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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological characteristics.METHODS We retrospectively reviewed 284 GC patients who underwent D2-gastrectomy.PD-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive score.All PD-L1+PT staged as pN+were also tested for PD-L1 expression in their LNM.PD-L1(-)GC with pN+served as the comparison group.RESULTS Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the LNM.Regarding PD-L1(-)PT,9.1%(4/44)had PD-L1+in the LNM.The agreement between PT and LNM had a kappa value of 0.483.Larger tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both sites.There was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched LNM.This disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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书赞桉诺:畅想下一个百年——采访书赞桉诺木浆业务与物流全球负责人leonardo Grimaldi先生

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中华纸业 2024年第4期45卷 18-21,M0003页

作者：李玉峰 leonardo Grimaldi 不详书赞桉诺木浆业务与物流

起源于巴西的书赞桉诺,日前在上海与中国利益相关方共同庆祝了其成立100周年。“一诺百年,初心如一(Planting the future for the next 100 years)”的庆祝主题也完美地诠释了书赞桉诺百年奋斗路的执着、专一和创新。成立于1924年的书... 详细信息

起源于巴西的书赞桉诺,日前在上海与中国利益相关方共同庆祝了其成立100周年。“一诺百年,初心如一(Planting the future for the next 100 years)”的庆祝主题也完美地诠释了书赞桉诺百年奋斗路的执着、专一和创新。成立于1924年的书赞桉诺,在2024年正式踏入了百年企业的行列。据统计,从全球范围来看,百年企业的数量也不过是几万家。几乎所有的人都会好奇百年企业的秘诀是什么?

关键词：利益相关方百年企业物流全球范围

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Clinical implications of single cell sequencing for bladder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： REZA YADOLLAHVANDMIANDOAB MEHRSA JALALIZADEH FRANCIELE APARECIDA VECHIA DIONATO KEINI BUOSI PATRÍCIA A.F.LEME LUCIANA S.B.DAL COL CRISTIANE F.GIACOMELLI ALEX DIAS ASSIS NASIM BASHIRICHELKASARI leonardo OLIVEIRA REIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per year.In this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines.We searched PubMed,CENTRAL,Embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February 2023.We included original studies that used at least one single-cell technology to study bladder cancer.Forty-one publications were included in the review.Twenty-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition therapy.Two studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine samples.The remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell level.Single-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer management.This nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

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Robotic Surgery: An Effective Treatment Option for Epiphrenic Diverticulum Associated with Nutcracker Esophagus

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Surgical Science 2024年第1期15卷 1-6页

作者： Augusto Tinoco Gilberto Carvalho leonardo Tinoco Ana Paula Quintão Department of Digestive Surgery Hospital S&#227o Jos&#233 do Ava&#237 Itaperuna Brazil

Background: Epiphrenic Diverticulum is frequently associated with esophageal motility disorders, such as nutcrackers esophagus. The diagnosis is usually made using imaging studies such as a Barium esophagogram, and esophageal manometry. Surgical treatment options for epiphrenic diverticulum and EN include diverticulectomy and wide myotomy. Aim: The resection of three epiphrenic diverticula and extensive myotomy were performed by robotic thoracoscopy uneventfully. Case presentation: A 65-year-old female complaining of dysphagia for solid foods, Chest pain and regurgitation. Esophagogastroduodenoscopy (EDG) with difficulty in advancing the endoscope at 25 cm and demonstrating an ED, no hiatal hernia and normal stomach and duodenum. Barium Esophagogram showed multiple diverticula and tortuosity throughout the esophagus. Conclusion: With robotic surgery, surgeons can perform highly precise operations with enhanced 3D vision and control. Through this cutting-edge approach, the treatment of ED associated with EN can be drastically changed, promising better outcomes for patients.

关键词： Robotic Surgery Myotomy Nutcracker Esophagus Epiphrenic Diverticulum

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Bruton’s tyrosine kinase inhibitors in primary central nervous system lymphoma:New hopes on the horizon

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World Journal of Clinical Oncology 2024年第5期15卷 587-590页

作者： leonardo S Lino-Silva Sabrina B Martínez-Villavicencio Luisa Fernanda Rivera-Moncada Department of Pathology Oncology National Cancer Institute(Mexico)TlalpanMexico City 14080Mexico

In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotrexate(HD-MTX)as a therapeutic intervention for primary central nervous system lymphoma(PCNSL).The study involves a retrospective analysis of 19 PCNSL patients,highlighting clinicopathological characteristics,treatment outcomes,and genomic biomarkers.The results indicate the combination’s good tolerance and strong antitumor activity,with an 84.2%overall response rate.The authors emphasize the potential of zanubrutinib to modulate key genomic features of PCNSL,particularly mutations in myeloid differentiation primary response 88 and cluster of differentiation 79B.Furthermore,the study investigates the role of circulating tumor DNA in cerebrospinal fluid for disease surveillance and treatment response monitoring.In essence,the study provides valuable insights into the potential of combining zanubrutinib with HD-MTX as a frontline therapeutic regimen for PCNSL.The findings underscore the importance of exploring alternative treatment modalities and monitoring genomic and liquid biopsy markers to optimize patient outcomes.While the findings suggest promise,the study’s limitations should be considered,and further research is needed to establish the clinical relevance of this therapeutic approach for PCNSL.

关键词： Primary central nervous system lymphoma Zanubrutinib Bruton’s tyrosine kinase Prognosis Myeloid differentiation primary response 88 gene Cluster of differentiation 79B gene

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Solar-driven CO_(2) conversion to methane and methanol using different nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

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Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian D.Moura Torquato Juliana Fde Brito Gustavo A.Andolpho Mateus A.Gonçalves leonardo D.De Angelis Lucas D.Germano Susana I.Córdoba de Torresi Teodorico C.Ramalho Maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron system.The highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,respectively.The performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for CH4production.Density functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au atoms.Studies using isotope-labeling and analysis by gas chromatograph-mass(GC-MS)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction DFT calculations

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渴！渴！渴！墨西哥城即将用光最后一滴水！

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环球人文地理 2024年第11期 46-55页

作者：方小白陈曦Stanley ulrikestein 欧德立 Alex Wolf leonardo fforriol

2024年春夏之交，“干渴的墨西哥城”频繁作为主角，登上其他国家的新闻：“约2100万居民面临缺水”“零日即将到来！或用光最后一滴水”“谁来给墨西哥城解渴”……电视上接受采访的墨城居民无不忧心忡忡。或许他们并不知道，此时此刻...

2024年春夏之交，“干渴的墨西哥城”频繁作为主角，登上其他国家的新闻：“约2100万居民面临缺水”“零日即将到来！或用光最后一滴水”“谁来给墨西哥城解渴”……电视上接受采访的墨城居民无不忧心忡忡。或许他们并不知道，此时此刻整个城市如此缺水，跟他们祖先之间的一场战争有关，也跟一场“杀湖案”有关—为了扩大居住面积，墨城人花几百年时间排光了一个巨湖的水，“杀死”了湖，利用湖底平整的土地建起了伟大的墨西哥城。

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Can foods influence the onset and progress of neurodegenerative diseases?

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Neural Regeneration Research 2022年第11期17卷 2443-2444页

作者： Luca Piemontese leonardo Brunetti Rosalba Leuci Department of Pharmacy and Pharmaceutical Sciences University of Bari Aldo Moro

Over the course of the last few years,the advertisement and marketing of commercial food products in the European market has seen an increasing focus on the beneficial effects of such products for consumer health(Regulation,2006).These so-called"health claims", which can be found on the label of some food products,have become a very important medium,aiming to reach the maximum amount of potential consumers possible,and the delivery of these promises has become a crucial objective for food companies or consortia.However,in most cases,the evidence backing up such claims(and their coveted acknowledgment on the product label) has often been cited as insufficient by institutions such as the European Food and Safety Authority (EFSA,Parma,Italy).

关键词： companies Authority claims

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Toxicological effects of mining hazard elements

Energy Geoscience

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Energy Geoscience 2022年第3期3卷 255-262页

作者： leonardo Lucas da Silva-Rego leonardo Augusto de Almeida Juciano Gasparotto Instituto de Ciencias Biomedicas-Universidade Federal de Alfenas AlfenasMinas GeraisRua Gabriel Monteiro da Silva700CEP:37130-001Centro-Alfenas/MGBrazil

Mining plays a prominent role in the economy worldwide since human efforts have been more concentrated in extraction than recycling of natural resources.Ores composed of various minerals vary according to the geological evolution.These are raw materials for the conventional industries or fossil fuels for power generation.They can also be used in new technologies.The mining industry triggers intense environmental impacts.Human exposure to multiple small particles from mining effluent,such as dust,uranium,iron,lead,zinc,silicon,titanium,sulfur,nitrogen,platinum,chromium,vanadium,manganese,and mercury,is a health risk.Such elements can have several pathological effects,such as respiratory and cardiovascular,multiple chronic inflammation,and neurodegenerative diseases.Additionally,mining results in severe soil,water(surface and aquifer),and air contamination,reaching large areas far away from the source.Negligence of mining companies,with the recovery of ancient mined areas during the early development of environmental laws and regulations,compromises environmental integrity for more extended periods,increasing coverage of the affected areas.This review evaluates the toxicological effects on humans exposed to the mining wastes and the impact of these compounds on the ecosystem.The results of our evaluation can be used by the government,manufacturers,scientists,private environmental organizations,decision-makers,and readers from different areas of knowledge to explore the potential risk of mining to the ecosystem and human health.

关键词： Mining operation Toxicology Environmental impact Ecosystem Human health

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