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Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics?A systematic review and narrative synthesis

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Bone Research 2022年第4期10卷 661-678页

作者： Anja R.Zelmer Renjy nelson Katharina Richter Gerald j.Atkins Centre for Orthopaedic and Trauma Research Faculty of Health and Medical SciencesUniversity of AdelaideAdelaideSA 5000Australia Department of Infectious Diseases Central Adelaide Local Health NetworkAdelaideSA 5000Australia Royal Adelaide Hospital AdelaideSA 5000Australia Richter Lab Department of SurgeryBasil Hetzel Institute for Translational Health ResearchUniversity of AdelaideAdelaideSA 5011Australia

Approximately 40%of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial *** aureus,the predominant pathogen in human osteomyelitis,is known to persist by phenotypic adaptation as small-colony variants(SCVs)and by formation of intracellular reservoirs,including those in major bone cell types,reducing susceptibility to *** infections with *** are difficult to treat;however,there are no evidence-based clinical guidelines addressing these infections in *** conducted a systematic review of the literature to determine the demonstrated efficacy of all antibiotics against intracellular *** relevant to osteomyelitis,including protein biosynthesis inhibitors(lincosamides,streptogramins,macrolides,oxazolidines,tetracyclines,fusidic acid,and aminoglycosides),enzyme inhibitors(fluoroquinolones and ansamycines),and cell wall inhibitors(beta-lactam inhibitors,glycopeptides,fosfomycin,and lipopeptides).The PubMed and Embase databases were screened for articles related to intracellular *** infections that compared the effectiveness of multiple antibiotics or a single antibiotic together with another treatment,which resulted in 34 full-text articles fitting the inclusion *** combined findings of these studies were largely inconclusive,most likely due to the plethora of methodologies ***,the reported findings in the context of the models employed and possible solutions for improved understanding are explored *** rifampicin,oritavancin,linezolid,moxifloxacin and oxacillin were identified as the most effective potential intracellular treatments,the scientific evidence for these is still relatively *** advocate for more standardized research on determining the intracellular effectiveness of antibiotics in *** osteomyelitis to improve treatments and patient outcomes.

关键词： treatment finding synthesis

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Biosphere 2’s Lessons about Living on Earth and in Space

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Space(Science & Technology) 2021年第1期2021卷 274-284页

作者： Mark nelson Institute of Ecotechnics(US/UK) USA

Biosphere 2,the largest and most biodiverse closed ecological system facility yet created,has contributed vital lessons for living with our planetary biosphere and for long-term habitation in *** the space life support perspective,Biosphere 2 contrasted with previous BLSS work by including areas based on Earth wilderness biomes in addition to its provision for human life support and by using a soil-based intensive agricultural system producing a complete human *** previous BLSS system had included domestic farm *** human and domestic animal wastes were also recycled and returned to the crop *** 2 was important as a first step towards learning how to miniaturize natural ecosystems and develop technological support systems compatible with *** 2’s mostly successful operation for three years(1991-1994)changed thinking among space life support scientists and the public at large about the need for minibiospheres for long-term habitation in *** an Earth systems laboratory,Biosphere 2 was one of the first attempts to make ecology an experimental science at a scale relevant to planetary issues such as climate change,regenerative agriculture,nutrient and water recycling,loss of biodiversity,and understanding of the roles wilderness biomes play in the Earth’s *** 2 aroused controversy because of narrow definitions and expectations of how science is to be *** cooperation between engineers and ecologists and the requirement to design a technosphere that supported the life inside without harming it have enormous relevance to what is required in our global *** of bioregenerative life support systems for near-term space applications such as initial Moon and/or Mars bases,will be severely limited by high costs of transport to space and so will rely on lighter weight,hydroponic systems of growing plants which will focus first on water and air regeneration and gradually increase its production of fo

关键词： Earth Biosphere bases

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Immune stress and diet influence reproductive fitness in male tuatara (Sphenodon punctatus)

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Current Zoology 2024年第6期70卷 786-794页

作者： Sarah K.Lamar Diane K.Ormsby Nicola j.nelson School of Biological Sciences Level 2Te Toki a Rata BuildingVictoria University of WellingtonWellington 6012New Zealand Centre for Biodiversity and Restoration Ecology Level 2Te Toki a Rata BuildingVictoria University of WellingtonWellington 6012New Zealand

The theoretical trade-off between immune and endocrine investment in mating animals has received mixed empirical support,particularly in *** investigated the relationship between male sexual characteristics,diet,and immune response to stress in an island population of tuatara(Sphenodon punctatus)across two mating *** are promiscuous,with a highly skewed mating system where males face significant competition for access to mates and postcopulatory competition for fertilization *** found that tuatara sperm viability and swim speed were negatively associated with male body condition and the ratio of heterophils to ***,sperm swim speed was negatively associated with spine area,mite load,and the total number of circulating white blood cells,but was positively associated with tick *** is likely a function of social dynamics in this system where larger male size predicts greater spatial overlap with potential rivals and increased tick *** the production of sexual characteristics may be costly,we also investigated the effect of diet on sperm *** did not identify an association between diet and sperm ***,sperm swim speed was negatively associated with carbon-13 and positively associated with *** suspect that these results reflect the influence of seabird-based nutrients in this island ecosystem,particularly polyunsaturated fatty acid,and antioxidant damage on tuatara *** total,these results provide evidence of a trade-off between pre-and post-copulatory sexual characteristics and the immune and endocrine systems in male tuatara.

关键词： reproductive ftness reptiles sexual selection sperm characteristics tuatara

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Mercury photoreduction and photooxidation in lakes：Effects of filtration and dissolved organic carbon concentration

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journal of Environmental Sciences 2018年第6期30卷 151-159页

作者： nelson j.O’Driscoll Emma Vost Erin Mann Sara Klapstein Robert Tordon Matthew Lukeman Department of Earth & Environmental Science Acadia University Wolfville B4P 2R6 Nova Scotia Canada Environment Canada Dartmouth Nova Scotia Canada Department of Chemistry Acadia University Wolfville B4P 2R6 Nova Scotia Canada

Mercury is a globally distributed, environmental contaminant. Quantifying the retention and loss of mercury is integral for predicting mercury-sensitive ecosystems. There is little information on how dissolved organic carbon（DOC） concentrations and particulates affect mercury photoreaction kinetics in freshwater lakes. To address this knowledge gap,samples were collected from ten lakes in Kejimkujik National Park, Nova Scotia（DOC： 2.6–15.4 mg/L）. Filtered（0.2 μm） and unfiltered samples were analysed for gross photoreduction, gross photooxidation, and net reduction rates of mercury using pseudo first-order curves. Unfiltered samples had higher concentrations（p = 0.04） of photoreducible divalent mercury（Hg（II）RED）（mean of 754 ± 253 pg/L） than filtered samples（mean of 482 ± 206 pg/L）;however, gross photoreduction and photooxidation rate constants were not significantly different in filtered or unfiltered samples in early summer. DOC was not significantly related to gross photoreduction rate constants in filtered（R2= 0.43; p = 0.08） and unfiltered（R2= 0.02; p = 0.71） samples; DOC was also not significantly related to gross photooxidation rate constants in filtered or unfiltered samples. However, DOC was significantly negatively related with Hg（Ⅱ）RED in unfiltered（R2= 0.53; p = 0.04）, but not in filtered samples（R2= 0.04;p = 0.60）. These trends indicate that DOC is a factor in determining dissolved mercury photoreduction rates and particles partially control available Hg（Ⅱ）RED in lake water. This research also demonstrates that within these lakes gross photoreduction and photooxidation processes are close to being in balance. Changes to catchment inputs of particulate matter and DOC may alter mercury retention in these lakes and could partially explain observed increases of mercury accumulation in biota.

关键词： Mercury Photoreduction Photooxidation Dissolved organic carbon(DOC) Particulates Kejimkujik National Park

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Geographic information technology usage in developing countries – A case study in Mozambique

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Geo-Spatial Information Science 2018年第4期21卷 331-345页

作者： nelson Amade Marco Painho Tiago Oliveira Universidade Catolica de Mocambique BeiraMozambique Nova Information Management School Universidade Nova de LisboaLisboaPortugal

Geographic information technologies(GIT)have matured,have become pervasive throughout many types of organizations over recent decades and gained a wide range of attention in diverse sectors of *** goal of this paper is to identify the main drivers and uses of GIT in organizations and to give an overview of GIT uses in developing countries with a focus on a case study developed for Mozambique by analyzing the results of a survey of 123 Mozambican organizations that are current GIT *** results show that the main drivers behind are compatibility,complexity,competitive pressure,donor pressure,government policy,intention to adopt,innovation,relative advantage,security,and technology *** of the public and private sectors use GIT for customer/resource/risk management,decision support,education,research,monitoring,prediction,simulation,suitability analysis,sustainability,use and access.

关键词： Geographic information technologies organizations remote sensing GPS geographic information systems Mozambique

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Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications

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Nano-Micro Letters 2024年第3期16卷 1-35页

作者： Sourav Dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen Salvador Pané Bradley j.nelson Hongsoo Choi Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea DGIST‑ETH Microrobotics Research Center DGISTDaegu 42988Republic of Korea Multi‑Scale Robotics Lab Institute of Robotics and Intelligent SystemsETH Zurich8092 ZurichSwitzerland Institute of Optoelectronics State Key Laboratory of Photovoltaic Science and TechnologyShanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionFudan UniversityShanghai 200433People’s Republic of China

Synthetic micromotor has gained substantial attention in biomedicine and environmental ***-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A noteworthy number of degradable metal-based micromotors employ bubble propulsion,utilizing water as fuel to generate hydrogen *** novel feature has projected degradable metallic micromotors for active in vivo drug delivery *** addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and *** propulsion efficiency and life span govern the overall performance of a degradable metallic *** we review the design and recent advancements of metallic degradable ***,we describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical ***,we discuss micromotors’efficacy in detecting and destroying environmental ***,we address the limitations and future research directions of degradable metallic micromotors.

关键词： Magnesium Zinc Iron Biodegradable microrobot Biomedical Environmental

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Perspectives on the clinical management ocalized prostate cancer

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Asian journal of Andrology 2014年第4期16卷 511-514页

作者： joel B nelson Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.

Defined broadly, prostate cancer has two states： An indolent histologicalmanifestation of a locally proliferative and invasive process or a clinically relevant, potentially lethal disease. Likewise, the management of clinically localized prostate cancer must address two questions： what sort of disease is this and what needs to be done.

关键词： @@

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Evolutionary implications of deception in mimicry and masquerade

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Current Zoology 2014年第1期60卷 6-15页

作者： Ximena j. nelson School of Biological Sciences University of Canterbury Private Bag 4800 Christchurch New Zealand

Aggressive mimicry occurs when an organism resembles some aspect of another organism （the model） in order to obtain prey through its deceptive resemblance. This may function either through the overt response of the receiver or through the lack of response of the receiver. Reviewing selected examples, I discuss some of the difficulties in ascribing a model for the mimic. I also discuss how a single animal can have multiple ploys in its armoury of deceptive signals, thus belonging within two or more categories of deceptive signalling. In addition to aggressive mimicry, these may include crypsis or camouflage, mas- querade （mimicry of inanimate objects）, and Batesian or protective mimicry. Each of these examples of deception has multiple evolutionary pathways, and some deceptive signals may be more costly to receivers than others, but no single organism is subject to a single selection pressure, leading to the reality that many evolutionary pathways contribute to the diversity we see around us. New technologies are opening new channels of investigation into deceptive signaling in many different sensory modalities, and this is reflected in the recent increase in studies investigating the structure and function of deceptive signals. In turn, these studies are beginning to expose the fascinating complexity of deceptive signaling systems, allowing us to discover the myriad, non-mutually exclusive, solutions that can be selected for to obtain prey

关键词： Mimicry Masquerade Crypsis Deceptive communication Cleaner fish Pre-existing biases

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Refining spatial neighbourhoods to capture terrain effects

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Ecological Processes 2012年第1期1卷 98-108页

作者： Trisalyn A nelson Colin Robertson Spatial Pattern Analysis and Research Lab Department of GeographyUniversity of VictoriaPO Box 3060VictoriaBritish ColumbiaV8W 3R4SCanada Department of Geography and Environmental Studies Wilfrid Laurier UniversityWaterlooOntarioN2L 3C5Canada

Introduction:Spatially explicit ecological research has increased substantially in the past 20 *** spatial approaches require the definition of a spatial neighbourhood or the region over which spatial relationships are modelled or *** neighbourhood definitions impact analysis results,and there are benefits in considering neighbourhood definitions that better capture ecological *** goal of this research is to present a simple and flexible approach in constraining ecological spatial neighbourhoods using terrain ***:Using watershed boundaries,we can restrict spatial neighbourhoods from combining populations or processes that should be separated by terrain *** demonstrate the need for ecological constraints by way of a simulation study and highlight our approach with a case study examining mountain pine beetle(Dendroctonus ponderosae,Coleoptera;Hopkins)infestation hot ***:Our results demonstrate how failure to constrain neighbourhoods can lead to errors when the spatial signals from unrelated populations are ***,unconstrained spatial neighbourhoods can unintentionally detect spatial relationships across many ***:There will be benefits to studies that develop new,ecology-based approaches in defining spatial neighbourhoods that better illuminate ecological function of phenomena under study.

关键词： spatial weights spatial analysis spatial ecology hot spots topography

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On the Coherent States and the Squeezed States

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Chinese Physics Letters 1995年第6期12卷 321-323页

作者： YU Zurong C.A.nelson Department of Physics Nanjing UniversityNanjing 210008 Department of Physics Tongji UniversityShanghai 200092 State University of New York at Binghamton BinghamtonNY 139026000

In this paper the coherent and the squeezed state of the bose field is written as a universal form by means of a projector which transforms the old vacuum state to the new vacuum *** transformed vacuum state is the co... 详细信息

关键词： state. vacuum coherent

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