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The Production of Interleukin-8 is Increased in Plasma and Peripheral Blood Mononuclear Cells of Patients with Fatigue

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Neuroscience & Medicine 2012年第1期3卷 47-53页

作者： Matthew Sorenson leonard jason Athena Lerch Nicole Porter Jonna Peterson Herbert Mathews Department of Psychology DePaul University Chicago Illinois Microbiology and Immunology Loyola University Chicago Chicago Illinois United States Rush University Medical Center Chicago Illinois United States School of Nursing DePaul University Chicago Illinois United States

Background and Objective: Previous research has speculated on the role of pro- and inflammatory immune mediators in the etiologic process of fatigue, with contrasting findings. The preponderance of the evidence supports the role of inflammatory mediators in the disease process of Chronic Fatigue Syndrome (CFS). The purpose of this study was to evaluate the production of interleukin (IL)-8 by peripheral blood mononuclear cells derived from individuals with chronic fatigue. A secondary objective was to determine if there was a significant relationship between IL-8 production and plasma cortisol level. Materials and Methodology: Data was collected from three groups, a sample of individuals with CFS (n = 15), a comparison sample of individuals with fatigue that did not meet criteria for CFS (n = 30) and a group of putatively health normative controls (n = 23). Peripheral blood was drawn and plasma samples derived. Peripheral blood mononuclear cells were stimulated with a mitogenic protocol and levels of IL8 in unstimulated and stimulated bulk supernatant determined. Results: Both fatigue groups displayed significantly higher levels of IL8 than the control group. The CFS group demonstrated higher levels of IL8 in plasma than the fatigue comparison group. Conclusion: The findings demonstrate a clear association between fatigue and IL8. The ability to identify an inflammatory marker in association with fatigue could provide a means of identifying those who may be at risk for the development of this disorder.

关键词： Cytokines Fatigue Interleukin PBMC

Continued Successful SA Recovery during the Maintenance Stage: Intra-Individual Resource Loss &Gain Predict Relapse

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Open Journal of Medical Psychology 2012年第1期1卷 1-7页

作者： Lisa C. Walt Ed Stevens leonard A. jason Joseph R. Ferrari DePaul University.

Objectives: We combine Hobfoll’s Conservation of Resources (COR) theory and key components of self-help group “step work” ideology to investigate how dynamic changes in key intra-individual resource loss and gains (self-esteem, abstinence self-efficacy, existential growth) influence relapse rates in a sample of individuals in the Maintenance Stage of substance abuse recovery. Methods: Participants (n = 579) completed two surveys over a nine month period that assessed baseline and changes in intra-individual loss and gain resources as well as relapse rates over study course. Multiple regression analyses were performed to predict whether baseline and dynamic changes in intra-individual scores predict relapse rates over time. Results: Individuals that reported lower levels of resource gain at baseline, as well as decreased gain trajectories and increased loss trajectories over time were more likely to relapse. Conclusions: Findings support self-help group “step work” models and the application of COR theory for relapse likelihood prediction in a sample of individuals in longer term substance abuse recovery. Research efforts should examine the complex relationship between these dynamic intra-individual resources, social cognition, self-regulation and relapse risk. Future interventions should address the importance of the continual development and protection of these valuable intra-individual resources to prevent relapse.

关键词： Substance Abuse Core Maintenance

Subgroups of chronic fatigue syndrome based on psychiatric disorder onset and current psychiatric status

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Health 2010年第2期2卷 90-96页

作者： Molly M. Brown Carly Kaplan leonard A. jason Christopher B. Keys 不详

Few studies have examined the effects of psy-chiatric disorders occurring over a long dura-tion among patients with chronic fatigue syn-drome (CFS). The role of premorbid and current psychiatric disorders in impairment was ex-plored with a sample of 113 participants with CFS. Subgroups were created based on past and current psychiatric status including those whose psychiatric history was premorbid and current, postmorbid and current, past but not current, and those with no lifetime diagnosis. Results from a one-way MANOVA revealed that patients with a premorbid and current psychiat-ric disorder reported significantly higher pain severity, more somatic symptoms, poorer sleep quality, and poorer quality of life than those with no psychiatric history. Levels of fatigue and physical functioning among patients with CFS were unrelated to the four subgroups in this study. Although those with a premorbid and current psychiatric disorder were differentiated from those with no psychiatric history on some markers of impairment, the sample as a whole had severe fatigue-related impairment, which is the cardinal symptom of CFS. Implications for research are discussed.

关键词： Chronic Fatigue Syndrome Psychiatric Comorbidity Subgroups Impairment

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索尼音乐CEO古稀老将搏激流

商业周刊（中文版） 2013年第8期 92-97页

作者： Devin leonard jason Nocito(摄影) 小凡(译)

现年74岁的索尼音乐娱乐公司（Sony Music Entertainment）首席执行官道格·莫里斯（Doug Morris）七世纪50年代在纽约长岛长大．按他自己的话说．

关键词：音乐索尼 CEO 首席执行官娱乐公司 50年代莫里斯长岛

Ultra-large aluminum shape casting:Opportunities and challenges

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China Foundry 2024年第5期21卷 397-408页

作者： Qi-gui Wang Andy Wang jason Coryell Advanced Materials Technology&Virtualization GM Global Technical CenterWarrenMI USA

Ultra-large aluminum shape castings have been increasingly used in automotive vehicles,particularly in electric vehicles for light-weighting and vehicle manufacturing cost *** most of them are structural components subject to both quasi-static,dynamic and cyclic loading,the quality and quantifiable performance of the ultra-large aluminum shape castings is critical to their success in both design and *** paper briefly reviews some application examples of ultra-large aluminum castings in automotive industry and outlines their advantages and *** affecting quality,microstructure and mechanical properties of ultra-large aluminum castings are evaluated and discussed as aluminum shape casting processing is very complex and often involves many competing mechanisms,multi-physics phenomena,and potentially large uncertainties that significantly influence the casting quality and *** analysis and mechanical property assessment of an ultra-large aluminum shape casting are *** are highlighted and suggestions are made for robust design and manufacturing of ultra-large aluminum castings.

关键词： ultra-large castings aluminum light-weighting quality microstructure materials properties

Piezoelectric resonant ice protection systems–Part1/2:Prediction of power requirement for de-icing a NACA 0024 leading edge

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Chinese Journal of Aeronautics 2024年第3期37卷 92-103页

作者： Valerian PALANQUE jason POTHIN Vale′rie POMMIER-BUDINGER Marc BUDINGER Institut Clement Ader University of ToulouseINSAISAE-SUPAEROMINES ALBIUPSCNRSToulouse 31055France ISAE-SUPAERO University of Toulouse10 Avenue Edouard BelinToulouse 31055France

This paper proposes a numerical method to analyze the ice protection capability and predict the power requirements of a piezoelectric resonant de-icing *** method is based on a coupled electro-mechanical finite element analysis which enables the fast computation of the modes of resonance of interest to de-ice curved surfaces and the estimation of the input voltage and current required for a given configuration(defined by its mode,actuator location,ice deposit,etc.).Eventually,the electric power to be supplied can be also *** method is applied to a NACA 0024 leading edge equipped with piezoelectric ***,two extension modes are analyzed and compared with respect to their efficiency and power ***,tests are carried out in an icing tunnel to verify the effectiveness of the piezoelectric ice protection system and the predictions of the maximal required *** system allows de-icing the leading edge in less than 2 s for a glaze ice deposit.

关键词： Ice protection system Piezoelectric Resonance mode Ice fracture Leading edge de-icing

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov jason H.Huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

Alcohol intolerance and myalgic encephalomyelitis/chronic fatigue

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World Journal of Neurology 2023年第3期9卷 17-27页

作者： Jessica Maciuch leonard A jason Center for Community Research DePaul UniversityChicagoIL 60614United States

BACKGROUND The literature is mixed about the occurrence of alcohol intolerance among patients with myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS).Surveys that asked respondents with ME/CFS whether they experienced alcohol intolerance within a recent time frame might produce inaccurate results because respondents may indicate that the symptom was not present if they avoid alcohol due to alcohol *** To overcome this methodologic problem,participants in the current study were asked whether they have avoided alcohol in the past 6 mo,and if they had,how severe their alcohol intolerance would be if they were to drink *** The instrument used was a validated scale called the DePaul symptom *** t-tests were performed among the alcohol intolerant or not alcohol intolerant *** alcohol intolerant group had 208 participants,and the not alcohol intolerant group had 96 *** Using specially designed questions to properly identify those with alcohol intolerance,those who experienced alcohol intolerance vs those who did not experience alcohol intolerance experienced more frequent/severe symptoms and *** addition,using a multiple regression analysis,the orthostatic intolerance symptom domain was related to alcohol *** The findings from the current study indicated that those with ME/CFS are more likely to experience alcohol *** addition,those with this symptom have more overall symptoms than those without alcohol intolerance.

关键词： Myalgic encephalomyelitis/chronic fatigue syndrome Alcohol intolerance Orthostatic intolerance DePaul symptom questionnaire Symptom burden Methodology

Modeling displacement flow inside a full-length casing string for well cementing

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Petroleum Research 2024年第1期9卷 1-16页

作者： Hu Dai Ali Eslami jason Schneider Gefei Liu Fred Schwering Pegasus Vertex Inc.USA Laval University Canada Sanjel Energy Services Canada Athabasca Oil Corporation Canada

While computer modeling of annular displacement efficiency is widely applied in cementing engineering,modeling the displacement flow inside a casing or drill string for cementing operations has received less *** predicting displacement efficiency inside a full-length pipe is desired by cementing engineers,the attempt of developing a model with both efficiency and accuracy faces *** to computer simulators for this purpose is *** with annular flow,the displacement flow inside pipe,although within a simpler geometry and without eccentricity effect,is not simpler in physics,modelling strategy and predictability,because a variety of flow patterns and flow instabilities can develop to create complicated fluid *** this paper,we present an integrated numerical model developed to simulate displacement flows inside a full-length pipe,which connects an existing annulus model to enable complete displacement simulations of cementing *** model uses three-dimensional grid to solve fluid concentrations with degrees of mixing,and incorporates flow instability detection and flow regime *** in cementing,the model accounts for effects of pumping rate,well inclination,pipe rotation,fluid densities,rheological parameters and *** computationally efficient model does not rely on high-resolution mesh as often required by conventional Computational Fluid Dynamics models,thus it is suitable to be implemented in a cementing software for daily use by well cementing *** methodology of the model is discussed in detail in this *** validate the model,we examine simulation results against experimental results obtained in our laboratory tests and CFD simulations;acceptable agreement is found under different testing *** also presented two case studies of real cementing jobs with cement evaluation logs compared to simulation results,showing that the model can predict consistent displacement efficie

关键词： Inside pipe displacement Displacement efficiency Numerical model Primary cementing Displacement flow