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Hair Growth Promoting Effect of Trichoxidil<up>TM</up>: A New Natural Compound for Hair Loss

Journal of Cosmetics, Dermatological Sciences and Applications 2020年第4期10卷 176-190页

作者： Glaucia Labinas Fernando Amaral Valeria Maria de Souza Antunes Maira Jardim leonardo mendes bella Carlos Rocha Oliveira Universidade Anhembi Morumbi S&#227 o Paulo Brazil

Background: Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of TrichoxidilTM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. Methods: The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of TrichoxidilTM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);TrichosolTM vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);TrichosolTM vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);TrichosolTM group with 2.5% TrichoxidilTM (n = 5) and Hydroalcoholic vehicle group with 2.5% TrichoxidilTM (n = 4) to dermoscopic and histologic. Results: Fibroblasts exhibited higher proliferation when treated with higher concentrations of TrichoxidilTM. TrichoxidilTM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that TrichoxidilTM associated with TrichosolTM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. Conclusion: TrichoxidilTM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.

关键词： TrichoxidilTM Hair Growth Anagen Telogen KGF IGF-1

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Light tuning CO/H_(2)composition on Ag:Unraveling CO_(2)mass transfer and electron-phonon coupling in plasmon-enhanced electrocatalysis

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Nano Research 2025年第1期18卷 173-185页

作者： Rui Lin Dong Fan Luca MBerger Thomas Possmayer Yu Zhou Jiexin Zhu Xingbao Chen Wen Luo Lars Allmendinger Andreas Tittl leonardo de Souza Menezes Guillaume Maurin Shihe Yang and Stefan AMaier Nanoinstitute Munich Faculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Institut Charles Gerhardt Montpellier UMR 5253 CNRS ENSCM UniversitéMontpellierPlace E.Bataillon34090 MontpellierFrance Guangdong Provincial Key Lab of Nano-Micro Material Research School of Advanced MaterialsPeking University Shenzhen Graduate SchoolShenzhen 518055China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München81377 MunichGermany Departamento de Física Universidade Federal de Pernambuco50670-901 Recife-PEBrazil School of Physics and Astronomy Monash University Clayton CampusMelbourneVictoria 3800Australia Department of Physics Imperial College LondonSW72AZ LondonUK

Plasmon-enhanced electrocatalysis(PEEC)is an emerging approach to mitigate CO_(2)*** mechanisms behind CO_(2)adsorption and reduction at the catalyst-electrolyte interface in PEEC still need to be further ***,we employ a well-defined Ag nanostructure to elucidate these pivotal *** shining light with wavelengths of 625,525,405 nm on Ag,an adjustable CO/H_(2)ratio from 35 to 1 can be *** reaction pathway changing under plasmonic excitation does not originate from the lowered CO_(2)mass transfer in the vicinity of Ag,as the electrochemical quartz crystal microbalance results unravel that a slightly elevated temperature in bulk electrolyte caused by light irradiation cannot weaken the CO_(2)adsorption at the Ag catalyst-electrolyte *** calculations reveal that optical excitation towards shorter wavelengths leads to a progressive lowered energy barrier for H_(2)formation together with an enhanced energy barrier for^(*)COOH *** thermodynamically suppressed,CO_(2)reduction can still be improved kinetically by optimizing the excitation wavelength and intensity,being accompanied with the enhanced *** absorption spectroscopy results further correlate the higher photocurrent with a prolonged electron-phonon coupling time,verifying that the improvement of CO_(2)reduction kinetics in PEEC can be realized by hot electron harnessing.

关键词： plasmonic catalysis photoelectrochemical CO_(2)reduction CO/H_(2)ratio hot electron generation electronphonon coupling thermal effect

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Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

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World Journal of Stem Cells 2019年第7期11卷 421-430页

作者： JoséBraganca Joao AndréLopes leonardo mendes-Silva Joao Miguel Almeida Santos Department of Biomedical Sciences and Medicine University of AlgarveFaro 8005-139Portugal Centre for Biomedical Research(CBMR) University of AlgarveFaro 8005-139Portugal

Induced pluripotent stem cells(iPSC)technology has propelled the field of stem cells biology,providing new cells to explore the molecular mechanisms of pluripotency,cancer biology and aging.A major advantage of human iPSC,compared to the pluripotent embryonic stem cells,is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human *** addition,iPSC can be generated from somatic cells harvested from normal individuals or patients,and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible *** these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells,these cells hold an immense potential for cell-based therapies,and for the discovery of new or personalized pharmacological treatments for many ***,we review some of the current challenges and concerns about iPSC *** introduce the potential held by iPSC for research and development of novel health-related *** briefly present the efforts made by the scientific and clinical communities to create the necessary guidelines and regulations to achieve the highest quality standards in the procedures for iPSC generation,characterization and long-term ***,we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells.

关键词： Induced pluripotent stem cells Reprogramming Cell-based therapy Stem cell banking Disease modelling

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Iterative Learning Control for homing guidance design of missiles

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Defence Technology（防务技术） 2017年第5期13卷 360-366页

作者： leonardo Acho Escola d'Enginyeria de Barcelona Est-EEBE Universitat Politecnica de Catalunya-UPCSpain

This paper presents an Iterative Learning Control design applied to homing guidance of missiles against maneuvering targets. According to numerical experiments, although an increase of the control energies is appreciated with respect to a previous published base controller for comparison, this strategy, which is simple to realize, is able to reduce the time to reach the head-on condition to target destruction. This fact is important to minimize the missile lateral force-level to fulfill engaging in hyper-sonic target persecutions.

关键词： Terminal guidance law Missiles Iterative learning control

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CHARACTERISATION OF RATIONAL AND NURBS DEVELOPABLE SURFACES IN COMPUTER AIDED DESIGN

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Journal of Computational Mathematics 2021年第4期39卷 556-573页

作者： leonardo Fernandez-Jambrina ETSI Navales Universidad Politecnica de Madrid28040-MadridSpain

In this paper we provide a characterisation of rational developable surfaces in terms of the blossoms of the bounding curves and three rational functions∧,M,ν.Properties of developable surfaces are revised in this *** particular,a closed algebraic formula for the edge of regression of the surface is obtained in terms of the functions∧,M,ν,which are closely related to the ones that appear in the standard decomposition of the derivative of the parametrisation of one of the bounding curves in terms of the director vector of the rulings and its *** is also shown that all rational developable surfaces can be described as the set of developable surfaces which can be constructed with a constant∧,M,ν.The results are readily extended to rational spline developable surfaces.

关键词： NURBS Bezier Rational Spline NURBS Developable surfaces

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Early Permian arc-related volcanism and sedimentation at the western margin of Gondwana： Insight from the Choiyoi Group lower section

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Geoscience Frontiers 2016年第5期7卷 715-731页

作者： leonardo Strazzere Daniel A.Gregori leonardo Benedini CONICET and Catedra de Ceologia Argentina Departamento de Geologia Universidad Nacional del Sur San Juan 670 8000 Bahia Blanca Argentina

Permian sedimentary and basic to intermediate volcanic rocks assigned to the Conglomerado del Río Blanco and Portezuelo del Cenizo Formation, lower part of the Choiyoi Group, crop out between the Cordon del Plata, Cordillera Frontal and Precordillera of Mendoza Province, Argentina. The sedimentary rocks are represented by six lithofacies grouped in three facies associations. They were deposited by mantled and gravitational flows modified by high-energy fluvial currents that evolved to low-energy fluvial and lacustrine environments. They constitute the Conglomerado del Río Blanco, which cover unconformably marine Carboniferous sequences. Five volcanic and volcaniclastic facies make up the beginning of volcanic activity. The first volcanic event in the Portezuelo del Cenizo is basaltic to andesitic lava-flows emplaced in the flanks of volcanoes. Lava collapse produced thick block and ash *** in the intermediate volcanic rocks, there are dacites of different geochemical signature,which indicate that the development of acidic volcanism was coetaneous with the first volcanic *** geochemistry of these rocks induces to consider that the Choiyoi Group Lower section belongs to a magmatic arc on continental crust. The age of this section is assigned to the lower Permian（277 ？ 3.0Ma, Kungurian age）.

关键词： Choiyoi group lower section Conglomerado del Río Blanco Cordillera Frontal Argentina

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Modeling the effect of sediment concentration on the flow-like behavior of natural debris flow

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International Journal of Sediment Research 2020年第4期35卷 315-327页

作者： leonardo Schippa Department of Engineering University of Ferrara 1 Via Saragat

The rheological behavior of natural slurries consisting of fine-grained,reconstituted debris-flow deposits on pyroclastic terrains having different solid concentrations(ranging from 30 to 42%) has been investigated using a rotational rheometer equipped with a vane rotor *** were done by increasing the applied shear stress step by step;then a decreasing stress ramp was applied following the same shear stress *** slurry mixtures exhibit a typical yield-stress fluid behavior with a static yield stress larger than the dynamic yield *** the range of the shear rate corresponding to the flowlike behavior the slurry mixtures behave as a dilatant fluid at lower grain concentrations and as a pseudoplastic fluid in correspondence with the higher grain content,showing a strong discrepancy from the Bingham *** rheological behavior is better interpreted by a Herschel-Bulkley model,whose rheological parameters strongly depend on the granular ***,a generalized Herschel-Bulkley model accounting for the bulk sediment concentration effect is *** rheological behavior of natural slurries consisting of fine-grained, reconstituted debris-flow deposits on pyroclastic terrains having different solid concentrations(ranging from 30 to 42%) has been inves?tigated using a rotational rheometer equipped with a vane rotor system. Experiments were done by increasing the applied shear stress step by step; then a decreasing stress ramp was applied following the same shear stress levels. The slurry mixtures exhibit a typical yield-stress fluid behavior with a static yield stress larger than the dynamic yield stress. In the range of the shear rate corresponding to the flow?like behavior the slurry mixtures behave as a dilatant fluid at lower grain concentrations and as a pseudoplastic fluid in correspondence with the higher grain content, showing a strong discrepancy from the Bingham idealization. The rheological behavior is better i

关键词： Debris flow Rheology Grain concentration Herschel-Bulkley model

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SARS-CoV-2 spike protein:flexibility as a new target for fighting infection

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Signal Transduction and Targeted Therapy 2020年第1期5卷 321-323页

作者： Ciro leonardo Pierri Laboratory of Biochemistry Molecular and Structural BiologyDepartment of BiosciencesBiotechnologiesBiopharmaceuticsUniversity of BariVia E.Orabona470125 BariItaly BROWSer S.r.l.(https://***/)c/o Department of Biosciences BiotechnologiesBiopharmaceuticsUniversity“Aldo Moro”of BariVia E.Orabona470126 BariItaly

The recent study of Turoňováet al.,is the first to combine cryoelectron tomography,subtomogram averaging,and molecular dynamics simulations for analyzing the structure of the SARS-CoV-2 spike protein in situ,1 *** t... 详细信息

关键词： al infection fighting

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