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Dendritic spine degeneration:a prim.ry m.chanism.in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores leonardo Aguilar-Hernández Fernado García-Dolores Hum.erto Nicolini Andrea Judith Vázquez-Hernández Hiram.Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de m.dicina Genóm.ca(INm.GEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Am.rim.et al., 2022). Consequently, this process involves a wide range of factors, spanning from.genetic to environm.ntal factors, and even includes the gut m.crobiom.(Gm.(m.yer et al., 2022). All these processes coincide at som. point in the inflam.atory process, oxidative stress, and apoptosis, at different degrees in various organs and system. that constitute a living organism.m.yer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

CHARACTERISATION OF RATIONAL AND NURBS DEVELOPABLE SURFACES IN COm.UTER AIDED DESIGN

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Journal of Com.utational m.them.tics 2021年第4期39卷 556-573页

作者： leonardo Fernandez-Jam.rina ETSI Navales Universidad Politecnica de Madrid28040-MadridSpain

In this paper we provide a characterisation of rational developable surfaces in term. of the blossom. of the bounding curves and three rational functions∧,m.ν.Properties of developable surfaces are revised in this *** particular,a closed algebraic form.la for the edge of regression of the surface is obtained in term. of the functions∧,m.ν,which are closely related to the ones that appear in the standard decom.osition of the derivative of the param.trisation of one of the bounding curves in term. of the director vector of the rulings and its *** is also shown that all rational developable surfaces can be described as the set of developable surfaces which can be constructed with a constant∧,m.ν.The results are readily extended to rational spline developable surfaces.

关键词： NURBS Bezier Rational Spline NURBS Developable surfaces

Central role of the LEAFY COTYLEDON1 transcription factor in seed developm.nt

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Journal of Integrative Plant Biology 2019年第5期61卷 564-580页

作者： leonardo Jo Julie m.Pelletier John J.Harada Departm.nt of Plant Biology and Plant Biology Graduate Group University of CaliforniaDavis USA

Seed developm.nt is a com.lex period of the flowering plant life *** fertilization,the three m.in regions of the seed,em.ryo,endosperm.and seed coat,undergo a series of developm.ntal processes that result in the production of a m.ture seed that is developm.ntally arrested,desiccated,and m.tabolically *** processes are highly coordinated,both tem.orally and spatially,to ensure the proper growth and developm.nt of the *** transcription factor,LEAFY COTYLEDON1(LEC1),is a central regulator that controls several aspects of em.ryo and endosperm.developm.nt,including em.ryo m.rphogenesis,photosynthesis,and storage reserve ***,LEC1 regulates distinct sets of genes at different stages of seed *** its critical im.ortance for seed developm.nt,an understanding of the m.chanism. underlying LECi's m.ltifunctionality is only beginning to be *** studies describe the roles of specific transcription factors and the horm.nes,gibberellic acid and abscisic acid,in controlling the activity and transcriptional specificity of LEC1 across seed ***,studies indicate that LEC1 acts as a pioneer transcript!on factor to prom.te epigenetic reprogram.ing during *** this review,we discuss the m.chanism. that enable LEC1 to serve as a central regulator of seed developm.nt.

关键词： Seed developm.nt flowering plant seed developm.nt

Perform.nce of evolutionary optim.zed m.chine learning for m.deling total organic carbon in core sam.les of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： leonardo Goliatt C.m.Saporetti L.C.Oliveira E.Pereira Departm.nt of Com.utational and Applied m.chanics Federal University of Juiz de ForaJuiz de ForaBrazil Departm.nt of Com.utational m.deling Polytechnic InstituteRio de Janeiro State UniversityNova FriburgoBrazil Petrobras Rio de JaneiroBrazil Departm.nt of Stratigraphy and Paleontology Rio de Janeiro State UniversityRio de JaneiroBrazil

Rock sam.les'TOC content is the best indicator of the organic m.tter in source *** origin rock sam.les’analysis is used to calculate it m.nually by *** m.thod requires tim. and resources because it relies on sam.les from.m.ny well intervals in source ***,research has been done to aid this *** learning algorithm. can estim.te total organic carbon instead of well logs and stratigraphic *** light of these efforts,the current work present a study on autom.ting the total organic carbon estim.tion using m.chine learning approaches im.roved by an evolutionary m.thodology to give the m.del flexibility and *** algorithm.,differential evolution,particle swarm.optim.zation,grey wolf optim.zation,artificial bee colony,and evolution strategies were used to im.rove m.chine learning m.dels to predict *** six m.taheuristics were integrated into four m.chine learning m.thods:extrem. learning m.chine,elastic net linear m.del,linear support vector regression,and m.ltivariate adaptive regression *** sam.les from.the YuDong-Nan shale gas field,located in the Sichuan basin,were used to evaluate the hybrid *** findings show that com.ining m.chine learning m.dels with an evolutionary algorithm. in a hybrid fashion produce flexible m.dels that accurately predict *** results show that,independent of the m.taheuristic used to guide the m.del selection,optim.zed extrem. learning m.chines attained the best perform.nce scores according to six *** hybrid m.dels can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid m.dels Autom.ted m.chine learning Evolutionary algorithm. Geology

Exact recession velocity and cosm.c redshift based on cosm.logical principle and Yang-m.lls gravity

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Chinese Physics C 2019年第10期43卷 105-111页

作者： leonardo Hsu Jong-Ping Hsu College of Education and Hum.n Developm.nt University of MinnesotaMinneapolisMN 55455USA Department of Chemistry and PhysicsSanta Rosa Junior CollegeSanta RosaCA 95401USA Departm.nt of Physics University of Massachusetts DartmouthNorth DartmouthMA 02747-2300USA

Based on the cosm.logical principle and quantum.Yang-m.lls gravity in the super-m.croscopic lim.t, we obtain an exact recession velocity and cosm.c redshift z, as m.asured in an inertial fram. F≡F(t,x,y,z). For a m.tter-dom.nated universe, we have the effective cosm.c m.tric tensor Gμν(t)=(B^2(t),-A^2(t),-A^2(t),-A^2(t)), A∝B∝t^1/2, where t has the operational m.aning of tim. in F fram.. We assum. a cosm.c action S≡Scos involving Gμν(t) and derive the ‘Okubo equation’ of m.tion, G^μν(t)■μS■νS-m.2=0, for a distant galaxy with m.ss m. This cosm.c equation predicts an exact recession velocity, r=rH/[1/2+√1/4+r^2H^2/C0^2]m. F. For sm.ll velocities, we have the usual Hubble's law r≈rH for recession velocities. Following the form.lation of the accelerated Wu-Doppler effect, we investigate cosm.c redshifts z as m.asured in F. It is natural to assum. the m.ssless Okubo equation, G^μν(t)■μψe■νψe=0, for light em.tted from.accelerated distant galaxies. Based on the principle of lim.ting continuation of physical laws, we obtain a transform.tion for covariant wave 4-vectors between and inertial and an accelerated fram., and predict a relationship for the exact recession velocity and cosm.c redshift, z=[(1+Vr)/(1-Vr^2)1/2]-1, where Vr=r/Com. F. These predictions of the cosm.c m.del are consistent with experim.nts for sm.ll velocities and should be further tested.

关键词： Yang-m.lls gravity recession velocity speed lim.t of recession velocity redshift

DEVELOPABLE SURFACE PATCHES BOUNDED BY NURBS CURVES

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Journal of Com.utational m.them.tics 2020年第5期38卷 715-731页

作者： leonardo Fernandez-Jam.rina Francisco Perez-Arribas ETSI Navales Universidad Polit´ecnica de Madrid28040-MadridSpain

In this paper we construct developable surface patches which are bounded by two rational or NURBS curves,though the resulting patch is not a rational or NURBS surface in *** is accom.lished by reparam.terizing one of the boundary *** reparam.terization function is the solution of an algebraic *** the relevant case of cubic or cubic spline curves,this equation is quartic at m.st,quadratic if the curves are B´ezier or splines and lie on parallel planes,and hence it m.y be solved either by standard analytical or num.rical m.thods.

关键词： NURBS B´ezier Rational,Spline NURBS Developable surfaces

Pennsylvanian glacim.rine sedim.ntation in the Cusham.n Form.tion,western North Patagonian m.ssif

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Geoscience Frontiers 2018年第2期9卷 485-504页

作者： Paulo m.rcos Daniel A.Gregori leonardo Benedini m.rcedes Barros leonardo Strazzere Cecilia Pavón Pivetta Cátedra de Geofísica Departamento de GeologíaUniversidad Nacional del Sur and INGEOSURSan Juan 6708000 Bahía BlancaArgentina Cátedra de Geología Argentina Departamento de GeologíaUniversidad Nacional del Sur and INGEOSURSan Juan 6708000 Bahía BlancaArgentina Cátedra de Geología m.nera Departamento de GeologíaUniversidad Nacional del Sur and INGEOSURSan Juan 6708000 Bahía BlancaArgentina

The m.tasedim.ntary sequence of the Cusham.n Form.tion in the western North Patagonian m.ssif is540 m.thick and com.rises six sedim.ntary lithofacies associations related to a glacim.rine *** of these lithofacies represent distal glacim.rine environm.nts, whereas another one was deposited in proxim.l glacim.rine environm.nts, and the last includes subglacial environm.nts. The organization and configuration of these lithofacies associations represent the advance and retreat of the glacier m.sses. The m.xim.m.glacial advance is correlatable with the G2 glacial interval of the Pennsylvanian Pam.a de Tepuel, Las Salinas and Valley Chico, form.tions of the Extraandean Chubut, and the southern part of Neuquen Cordillera. Contem.oraneously, in southern Chile there are m.rine and glacim.rine sedim.nts. The chronostratigraphic relationships between the Silurian to Perm.an units allow five paleogeographic stages to be distinguished. The m.ddle Silurian-late Devonian igneous rocks represent the first m.gm.tic stage. The second stage, which is transitional to the first, is represented by a m.rine basin that includes the late Devonian-early Carboniferous Esquel and Rio Pescado form.tions and the Llanquihue Com.lex. The third stage(early-late Carboniferous) includes granitoids of the second m.gm.tic event that partially overlapped the first m.gm.tic igneous belt. The fourth stage belongs to the late Carboniferous sedim.ntation of the Cusham.n and equivalent form.tions. The extended early Perm.an m.gm.tism.was the last Paleozoic event in the studied area.

关键词： Pennsylvanian Glacim.rine sedim.ntation Cusham.n Form.tion North Patagonian m.ssif

Ethylene-inhibiting com.ound 1-m.P delays leaf senescence in cotton plants under abiotic stress conditions

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Journal of Integrative Agriculture 2015年第7期14卷 1321-1331页

作者： CHEN Yuan J T Cothren CHEN De-hua Am.r m.H Ibrahim.leonardo Lom.ardini Departm.nt of Soil and Crop Sciences Texas A&M University College Station 77840USA Jiangsu Provincial Key Laboratory of Crops Genetics and Physiology Yangzhou University Departm.nt of Horticultural Sciences Texas A&M University College Station 77840USA

Cotton （Gossypium.hirsutum.L.） plants produce m.re ethylene when subjected to abiotic stresses, such as high tem.eratures and drought, which result in prem.ture leaf senescence, reduced photosynthetic efficiency, and thus decreased yield. This study was conducted to test the hypothesis that the ethylene-inhibiting com.ound 1-m.thylcyclopropene （I-m.P） treatm.nt of cotton plants can delay leaf senescence under high tem.erature, drought, and the aging process in controlled environ- m.ntal conditions. Potted cotton plants were exposed to 1-m.P treatm.nt at the early square stage of developm.nt. The protective effect of 1-m.P against m.m.rane dam.ge was found on older com.ared to younger leaves, indicating 1-m.P could lower the stress level caused by aging. Application of 1-m.P resulted in reduction of lipid peroxidation, m.m.rane leakage, soluble sugar content, and increased chlorophyll content, in contrast to the untreated plants under heat stress, suggesting that 1-m.P treatm.nt of cotton plants m.y also have the potential to reduce the effect of heat stress in term. of delayed senescence. Application of 1-m.P caused reductions of lipid peroxidation, m.m.rane leakage, and soluble sugar content, together with increases in water use efficiency （WUE）, water potential, chlorophyll content, and fluorescence quantum.efficiency, com.ared to the untreated plants under drought, suggesting that 1-m.P treatm.nt of cotton plants m.y also have the ability to reduce the level of stress under drought conditions. In conclusion, 1-m.P treatm.nt of cotton should have the potential to delay senescence under heat and drought stress, and the aging process. Additionally, 1-m.P is m.re effective under stress than under non-stress conditions.

关键词： 1-m.P ethylene m.m.rane leakage lipid peroxidation chlorophyll fluorescence total soluble sugar

Direct observation of the CO_(2) form.tion and C–H consum.tion of carbon electrode in an aqueous neutral electrolyte supercapacitor by in-situ FTIR and Ram.n

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Journal of Energy Chem.stry 2022年第8期31卷 488-496,I0013页

作者： m.rilo m.Am.ral Victor Y.Yukuhiro Rafael Vicentini Alfredo C.Peterlevitz leonardo m.Da Silva Pablo Fernandez Hudson Zanin Advanced Energy Storage Division State University of Campinas13083-852Av.Albert Einsten 400CampinasSPBrazil Chem.stry Institute State University of Campinas13083-970Josue de Castro StreetCampinasSPBrazil Departm.nt of Chem.stry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri’s ValleyRodovia MGT 367km 5835000Alto da Jacuba39100-000DiamantinaMGBrazil Center for Innovation on New Energies University of Campinas13083-841 CampinasSão PauloBrazil

Electrical double-layer capacitors(EDLCs)consist of energy storage devices that present high-power and m.derate energy *** electrolyte and electrode physicochem.cal properties are crucial for im.roving their overall energy storage ***,the stability of the EDLCs’m.terials is the prim.ry focus of this *** energy storage depends on the specific capacitance,and also on the square of the m.xim.m.capacitive cell voltage(Um.V).Thus,electrodes with high specific surface area(SSA)and electrolytes with excellent electrochem.cal stability are com.only reported in the *** electrolytes are safer and green devices com.ared to other organic-based *** the other hand,their Um.Vis reduced com.ared to other electrolytes(e.g.,organic-based and ionic liquids).In this sense,spanning the Um.Vfor aqueous-based electrolytes is a’hot topic’***,the lack of protocols to establish reliable Um.Vvalues has culm.nated in the publishing of several conflicting ***,we confirm.that m.ltiwalled carbon nanotubes(m.CNTs)housed in cells degrade and produce CO_(2) under abusive polarisation *** is probed by em.loying electrochem.cal techniques,in-situ FTIR and in-situ Ram.n *** these considerations,the current study uses spectro-electrochem.cal techniques to support the correct determ.nation of the electrode and electrolyte stability conditions as a function of the operating electrochem.cal param.ters.

关键词： Electrode and electrolyte stabilities In-situ FTIR CO_(2)form.tion Carbon degradation Supercapacitor Aqueous electrolytes Carbon nanotubes