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Change in neoadjuvant chemotherapy could alter the prognosis of patients with pancreatic adenocarcinoma: A case report

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World Journal of Clinical Cases 2021年第14期9卷 3418-3423页

作者： Alberto Meyer Bárbara J Carvalho Kayo AA Medeiros leonardo z pipek Fernanda S Nascimento Milena O Suzuki João VT Munhoz Leandro R Iuamoto Luiz A Carneiro-D'Alburquerque Wellington Andraus Gastroenterologia Hospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01426-010Brazil Gastroenterologia Faculdade de Medicinada Universidade de São PauloSão Paulo 05403-000Brazil Orthopaedics and Traumatology Faculdade de Medicinada Universidade de São PauloSão Paulo 05403-000Brazil

BACKGROUND Neoadjuvant treatment has become a standard of care for borderline or locally advanced pancreatic cancer and is increasingly considered even for up-front resectable *** aim of this article is to present the case of a 62-year-old patient with locally advanced pancreatic adenocarcinoma who was successfully treated with gemcitabine plus nab-paclitaxel after the failure of the first line *** SUMMARY Computerized tomography scan and magnetic resonance imaging demonstrated a nodular lesion of ill-defined limits in the body of the pancreas,measuring approximately 4.2 cm×2.7 cm,with an infiltrative *** tumor had contact with the superior mesenteric vein,splenomesenteric junction and the proximal segment of the splenic artery,causing focal reduction of its *** to vascular involvement,neoadjuvant chemotherapy treatment with eight cycles of“folinic acid,5-fluorouracil,irinotecan and oxa-liplatine”(FOLFIRINOX)were *** the end of the cycles,surgery was performed,but the procedure was interrupted due to finding of lesions suspected of *** plus nab-paclitaxel was then successfully used for neoadjuvant treatment with subsequent R0 surgical *** Gemcitabine plus nab-paclitaxel may be effective as an alternative regimen when FOLFIRINOX fails as the first line of treatment,suggesting the need for further studies to identify which patients would benefit from each type of therapeutic approach.

关键词： Neoadjuvant chemotherapy Pancreatic cancer Resectable pancreatic cancer Borderline resectable Neoadjuvant Pancreas Case report

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Reevaluation of dialect boundaries in the Yellowhammer(Emberiza citrinella)based on citizen science data:Should we split or lump?

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Avian Research 2023年第3期14卷 361-368页

作者： Lucie Diblíkova Pavel pipek Stanislav Vosolsobe Adam Petrusek Tereza Petruskova Charles University Faculty of ScienceDepartment of EcologyVinicna 7PragueCZ-12800Czech Republic Czech Academy of Sciences Institute of BotanyDepartment of Invasion EcologyZamek 1PrůhoniceCZ-25243Czech Republic Charles University Faculty of ScienceDepartment of Experimental Plant BiologyVinicna 5PragueCZ-12800Czech Republic

Dialects are a specific form of geographic variation of birdsong with relatively sharp boundaries between distinct song characteristics,which provide opportunities for focused studies of processes underlying the emergence of spatial patterns in *** songbird species that exhibit dialects became models for such research,and for some of them large-scale datasets were assembled that included recordings provided by the *** them,the Yellowhammer(Emberiza citrinella,Emberizidae) is particularly prominent,as it has been recently a subject of dedicated citizen science projects focusing on its dialect *** most successful,in terms of public participation as well as the number and density of obtained recordings,was the Dialects of Czech Yellowhammers(DCY) project,which assembled detailed data at the whole-country level.A mosaic of almost all common song variants known across Europe was observed in Czechia,but the results indicated that some of the traditionally recognized Yellowhammer dialects may not represent geographically clustered song variants,at least not in Central *** quantitatively analysed variation(frequency and temporal characteristics and modulation) of the terminal song element in three dialects defined by arbitrary frequency thresholds in *** analyses indicated that pooling these to two distinct groups reflects the variation in the songs,as well as their spatial distribution,better than retaining the current classification to three dialects or their finer splitting to even more *** provide simple measures that may be used for classification of these Yellowhammer song variants in Central ***,we warn from indiscriminate transposing of results from one region to another,as that may lead to substantial *** studies of birdsong variation will benefit from big data assembled by citizen scientists,but to maximise their usefulness for further dialect research,careful delineation of d

关键词： Birdsong Geographic variation Bioacoustics Dialects Public participation

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Exact recession velocity and cosmic redshift based on cosmological principle and Yang-Mills gravity

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Chinese Physics C 2019年第10期43卷 105-111页

作者： leonardo Hsu Jong-Ping Hsu College of Education and Human Development University of MinnesotaMinneapolisMN 55455USA Department of Chemistry and PhysicsSanta Rosa Junior CollegeSanta RosaCA 95401USA Department of Physics University of Massachusetts DartmouthNorth DartmouthMA 02747-2300USA

Based on the cosmological principle and quantum Yang-Mills gravity in the super-macroscopic limit, we obtain an exact recession velocity and cosmic redshift z, as measured in an inertial frame F≡F(t,x,y,z). For a matter-dominated universe, we have the effective cosmic metric tensor Gμν(t)=(B^2(t),-A^2(t),-A^2(t),-A^2(t)), A∝B∝t^1/2, where t has the operational meaning of time in F frame. We assume a cosmic action S≡Scos involving Gμν(t) and derive the ‘Okubo equation’ of motion, G^μν(t)■μS■νS-m^2=0, for a distant galaxy with mass m. This cosmic equation predicts an exact recession velocity, r=rH/[1/2+√1/4+r^2H^2/C0^2]z as measured in F. It is natural to assume the massless Okubo equation, G^μν(t)■μψe■νψe=0, for light emitted from accelerated distant galaxies. Based on the principle of limiting continuation of physical laws, we obtain a transformation for covariant wave 4-vectors between and inertial and an accelerated frame, and predict a relationship for the exact recession velocity and cosmic redshift, z=[(1+Vr)/(1-Vr^2)1/2]-1, where Vr=r/Co<1, as observed in the inertial frame F. These predictions of the cosmic model are consistent with experiments for small velocities and should be further tested.

关键词： Yang-Mills gravity recession velocity speed limit of recession velocity redshift

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Large primary hepatic gastrinoma in young patient treated with trisegmentectomy: A case report and review of the literature

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World Journal of Hepatology 2018年第7期10卷 517-522页

作者： leonardo zumerkorn pipek Yuri Justi Jardim Gustavo Heluani Antunes de Mesquita Fernanda Nii Kayo Augusto de Almeida Medeiros Bárbara Justo Carvalho Diego Ramos Martines Leandro Ryuchi Iuamoto Daniel Reis Waisberg Luiz Augusto Carneiro D'Albuquerque Alberto Meyer Wellington Andraus Faculdade de Medicina FMUSP Universidade de Sa?o Paulo Program in Global Surgery and Social Change Department of Global Health and Social Medicine Harvard Medical School Departamento de Gastroenterologia Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo

Primary hepatic gastrinoma is a rare disease, with fewer than 40 cases reported in the medical literature. Because it is located in an organ in which metastases are common, its diagnosis is difficult. We report a case of a 19 years old male patient with a history of gastric ulcers since the age of nine. Following gastric surgery, an antrectomy and a vagotomy, there was some alleviation of symptoms. Subsequently, the patient reported various intermittent episodes of diarrhea, diffuse abdominal pain, and vomiting. The patient underwent tomography, which revealed the presence of a hepatic mass measuring 19.5 cm × 12.5 cm × 17 cm. Primary hepatic gastrinoma was diagnosed based on laboratory examinations that indicated hypergastrinemia and a positron emission tomography/magnetic resonance study with somatostatin analogue that confirmed the liver as the primary site. After hepatic trisegmentectomy(Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅷ), the patient's symptoms improved. The case is notable for the presence of a rare tumor with uncommon dimensions.

关键词： Gastrinoma Primary hepatic gastrinoma zollinger-Ellison syndrome Hepatic trisegmentectomy Gastric surgery

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Learning the Mapping x→Σi=1^d xi^(2):the Cost of Finding the Needle in a Haystack

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Communications on Applied Mathematics and Computation 2021年第2期3卷 313-335页

作者： Jiefu zhang leonardo zepeda-Nunez Yuan Yao Lin Lin Department of Mathematics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Mathematics University of Wisconsin-MadisonMadisonWI 53706USA Department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Computational Research Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

The task of using the machine learning to approximate the mapping x→Σi=1^d xi^(2)with Xi∈[-1,1]seems to be a trivial *** the knowledge of the separable structure of the function,one can design a sparse network to represent the function very accurately,or even *** such structural information is not available,and we may only use a dense neural network,the optimization procedure to find the sparse network embedded in the dense network is similar to finding the needle in a haystack,using a given number of samples of the *** demonstrate that the cost(measured by sample complexity)of finding the needle is directly related to the Barron norm of the *** only a small number of samples are needed to train a sparse network,the dense network trained with the same number of samples exhibits large test loss and a large generalization *** control the size of the generalization gap,we find that the use of the explicit regularization becomes increasingly more important as d *** numerically observed sample complexity with explicit regularization scales as G(d^(2.5)),which is in fact better than the theoretically predicted sample complexity that scales as 0(d^(4)).Without the explicit regularization(also called the implicit regularization),the numerically observed sample complexity is significantly higher and is close to 0(d^(4.5)).

关键词： Machine learning Sample complexity Generalization error

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Mismatch repair protein expression and intratumoral budding in rectal cancer are associated with an increased pathological complete response to preoperative chemoradiotherapy: A case-control study

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World Journal of Clinical Oncology 2018年第7期9卷 133-139页

作者： leonardo S Lino-Silva Armando Gamboa-Domínguez Diego zú?iga-Tamayo Rosa A Salcedo-Hernández Lucely Cetina David Cantú-de-León Surgical Pathology Instituto Nacional de Cancerología Surgical Pathology Instituto Nacional de ciencias Médicas y Nutrición salvador Zubirán Surgical Oncology Instituto Nacional de Cancerología Medical Oncology Instituto Nacional de Cancerología

AIM To determine whether the association of rectal adenocarcinoma with a defective-mismatch repair system(dMMR) was associated with a pathological complete response(pCR) to preoperative *** A case-control study was designed with the aim of determining if patients with rectal adenocarcinoma with dM MR had an associated high pCR rate in response to neoadjuvant chemoradiotherapy(nCRT).RESULTS Seventy-two cases with pCR were compared against 144 controls without pCR. Across 216 cases, the mean age was 56.8 years, 140(64.8%) were men, and 63(29.2%) demonstrated the dMMR system. The pCR was associated with G1 tumors, dMMR, the absence of vascular invasion, and low tumor budding in the pretreatment biopsy. In a multivariant analysis, the factors associated with pCR were dMMR(OR: 2.61; 95%CI: 1.355-5.040, P = 0.004) and a low degree of tumor budding(OR: 2.52; 95%CI: 1.366-4.894, P = 0.025).CONCLUSION We found an independent association between dMMR and a low rate of tumor budding, with a higher rate of pCR, in the basal biopsies of patients with rectal carcinoma subjected to nCRT.

关键词： Rectal cancer Chemoradiotherapy Tumor budding Mismatch repair Pathological complete response

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Understanding electricity prices beyond the merit order principle using explainable AI

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Energy and AI 2023年第3期13卷 149-159页

作者： Julius Trebbien leonardo Rydin Gorjao Aaron Praktiknjo Benjamin Schafer Dirk Witthaut Forschungszentrum Julich Institute for Energy and Climate Research–Systems Analysis and Technology Evaluation(IEK-STE)52428 JülichGermany University of Cologne Institute for Theoretical PhysicsZülpicher Str.7750937 CologneGermany Faculty of Science and Technology Norwegian University of Life Sciences1432 AsNorway Chair for Energy System Economics Institute for Future Energy Consumer Needs and Behavior(FCN)E.ON Energy Research CenterRWTH Aachen UniversityMathieustr.1052074 AachenGermany Institute for Automation and Applied Informatics Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany JARA-ENERGY 52074 AachenGermany

Electricity prices in liberalized markets are determined by the supply and demand for electric power,which are in turn driven by various external influences that vary strongly in *** perfect competition,the merit order principle describes that dispatchable power plants enter the market in the order of their marginal costs to meet the residual load,*** difference of load and renewable *** market models are based on this principle when attempting to predict electricity prices,yet the principle is fraught with assumptions and simplifications and thus is limited in accurately predicting *** this article,we present an explainable machine learning model for the electricity prices on the German day-ahead market which foregoes of the aforementioned assumptions of the merit order *** model is designed for an ex-post analysis of prices and builds on various external *** SHapley Additive exPlanation(SHAP)values we disentangle the role of the different features and quantify their importance from empiric data,and therein circumvent the limitations inherent to the merit order *** show that load,wind and solar generation are the central external features driving prices,as expected,wherein wind generation affects prices more than solar ***,fuel prices also highly affect prices,and do so in a nontrivial ***,large generation ramps are correlated with high prices due to the limited flexibility of nuclear and lignite ***,we offer a model that describes the influence of the main drivers of electricity prices in Germany,taking us a step beyond the limited merit order principle in explaining the drivers of electricity prices and their relation to each other.

关键词： Electricity prices Merit order principle Explainable artificial intelligence Machine learning Fuel prices Energy market

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First histopathological study in kidneys of rodents naturally infected with Leptospira pathogenic species from Yucatan, Mexico

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 140-142页

作者： Marco Torres-Castro leonardo Guillermo-Cordero Silvia Hernández-Betancourt Edwin Gutiérrez-Ruíz Piedad Agudelo-Flórez Ronald Peláez-Sánchez Jorge zavala-Castro Fernando I.Puerto Centro de Investigaciones Regionales ‘Dr.Hideyo Noguchi' Universidad Autónoma de Yucatán Campus de Ciencias Biológicas y Agropecuarias Universidad Autónoma de Yucatán Facultad de Medicina Universidad CES

Objective: To report the renal histological lesions in synanthropic rodents, Mus musculus and Rattus rattus, naturally infected with Leptospira spp., captured in a rural community in Yucatan, Mexico. Methods: Kidney samples of synanthropic rodents were collected from a rural community in Yucatan, Mexico. Polymerase chain reaction was used to detect Leptospira spp. infection. Tissue kidney was fixed in 10% buffered formalin, processed according to the usual techniques for paraffin inclusion, cut and stained with hematoxylin and eosin, and examined using a conventional electronic microscope. Results: A total of 187 rodents were captured. Nine individuals(4.8%) were positive for Leptospira spp. in the molecular analysis. All renal lesions observed in the histopathological study had been reported previously for Leptospira spp. infection. Conclusions: The histopathological lesions are present in the kidneys, plus the results of the polymerase chain reaction confirm that these rodents are true carriers of Leptospira spp.

关键词： Leptospira spp. Renal histopathological lesions Mus musculus Rattus rattus

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Influence of oxidation of automatic transmission fluids (ATFs) and sliding distance on friction coefficients of a wet clutch in the running-in stage

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Friction 2021年第2期9卷 401-414页

作者： leonardo Israel FARFAN-CABRERA Ezequiel Alberto GALLARDO-HERNÁNDEz Manuel VITE-TORRES Jesús Gilberto GODÍNEz-SALCEDO Tecnologico de Monterrey Escuela de Ingeniería y CienciasAve.Eugenio Garza Sada 2501Monterrey 64849México Instituto Politécnico Nacional SEPI-Escuela Superior de Ingeniería Mecánica y EléctricaUnidad ZacatencoGrupo de TribologíaCol.LindavistaCiudad de México 07738México Instituto Politécnico Nacional ESIQIEIPNCol.LindavistaCiudad de México 07738México

In this paper,the influence of oxidation of automatic transmission fluids(ATFs)and sliding distance on the friction coefficients of a wet clutch in approached running-in conditions was *** ATFs were oxidized by a laboratory process approaching oxidation occurred in actual *** was evaluated by means of increase in carbonyl compounds and depletion of zinc dialkyldithiophosphates(zDDPs)***,the changes in kinematic viscosity and viscosity index were ***-ondisk tests were conducted to replicate the actual sliding contact in a wet *** pin specimens were cut from friction material composite plates and the disks were actual steel separators both from an automotive wet *** coefficient, μ,was measured at progressive sliding velocity,ν,to obtain μ–νcurves at 26 and 100°*** μ–νtests were consecutively run using the same pair of specimens and *** cumulative sliding distance for each μ–νtest generated surface flattening using the *** friction coefficients of the wet clutch increased due to the ATFs oxidation meanwhile the dm/dv values decreased in most *** suggests that ATF oxidation can enhance torque capacity of the wet clutch,but it could reduce anti-shudder *** sliding distance improved the slopes in the μ–νresults using fresh ATFs meanwhile it generated a slope decrease by using aged ATFs.

关键词： wet clutch friction oil oxidation automatic transmission fluid(ATF)

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Indentation fracture toughness of single-crystal Bi2Te3 topological insulators

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Nano Research 2016年第4期9卷 1032-1042页

作者： Caterina Lamuta Anna Cupolillo Antonio Politano ziya S. Aliev Mahammad B. Babanly Evgueni V. Chulkov leonardo Pagnotta Department of Mechanical Energy and Management Engineering University ofCalabria Ponte P Bucci Cuba 44C 87036 Rende Italy Department of Physics University of Calabria Ponte P Bucci Cuba 31 C 87036 Rende Italy Institute of Catalysis and Inorganic Chemistry ANAS AZ1143 Baku Azerbaijian Institute of Physics ANAS AZ1143 Baku Azerbaijian Donostia International Physics Center (DIPC) Paseo de Manuel Lardizabal 4 20018 San Sebastian/Donostia Spain Departamento de Fisica de Materiales Universidad del Pals Vasco Apartado 1072 20080 San Sebastidn/Donostia Spain Centro de Fisica de Materiales CFM-Materials Physics Center MPC Centro Mixto CSIC-UPV/EHU Paseo de Manuel Lardizabal 5 20018 San Sebastion/Donostia Spain Saint Petersburg State University 198504 Saint Petersburg Russian Federation Tomsk State University 634050 Tomsk Russian Federation

Bismuth teUuride （Bi2Te3） is one of the most important commercial thermoelectric materials. In recent years, the discovery of topologically protected surface states in Bi chalcogenides has paved the way for their application in nanoelectronics. Determination of the fracture toughness plays a crucial role for the potential application of topological insulators in flexible electronics and nanoelectro- mechanical devices. Using depth-sensing nanoindentation tests, we investigated for the first time the fracture toughness of bulk single crystals of Bi2Te3 topological insulators, grown using the Bridgmantockbarger method. Our results highlight one of the possible pitfalls of the technology based on topological insulators.

关键词： topological insulators bismuth telluride (Bi2Te3) fracture toughness nanoindentation

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