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Alcoholic liver disease:Utility of animal models

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World journal of Gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-Paz Fengjie Hao leonard j nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of Genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： Steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte nelson Frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Crystalline compounds for remediation of rare-earth fission products:A review

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journal of Rare Earths 2022年第3期40卷 365-380,I0001页

作者： Saehwa Chong Brian j.Riley Zayne j.nelson Pacific Northwest National Laboratory RichlandWA99352USA

Rare earth(RE)-containing crystals have been investigated as media for the immobilization of RE fission products from nuclear waste *** reprocessing of spent nuclear fuel,fission products including REs,alkalis,and alkaline earths released from the *** viable option to immobilize the RE fission products is to incorporate them into chemically durable crystalline phases in specific waste *** study summarizes the crystal structures and synthesis methods of six RE-containing compounds that have applications in remediation of RE fission *** compounds include oxyapatite(AE_(2)RE_(8)(SiO_(4))_(6)O_(2)),oxychloride(REOCl),borosilicate(RE_(3)BSi_(2)O_(10)),pyrochlore(RE_(2)M_(2)O_(7)),monazite(REPO_(4)),and perovskite(REMO_(3))where AE denotes alkaline earth metals and M denotes transition *** review provides an overview of literature on the usage of these six compounds for immobilizing RE fission products and summarizes different synthesis methods for producing these *** of structural parameters with different REs in each compound are also discussed.

关键词： Rare-earth compounds Nuclear waste forms Crystal structures Synthesis of rare-earth compounds

Animal behavior can inform conservation policy, we just need to get on with the jobor can it？

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Current Zoology 2014年第4期60卷 479-485页

作者： Ximena j. nelson, Editor School of Biological Sciences University of Canterbury Private Bag 4800 Christchurch New Zealand

1 Conservation Behavior as an Emerging Discipline on the Brink of Success, or Unrealistic Ideal？ It seems intuitively sensible that an understanding of the behavioral characteristics of animals, such as their home ranges, diets, mating systems, and dispersal me- chanisms, may be useful to inform conservation efforts in determining, for example, suitable reintroduction areas, or the design of dispersal corridors.

关键词：行为特征动物减排新兴学科活动范围交配系统疏散通道再引入

Magnetic Helical Micro-and Nanorobots:Toward Their Biomedical Applications

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Engineering 2015年第1期1卷 21-26页

作者： Famin Qiu Bradley j.nelson Institute of Robotics and Intelligent Systems(IRIS) ETH Zurich

Magnetic helical micro- and nanorobots can perform 3D navigation in various liquids with a sub- micrometer precision under low-strength rotating magnetic fields （〈 10 rer）. Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/ nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications.

关键词： magnetic helical micro/nanorobots mobilemicro/nanorobots artificial bacterial flagella (ABFs) functionalization biomedical applications

Distance assessment of detours by jum ping spiders

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Current Zoology 2020年第3期66卷 263-273页

作者： Samuel AGUILAR-ARGUELLO Daniel GERHARD Ximena j.nelson School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch 8140New Zealand School of Mathem atics and Statistics University of CanterburyPrivate Bag 4800Christchurch 8140New Zealand

To take an indirect route(detour)in order to reach a specific target requires complex cognitive *** more demanding,from the cognitive point of view,is when the goal is only visible at the beginning of the *** spiders from the family Sa lticidae,vision is a key sensory modal-ity mediating navigation and prey *** acute vision allows them to perform complicated detours,possibly as a consequence of the multitude of potential routes in their typically complex 3-dimensional *** used a 4-route choice test,in which routes differed in being either short or long and in the presence or absence of a lure of a prey item,to investigate route assessment in 2 salticid species,Trite planiceps and Marpissa *** both species showed evidence of motivation to follow lured-routes,judging by the number of times they re-oriented toward them while detouring,we found that Trite chose short routes in preference to long routes,but did not prefer the *** contrast,Marpissa exhibited random route choice,although it ori-ented toward lured-routes more often than control routes(lure absent).Our results suggest that decision-making processes about which route to take occurs before embarking on a route,but this is cognitively *** exhibited cognitive limitations in which the lack of visibility of the goal affected ***,the severity of cognitive limitations depended on *** suggest that variability in spatial ability across the Salticidae may be related to the habitat complexity inhabited by each species.

关键词： cognition cognitive limitations decision-making detour behavior Salticidae spatial task

Interrelationship between some morphometric parameters and bodyweight of tank-based cultured African catfish(Clarias gariepinus Burchell,1822)

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Aquaculture and Fisheries 2021年第6期6卷 628-633页

作者： Ikenna Onyekwelu Chinenye Chukwuemeka Anyadike nelson Ike Ossai Oji Achuka Nwoke Emeka leonard Ndulue Department of Agricultural and Bioresources Engineering University of NigeriaNsukka410001Enugu StateNigeria Department of Zoology and Environmental Biology University of NigeriaNsukka410001Enugu StateNigeria

Morphometrics and fish bodyweight studies have shown great importance in estimation of productivity and stock assessment for some fish species. Herein, the aim of this study was to identify the morphometric parameter(s) that has most direct correlation with bodyweight of African catfish (Clarias gariepinus). The experimental layouts were four groups of experimental units, each group was replicated twice. Morphometric parameters considered in this study were total length, standard length, head length, head width and snout length. Data collected were processed and subjected to analysis of variance (ANOVA) and correlation analyses at 5% significant level. Results revealed significantly high correlations between bodyweight and morphometric parameters, with values ranging from 0.834 to 0.977 (upper and lower limits for total and snout lengths respectively). The results further revealed that relationship between bodyweight and morphometric parameters followed third-degree polynomial, with R2 ranging from 0.700 to 0.969 (upper and lower limits for total and snout lengths respectively). Significant high correlations (>0.85) exist between morphometric parameters selected for this study. In conclusion, in sampling programs of African catfish where the aim is to select fishes with high bodyweights, emphasis should be given to fishes with highest total length.

关键词： Clarias gariepinus Bodyweight Morphometrics Total length Parameters

Statistical distribution of geomechanical properties and‘Sweet Spots’identification in part of the upper Bakken

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Petroleum Research 2023年第3期8卷 301-308页

作者： nelson R.K.Tatsipie james j.Sheng Texas Tech University United States

Completions and Reservoir Quality are two key attributes that are used to characterize nonconventional hydrocarbon *** is because,for optimum exploitation of these unconventional assets,horizontal wells need to be drilled in“Sweet Spots”(i.e.,regions where Completions and Reservoir Quality are both superior).One way to quantify these qualities is to use reservoir and geomechanical *** properties can be estimated on a location basis from well logs,and then mapped over terrain using geostatistical *** study presents a‘Sweet Spots’identification workflow based on three performance indexes(Storage Potential Index,Brittleness Index,and Horizontal Stress Index)that can be used to quantify CQ and *** performance indexes are computed from petrophysical property volumes(of Young's Modulus,Bulk Modulus,Shear Modulus,Poisson's Ratio,Minimum Horizontal Stress,Volume of Shale,Total Organic Carbon,Thickness,and Porosity)which are in turn computed from well logs and geostatistical *** the end,the study offers a method to compare the predicted“Sweet Spots”against available production data via their correlation *** resulting reasonable formation property maps,the successful identification of‘Sweet Spots’,and a correlation coefficient of 0.88(between the predicted“Sweet Spots”and well production data)point to the potential of the proposed effort.

关键词： Sweet spots Sequential Gaussian simulation Storage potential index Brittleness index Horizontal stress index

Assessing the utility of dissolved organic matter photoreactivity as a predictor of in situ methylmercury concentration

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journal of Environmental Sciences 2018年第6期30卷 160-168页

作者： Sara j.Klapstein Susan E.Ziegler David A.Risk nelson j.O'Driscoll Environmental Science Program Memorial University of Newfoundland Department of Earth Sciences St. Francis Xavier University Department of Earth and Environmental Science Acadia University

Methylmercury（MeHg） bioaccumulation is a growing concern in ecosystems worldwide. The absorption of solar radiation by dissolved organic matter（DOM） and other photoreactive ligands can convert MeHg into less toxic forms of mercury through photodemethylation. In this study, spectral changes and photoreactivity of DOM were measured to assess the potential to control photoreactions and predict in situ MeHg concentration. Water samples collected from a series of lakes in southwestern Nova Scotia in june, August, and September were exposed to controlled ultraviolet-A（UV-A） radiation for up to 24 hr. Dissolved organic matter photoreactivity, measured as the loss of absorbance at 350 nm at constant UV-A irradiation, was positively dependent on the initial DOM concentration in lake waters（r^2=0.94）. This relationship was consistent over time with both DOM concentration and photoreactivity increasing from summer into fall across lakes. Lake in situ MeHg concentration was positively correlated with DOM concentration and likely catchment transport in june（r = 0.77） but not the other sampling months. Despite a consistent seasonal variation in both DOM and Fe, and their respective correlations with MeHg, no discernable seasonal trend in MeHg was observed. However, a 3-year dataset from the 6 study lakes revealed a positive correlation between DOM concentration and both Fe（r = 0.91） and MeHg concentrations（r = 0.51） suggesting a more dominant landscape mobility control on *** DOM-MeHg relationships observed in these lakes highlights the need to examine DOM photoreactivity controls on MeHg transport and availability in natural waters particularly given future climate perturbations.

关键词： Methylmercury Dissolved organic carbon Photoreactions Kejimkujik National Park Freshwater lakes