98 Ga and reveal long-lasting potassic magmatism within the BIMA,which is within the late-to-post-collisional stage of the São Francisco paleocontinent *** ultrapotassic rocks are compatible with a fluid-related metasomatized mantle source enriched by previous subduction events,whereas the potassic rocks are bimodal and have a transitional shoshonitic to A-type *** rocks have a hybrid nature,possible related to the mixing between the mafic potassic/ultrapotassic rocks and high temperature crustal melts of the Archean continental *** results also show an increase of within-plate signature towards the younger potassic *** participation of an important Archean crustal component in the genesis of these rocks is highlighted by the common and occasionally abundant occurrence of Archean inherited *** Hf isotopic record shows that most of the zircon inheritance has dominantly subchondriticεHf(t)values,which fits a crustal reworking derivation from a similar Eo-to Paleoarchean precursor ***,the presence of juvenile 2.36 Ga zircon inheritance in an ultrapotassic sample reveal the existence of a hidden reservoir that is somewhat similar to the described for the Mineiro Belt in southern São Francisco paleocontinent.

关键词： Late-to post-collisional Potassic-ultrapotassic rocks U–Pb dating São Francisco paleocontinent Rhyacian-Orosirian orogenic system

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Assessment of Genetic Stability Among In Vitro Plants of Arachis retusa Using RAPD and AFLP Markers for Germplasm Preservation

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Journal of Integrative Plant Biology 2007年第3期49卷 307-312页

作者： Rachel Fatima Gagliardi Luiz Ricardo Hanai Georgia Pacheco Carlos Alberto Oliveira leonardo alves Carneiro José Francisco Montenegro Valls Elisabeth Mansur Maria Lucia Carneiro Vieira Laboratório de micropropagacao e Transformacao de Plantas Universidade do Estado do Rio de Janeiro postal code 20550-013 Maracana Rio de Janeiro Brazil Departamento de Genética - Escola Superior de Agricultura Luiz de Queiroz Universidade de Sao Paulo postal code 13418-900 Piracicaba Brazil Embrapa Recursos Genéticos e Biotecnologia postal code 70770-901 Brasilia Brazil

Arachis retusa Krapov. et W. C. Gregory et Valls is endemic in the West-central region of Brazil, occurring In areas endangered by human actions. The establishment of in vitro preservation methods for wild species of Arachis is an alternative to seed banks for germplasm storage, multiplication and distribution. The risk of genetic changes Induced by tissue culture and the monitoring of the genetic stability of the biological material before, during and after storage must be considered In the context of conservation. Random amplified polymorphlc ONA （RAPO） and amplified fragment length polymorphism （AFLP） fingerprinting were used to evaluate the genetic stability of in vitro plants originated from cotyledons and embryo axes of A. retusa. Cotyledons originated shoots through direct organogenesls and embryo axes displayed muItishoot formation Induced by 110 mmol/L and 8.8 mmol/L BAP, respectively. Ninety genomlc regions （loci） generated from RAPO and 372 from AFLP analyses were evaluated. All amplified fragments detected by both techniques in plants derived from the two explant types were monomorphic. The results Indicate that the recovered shoots are genetically stable at the assessed genomic regions.

关键词： amplified fragment length polymorphism Arachis retusa in vitro preservation micropropagation random amplifiedpolymorphic DNA somaclonal variation

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Effects of environmental conditions and space on species turnover for three plant functional groups in Brazilian savannas

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Journal of Plant Ecology 2019年第6期12卷 1047-1058页

作者： Hélio Menegat Divino Vicente Silvério Henrique A.Mews Guarino R.Colli Ana Clara Abadia leonardo Maracahipes-Santos Lorrayne A.Gonçalves Jhany Martins Eddie Lenza Universidade do Estado de Mato Grosso Campus Universitário de Nova XavantinaRua Prof.Dr.Renato Figueiro VarellaCaixa Postal0878690-000Nova XavantinaMTBrazil Instituto de Pesquisa Ambiental da Amazônia Rua Horizontina 10478640-000CanaranaMTBrazil Centro de Ciências Biológicas e da Natureza Universidade Federal do AcreCaixa Postal 50069920-900Rio BrancoACBrazil Departamento de Zoologia Universidade de Brasília70910-900BrasíliaDFBrazil

Aims Different plant functional groups display diverging responses to the same environmental ***,we assess the effects of environmental and spatial predictors on species turnover of three functional groups of Brazilian savannas(Cerrado)plants—trees,palms and lianas—across the transition zone between the Cerrado and Amazon biomes in central *** We used edaphic,climatic and plant composition data from nine one-hectare plots to assess the effects of the environment and space on species turnover using a Redundancy Analysis and Generalized Dissimilarity Modeling(GDM),associated with variance *** Findings We recorded 167 tree species,5 palms and 4 liana *** variation was most important in explaining species turnover,relative to geographic distance,but the best predictors differed between functional groups:geographic distance and silt for lianas;silt for palms;geographic distance,temperature and elevation for *** distances alone exerted little influence over species turnover for the three functional *** pure environmental variation explained most of the liana and palm turnover,while tree turnover was largely explained by the shared spatial and environmental *** effects of geographic distance upon species turnover leveled off at about 300 km for trees,and 200 km for lianas,whereas they were unimportant for palm species *** results indicate that environmental factors that determine floristic composition and species turnover differ substantially between plant functional groups in ***,we recommend that studies that aim to investigate the role of environmental conditions in determining plant species turnover should examine plant functional groups separately.

关键词： environmental gradient spatial gradient Neotropical savannas ecological tension zone life forms ecological groups

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Characterization of porous cobalt hexacyanoferrate and activated carbon electrodes under dynamic polarization conditions in a sodium-ion pseudocapacitor

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Journal of Energy Chemistry 2021年第3期30卷 53-62页

作者： Bruno Morandi Pires Willian Goncalves Nunes Bruno Guilherme Freitas Francisca Elenice Rodrigues Oliveira Vera Katic Cristiane Barbieri Rodella leonardo Morais Da Silva Hudson Zanin Advanced Energy Storage Division Manufacturing CroupCarbon Sci-Tech LabsCenter for Innovation on New EnergiesUniversity of CampinasCampinas 13083-852SPBrazil Brazilian Synchrotron light Laboratory(LNLS/Brazilian Center of Energy and Materiab(CNPEM)) Campinas 13083-970SPBrazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri's VatleyAlto dajacuba 39100-000Diamantina-MGBrazil

We report here the activated carbon and cobalt hexacyanoferrate composite,which is applied as the electrode materials in symmetric supercapacitors containing a 1.0 M Na_(2)SO_(4) aqueous *** novel material combines high specific surface area and electrochemical stability of activated carbon with the redox properties of cobalt hexacyanoferrate,resulting in maximum specific capacitance of 329 F g^(-1) with large voltage working window of 2.0 *** studies indicated that cobalt hexacyanoferrate introduces important pseudocapacitive properties accounting for the overall charge-storage process,especially when Imic polarization conditions using the in situ Raman spectroscopy and synchrotron light Xray diffraction *** complementary findings were obtained in these *** believe that this novel electrode material is promising for applications regarding the energy-storage process in pseudocapacitors with long lifespan properties.

关键词： Operando studies Raman XRD synchrotron light Cobalt hexacyanoferrate Activated carbon High specific capacitance

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Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 612-622页

作者： Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr Department of Gastroenterology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil Department of Pathology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil

Objective:Remnant gastric cancer(RGC)is usually associated with a worse *** they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for *** study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated ***:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively *** resections with histological diagnosis of gastric adenocarcinoma were enrolled in the *** risk score based on immune parameters was developed using binary logistic regression *** were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune *** markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the *** score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR *** were no differences in clinicopathological and surgical characteristics between the three *** survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR *** the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse ***:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with ***,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic bi

关键词： Stomach neoplasms gastric remnant tumor-infiltrating lymphocytes immune microenvironment

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