检索结果-南通市图书馆

Health 2013年第11期5卷 16-34页

作者： Kenneth Blum David Han Marlene Oscar-Berman Gary Reinl Nicholas DiNubile Margaret A. Madigan Anish Bajaj Bernard William Downs John Giordano Wayne Westcott leonard smith Eric R. Braverman Kristina Dushaj Mary Hauser Thomas Simpatico Thomas McLaughlin Joan Borsten Debmayla Barh Center for Psychiatric Medicine North Andover USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Medinipur India Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Department of Executive Health Path Research Foundation NY New York USA Department of Exercise Science Quincy College Quincy USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Department of Management Science and Statistics The University of Texas at San Antonio San Antonio USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Igene LLC Austin USA Department of Psychiatry Anatomy & Neurobiology Boston VA and Boston University School of Medicine Boston USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Department of Executive Health Path Research Foundation NY New York USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Electronic Waveform Lab Department of Pain Research Huntington Beach USA Department of Orthopedic Surgery Hospital of the University of Pennsylvania Philadelphia USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Department of Executive Health Path Research Foundation NY New York USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Dominion Diagnostics LLC North Kingstown USA Department of Psychiatry Human Integrated Services Unit of Vermont Center for Clinical & Translational Science University of Vermont College of Medicine Burlington USA Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Me

The mounting endemic of prescription iatrogenic opioid dependence in pain patients provoked this treatise about an alternative method that can be used to treat pain, improve function and reduce the risk of opioid dependence. It is well known that as well as the side effects reported for chronic opioid therapy, genetically predisposed individuals are at risk for opioid dependence. We propose the use of the Genetic Addiction Risk Score (GARS) assessment to identify patients early in treatment who should avoid narcotic pain medications. Primarily, this review will be an exploration of the mechanisms of action of an electrotherapeutic alternative to narcotic treatment that can be used to augment tissue healing and reduce the pain associated with human injuries and neuropathies. This particular electrotherapeutic device was developed at the Electronic Waveform Laboratory in Huntington Beach, California and is called the H-Wave? device. The primary effect of the H-Wave?device is stimulation (HWDS) of small diameter fibers of “red-slow-twitch” skeletal muscle. Mechanisms of action of HWDS have been investigated in both animal and human studies. They include edema reduction, induction of nitric oxide dependent augmented microcirculation and angiogenesis, small muscle contraction that eliminates transcapillary fluid shifts, reducing the painful effects of tetanizing fatigue and gradual loading of healing injured muscle tissue that helps repair and remodeling. A recent metaanalysis found a moderate-to-strong-positive effect of the HWDS in providing pain relief, reducing the requirement for pain medication, with the most robust effect being increased functionality. We are proposing that GARS can be used to identify those at risk of developing opioid dependence and that the need for opioid analgesia can be reduced by use of this electro therapeutic alternative to opioid analgesia in the treatment of pain and injuries.

关键词： Microcirculation Angiogenesis Analgesic Therapy Electrical Device Stimulation Tissue Loading Remodeling Genetic Addiction Risk Score (GARS) Reward Deficiency Syndrome (RDS)

公共慈善、私营机构和国家干预:英格兰疯人的制度化护理(1600-1815)

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医疗社会史研究 2021年第1期11卷 116-135,317页

作者： [英]李奥纳多·史密斯傅益东(译) 赵炜煜(译) 伯明翰大学应用健康研究所南通大学历史系南京大学河南校信通教育科技有限公司

1600年至1815年是英国政治、经济和社会发生重大变革的时期之一。为社会伤病人员提供服务的范畴越来越广,其中包括那些患有精神疾病的人。1676年在伦敦重新开业的伯利恒医院规模宏大,成为公共慈善事业的典范。18世纪,其他精神病院在伦... 详细信息

1600年至1815年是英国政治、经济和社会发生重大变革的时期之一。为社会伤病人员提供服务的范畴越来越广,其中包括那些患有精神疾病的人。1676年在伦敦重新开业的伯利恒医院规模宏大,成为公共慈善事业的典范。18世纪,其他精神病院在伦敦等城市相继建立。此类机构主要为贫民提供服务。然而,社会中上层人群中日益严重的精神错乱问题也刺激了私营事业的发展。从1650年起,“私立疯人院”在伦敦乃至整个英国逐渐兴起,截至1800年至少已有60家机构成立。它们提供给病人的服务条件差异悬殊,这引起了公众关注度的与日俱增,并使政府在1774年予以立法管控。来自改革者的压力导致1808年立法的实现,国家开始资助疯人院的筹建工作。1815年,政府主导的一次重大调查,旨在将针对服务精神失常群体的公立和私立机构在实践过程中的优缺点公之于众。

关键词：社会阶层疯人院精神病院

A Case Study in the Use of Capsaicin in the Treatment of Neuropathic Chest Wall Pain and Post-thoracotomy Intercostal Neuralgia

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Open Journal of Anesthesiology 2012年第4期2卷 99-101页

作者： Charles Roberts leonard Morgan Kanisha Hall Prashant Kumar Stacy J.smith Department of Anesthesiology and Interventional Pain LSU Health Science Center School of MedicineShreveportUSA

Off label use of Quetenza? (capsaicin 8%) patch in relieving post-thoracotomy neuropathic pain proved temporarily effective, but to a degree indicating limited usefulness in a clinical setting.A 57 year-old male with chronic post-thoracotomy pain was treated with 8% capsaicin topically. Pre-procedure pain was rated as 8 on a 10 point scale, the 30 minute post procedure pain was reported as 2 - 3 on a 10 point scale. Neuralgia was completely resolved for the initial 48 hours post-procedure, then returned gradually over the next 5 days. Because pain transmission pathways are the same in post herpetic and post traumatic neuralgias, the use of 8% capsaicin merits additional study.

关键词： Post-thoracotomy Neuralgia Capsaicin Qutenza^(█)

Recent advances in targeting the“undruggable”proteins:from drugdiscover to clinical trials

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4477-4547页

作者： Xin Xie Tingting Yu Xiang Li Nan Zhang leonard J.Foster Cheng Peng Wei Huang Gu He State Key Laboratory of Southwestern Chinese Medicine Resources College of Medical Technology and School of PharmacyChengdu University of Traditional Chinese Medicine611137 ChengduChina Michael smith Laboratories University of British ColumbiaVancouverBC V6T 1Z4Canada Department of Dermatology and State Key Laboratory of Biotherapy West China HospitalSichuan University610041 ChengduChina

Undruggable proteins are a class of proteins that are often characterized by large,complex structures or functions that are diffcult to interfere with using conventional drug design *** such undruggable targets has been considered also a great opportunity for treatment of human diseases and has attracted substantial efforts in the field of ***,in this review,we focus on the recent development of drug discovery targeting"undruggable"proteins and their application in *** make this review well organized,we discuss the design strategies targeting the undruggable proteins,including covalent regulation,allosteric inhibition,protein-protein/DNA interaction inhibition,targeted proteins regulation,nucleic acid-based approach,immunotherapy and others.

关键词： drug diseases clinical

名人偶像去世，幽灵律师登场迈克尔·杰克逊遗产管理指南

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商业周刊（中文版） 2017年第3期 72-77页

作者： Devin leonard Angie smith 汪泽王忠

迈克尔·杰克逊（Michael Jackson）2009年因过砒注射异丙酚和劳拉两泮致死，八年后的今天，八卦这位流行音乐巨星的缄口期显然已经过去。在美国总统唐纳德·特朗普（Donald Trump）竞选期间，尚未成为第一夫人的梅兰妮·特朗普（Melani... 详细信息

迈克尔·杰克逊（Michael Jackson）2009年因过砒注射异丙酚和劳拉两泮致死，八年后的今天，八卦这位流行音乐巨星的缄口期显然已经过去。在美国总统唐纳德·特朗普（Donald Trump）竞选期间，尚未成为第一夫人的梅兰妮·特朗普（Melania Truinp）向奢侈品杂志《Du Jour》讲述杰克逊曾经恶作剧地建议他俩接吻，好让她丈夫嫉妒。

关键词：杰克逊迈克尔遗产管理去世偶像名人律师幽灵

雌、雄草原田鼠外周骨骼肌肌球蛋白重链的表达(英文)

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动物学报 2008年第1期54卷 104-110页

作者： Andrew C. FRY Michael H. FERKIN Brian K. SCHILLING Stuart T. leonard Matthew P. HARBER Martyn R. RUBIN J. Chadwick smith Department of Health Sport & Exercise Sciences The University of Kansas Lawrence KS 66045 USA Department of Biology The University of Memphis Memphis TN 38152 USA Department of Health and Sport Sciences The University of Memphis Memphis TN 38152 USA

已往的研究对于实验室应用的各种啮齿类动物,如大鼠和小鼠骨骼肌蛋白表达的特性已有报道。然而,至今不清楚其它啮齿类动物如野生鼠骨骼肌蛋白的表达或性双态性的特征,而这些野生鼠的行为学、形态学及生理学特点均已有报道。已知骨骼肌... 详细信息

已往的研究对于实验室应用的各种啮齿类动物,如大鼠和小鼠骨骼肌蛋白表达的特性已有报道。然而,至今不清楚其它啮齿类动物如野生鼠骨骼肌蛋白的表达或性双态性的特征,而这些野生鼠的行为学、形态学及生理学特点均已有报道。已知骨骼肌的肌球蛋白重链( MHC)成分与其功能特性有关。我们研究了草原田鼠的肱三头肌、胫骨前肌、腓肠肌和比目鱼肌MHC蛋白表达的性别特性。应用SDS聚丙烯酰胺凝胶电泳法测定MHCⅠ型、Ⅱa型、Ⅱd/x和Ⅱb型的蛋白表达相对含量。结果表明:与雌鼠相比,雄鼠的比目鱼肌湿重较大,胫骨前肌的MHCⅡa蛋白量表达较高。未见骨骼肌重量及MHC蛋白表达含量在雌雄鼠间的性别差异。血中睾酮的浓度差异可能不影响外周骨骼肌蛋白的表达特性。然而,与过去在大鼠、兔和小鼠中的已报道的结果相比,草原田鼠骨骼肌MHC的表达显示了更多异质性。推测这可能与草原田鼠和其它小型哺乳类动物生存的自然环境和功能需要有关。

关键词：性二态性骨骼肌蛋白同分异构性别

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石英微量天平/热传导量热仪

生命科学仪器 2007年第5期5卷 28-32页

作者： AllanL.smith Masscal Corp. 96 A. Leonard WayChathamMA 02633U.S.A.

石英微量天平是一种新型高效的薄膜热分析和热量测定仪器。薄膜的物理和化学性质均可以在此仪器上得到研究。水的吸附,药物薄膜的软化行为,富勒稀碳分子膜中溶剂的提取是其典型的应用。也可用于油漆和喷釉的烘干和加工以及通过监控质量... 详细信息

石英微量天平是一种新型高效的薄膜热分析和热量测定仪器。薄膜的物理和化学性质均可以在此仪器上得到研究。水的吸附,药物薄膜的软化行为,富勒稀碳分子膜中溶剂的提取是其典型的应用。也可用于油漆和喷釉的烘干和加工以及通过监控质量的变化和新陈代谢的放热进行营养环境中生长细菌的检测。

关键词：微量天平石英量热仪热传导测定仪器化学性质营养环境新陈代谢

A Case Study in the Use of Capsaicin in the Treatment of Neuropathic Chest Wall Pain and Post-Thoracotomy Intercostal Neuralgia

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